Search Within


Applied Filters:
Showing 1-30 of 34 results for "G0549" within Papers
Jiajia Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(9), 1198-1201 (2011-08-17)
To study the chemical constituents of Exochorda racemosa. Compounds were isolated and purified by silica gel, Sephadex LH-20, MCI gel and RP-18 column chromatography, and their structures were determined by spectroscopic analysis. Twenty compounds were isolated and identified as N-p-coumaroyl-N'-caffeoylputrescine
Corosolic acid-induced acute kidney injury and lactic acidosis in a patient with impaired kidney function.
Jing-Quan Zheng et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 56(2), 419-420 (2010-07-28)
Myung Sun Lee et al.
Phytotherapy research : PTR, 24(12), 1857-1861 (2010-06-22)
Corosolic acid is one of the triterpenoids present in the leaves of Weigela subsessilis. The antidiabetic activity of corosolic acid has been reported previously, but to date, the anticancer effects on gastric cancer have been poorly studied. In this study
Han Lv et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 31(9), 1351-1354 (2009-02-03)
To investigate the chemical constituents from Loquat leaf (Eriobotrya japonica). Compounds were isolated by a combination of silica gel and ODS column chromatographies and preparative TLC and HPLC, their structures were identified by chemical and spectral methods. Nine triterpenes were
Yanfeng Xu et al.
Cancer letters, 284(2), 229-237 (2009-05-22)
We investigated the response of human cervix adenocarcinoma HeLa cells to Corosolic acid (CRA) treatment. Our results showed that CRA significantly inhibited cell viability in both a dose- and a time-dependent manner. CRA treatment induced S cell-cycle arrest and caused
Satoshi Takagi et al.
Biomedical research (Tokyo, Japan), 31(4), 213-218 (2010-09-14)
Corosolic acid (CA), contained in the leaves of the banaba plant (Lagerstroemia speciosa L.), is a pentacyclic triterpene, and has hypoglycemic effects. The effects of CA on dietary hypercholesterolemia and hepatic steatosis were assessed in KK-Ay mice, an animal model
Sidney J Stohs et al.
Phytotherapy research : PTR, 26(3), 317-324 (2011-11-19)
Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This review summarizes the current literature regarding banaba and its constituents. The hypoglycemic
Hong Chen et al.
Circulation journal : official journal of the Japanese Circulation Society, 76(4), 995-1003 (2012-02-02)
Corosolic acid (CRA) is a pentacyclic triterpene acid that has been shown to exhibit an anti-atherosclerotic effect when added to diets of low-density lipoprotein-deficient mice, but the mechanisms are unclear. The purpose of the present study was to investigate the
Myung Sun Lee et al.
Biological & pharmaceutical bulletin, 33(6), 931-937 (2010-06-05)
Overexpression/amplification of human epidermal growth factor receptor (HER)2/neu (erbB-2) oncogene plays a causal role in carcinogenesis and correlates with a poor clinical prognosis. However, little is known about HER2 in gastric cancer. In this study, we explored the pharmacological activities
Yu Yamaguchi et al.
Life sciences, 79(26), 2474-2479 (2006-09-09)
Corosolic acid (CRA), a constituent of banaba leaves, has been reported to have anti-inflammatory and hypoglycemic activities. The aim of this study was to determine the effects of CRA on metabolic risk factors including obesity, hypertension, hyperinsulinemia, hyperglycemia, and hyperlipidemia
Baohong Li et al.
Pakistan journal of pharmaceutical sciences, 27(3), 511-516 (2014-05-09)
A sensitive and robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of corosolic acid (CRA) in rat plasma. The plasma samples were prepared by a simple protein precipitation treatment. Chromatographic separation was performed on
Ajmeera Rama Rao et al.
Phytotherapy research : PTR, 27(5), 753-760 (2012-07-25)
The polyol enzyme aldose reductase (AR) and advanced glycation endproducts (AGEs) play an important role in diabetic complications such as cataracts. The purpose of this study was to investigate four standardized plant extracts used for the treatment of diabetes and
Toshihiro Miura et al.
Biological & pharmaceutical bulletin, 29(3), 585-587 (2006-03-02)
The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. CA
Joo-Hyun Kim et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 67, 87-95 (2014-02-26)
Ursolic acid (UA) and corosolic acid (CA), naturally occurring pentacyclic triterpene acids, exhibit antiproliferative activities against various cancer cells, but a clear chemopreventive mechanism of these triterpenoids in colon cancer cells remains to be answered. Here we used a cell-based
Xiaoan Wen et al.
Journal of medicinal chemistry, 51(12), 3540-3554 (2008-06-04)
Twenty-five naturally occurring pentacyclic triterpenes, 15 of which were synthesized in this study, were biologically evaluated as inhibitors of rabbit muscle glycogen phosphorylase a (GPa). From SAR studies, the presence of a sugar moiety in triterpene saponins resulted in a
Ganapathy Sivakumar et al.
Biotechnology journal, 4(12), 1704-1711 (2009-12-01)
Diabetes is one of the nation's most prevalent, debilitating and costly diseases. For diabetes, frequent insulin treatment is very expensive and may increase anti-insulin antibody production, which may cause unwanted side effects. Corosolic acid may also have some efficacy in
Satoshi Takagi et al.
Journal of nutritional science and vitaminology, 54(3), 266-268 (2008-07-19)
The banaba leaf (Lagerstroemia speciosa L.) has been used in traditional Oriental medicine to treat diabetes in the Philippines. It contains corosolic acid (CA), a compound which has a hypoglycemic effect. We examined the effect of CA on blood glucose
Shu-He Kang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 31(11), 1669-1671 (2009-03-06)
To investigate the chemical constituents of root of Rubus biflorus. Isolation and purification were carried out by silica gel column chromatography and recrystallization and so on. Structural determination of the pure compounds was based on physico-chemical properties and various spectral
Ki Shuk Shim et al.
Phytotherapy research : PTR, 23(12), 1754-1758 (2009-05-15)
Recently, the use of anabolic agents to enhance bone mass has been a source of interest. Previous work by us suggested that corosolic acid (2alpha-hydroxyursolic acid), an active component of banaba leaves (Lagerstroemia speciosa L.), potentially stimulates the differentiation of
Ki Hyun Yoo et al.
Phytotherapy research : PTR, 29(5), 714-723 (2015-02-04)
We describe the anti-angiogenic and anti-lymphangiogenic effects of corosolic acid, a pentacyclic triterpenoid isolated from Cornus kousa Burg. A mouse colon carcinoma CT-26 animal model was employed to determine the in vivo anti-angiogenic and anti-lymphangiogenic effects of corosolic acid. Corosolic
M Fukushima et al.
Diabetes research and clinical practice, 73(2), 174-177 (2006-03-22)
Corosolic acid (CRA) is a substance extracted from Lagerstroemia speciosa L. and has been reported to have biological activities in in vitro and experimental animal studies. In this study, 31 subjects were orally administered 10mg CRA or a placebo, on
Jian-rong He et al.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 30(11), 2533-2535 (2010-11-26)
To extract corosolic acid from loquat leaves for medical use. Loquat leaves were boiled in water to remove the water-soluble substances followed by 3 cycles of extraction with 25% aqueous methanol for 30 min and then by 95% aqueous methanol
Augusta Caligiani et al.
Food chemistry, 136(2), 735-741 (2012-11-06)
The occurrence of triterpene pentacyclic acids in plants is extensive, but little is known about their availability in commercial extracts. A simple GC-MS method for the simultaneous determination of betulinic, corosolic, maslinic, oleanolic and ursolic acids was developed and applied
Chung-Yu Ku et al.
PloS one, 10(5), e0126725-e0126725 (2015-05-16)
Inhibition of VEGFR2 activity has been proposed as an important strategy for the clinical treatment of hepatocellular carcinoma (HCC). In this study, we identified corosolic acid (CA), which exists in the root of Actinidia chinensis, as having a significant anti-cancer
Zhen-Hua Li et al.
Biomedical chromatography : BMC, 29(12), 1791-1797 (2015-06-03)
Folium Eriobotryae effective fraction (FEA), the extract of Folium Eriobotryae, had been used as anti-hyperglycemia and anti-hyperlipemia medicine in China. A previous study indicated that euscaphic acid, maslinic acid, corosolic acid, oleanolic acid and ursolic acid, the five structurally similar
Jiayi Tao et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(10), 1399-1401 (2012-08-07)
Five compounds were separated from Sambucus chinensis and identified as maslinic acid(1), 12alpha, 13-dihydroxyolean-3-oxo-28-oic acid(2), 13-hydroxyolean-3-oxo-28-oic acid (3), 3-oxo oleanolic acid (4), corosolic acid (5). Of them,compound 3 was a new compound, and compounds 1, 2, 4, and 5 were
Wenli Hou et al.
Phytotherapy research : PTR, 23(5), 614-618 (2008-12-25)
The potential antidiabetic activity of ethyl acetate extract of the leaves of Lagerstroemia speciosa (LSL) was investigated by alpha-amylase and alpha-glucosidase inhibition assay. Six pentacyclic triterpenes (oleanolic acid, arjunolic acid, asiatic acid, maslinic acid, corosolic acid and 23-hydroxyursolic acid) were
Pu Zhang et al.
Journal of natural products, 72(8), 1414-1418 (2009-08-01)
The 3-deoxy-2-keto derivatives 5 and 7 of oleanolic acid (1) and ursolic acid (2), respectively, served as precursors to the synthesis of 35 3-deoxy derivatives of pentacyclic triterpenes. The synthesized compounds were biologically assayed for their inhibitory activity against rabbit
G Sivakumar et al.
Current medicinal chemistry, 18(1), 79-90 (2010-11-30)
Globally, diabetes and obesity are two of the most common metabolic diseases of the 21(st) century. Increasingly, not only adults but children and adolescents are being affected. New approaches are needed to prevent and treat these disorders and to reduce
Kotaro Yamada et al.
Biological & pharmaceutical bulletin, 31(4), 651-655 (2008-04-02)
Corosolic acid (CRA), a constituent of Banaba leaves, has been reported to exert anti-hypertension, anti-hyperinsulinemia, anti-hyperglycemia, and anti-hyperlipidemia effects as well as to induce anti-inflammatory and anti-oxidative activities. The aim of this study was to investigate the inhibitory effects of
Page 1 of 2