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Showing 1-30 of 297 results for "G2654" within Papers
Jinrang Kim et al.
Cell metabolism, 25(6), 1348-1361 (2017-06-08)
Glucagon supports glucose homeostasis by stimulating hepatic gluconeogenesis, in part by promoting the uptake and conversion of amino acids into gluconeogenic precursors. Genetic disruption or pharmacologic inhibition of glucagon signaling results in elevated plasma amino acids and compensatory glucagon hypersecretion involving
Israel Morales-Reyes et al.
Islets, 14(1), 149-163 (2022-06-28)
Biotin supplemented diet (BSD) is known to enhance β-cell replication and insulin secretion in mice. Here, we first describe BSD impact on the islet β-cell membrane potential (Vm) and glucose-induced electrical activity. BALB/c female mice (n ≥ 20) were fed for nine
Xianming Wang et al.
Molecular metabolism, 24, 80-97 (2019-04-02)
Hundreds of missense mutations in the coding region of PDX1 exist; however, if these mutations predispose to diabetes mellitus is unknown. In this study, we screened a large cohort of subjects with increased risk for diabetes and identified two subjects
Bart Keymeulen et al.
Nature biotechnology (2023-11-28)
Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from human embryonic stem cells found that insulin output was insufficient for clinical benefit. We are conducting a phase 1/2, open-label, multicenter trial aimed at
Melissa L Brown et al.
Endocrinology, 157(3), 1043-1054 (2016-01-05)
Diabetes results from inadequate β-cell number and/or function to control serum glucose concentrations so that replacement of lost β-cells could become a viable therapy for diabetes. In addition to embryonic stem cell sources for new β-cells, evidence for transdifferentiation/reprogramming of
Katrina Viloria et al.
Diabetes (2022-11-30)
GC-globulin (GC), or vitamin D-binding protein, is a multifunctional protein involved in transport of circulating vitamin 25(OH)D and fatty acids, as well as actin-scavenging. In the pancreatic islets, the gene encoding GC, GC, is highly-localized to glucagon-secreting α cells. Despite
Maria M Glavas et al.
Scientific reports, 11(1), 14032-14032 (2021-07-09)
Overconsumption of saturated fats promotes obesity and type 2 diabetes. Excess weight gain in early life may be particularly detrimental by promoting earlier diabetes onset and potentially by adversely affecting normal development. In the present study we investigated the effects
David Bergemann et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 26(2), 238-244 (2018-04-18)
The zebrafish is a popular animal model with well-known regenerative capabilities. To study regeneration in this fish, the nitroreductase/metronidazole-mediated system is widely used for targeted ablation of various cell types. Nevertheless, we highlight here some variability in ablation efficiencies with
Thomas Aga Legøy et al.
Frontiers in cell and developmental biology, 8, 109-109 (2020-03-13)
Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating cells into living hosts was demonstrated to improve β-cell maturation. Nevertheless, the cellular and
A M James Shapiro et al.
Cell reports. Medicine, 2(12), 100466-100466 (2022-01-15)
These preliminary data from an ongoing first-in-human phase 1/2, open-label study provide proof-of-concept that pluripotent stem cell-derived pancreatic endoderm cells (PEC-01) engrafted in type 1 diabetes patients become islet cells releasing insulin in a physiologically regulated fashion. In this study
Jingyi Qian et al.
Diabetes, 62(10), 3469-3478 (2013-06-19)
There is a correlation between circadian disruption, type 2 diabetes mellitus (T2DM), and islet failure. However, the mechanisms underlying this association are largely unknown. Pancreatic islets express self-sustained circadian clocks essential for proper β-cell function and survival. We hypothesized that
Lesly Nava-Molina et al.
Nutrition & diabetes, 10(1), 7-7 (2020-03-07)
Cannabinoid receptor antagonists have been suggested as a novel treatment for obesity and diabetes. We have developed a synthetic cannabinoid receptor antagonist denominated BAR-1. As the function and integrity of a β-cell cellular structure are important keys for diabetes onset
Mariko Kuroda et al.
The Journal of clinical investigation, 127(9), 3496-3509 (2017-08-22)
Demyelination in the central nervous system (CNS) leads to severe neurological deficits that can be partially reversed by spontaneous remyelination. Because the CNS is isolated from the peripheral milieu by the blood-brain barrier, remyelination is thought to be controlled by
Ebrahim H Ghazvini Zadeh et al.
Cell reports, 32(2), 107904-107904 (2020-07-16)
Numerous mammalian cells contain abundant Zn2+ in their secretory granules, yet available Zn2+ sensors lack the desired specificity and sensitivity for imaging granular Zn2+. We developed a fluorescent zinc granule indicator, ZIGIR, that possesses numerous desired properties for live cell
Anna M D'souza et al.
Molecular metabolism, 5(11), 1103-1112 (2016-11-08)
Hyperinsulinemia is commonly associated with obesity. Mice deficient in the adipose-derived hormone leptin (Lepob/ob) develop hyperinsulinemia prior to onset of obesity and glucose intolerance. Whether the excess of circulating insulin is a major contributor to obesity and impaired glucose homeostasis
Yu Chen et al.
Cell death & disease, 14(9), 597-597 (2023-09-08)
Insulin signaling often plays a role in the regulation of cancer, including tumor initiation, progression, and response to treatment. In addition, the insulin-regulated PI3K-Akt-mTOR pathway plays an important role in the regulation of islet cell proliferation, and this pathway is
Roman Vangoitsenhoven et al.
Surgical endoscopy, 35(6), 3104-3114 (2020-07-02)
Metabolic surgery has beneficial metabolic effects, including remission of type 2 diabetes. We hypothesized that duodenojejunal bypass (DJB) surgery can protect against development of type 1 diabetes (T1D) by enhancing regulation of cellular and molecular pathways that control glucose homeostasis.
Zhong-Dong Shi et al.
Cell stem cell, 20(5), 675-688 (2017-02-16)
Human disease phenotypes associated with haploinsufficient gene requirements are often not recapitulated well in animal models. Here, we have investigated the association between human GATA6 haploinsufficiency and a wide range of clinical phenotypes that include neonatal and adult-onset diabetes using
Rebecca L Hull et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 60(10), 749-760 (2012-07-24)
The pancreatic islet comprises endocrine, vascular, and neuronal cells. Signaling among these cell types is critical for islet function. The extracellular matrix (ECM) is a key regulator of cell-cell signals, and while some islet ECM components have been identified, much
G J Taborsky et al.
Diabetologia, 52(12), 2602-2611 (2009-10-03)
We hypothesised that non-obese diabetic mice (NOD) mice have an autoimmune-mediated loss of islet sympathetic nerves and an impairment of sympathetically mediated glucagon responses. We aimed: (1) to determine whether diabetic NOD mice have an early impairment of the glucagon
Hiroshi Nomoto et al.
Diabetologia, 63(1), 149-161 (2019-11-14)
The conserved hypoxia inducible factor 1 α (HIF1α) injury-response pro-survival pathway has recently been implicated in early beta cell dysfunction but slow beta cell loss in type 2 diabetes. We hypothesised that the unexplained prolonged prediabetes phase in type 1
Elena Zambrano et al.
The Journal of endocrinology, 231(1), 49-57 (2016-08-09)
Maternal obesity (MO) is a deleterious condition that enhances susceptibility of adult offspring to metabolic diseases such as type 2 diabetes. The objective is to study the effect of MO on in vitro insulin secretion and pancreatic cellular population in
Shenghui Liang et al.
Cell reports methods, 3(5), 100466-100466 (2023-06-16)
Orbital shaker-based suspension culture systems have been in widespread use for differentiating human pluripotent stem cell (hPSC)-derived pancreatic progenitors toward islet-like clusters during endocrine induction stages. However, reproducibility between experiments is hampered by variable degrees of cell loss in shaking
Glucagonoma syndrome: a review and update on treatment.
John A M and Schwartz R A
Journal of the European Academy of Dermatology and Venereology : JEADV, 30(12), 2016-2022 (2016)
Soren K Thomsen et al.
Nature genetics, 50(8), 1122-1131 (2018-07-29)
The molecular mechanisms underpinning susceptibility loci for type 2 diabetes (T2D) remain poorly understood. Coding variants in peptidylglycine α-amidating monooxygenase (PAM) are associated with both T2D risk and insulinogenic index. Here, we demonstrate that the T2D risk alleles impact negatively
Keiichi Katsumoto et al.
Nature communications, 13(1), 6255-6255 (2022-10-22)
Diabetes is a multifactorial disorder characterized by loss or dysfunction of pancreatic β-cells. β-cells are heterogeneous, exhibiting different glucose sensing, insulin secretion and gene expression. They communicate with other endocrine cell types via paracrine signals and between β-cells via gap
Anna M D'souza et al.
Molecular metabolism, 6(6), 585-593 (2017-06-06)
The adipose-derived hormone leptin plays an important role in regulating body weight and glucose homeostasis. Leptin receptors are expressed in the central nervous system as well as peripheral tissues involved in regulating glucose homeostasis, including insulin-producing β cells of the
Ron Piran et al.
Cell death & disease, 7(11), e2452-e2452 (2016-11-04)
Understanding the mechanisms by which cells sense and respond to injury is central to developing therapies to enhance tissue regeneration. Previously, we showed that pancreatic injury consisting of acinar cell damage+β-cell ablation led to islet cell transdifferentiation. Here, we report
Harshita Chodavarapu et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 311(6), R1223-R1233 (2016-11-04)
While restoration of ACE2 activity in the pancreas leads to improvement of glycemia in experimental models of Type 2 diabetes, global deficiency in ACE2 disrupts β-cell function and impairs glucose tolerance in mice, demonstrating the physiological role of ACE2 in
Yu Hsuan Carol Yang et al.
eLife, 11 (2022-04-05)
The importance of pancreatic endocrine cell activity modulation by autonomic innervation has been debated. To investigate this question, we established an in vivo imaging model that also allows chronic and acute neuromodulation with genetic and optogenetic tools. Using the GCaMP6s
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