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fibroblast growth factor 6
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Showing 1-30 of 31893 results for "fibroblast growth factor 6" within Papers
Meghan June Hirsch et al.
Medicina (Kaunas, Lithuania), 59(9) (2023-09-28)
Background and Objectives: Chronic inflammation due to Pseudomonas aeruginosa (PA) infection in people with cystic fibrosis (CF) remains a concerning issue in the wake of modulator therapy initiation. Given the perpetuating cycle of colonization, infection, chronic inflammation, and recurrent injury
Lujun Yang et al.
Skin pharmacology and physiology, 31(5), 229-237 (2018-05-31)
To elucidate the possible mechanisms of how basic fibroblast growth factor (bFGF) influences epidermal homeostasis in a living skin equivalent (LSE) model. Several wound healing-related growth factors were analyzed at protein and mRNA levels for dermal fibroblasts of induced alpha-smooth
Mafaz Ullah et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 44(8), 591-601 (2014-12-23)
Areca nut chewing is associated with oral submucous fibrosis (OSF). Raised vascular basic fibroblast growth factor may induce fibrosis. Arecoline is a muscarinic alkaloid in areca nut, which we earlier reported causes injury and necrosis of human endothelium. Human umbilical
Victor Schultz et al.
The Journal of biological chemistry, 292(6), 2495-2509 (2016-12-30)
A small library of well defined heparan sulfate (HS) polysaccharides was chemoenzymatically synthesized and used for a detailed structure-activity study of fibroblast growth factor (FGF) 1 and FGF2 signaling through FGF receptor (FGFR) 1c. The HS polysaccharide tested contained both
Shin-ichi Nakano et al.
Animal science journal = Nihon chikusan Gakkaiho, 87(1), 99-108 (2015-07-15)
Intramuscular adipose tissue (IMAT) formation is a hallmark of marbling in cattle. IMAT is considered to originate from skeletal muscle progenitor cells with adipogenic potential. However, the mechanism involved in IMAT formation from these progenitor cells in vivo remains unclear.
D Correa et al.
Osteoarthritis and cartilage, 23(3), 443-453 (2014-12-03)
To test the effects of sequential exposure to FGF2, 9 and 18 on human Mesenchymal Stem Cells (hMSC) differentiation during in vitro chondrogenesis. Control and FGF2-expanded hMSC were cultured in aggregates in the presence of rhFGF9, rhFGF18 or rhFGFR3-specific signaling
F Coulier et al.
Progress in growth factor research, 5(1), 1-14 (1994-01-01)
FGF6 is structurally very similar to the other members of the FGF gene family, and particularly to the FGF4 gene, which was instrumental in its isolation. Its longest open reading frame encodes a 208 amino acid residues long protein, both
Guojun Yang et al.
Nanotheranostics, 7(4), 380-392 (2023-07-10)
Rationale: UV light deeply penetrates the dermis, leading to inflammation and cell death with prolonged exposure. This is a major contributor to skin photoaging. In the pharmaceutical field, fibroblast growth factors (FGFs) have gained popularity for enhancing skin quality as
Michaela Kunova Bosakova et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(10), 4316-4325 (2019-02-21)
Vertebrate primary cilium is a Hedgehog signaling center but the extent of its involvement in other signaling systems is less well understood. This report delineates a mechanism by which fibroblast growth factor (FGF) controls primary cilia. Employing proteomic approaches to
Mariam Bagher et al.
International journal of molecular sciences, 22(2) (2021-01-10)
Mast cells play an important role in asthma, however, the interactions between mast cells, fibroblasts and epithelial cells in idiopathic pulmonary fibrosis (IPF) are less known. The objectives were to investigate the effect of mast cells on fibroblast activity and
Hiroya Urabe et al.
Molecular and cellular biochemistry, 476(1), 361-368 (2020-09-25)
Human dermal fibroblast proliferation plays an important role in skin wound healing, and electrical stimulation (ES) promotes skin wound healing. Although the use of ES for skin wound healing has been investigated, the mechanism underlying the effects of ES on
F Ropiquet et al.
Cancer research, 60(15), 4245-4250 (2000-08-17)
Fibroblast growth factors (FGFs) are known to play an important role in the growth of normal prostatic epithelial cells. In addition to their effects on proliferation, FGFs can promote cell motility, increase tumor angiogenesis, and inhibit apoptosis, all of which
Nasisorn Suksridechacin et al.
Physiological reports, 10(7), e15247-e15247 (2022-04-07)
In the present study, we examined the systemic and direct effects of parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23) on duodenal, jejunal, and ileal Mg2+ absorption. The rats were injected with FGF-23 or PTH for 5 h before collecting the
K Sakuma et al.
Biochimica et biophysica acta, 1497(1), 77-88 (2000-06-06)
Mice genetically deficient in growth and differentiation factor 8 (GDF8/myostatin) had markedly increased muscle fiber numbers and fiber hypertrophy. In the regenerating muscle of mice possessing FGF6 mutation, fiber remodeling was delayed. Although myostatin and FGF6 may be important for
Mikito Inokuchi et al.
World journal of surgical oncology, 15(1), 2-2 (2017-01-07)
Receptor tyrosine kinases promote tumor progression in many cancers, although oncologic activation differs between diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC). Fibroblast growth factor receptor (FGFR) is one RTK, and we previously reported the clinical significance of FGFR1
Patricia Gallego-Muñoz et al.
Journal of tissue engineering and regenerative medicine, 12(2), e737-e746 (2016-11-20)
The development of treatments that modulate corneal wound healing to avoid fibrosis during tissue repair is important for the restoration of corneal transparency after an injury. To date, few studies have studied the influence of growth factors (GFs) on human
Guido Bisping et al.
Blood, 101(7), 2775-2783 (2003-01-09)
Myeloma cells express basic fibroblast growth factor (bFGF), an angiogenic cytokine triggering marrow neovascularization in multiple myeloma (MM). In solid tumors and some lymphohematopoietic malignancies, angiogenic cytokines have also been shown to stimulate tumor growth via paracrine pathways. Since interleukin-6
Daria Nawrocka et al.
International journal of molecular sciences, 24(12) (2023-06-28)
Targeting fibroblast growth factor receptor 1 (FGFR1) is a promising therapeutic strategy for various cancers associated with alterations in the FGFR1 gene. In this study, we developed a highly cytotoxic bioconjugate based on fibroblast growth factor 2 (FGF2), which is
Gyoyeon Hwang et al.
International journal of nanomedicine, 12, 5345-5357 (2017-08-11)
Fibroblast growth factor receptors (FGFRs) play an important role in determining cell proliferation, differentiation, migration, and survival. Although a variety of small-molecule FGFR inhibitors have been developed for cancer therapeutics, the interaction between FGFRs and FGFR inhibitors has not been
J Rödel et al.
Infection and immunity, 68(6), 3635-3641 (2000-05-19)
Chlamydia pneumoniae infection has been associated with asthma and atherosclerosis. Smooth muscle cells represent host cells for chlamydiae during chronic infection. In this study we demonstrated that C. pneumoniae infection of human smooth muscle cells in vitro increased production of
Olivier Cases et al.
The Journal of biological chemistry, 288(23), 16655-16670 (2013-04-18)
Cubilin (Cubn) is a multiligand endocytic receptor critical for the intestinal absorption of vitamin B12 and renal protein reabsorption. During mouse development, Cubn is expressed in both embryonic and extra-embryonic tissues, and Cubn gene inactivation results in early embryo lethality
Olivier Cases et al.
The Journal of biological chemistry, 288(23), 16655-16670 (2013-04-18)
Cubilin (Cubn) is a multiligand endocytic receptor critical for the intestinal absorption of vitamin B12 and renal protein reabsorption. During mouse development, Cubn is expressed in both embryonic and extra-embryonic tissues, and Cubn gene inactivation results in early embryo lethality
Ingrid C Rulifson et al.
The Journal of biological chemistry, 292(5), 1951-1969 (2016-12-25)
The discovery of brown adipose tissue (BAT) as a key regulator of energy expenditure has sparked interest in identifying novel soluble factors capable of activating inducible BAT (iBAT) to combat obesity. Using a high content cell-based screen, we identified fibroblast
Kai Hung Tiong et al.
Oncotarget, 7(36), 57633-57650 (2016-05-19)
Basal-like breast cancer is an aggressive tumor subtype with poor prognosis. The discovery of underlying mechanisms mediating tumor cell survival, and the development of novel agents to target these pathways, is a priority for patients with basal-like breast cancer. From
Solange Le Blanc et al.
Experimental cell research, 338(2), 136-148 (2015-09-20)
Multipotent human bone marrow stromal cells (hBMSCs) are the common progenitors of osteoblasts and adipocytes. A shift in hBMSC differentiation in favor of adipogenesis may contribute to the bone loss and marrow fat accumulation observed in aging and osteoporosis. Hence
Claire L Cole et al.
The Journal of biological chemistry, 289(15), 10488-10501 (2014-02-25)
Heparan sulfate (HS) is a component of cell surface and extracellular matrix proteoglycans that regulates numerous signaling pathways by binding and activating multiple growth factors and chemokines. The amount and pattern of HS sulfation are key determinants for the assembly
Leah R Brooks et al.
Behavioural brain research, 264, 74-81 (2014-02-12)
Serotonergic neurons in the dorsal raphe nucleus (DR) are organized in anatomically distinct subregions that form connections with specific brain structures to modulate diverse behaviors, including anxiety-like behavior. It is unclear if the functional heterogeneity of these neurons is coupled
Guo-Qing Chang et al.
Progress in neuro-psychopharmacology & biological psychiatry, 116, 110536-110536 (2022-02-18)
Prenatal alcohol exposure (PAE) increases alcohol consumption and risk for alcohol use disorder. This phenomenon in rodents is suggested to involve a stimulatory effect of PAE, in female more than male offspring, on neurogenesis and density of neurons expressing neuropeptides
J K Han et al.
Developmental biology, 158(2), 549-554 (1993-08-01)
As part of an ongoing examination of the functions of the fibroblast growth factor (FGF) gene family in mammalian development, we have carried out an RNA in situ hybridization analysis of the Fgf-6 gene in the mouse embryo. In contrast
W Bruce Sneddon et al.
The Journal of biological chemistry, 291(36), 18632-18642 (2016-07-20)
Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis. Human renal proximal tubule cells (RPTECs) were used to characterize the mechanism and signaling pathways of PTH and FGF23 on phosphate transport and the role of the
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