Search Within
fibroblast growth factor 21
Applied Filters:
Keyword:'fibroblast growth factor 21'
Showing 1-30 of 22212 results for "fibroblast growth factor 21" within Papers
Zhuofeng Lin et al.
Circulation, 131(21), 1861-1871 (2015-03-22)
Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts as a key downstream target of both peroxisome proliferator-activated receptor α and γ, the agonists of which have
Xinxin Yan et al.
Lipids in health and disease, 17(1), 203-203 (2018-08-31)
FGF21 is a critical endogenous regulator in energy homeostasis and systemic glucose and lipid metabolism. Despite intensive study of the metabolic functions of FGF21, its important role in heart disease needs further exploration. Apoptosis induced by ox-LDL in vascular endothelial
Xi Wu et al.
Heart and vessels, 30(5), 657-668 (2014-08-06)
Fibroblast growth factor 21 (FGF-21) is an endocrine factor that can be secreted into circulation by the liver. FGF-21 takes part in metabolic actions and is thought to be a promising candidate for the treatment of diabetes. However, the role
Hyo Jin Maeng et al.
International journal of molecular sciences, 21(18) (2020-09-23)
Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism. We aimed to investigate the effect of an FGF21 analogue (LY2405319) on the development of atherosclerosis and its associated parameters. ApoE-/- mice were fed an atherogenic
Aimin Wu et al.
Redox biology, 46, 102131-102131 (2021-09-17)
Ferroptosis plays a role in several diseases such as iron overload-induced liver diseases. Manipulation of ferroptosis has been explored as a potential therapeutic strategy to treat related diseases. Numerous antioxidants have been identified to control ferroptosis but the cell-autonomous mechanisms
Joost Besseling et al.
Atherosclerosis, 241(2), 322-325 (2015-06-13)
Fibroblast growth factor 21 (FGF21) has been described to have beneficial effects on glucose and lipid metabolism, and FGF21 analogs are currently evaluated in phase 1 trials. However, the complete spectrum of effects and regulators of FGF21 is yet partly
Fangying Cao et al.
Biochemical and biophysical research communications, 491(3), 578-586 (2017-08-05)
Vascular calcification is prevalent and associated with adverse outcome without available therapy. The benefits of fibroblast growth factor (FGF)-21 on metabolism and atherosclerosis make it a promising therapeutic agent for vascular calcification. We investigated the effects of FGF21 on vascular
Lujun Yang et al.
Skin pharmacology and physiology, 31(5), 229-237 (2018-05-31)
To elucidate the possible mechanisms of how basic fibroblast growth factor (bFGF) influences epidermal homeostasis in a living skin equivalent (LSE) model. Several wound healing-related growth factors were analyzed at protein and mRNA levels for dermal fibroblasts of induced alpha-smooth
Cheng Xu et al.
EMBO molecular medicine, 9(10), 1379-1397 (2017-07-30)
Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic form of isolated gonadotropin-releasing hormone (GnRH) deficiency caused by mutations in > 30 genes. Fibroblast growth factor receptor 1 (FGFR1) is the most frequently mutated gene in CHH and is implicated in GnRH
Junling Liu et al.
EBioMedicine, 41, 73-84 (2019-03-05)
Glucagon-like peptide-1 (GLP-1) and its based agents improve glycemic control. Although their attenuating effect on hepatic glucose output has drawn our attention for decades, the potential mechanisms remain unclear. Cytokine array kit was used to assess cytokine profiles in db/db
Albert Pérez-Martí et al.
Molecular nutrition & food research, 61(8) (2017-01-13)
Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity. Since FGF21 production is regulated by various nutritional factors, we analyze the impact of low protein intake on circulating levels of this growth hormone
Yajie Zhang et al.
Journal of neuroendocrinology, 32(5), e12848-e12848 (2020-04-21)
Perfluorooctanoic acid (PFOA) is widely used in household applications. High-dose exposure to PFOA has been associated with increased risks of infertility and premature ovarian insufficiency in woman. PFOA can alter hepatic gene expression by activating peroxisome proliferator-activated receptor α (PPARα).
Christine Loyd et al.
Journal of applied physiology (Bethesda, Md. : 1985), 121(3), 687-698 (2016-07-23)
Exercise is an effective therapy against the metabolic syndrome. However, the molecular pathways underlying the advantageous effects of exercise are elusive. Glucagon receptor signaling is essential for exercise benefits, and recent evidence indicates that a downstream effector of glucagon, fibroblast
Victor Schultz et al.
The Journal of biological chemistry, 292(6), 2495-2509 (2016-12-30)
A small library of well defined heparan sulfate (HS) polysaccharides was chemoenzymatically synthesized and used for a detailed structure-activity study of fibroblast growth factor (FGF) 1 and FGF2 signaling through FGF receptor (FGFR) 1c. The HS polysaccharide tested contained both
Shin-ichi Nakano et al.
Animal science journal = Nihon chikusan Gakkaiho, 87(1), 99-108 (2015-07-15)
Intramuscular adipose tissue (IMAT) formation is a hallmark of marbling in cattle. IMAT is considered to originate from skeletal muscle progenitor cells with adipogenic potential. However, the mechanism involved in IMAT formation from these progenitor cells in vivo remains unclear.
D Correa et al.
Osteoarthritis and cartilage, 23(3), 443-453 (2014-12-03)
To test the effects of sequential exposure to FGF2, 9 and 18 on human Mesenchymal Stem Cells (hMSC) differentiation during in vitro chondrogenesis. Control and FGF2-expanded hMSC were cultured in aggregates in the presence of rhFGF9, rhFGF18 or rhFGFR3-specific signaling
Yori Ozaki et al.
The British journal of nutrition, 114(9), 1410-1418 (2015-09-04)
Protein malnutrition promotes hepatic steatosis, decreases insulin-like growth factor (IGF)-I production and retards growth. To identify new molecules involved in such changes, we conducted DNA microarray analysis on liver samples from rats fed an isoenergetic low-protein diet for 8 h.
Wen-Pin Huang et al.
Journal of cellular and molecular medicine, 26(8), 2451-2461 (2022-03-22)
Circulating endothelial progenitor cells (EPCs), which function in vascular repair, are the markers of endothelial dysfunction and vascular health. Fibroblast growth factor 21 (FGF21), a liver-secreted protein, plays a crucial role in glucose homeostasis and lipid metabolism. FGF21 has been reported
Rong Ouyang et al.
Molecular medicine reports, 25(1) (2021-12-02)
Uric acid (UA) is the final oxidation product of purine metabolism. Hyperuricemia has been previously reported to contribute to vascular endothelial dysfunction and the development of cardiovascular diseases, metabolic syndrome and chronic kidney diseases. In addition, it has been reported
Guojun Yang et al.
Nanotheranostics, 7(4), 380-392 (2023-07-10)
Rationale: UV light deeply penetrates the dermis, leading to inflammation and cell death with prolonged exposure. This is a major contributor to skin photoaging. In the pharmaceutical field, fibroblast growth factors (FGFs) have gained popularity for enhancing skin quality as
Rong Ouyang et al.
Molecular medicine reports, 25(1) (2021-12-02)
Uric acid (UA) is the final oxidation product of purine metabolism. Hyperuricemia has been previously reported to contribute to vascular endothelial dysfunction and the development of cardiovascular diseases, metabolic syndrome and chronic kidney diseases. In addition, it has been reported
Michaela Kunova Bosakova et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(10), 4316-4325 (2019-02-21)
Vertebrate primary cilium is a Hedgehog signaling center but the extent of its involvement in other signaling systems is less well understood. This report delineates a mechanism by which fibroblast growth factor (FGF) controls primary cilia. Employing proteomic approaches to
Xiaoqing Yan et al.
Journal of cellular and molecular medicine, 19(7), 1557-1568 (2015-04-01)
Fibroblast growth factor 21 (FGF21) plays an important role in energy homoeostasis. The unaddressed question of FGF21's effect on the development and progression of diabetic cardiomyopathy (DCM) is investigated here with FGF21 knockout (FGF21KO) diabetic mice. Type 1 diabetes was
Hiroya Urabe et al.
Molecular and cellular biochemistry, 476(1), 361-368 (2020-09-25)
Human dermal fibroblast proliferation plays an important role in skin wound healing, and electrical stimulation (ES) promotes skin wound healing. Although the use of ES for skin wound healing has been investigated, the mechanism underlying the effects of ES on
Hua-Chun Weng et al.
Molecular medicine (Cambridge, Mass.), 27(1), 147-147 (2021-11-15)
Patients with salt-sensitive hypertension are often accompanied with severe renal damage and accelerate to end-stage renal disease, which currently lacks effective treatment. Fibroblast growth factor 21 (FGF21) has been shown to suppress nephropathy in both type 1 and type 2
Ana Luísa De Sousa-Coelho et al.
Journal of lipid research, 54(7), 1786-1797 (2013-05-11)
Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we
Nasisorn Suksridechacin et al.
Physiological reports, 10(7), e15247-e15247 (2022-04-07)
In the present study, we examined the systemic and direct effects of parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23) on duodenal, jejunal, and ileal Mg2+ absorption. The rats were injected with FGF-23 or PTH for 5 h before collecting the
Mikito Inokuchi et al.
World journal of surgical oncology, 15(1), 2-2 (2017-01-07)
Receptor tyrosine kinases promote tumor progression in many cancers, although oncologic activation differs between diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC). Fibroblast growth factor receptor (FGFR) is one RTK, and we previously reported the clinical significance of FGFR1
Patricia Gallego-Muñoz et al.
Journal of tissue engineering and regenerative medicine, 12(2), e737-e746 (2016-11-20)
The development of treatments that modulate corneal wound healing to avoid fibrosis during tissue repair is important for the restoration of corneal transparency after an injury. To date, few studies have studied the influence of growth factors (GFs) on human
Daria Nawrocka et al.
International journal of molecular sciences, 24(12) (2023-06-28)
Targeting fibroblast growth factor receptor 1 (FGFR1) is a promising therapeutic strategy for various cancers associated with alterations in the FGFR1 gene. In this study, we developed a highly cytotoxic bioconjugate based on fibroblast growth factor 2 (FGF2), which is
Page 1 of 741