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fibroblast growth factor 1 (acidic)
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Showing 1-30 of 14829 results for "fibroblast growth factor 1 (acidic)" within Papers
D Ron et al.
The Journal of biological chemistry, 268(8), 5388-5394 (1993-03-15)
A cDNA predicted to encode a transmembrane tyrosine kinase receptor with sequence features characteristic of known fibroblast growth factor (FGF) receptors was isolated from an expression library constructed from the human mammary epithelial cell line B5/589. This cDNA, designated cl44
Xue Xia et al.
Journal of pharmaceutical sciences, 105(12), 3507-3519 (2016-10-25)
Fibroblast growth factor-1 (FGF-1), a potent human mitogen and insulin sensitizer, signals through both tyrosine kinase receptor-mediated autocrine/paracrine pathways as well as a nuclear intracrine pathway. Phosphorylation of FGF-1 at serine 116 (S116) has been proposed to regulate intracrine signaling.
Mikito Inokuchi et al.
World journal of surgical oncology, 15(1), 2-2 (2017-01-07)
Receptor tyrosine kinases promote tumor progression in many cancers, although oncologic activation differs between diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC). Fibroblast growth factor receptor (FGFR) is one RTK, and we previously reported the clinical significance of FGFR1
Anna Szlachcic et al.
Drug design, development and therapy, 10, 2547-2560 (2016-08-27)
Fibroblast growth factor receptors (FGFRs) are attractive candidate cancer therapy targets as they are overexpressed in multiple types of tumors, such as breast, prostate, bladder, and lung cancer. In this study, a natural ligand of FGFR, an engineered variant of
Rong Ouyang et al.
Molecular medicine reports, 25(1) (2021-12-02)
Uric acid (UA) is the final oxidation product of purine metabolism. Hyperuricemia has been previously reported to contribute to vascular endothelial dysfunction and the development of cardiovascular diseases, metabolic syndrome and chronic kidney diseases. In addition, it has been reported
Rong Ouyang et al.
Molecular medicine reports, 25(1) (2021-12-02)
Uric acid (UA) is the final oxidation product of purine metabolism. Hyperuricemia has been previously reported to contribute to vascular endothelial dysfunction and the development of cardiovascular diseases, metabolic syndrome and chronic kidney diseases. In addition, it has been reported
C Gabler et al.
Journal of reproduction and fertility, 109(2), 213-221 (1997-03-01)
The heparin-binding acidic and basic fibroblast growth factors (aFGF, bFGF) and their receptors in the bovine oviduct are described. By means of western blot analysis one 18 kDa aFGF and two bFGF proteins (16 and 18 kDa, respectively) were detected
D M Ornitz et al.
The Journal of biological chemistry, 267(23), 16305-16311 (1992-08-15)
The heparin-binding growth factors include a family of seven structurally related proteins that can potentially interact with four known high affinity receptors. We have cloned the murine homologues of fibroblast growth factor receptors 1 and 3 (mFR1 and mFR3). To
Alliny F Naves et al.
Colloids and surfaces. B, Biointerfaces, 139, 79-86 (2015-12-25)
Layer-by-Layer (LbL) assemblies of heparin (Hep) and chitosan (Chi) were prepared for use as reservoirs for acidic and basic fibroblast growth factors (aFGFs and bFGFs, respectively). The effects of the architecture and composition of the reservoirs on the viability and
Cheng Xu et al.
EMBO molecular medicine, 9(10), 1379-1397 (2017-07-30)
Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic form of isolated gonadotropin-releasing hormone (GnRH) deficiency caused by mutations in > 30 genes. Fibroblast growth factor receptor 1 (FGFR1) is the most frequently mutated gene in CHH and is implicated in GnRH
Magdalena Lipok et al.
FEBS open bio, 9(5), 914-924 (2019-04-11)
Overexpression of fibroblast growth factor receptor 1 (FGFR1) is a common aberration in lung and breast cancers and has necessitated the design of drugs targeting FGFR1-dependent downstream signaling and FGFR1 ligand binding. To date, the major group of drugs being
H Fan et al.
IUBMB life, 49(6), 545-548 (2000-10-14)
Acid fibroblast growth factor (aFGF) binds to its cell-surface receptors in a heparin-dependent manner. In an attempt to define the aFGF recognition site on fibroblast growth factor receptor 1 (FGFR1), we developed a screening strategy for identifying FGF ligands that
E Brogi et al.
The Journal of clinical investigation, 92(5), 2408-2418 (1993-11-01)
Because fibroblast growth factors (FGFs) modulate important functions of endothelial cells (EC) and smooth muscle cells (SMC), we studied FGF expression in human vascular cells and control or atherosclerotic arteries. All cells and arteries contained acidic (a) FGF and basic
X Wu et al.
Cancer research, 61(13), 5295-5302 (2001-06-30)
The abnormal appearance and age-dependent loss of resident fibroblast growth factor receptor-2 (FGFR2) and gain of activity of FGFR1 in epithelial cells is a hallmark of the slow progression to malignancy in some models of prostate cancer. Pericellular matrix heparan
Guowei Chen et al.
Pancreas, 37(2), 159-164 (2008-07-31)
Fibroblast growth factor receptor 1 (FGFR1) isoform IIIc enhances and FGFR1-IIIb inhibits pancreatic cancer cell growth. Nothing is presently known about the expression and regulation of human FGFR1-III isoforms. The aim of this study was to identify regulators modulating the
Yu-Ping Hsieh et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 116(2), 107-113 (2016-02-29)
Transforming growth factor (TGF)-β is a key regulator in the pathogenesis of oral submucous fibrosis (OSF). Early growth response (Egr)-1 is essential for fibrotic responses to TGF-β. Because TGF-β signaling is cell-type- and context-dependent, we investigated the signaling involved in
J W Harper et al.
Biochemistry, 25(14), 4097-4103 (1986-07-15)
The structure of the major class 1 heparin-binding growth factor from human brain has been analyzed. Edman degradation performed on the native mitogen and on fragments generated by chemical and enzymatic cleavage allows the sequence to be described by four
Baojiang Chen et al.
Bioengineered, 13(1), 1530-1540 (2022-01-11)
Psoriasis is a common chronic immune-mediated disease that often has a serious negative impact on the physical and mental health of patients. Dihydroartemisinin (DHA) is a drug with anti-fibrotic and anti-inflammatory effects that may be involved in the autoimmune regulation
Niko Hensel et al.
Journal of neuroinflammation, 16(1), 248-248 (2019-12-04)
Herpes simplex virus-1 (HSV-1) infections of the central nervous system (CNS) can result in HSV-1 encephalitis (HSE) which is characterized by severe brain damage and long-term disabilities. Different cell types including neurons and astrocytes become infected in the course of
Rachel G Scheraga et al.
American journal of physiology. Lung cellular and molecular physiology, 311(5), L941-L955 (2016-11-04)
We previously showed that coincident exposure to heat shock (HS; 42°C for 2 h) and TNF-α synergistically induces apoptosis in mouse lung epithelium. We extended this work by analyzing HS effects on human lung epithelial responses to clinically relevant injury.
L C Baia et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 24(12), 1310-1316 (2014-07-27)
A high circulating fibroblast growth factor 23 (FGF23) level is an independent risk factor for cardiovascular mortality in renal transplant recipients and the general population. N-3 fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) may contribute to cardiovascular risk reduction.
X Zhu et al.
Science (New York, N.Y.), 251(4989), 90-93 (1991-01-04)
Members of the fibroblast growth factor (FGF) family of proteins stimulate the proliferation and differentiation of a variety of cell types through receptor-mediated pathways. The three-dimensional structures of two members of this family, bovine acidic FGF and human basic FGF
K Kusafuka et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 27(7), 287-292 (1998-09-02)
Basic and acidic fibroblast growth factors (bFGF and aFGF) are heparin-binding growth factors, and promote fibrogenesis and angiogenesis. We investigated the immunohistochemical localization of bFGFE, aFGF, and FGF receptor-1 in pleomorphic adenomas. In the normal salivary glands, bFGF was localized
Yoshie S Weems et al.
Theriogenology, 82(9), 1224-1230 (2014-09-16)
Previously, it was reported that intraluteal implants containing prostaglandin E1 or E2 (PGE1 and PGE2) in Angus or Brahman cows prevented luteolysis by preventing loss of mRNA expression for luteal LH receptors and luteal unoccupied and occupied LH receptors. In
S Lee et al.
Plastic and reconstructive surgery, 107(7), 1776-1784 (2001-06-08)
Recent evidence has implicated mutations of fibroblast growth factor receptors (FGF-R) in the pathogenesis of craniosynostotic syndromes. Cleft palate can be a component of such syndromes. The expression of FGF-R1 and FGF-R2 has been delineated in normally developing cranium, where
Sung Hae Bae et al.
Growth factors (Chur, Switzerland), 33(2), 71-78 (2015-02-26)
l-ascorbic acid 2-phosphate (Asc-2P) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production. Previously, we reported that depletion of growth factors such as fibroblast growth factor (FGF)-2, epidermal growth factor (EGF), FGF-4 and HGF during serial
Tsutomu Sato et al.
Oncology reports, 21(1), 211-216 (2008-12-17)
Expression of the fibroblast growth factor (FGF)-1, FGF-2, fibroblast growth factor receptor (FGFR)-1, and FGFR-2 genes has been reported in various cancers and is associated with poor outcomes in patients with solid tumors. This study examined the relations between the
Y Yasuda et al.
Developmental biology, 150(2), 397-413 (1992-04-01)
Vasculogenesis depends on autocrine secretion of basic fibroblast growth factor (bFGF) from capillary endothelial cells. Retinoic acid (RA) induced avascular yolk sac (AVY) of mouse embryos of dams given 60 mg/kg of RA orally on Day 8 of gestation and
Junling Liu et al.
EBioMedicine, 41, 73-84 (2019-03-05)
Glucagon-like peptide-1 (GLP-1) and its based agents improve glycemic control. Although their attenuating effect on hepatic glucose output has drawn our attention for decades, the potential mechanisms remain unclear. Cytokine array kit was used to assess cytokine profiles in db/db
Victor Schultz et al.
The Journal of biological chemistry, 292(6), 2495-2509 (2016-12-30)
A small library of well defined heparan sulfate (HS) polysaccharides was chemoenzymatically synthesized and used for a detailed structure-activity study of fibroblast growth factor (FGF) 1 and FGF2 signaling through FGF receptor (FGFR) 1c. The HS polysaccharide tested contained both
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