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Showing 1-30 of 54 results for "FD40S" within Papers
Dan Vershkov et al.
Cell reports, 26(10), 2531-2539 (2019-03-07)
Fragile X syndrome (FXS) is caused primarily by a CGG repeat expansion in the FMR1 gene that triggers its transcriptional silencing. In order to investigate the regulatory layers involved in FMR1 inactivation, we tested a collection of chromatin modulators for
Gong Chen et al.
PloS one, 11(4), e0153288-e0153288 (2016-04-08)
To investigate the effects and underlying mechanism of dexmedetomidine on the cultured human dendritic cells (DCs). Human DCs and cytotoxic T lymphocytes (CTLs) were obtained from human cord blood mononuclear cells by density gradient centrifugation. Cultured DCs were divided into
Yun Mi Lee et al.
International journal of molecular sciences, 16(12), 29900-29910 (2015-12-24)
Ocular pathologic angiogenesis is an important causative risk factor of blindness in retinopathy of prematurity, proliferative diabetic retinopathy, and neovascular macular degeneration. Guibi-tang (GBT) is a frequently used oriental herbal formula in East Asian countries, and is also called Qui-pi-tang
Jianxin Chen et al.
Molecular medicine reports, 23(2) (2021-03-04)
Atezolizumab can reduce immunosuppression caused by T lymphocyte apoptosis in various cancer types. The current study aimed to investigate whether this drug can also alleviate immunosuppression during sepsis. For that purpose, a C57BL/6 mouse sepsis model was generated. Mice were randomly
Richard Beatson et al.
Communications biology, 3(1), 644-644 (2020-11-06)
The tumour microenvironment plays a crucial role in the growth and progression of cancer, and the presence of tumour-associated macrophages (TAMs) is associated with poor prognosis. Recent studies have demonstrated that TAMs display transcriptomic, phenotypic, functional and geographical diversity. Here
Yun Mi Lee et al.
BMC complementary and alternative medicine, 16, 231-231 (2016-07-21)
Retinal neovascularization, which is the pathological growth of new blood vessels, is associated with retinopathy of prematurity, neovascular age-related macular degeneration, diabetic retinopathy and retinal vein occlusion. In this study, we evaluated the effect of an extract of Cnidium officinale
Jong-Hee Ko et al.
Biomolecules, 10(6) (2020-06-21)
Although bevacizumab (Avastin®) has been approved as an antiangiogenic agent against some cancers, the efficacy is transient and unsatisfactory in other cancers most likely owing to the presence of alternative proangiogenic factors. Therefore, simultaneous blocking of several proangiogenic factors may
Jianxin Gao et al.
Immunology, 148(3), 253-265 (2016-02-16)
Sertoli cells (SCs) possess inherent immunosuppressive properties and are major contributors to the immunoprivileged status of mammalian testis. SCs have been reported to inhibit the activation of B cells, T cells and natural killer cells but not dendritic cells (DCs).
Kristina Krempaska et al.
Respiratory research, 21(1), 25-25 (2020-01-17)
Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease without a cure and new drug strategies are urgently needed. Differences in behavior between diseased and healthy cells are well known and drug response can be different between cells isolated
Rodrigo Berzaghi et al.
Frontiers in immunology, 12, 662594-662594 (2021-06-29)
Cancer-associated fibroblasts (CAFs) participate actively in tumor development and affect treatment responses, by among other mechanisms, promoting an immunosuppressive tumor microenvironment. In contrast to normal fibroblasts, reactive CAFs secrete a myriad of immunomodulatory soluble factors at high levels, i.e. growth
Fuyan Liu et al.
Marine drugs, 15(9) (2017-09-21)
The hard-shelled mussel (Mytilus coruscus) has been used as Chinese traditional medicine for thousands of years; however, to date the ingredients responsible for the various beneficial health outcomes attributed to Mytilus coruscus are still unclear. An α-d-Glucan, called MP-A, was
O Baron-Epel et al.
Planta, 175(3), 389-395 (1988-09-01)
The non-invasive technique of fluorescence redistribution after photobleaching was employed on soybean (Glycine max (L.) Merr.) root cells grown in suspension culture to examine macromolecular transport across plant cell walls. Using both fluorescently derivatized dextrans and proteins of graded size
Meenakshi Rao et al.
Gastroenterology, 153(4), 1068-1081 (2017-07-18)
When the glial fibrillary acidic protein (GFAP) promoter is used to express cellular toxins that eliminate glia in mice, intestinal epithelial permeability and proliferation increase; this led to the concept that glia are required for maintenance of the gastrointestinal epithelium.
Brigid Orr et al.
Veterinary research, 52(1), 142-142 (2021-11-26)
The intestinal epithelium plays a variety of roles including providing an effective physical barrier and innate immune protection against infection. Two-dimensional models of the intestinal epithelium, 2D enteroids, are a valuable resource to investigate intestinal cell biology and innate immune
Jeroen de Vrij et al.
International journal of cancer, 137(7), 1630-1642 (2015-03-25)
Glioblastoma multiforme (GBM) is the most common primary brain tumor and is without exception lethal. GBMs modify the immune system, which contributes to the aggressive nature of the disease. Particularly, cells of the monocytic lineage, including monocytes, macrophages and microglia
M S Gilardini Montani et al.
Autophagy, 15(4), 652-667 (2018-10-17)
EBV has been reported to impair monocyte in vitro differentiation into dendritic cells (DCs) and reduce cell survival. In this study, we added another layer of knowledge to this topic and showed that these effects correlated with macroautophagy/autophagy, ROS and
Thomas Colunga et al.
Cell reports, 26(10), 2566-2579 (2019-03-07)
In this report we describe a human pluripotent stem cell-derived vascular progenitor (MesoT) cell of the mesothelium lineage. MesoT cells are multipotent and generate smooth muscle cells, endothelial cells, and pericytes and self-assemble into vessel-like networks in vitro. MesoT cells transplanted
Chan-Sik Kim et al.
Molecular medicine reports, 12(5), 7279-7284 (2015-10-16)
In the pathophysiology of diabetic retinopathy (DR), advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) are thought to have important roles. It is known that VEGF causes a breakdown of the blood‑retinal barrier (BRB) and retinal neovascularization;
Don-Hong Wang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(3), 778-788 (2016-08-09)
Lung adenocarcinomas with mutations in the EGFR have unprecedented initial responses to targeted therapy against the EGFR. Over time, however, these tumors invariably develop resistance to these drugs. We set out to investigate alternative treatment approaches for these tumors. To
Deepthi Y Tulasi et al.
Cellular and molecular gastroenterology and hepatology, 11(5), 1437-1462 (2021-01-27)
Defining the genetic heterogeneity of intrahepatic biliary epithelial cells (BECs) is challenging, and tools for identifying BEC subpopulations are limited. Here, we characterize the expression of a Sox9EGFP transgene in the liver and demonstrate that green fluorescent protein (GFP) expression
Christina M McGuire et al.
The Journal of biological chemistry, 293(23), 9113-9123 (2018-03-16)
The vacuolar H+-ATPase (V-ATPase) is an ATP-driven proton pump involved in many cellular processes. An important mechanism by which V-ATPase activity is controlled is the reversible assembly of its two domains, namely the peripheral V1 domain and the integral V0
Yu-Chih Chen et al.
Lab on a chip, 14(16), 2941-2947 (2014-06-07)
Cancer-stromal cell interactions are a critical process in tumorigenesis. Conventional dish-based assays, which simply mix two cell types, have limitations in three aspects: 1) limited control of the cell microenvironment; 2) inability to study cell behavior in a single-cell manner;
Neil Y C Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(12), 5399-5404 (2019-03-06)
Three-dimensional renal tissues that emulate the cellular composition, geometry, and function of native kidney tissue would enable fundamental studies of filtration and reabsorption. Here, we have created 3D vascularized proximal tubule models composed of adjacent conduits that are lined with
M M Iversen et al.
Scientific reports, 8(1), 10257-10257 (2018-07-08)
Individuals suffering from Tullio phenomena experience dizziness, vertigo, and reflexive eye movements (nystagmus) when exposed to seemingly benign acoustic stimuli. The most common cause is a defect in the bone enclosing the vestibular semicircular canals of the inner ear. Surgical
Sandra Dittmar et al.
Journal of virology, 82(22), 11273-11282 (2008-09-05)
In order to analyze whether measles virus (MV) is transported via transmigrating leukocytes across endothelial barriers or whether virus spreads via infection of endothelial cells and basolateral release, we investigated the migratory behavior of infected human primary T lymphocytes across
Wei Yuan et al.
Microvascular research, 80(1), 148-157 (2010-04-07)
Previous studies have shown that the glycoprotein orosomucoid modulates permeability of peripheral microvessels to charged molecules by contributing to the net charge on the microvessel wall. To investigate whether or not orosomucoid also modulates the permeability of the blood-brain barrier
Erika M J Siren et al.
Scientific reports, 8(1), 7581-7581 (2018-05-17)
Here we present a simple technique for re-directing reactions on the cell surface to the outermost region of the glycocalyx. Macromolecular crowding with inert polymers was utilized to reversibly alter the accessibility of glycocalyx proteoglycans toward cell-surface reactive probes allowing
Iolanda Ferro et al.
Autophagy, 18(1), 191-203 (2021-05-08)
The small non-coding VTRNA1-1 (vault RNA 1-1) is known to confer resistance to apoptosis in several malignant cell lines and to also modulate the macroautophagic/autophagic flux in hepatocytes, thus highlighting its pro-survival role. Here we describe a new function of
Siavash Ghaffari et al.
Development (Cambridge, England), 142(23), 4158-4167 (2015-10-08)
Normal vascular development requires blood flow. Time-lapse imaging techniques have revolutionised our understanding of developmental biology, but measuring changes in blood flow dynamics has met with limited success. Ultrasound biomicroscopy and optical coherence tomography can concurrently image vascular structure and
Jing-Jing Wu et al.
OncoTargets and therapy, 12, 5499-5513 (2019-08-03)
Background: β2-adrenoceptors (β2-ARs) are expressed on the surface of immune cells, including tumor-associated macrophages (TAMs). Previous studies have demonstrated that the expression of β2-ARs in hepatocellular carcinoma (HCC) is significantly increased in vitro. However, the role of β2-AR in M2-polarized
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