Drug delivery

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RESOMER® Biodegradable Polymers for Medical Device Applications Research

Find use of RESOMER® biodegradable polymers in medical device applications research.

Gold Nanoparticles: Properties and Applications

Gold (Au) nanoparticles have tunable optical and electronic properties and are used in a number of applications including photovoltaics, sensors, drug delivery & catalysis.

Quantum Dots

Quantum dots are tiny particles or nanocrystals of a semiconducting material with diameters in the range of 2-10 nanometers.

Poly(Glycerol Sebacate) in Tissue Engineering and Regenerative Medicine

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long

Injectable Hydrogels for Cell Delivery and Tissue Regeneration

The use of hydrogel-based biomaterials for the delivery and recruitment of cells to promote tissue regeneration in the body is of growing interest. This article discussed the application of hydrogels in cell delivery and tissue regeneration.

Tools for PEGylation

Polyethylene glycol (PEG) reagents offer numerous favorable characteristics, including high water solubility, high mobility in solution, lack of toxicity and immunogenicity, and ready clearance from the body.

Applications of Y-Shape Peg Derivatives for Drug Delivery

The immune system protects the body from disease by resisting the invasion of foreign molecules into its cells, for example peptides and proteins are hydrolyzed by proteolytic enzymes; nucleic acids are hydrolyzed by nucleases; and most small molecules are eliminated

Biodegradable Polyester Based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

What Are Biomaterials?

Biocompatible / Biodegradable Polymer Tutorial

Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1Mn

Poly(2-oxazoline)s (POx) in Biomedical Applications

Poly(2-oxazoline)s (POx) can be viewed as conformational isomers of polypeptides. They are synthesized via living cationic ringopening polymerization (LCROP) of 2-oxazolines and were almost simultaneously discovered in 1966 by the groups of Litt, Tomalia, Fukui and Seeliger.

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Fabrication of Drug-loaded Microparticles Using Hydrogel Technology and Recent Innovation in Automation

Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a

Use of Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Bioimaging

Our highly fluorescent iron oxide incorporated conjugated polymer nanoparticles (CPNs) have an iron oxide and semiconductor light emitting polymer core, encapsulated within a biocompatible surfactant. The multi-modal particles can be used in both fluorescence and magnetic resonance imaging. Learn more

Layer-by-Layer (LbL) Assembly, A "Gentle Yet Flexible" Method Toward Functional Biomaterials

Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the

Functional RAFT Polymers for Biomedical Applications

Reversible addition–fragmentation chain transfer (RAFT) polymerization is rapidly moving to the forefront in construction of drug and gene delivery vehicles.

Delivery of Nucleic Acids Using Polymers

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Degradex® Microspheres and Nanoparticles for Drug Delivery Research and Formulation Development

Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique

Halloysite Nanotubes Applications in Nanomaterials Research

Halloysite Nanotubes in Nanomaterials Research. Halloysite, a naturally occurring aluminosilicate nanotube, has been undeservedly forgotten.

Preparation of Chitosan Microparticles by Spray Drying

Microparticles with controlled size and morphology are of significant interest in the fields of drug delivery and biopharmaceuticals. The objective of this study was to assess the effect of processing parameters on the ability to control the size and distribution

Chitosan-based Biomaterials

Chitin, a natural polysaccharide, is the second most abundant natural biopolymer in the world, after cellulose.

Polyethylene Glycol Building Blocks for PEGylation

Sigma-Aldrich.com presents an article regarding Polyethylene Glycol Building Blocks for PEGylation.

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

Poly(2-Oxazoline)s: The Versatile Polymer Platform for Biomedicine

The introduction of polymers into the biomedical field has opened new avenues in tissue engineering, implant design, biosensing, and drug delivery.

Dendrons and Hyperbranched Polymers: Multifunctional Tools for Materials Chemistry

Dendrons in nanomaterials - Find features and benefits of polyester dendrons and hyperbranched polymer products.

Silica-coated Gold Nanoparticles: Surface Chemistry, Properties, Benefits and Applications

In the past few decades, research and commercial use of gold nanoparticles has rapidly expanded into fields extending from biomedical engineering to photovoltaics. Most applications take advantage of the excellent optical properties of gold nanoparticles, which can be fine-tuned by

Iron Oxide Nanoparticles, Characteristics and Applications

Iron oxide (IO) nanoparticles consist of maghemite (γ-Fe2O3) and/or magnetite (Fe3O4) particles with diameters ranging from 1 and 100 nanometer and find applications in magnetic data storage, biosensing, drug-delivery etc.

Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation

Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.

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