Tissue engineering
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Poly(Glycerol Sebacate) in Tissue Engineering and Regenerative Medicine
The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long
Injectable Hydrogels for Cell Delivery and Tissue Regeneration
The use of hydrogel-based biomaterials for the delivery and recruitment of cells to promote tissue regeneration in the body is of growing interest. This article discussed the application of hydrogels in cell delivery and tissue regeneration.
Substituting Strat-M® Membrane for Human Skin in Evaluating Effect of Encapsulation on Diffusion of Sunscreen Formulations
Understand how a Strat-M synthetic membrane model can be an alternative to human or animal skin when screening for effectiveness of encapsulation on reducing transdermal diffusion of skin care actives
Tools for PEGylation
Polyethylene glycol (PEG) reagents offer numerous favorable characteristics, including high water solubility, high mobility in solution, lack of toxicity and immunogenicity, and ready clearance from the body.
Mesoporous Materials Synthesis
Mesoporous materials are formed by a self-assembly process from combined solutions of sol-gel precursors (e.g., metal alkoxides) and structure-directing amphiphiles, usually block-copolymers or surfactants.
Biomedical Implant Devices Fabricated from Low Young’s Modulus Titanium Alloys Demonstrating High Mechanical Biocompatibility
Biomedical implants are essentially foreign substances within the human body that must survive many years’ exposure to demanding mechanical and physiological conditions. Despite these challenges, metal implants have been widely used to substitute for or rebuild hard tissues such as
Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique
Preparation of Chitosan Microparticles by Spray Drying
Microparticles with controlled size and morphology are of significant interest in the fields of drug delivery and biopharmaceuticals. The objective of this study was to assess the effect of processing parameters on the ability to control the size and distribution
Chitosan-based Biomaterials
Chitin, a natural polysaccharide, is the second most abundant natural
biopolymer in the world, after cellulose.
Polymersomes for Drug Delivery
The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.
Poly(2-Oxazoline)s: The Versatile Polymer Platform for Biomedicine
The introduction of polymers into the biomedical field has opened new avenues in tissue engineering, implant design, biosensing, and drug delivery.
3D Printing Graphene Ink: Creating Electronic and Biomedical Structures and Devices
Since its discovery little more than a decade ago,1 the two-dimensional (2D) allotrope of carbon—graphene—has been the subject of intense multidisciplinary research efforts.
Dendrons and Hyperbranched Polymers: Multifunctional Tools for Materials Chemistry
Dendrons in nanomaterials - Find features and benefits of polyester dendrons and hyperbranched polymer products.
Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering
Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.
Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation
Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.
Microfluidics for Nanoencapsulation of Nucleic Acids Using Polymeric Carriers
Microfluidic assembly can efficiently overcome the general disadvantages of polyamine nanoencapsulation of nucleic acids, such as a less defined morphology and composition, polydispersity, and poor reproducibility.
Electrospinning: An Enabling Technique for Nanostructured Materials
In this article, we discuss issues critical to successful application of the electrospinning technique, including control of individual nanofibers to form secondary structures and assembly of nanofibers into 3D architectures.
Three-Dimensional Printing of Tissue Engineering Scaffolds
We will explore the technological advances that have contributed toward the progress of 3DP of tissue engineering scaffolds, current materials used to create 3DP scaffolds, and the challenges that remain.
Biogelx™ Peptide Bioinks
Biogelx™ self-assembling, non-animal-derived peptide products have rapidly gained a global reputation in the fields of 2D and 3D cell culture applications. The materials’ unique ability to emulate specific physical properties of a wide range of tissue types offers new opportunities
Stimuli-Responsive Materials as Intelligent Drug Delivery Systems
By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.
Photo-Crosslinkable Gelatin Hydrogel: Versatile Materials for (High Resolution) Additive Manufacturing
Discussion of synthetic modifications to gelatin, improving the three-dimensional (3D) print resolution, and resulting material properties.
Bioprinting for Tissue Engineering and Regenerative Medicine
In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.
RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering
Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.
Functional Polymers for Biomedical Applications
Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiphilic polymers, and stimuli responsive polymers have been prepared using controlled and directed functionalization
Chemistry in (Bio)Materials Science
"Click" Chemistry in (Bio)Materials Science
Photocrosslinkable Hydrogels for 3D Cell Culture and Tissue Engineering
Methacrylated collagen, hyaluronic acid, and gelatin (GelMA) hydrogels can be crosslinked with light and photoinitiators (Irgacure/LAP/Ruthenium), used as 3D cell culture scaffolds and bioinks for bioprinting.
Reversible Addition Fragmentation Chain Transfer (RAFT) Polymerization
RAFT (Reversible Addition Fragmentation chain Transfer) polymerization is a reversible deactivation radical polymerization (RDRP) and one of the more versatile methods for providing living characteristics to radical polymerization.
Protein- and Peptide- Polymer Conjugates by RAFT Polymerization
The modification of biomacromolecules, such as peptides and proteins, through the attachment of synthetic polymers has led to a new family of highly advanced biomaterials with enhanced properties.
Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions
Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.
Patterning of PEG-based Hydrogels - Engineering Spatial Complexity
In this article, we will discuss the benefits and limitations of several 2D and 3D scaffold patterning techniques that can be applied in the presence of cells. Although these methods will be discussed in the context of poly(ethylene glycol) (PEG)-based
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