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BASIONICS™, BASF’s Portfolio of Ionic Liquids
Under the trade name BASIONICS™, BASF offers a portfolio of Ionic Liquids—mainly based on imidazolium cations. The BASIONICS™ portfolio opens up a broad range of basic properties of Ionic Liquids and is classified into standard, acidic, basic, liquid at RT
N-Heterocyclic Carbene Ligands
A wide range of NHC ligands are commonly available which exhibit high activities.
Applications for Bis(pyridine)iodonium Tetrafluoroborate
Bis(pyridine)iodonium tetrafluoroborate is a mild iodinating and oxidizing reagent capable of selectively reacting with a wide range of unsaturated substrates and tolerates a variety of functional groups.
Ionic Liquids
Ionic Liquids have experienced a comet-like boost in the last few years. In this edition of ChemFiles, we highlight some current applications of this fascinating class of new materials. We present over 50 new additions to our portfolio of 130+
Organic Azides and Azide Sources
Since the preparation of the first organic azide, phenyl azide, by Peter Griess in 1864 this energy-rich and versatile class of compounds has enjoyed considerable interest.
Dess–Martin Periodinane
Dess-Martin Periodinane is used for the mild oxidation of alcohols to aldehydes and ketones. The neutral condition of the reaction makes DMP suitable for syntheses of sensitive, functionally complex intermediates.
Task-Specific Ionic Liquids
Task-Specific Ionic Liquids (TSILs) for the selective liquid/liquid extraction of heavy metals from aqueous systems were first published by Robin D. Rogers et al. in the year 2001.
Oxidizing and Reducing Agents
Oxidation and reduction reactions are some of the most common transformations encountered in organic synthesis
BINAP/SEGPHOS® Ligands and Complexes
We present an article concerning BINAP/SEGPHOS® Ligands and Complexes.
Imidazolium Derived Reagents
N-Acylimidazoles were recognized in the early 1950s as reactive intermediates suitable for the acylation of amino compounds. The search for better coupling reagents than DCC led to the development of CDI (1,1’-carbonyldiimidazole) and related carbonylimidazoles.
Functionalized Silica Gels for Organic Synthesis
Functionalized silica gel is used in size-exclusion chromatography of cationic polymers and in the separation of sugars, steroids, cholesterol, and triglycerides.
Organosilanols
Over the past several years, the Pd-catalyzed cross-coupling of silicon compounds (Hiyama coupling) has rapidly gained acceptance as a suitable alternative to more commonly used methods such as Stille (Sn), Kumada (Mg), Suzuki (B), and Negishi cross-couplings (Zn).
KitAlysis™ High-Throughput Screening Platform
KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.
BINOL and Derivatives
We present an article concerning BINOL and Derivatives.
Chiral Alcohols
Chiral Alcohols
Asymmetric Reduction of Ketones
The enantioselective reduction of ketones to alcohols gives access to a pool of chiral building blocks that can be used for the synthesis of natural products. Adolfsson and co-workers reported a novel class of ligands, based on a pseudo-dipeptide, for
Selective Metalations
Selective Metalations using i-PrMgCl·LiCl and s-BuMgCl·LiCl
Mild Mg – Halogen Exchange
Substantial progress has been made in magnesium–halogen exchange reactions used for the preparation of functionalized Grignard reagents containing sensitive moieties such as ester or cyano groups.
Q-Phos
Developed by Professor John Hartwig, pentaphenyl(di-tert-butylphosphino)ferrocene (Q-Phos) has emerged to be a premier ligand in coupling reactions with its remarkably broad utility in a variety of C–N, C–O, and C–C bondforming reactions.
PYBOX Ligand - Large Binding Site & Rigid Scaffold
The PYBOX ligand, consisting of a pyridine ring flanked by two oxazoline groups, was introduced in 1989 by Nishiyama.
Tetrakis(dimethylamino)ethylene (TDAE)
In 2001, Professor William Dolbier, Jr., at the University of Florida reported1 an approach to nucleophilic trifluoromethylation based on the generation of a trifluoromethyl anion using CF3I in the presence of a powerful twoelectron reductant, tetrakis(dimethylamino)ethylene (TDAE)
Phosgene and Phosgene Substitutes
Phosgene is 170 times more reactive than TP, the main phosgene substitute. Therefore, reactions with phosgene can be carried out under much milder conditions than with TP. Compounds will react faster and at lower temperatures (often at -78°C), preserving sensitive
Solvent Stabilizer Systems
A description of stabilizer systems for solvents including esters, ethyl ester, tetrahydrofuran, chlorinated solvents, chloroform and dichloromethane.
Scale-Up Guide: Photocatalysis Reaction
Scale-Up Guide for Photocatalysis Reaction to best enable scale-up success with High-Throughput Screening Kit.
Greener Methods: Catalytic Amide Bond Formation
We are proud to offer a number of products used in catalytic amidation technology.
Aldol Condensation Reaction
The aldol condensation reaction is an organic reaction introduced by Charles Wurtz, who first prepared the β-hydroxy aldehyde from acetaldehdye in 1872.
Glycosyltransferases: Tools for Synthesis and Modification of Glycans
The presence of multiple functional groups and stereocenters in complex carbohydrates makes them challenging targets for the organic chemist.
Spirocyclic Building Blocks for Scaffold Assembly
Spirocyclic modules containing four-membered rings are currently of growing interest to discovery chemists.
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