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Showing 1-30 of 632 results for "FGF+acidic" within Papers
Gi Fay Mok et al.
Developmental biology, 396(2), 214-223 (2014-12-03)
During limb development Pax3 positive myoblasts delaminate from the hypaxial dermomyotome of limb level somites and migrate into the limb bud where they form the dorsal and ventral muscle masses. Only then do they begin to differentiate and express markers
Ségolène Bernheim et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 375(1809), 20190556-20190556 (2020-08-25)
Retinoic acid (RA), derived from vitamin A, is a major teratogen, clinically recognized in 1983. Identification of its natural presence in the embryo and dissection of its molecular mechanism of action became possible in the animal model with the advent
F Samuel van Nierop et al.
American journal of physiology. Endocrinology and metabolism, 317(3), E494-E502 (2019-06-27)
Bile acids, glucagon-like peptide-1 (GLP-1), and fibroblast growth factor 19 (FGF19) play an important role in postprandial metabolism. In this study, we investigated the postprandial bile acid response in plasma and its relation to insulin, GLP-1, and FGF19. First, we
Edgar M Pera et al.
Experimental cell research, 321(1), 25-31 (2013-12-10)
The question of how the vertebrate embryo gives rise to a nervous system is of paramount interest in developmental biology. Neural induction constitutes the earliest step in this process and is tightly connected with development of the embryonic body axes.
Ingrid C Rulifson et al.
The Journal of biological chemistry, 292(5), 1951-1969 (2016-12-25)
The discovery of brown adipose tissue (BAT) as a key regulator of energy expenditure has sparked interest in identifying novel soluble factors capable of activating inducible BAT (iBAT) to combat obesity. Using a high content cell-based screen, we identified fibroblast
Dale Frank et al.
Cellular and molecular life sciences : CMLS, 76(5), 941-960 (2018-12-07)
The hindbrain is a key relay hub of the central nervous system (CNS), linking the bilaterally symmetric half-sides of lower and upper CNS centers via an extensive network of neural pathways. Dedicated neural assemblies within the hindbrain control many physiological
Sunmi Seok et al.
The Journal of biological chemistry, 288(32), 23252-23263 (2013-07-05)
Bile acids (BAs) are recently recognized key signaling molecules that control integrative metabolism and energy expenditure. BAs activate multiple signaling pathways, including those of nuclear receptors, primarily farnesoid X receptor (FXR), membrane BA receptors, and FXR-induced FGF19 to regulate the
S Wennström et al.
Growth factors (Chur, Switzerland), 4(3), 197-208 (1991-01-01)
We have isolated and characterized a cDNA clone, phFGFR, encoding a human fibroblast growth factor (FGF) receptor. phFGFR contains an open reading frame which encodes an 820 amino acid polypeptide with three immunoglobulin-like domains in the extracellular part and an
Feng Liu et al.
Stem cell research & therapy, 11(1), 284-284 (2020-07-18)
Biological pacemakers derived from pluripotent stem cell (PSC) have been considered as a potential therapeutic surrogate for sick sinus syndrome. So it is essential to develop highly efficient strategies for enrichment of sinoatrial node-like cells (SANLCs) as seed cells for
Sandrine Siffroi-Fernandez et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 123(3), 368-376 (2005-03-16)
Fibroblast growth factors (FGFs) represent potent effectors and play essential roles in both normal development and many pathological processes. Little is known about their possible implication in retinoblastoma growth. We sought to examine FGF high- and low-affinity receptor (FGFR) expression
P Böhlen et al.
The EMBO journal, 4(8), 1951-1956 (1985-08-01)
Acidic fibroblast growth factor (FGF) from bovine brain has been isolated by a combination of salt precipitation, ion-exchange chromatography, heparin-Sepharose affinity chromatography and reverse phase h.p.l.c. The amino acid composition of the mitogen is indistinguishable from that of acidic FGF
F Esch et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(19), 6507-6511 (1985-10-01)
The two major mitogenic polypeptides for endothelial cells have been purified to homogeneity. The complete primary structure of bovine pituitary basic fibroblast growth factor (FGF) and the amino-terminal amino acid sequence of bovine brain acidic FGF have been established by
Patricia Bagnasco et al.
Archives of biochemistry and biophysics, 419(2), 178-189 (2003-11-01)
To establish peroxynitrite (ONOO(-)) as a mediator of acidic fibroblast growth factor (FGF-1) function, preparations of recombinant human FGF-1 were treated with the pro-oxidant in vitro and identified amino acid modifications were correlated with biologic activity. The sequence of FGF-1
F Esch et al.
Biochemical and biophysical research communications, 133(2), 554-562 (1985-12-17)
The major anionic mitogenic polypeptide for endothelial cells, acidic fibroblast growth factor (FGF), has been purified to homogeneity from bovine brain and its complete primary structure established by gas-phase sequence analysis. The 140 amino acid (Mr 16,000) protein has been
A T Chellaiah et al.
The Journal of biological chemistry, 269(15), 11620-11627 (1994-04-15)
Fibroblast growth factors (FGF) regulate the growth and differentiation of cells through complex combinatorial signaling pathways. There are nine ligands that interact with a family of four tyrosine kinase FGF receptors (FGFR). Diversity in FGF signaling is determined in part
Javier Vaquero et al.
Biochemical pharmacology, 86(7), 926-939 (2013-08-10)
The farnesoid X receptor (FXR) is a key sensor in bile acid homeostasis. Although four human FXR isoforms have been identified, the physiological role of this diversity is poorly understood. Here we investigated their subcellular localization, agonist sensitivity and response
Tetsuhiro Kudoh et al.
Development (Cambridge, England), 129(18), 4335-4346 (2002-08-17)
Early neural patterning in vertebrates involves signals that inhibit anterior (A) and promote posterior (P) positional values within the nascent neural plate. In this study, we have investigated the contributions of, and interactions between, retinoic acid (RA), Fgf and Wnt
Virginie Sabado et al.
Developmental biology, 362(2), 254-262 (2011-12-28)
A small population of neuroendocrine cells in the rostral hypothalamus and basal forebrain is the key regulator of vertebrate reproduction. They secrete gonadotropin-releasing hormone (GnRH-1), communicate with many areas of the brain and integrate multiple inputs to control gonad maturation
J Alterio et al.
FEBS letters, 242(1), 41-46 (1988-12-19)
A cDNA encoding the acidic eye-derived growth factor (EDGF II) similar to the acidic fibroblast growth factor (aFGF), a potent cell mitogen, has been isolated from a bovine retinal cDNA library. The cDNA, 4.1 kb in size, has a sequence
Moonhee Lee et al.
The Journal of biological chemistry, 286(48), 41230-41245 (2011-10-13)
Previous studies indicate that astrocytes are the brain cells that express acidic fibroblast growth factor (aFGF) and that the expression is increased upon activation. However, there has been no study investigating the significance of this phenomenon. Here we report that
Juliya Kalinina et al.
Structure (London, England : 1993), 20(1), 77-88 (2012-01-17)
Uncontrolled fibroblast growth factor (FGF) signaling can lead to human malignancies necessitating multiple layers of self-regulatory control mechanisms. Fibroblast growth factor receptor (FGFR) autoinhibition mediated by the alternatively spliced immunoglobulin (Ig) domain 1 (D1) and the acid box (AB)-containing linker
Sunder Mudaliar et al.
Gastroenterology, 145(3), 574-582 (2013-06-04)
Obeticholic acid (OCA; INT-747, 6α-ethyl-chenodeoxycholic acid) is a semisynthetic derivative of the primary human bile acid chenodeoxycholic acid, the natural agonist of the farnesoid X receptor, which is a nuclear hormone receptor that regulates glucose and lipid metabolism. In animal
Shaoyan Chang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(4), 4688-4702 (2018-12-29)
Folate deficiency in early development leads to disturbance in multiple processes, including neurogenesis during which fibroblast growth factor (FGF) pathway is one of the crucial pathways. Whether folic acid (FA) directly affects FGF pathways to influence neurodevelopment and the possible
Diana M Shih et al.
Journal of lipid research, 47(2), 384-392 (2005-11-05)
Paraoxonase-1 (PON1), an enzyme that metabolizes organophosphate insecticides, is secreted by the liver and transported in the blood complexed to HDL. In humans and mice, low plasma levels of PON1 have also been linked to the development of atherosclerosis. We
Tadahiro Shimomura et al.
Journal of bioscience and bioengineering, 119(3), 260-266 (2014-09-23)
Expression of the LIM homeodomain transcription factor Lhx8 is restricted to and up-regulated in the mesenchyme of the upper face prominence before lip fusion. Msx1/2 acts in early development to control cell proliferation and differentiation. Deficiency of these genes is
E Brogi et al.
The Journal of clinical investigation, 92(5), 2408-2418 (1993-11-01)
Because fibroblast growth factors (FGFs) modulate important functions of endothelial cells (EC) and smooth muscle cells (SMC), we studied FGF expression in human vascular cells and control or atherosclerotic arteries. All cells and arteries contained acidic (a) FGF and basic
Xianling Zhao et al.
Gene expression patterns : GEP, 9(6), 430-435 (2009-06-23)
Cell-cell signaling regulated by retinoic acid (RA), Wnt/beta-catenin, and fibroblast growth factor (FGF) is important during body axis extension, and interactions between these pathways have been suggested. At early somite stages, Wnt/beta-catenin and FGF signaling domains exist both anterior and
Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein
Lee M, et al.
The Journal of Biological Chemistry, 286(48), 41230-41245 (2011)
Vanessa Ribes et al.
Development (Cambridge, England), 136(4), 665-676 (2009-01-27)
The progressive generation of embryonic trunk structures relies on the proper patterning of the caudal epiblast, which involves the integration of several signalling pathways. We have investigated the function of retinoic acid (RA) signalling during this process. We show that
Jyoti Sinha et al.
American journal of physiology. Gastrointestinal and liver physiology, 295(5), G996-G1003 (2008-09-06)
beta-Klotho, a newly described membrane protein, regulates bile acid synthesis. Fibroblast growth factor-15 (FGF-15) and FGF receptor-4 (FGFR4) knockout mice share a similar phenotype with beta-Klotho-deficient mice. FGF-15 secretion by the intestine regulates hepatic bile acid biosynthesis. The effects of
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