Small Molecules Analysis and Quality Control

Applied Filters:

facet applications:Small Molecules Analysis and Quality Control

facet content type:Technical Article

Showing 1-30 of 32 results

Optimising the LC-MS Analysis of Biomolecules

We present an article concerning optimising the LC-MS analysis of biomolecules.

Evaluation of Different Enzymes on Hydrolysis Efficiencies of Glucuronide Drug Metabolites in Urine

β-glucuronidase (GUS) enzymes are utilized to hydrolyze glucuronide (gluc) drug metabolites to the parent drug, facilitating analysis by LC-MS/MS.

Improving HILIC Mode Chromatography by Choosing the Proper Injection and Wash Solvent

Chromatographic Selectivity

Harnessing the Power of Chromatographic Selectivity

BIOshell™ A400 Protein C4 U/HPLC Columns

BIOshell™ A400 Protein C4 columns contain 3.4 μm particles with 400 Å pores, which are derivatized with dimethylbutyl silane and exhaustively endcapped for optimum protein recovery.

Extractables Studies of Single-Use Equipment Immediate Identification and Quantification of Unknown Extractables by GC/MS with a Certified Reference Material Mix for Extractables and Leachables

Identification and quantification of the most common extractables originating from single-use equipment by GC/MS and an Extractables and Leachables Screening Standard.

Sample Cleanliness Using BioSPME

Learn about Supel™ BioSPME C18 96-pin tool to prepare a clean sample with minimal matrix effects for an LC-MS/MS analysis from human plasma and its comparison with acetonitrile-based precipitation.

BioSPME for Plasma Protein Binding Assay: Details of Method Development and Optimization

Determination of plasma protein binding using a SupelTM C18 pin device based BioSPME method for efficient sample preparation, along with a comparison to the equilibrium dialysis method.

HPLC Troubleshooting Guide

Correct common HPLC issues to restore column performance, addressing peak problems, retention time, noise, and resolution with chromatograms.

HPLC Separation of Nitrosamines with Supel Carbon LC

Discover the efficient separation six nitrosamine impurities with high reproducibility and precise detection to ensure accurate analysis for regulatory compliance.

Caffeinated Energy Drink Analysis by HPLC

Ascentis Express Fused-Core® columns optimize HPLC experiments with efficient and selective phases for maximum information retrieval.

Analysis: Activated Nucleotide Sugars by LC-MS/MS

LC-MS/MS method quantifies similar polar nucleotide activated sugars using Supel™ Carbon LC column for simultaneous analysis.

Organic impurity profiling of Valacyclovir using TLC

Thin-layer chromatography method for detecting organic impurities in valacyclovir, an antiviral medication, following USP monograph guidelines.

Determination of Baicalin, Chlorogenic acid and Forsythin

Analyze Shuanghuang Lian oral liquid using Discovery® HS C18 HPLC column per Chinese Pharmacopeia 2020. Quantify baicalin, chlorogenic acid, and forsythin with high accuracy.

Analysis of Antioxidants in Bakery Products

HPLC-UV method detects 9 antioxidants like propyl gallate in food using a Discovery®</sup HS C18 column for excellent peak shapes.

Workflow for the Analysis of Polysorbate 80 in Erbitux® Formulation

A complete reversed phase HPLC-ELSD workflow, including sample preparation for the analysis of Polysorbate 80 in a monoclonal antibody formulation.

Quantitative Analysis of Nitrosamine Impurities by LC-MS Methods from the United States Pharmacopeia General Chapter <1469>

This application note describes the LC-MS-based quantitative analysis of known nitrosamine impurities following procedures 1 and 3 as given in USP general chapter .

Efficient Analysis of Kava Extract: New phytochemical certified reference material mixes for ginger and kava

Learn more about our Kava CRM solution for use in quantitative and qualitative analysis of kavalactones and flavokavains in kava products to confirm their potency and authenticity.

HPLC Assay and Impurity Profiling Methods for Safinamide and Safinamide Related Impurities

A sensitive and reproducible HPLC-DAD method for the purity analysis of safinamide and its related impurities using an Ascentis® Express C8 column (150 x 4.6 mm, 5 μm), meeting the system suitability criteria.

Protein Binding Determination Using Supel™ BioSPME C18 Pin Device as Part of the Manual Methodology With and Without Shaking

The application note describes a comparative analysis of plasma protein binding results for free/bound drugs using two different sample extraction steps, with and without agitation.

Piroxicam Capsules-Assay and Organic Impurities Following United States Pharmacopoeia Pending Forum Method

A reversed-phase high-performance liquid chromatography (RP- HPLC) based quantitative assay and organic impurity analysis of Piroxicam in its capsule dosage form.

Analysis of Arbutin and Hydroquinone in whitening serum

Development of an HPLC-UV method to determine Arbutin and Hydroquinone in whitening serum using a Chromolith® HighResolution C18 100x2mm HPLC column.

Speed, Simplicity and Accuracy of Protein Binding Determination using BioSPME

Learn about Supel™ BioSPME C18 high-throughput devices to determine plasma protein binding and decrease the sample preparation time to less than an hour.

Fluticasone Propionate Assay by HPLC UV USP Monograph

Learn how the Purospher® STAR RP-18e Hibar® HPLC column meets the system suitability criteria outlined in the USP monograph for the fluticasone propionate assay.

Milliflex Oasis^® Filtration System

Milliflex Oasis® system monitors bioburden in various samples, increasing lab productivity.

Gabapentin Assay: Ph. Eur. Monograph

LC-MS/MS quantitative method analyzes highly polar 11 nucleotide activated sugars using Supel™ Carbon LC column.

Newly Developed Porous Graphitic Carbon in U/HPLC

Polar graphitic carbon enables UHPLC separation of highly polar pesticides, herbicides, and Vitamin D metabolites, advancing liquid chromatography capabilities.

Extractables Study with LC-UV/MS

Ascentis® C18 column facilitates LC-UV/MS analysis of extractables from single-use systems, ensuring reliable identification and quantification.

N-Nitrosamines Determination in Valsartan

GC-MS method detects nitrosamines in Valsartan tablets, meeting US FDA guidelines for pharmaceutical quality control.

Assay of Betamethasone Sodium Phosphate by HPTLC

Development of an HPTLC based method, using Silica Gel 60 F254 plate, to determine Betamethasone Sodium Phosphate over a concentration range of 1 to 7 µg/spot.

Page 1 of 2