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Showing 1-30 of 85 results for "G3664" within Papers
Adam C Straub et al.
Arteriosclerosis, thrombosis, and vascular biology, 31(2), 399-407 (2010-11-13)
To determine whether S-nitrosylation of connexins (Cxs) modulates gap junction communication between endothelium and smooth muscle. Heterocellular communication is essential for endothelium control of smooth muscle constriction; however, the exact mechanism governing this action remains unknown. Cxs and NO have
Eduardo de-Souza-Ferreira et al.
Journal of neurochemistry, 149(5), 624-640 (2019-04-20)
The adult brain is a high-glucose and oxygen-dependent organ, with an extremely organized network of cells and large energy-consuming synapses. To reach this level of organization, early stages in development must include an efficient control of cellular events and regulation
Raisa Turja et al.
Environmental science and pollution research international, 27(13), 15498-15514 (2020-02-23)
In the brackish water Baltic Sea, oil pollution is an ever-present and significant environmental threat mainly due to the continuously increasing volume of oil transport in the area. In this study, effects of exposure to crude oil on two common
Xiaobing Zhu et al.
The Journal of biological chemistry, 296, 100369-100369 (2021-02-06)
Previous studies have identified GAPDH as a promising target for treating cancer and modulating immunity because its inhibition reduces glycolysis in cells (cancer cells and immune cells) with the Warburg effect, a modified form of cellular metabolism found in cancer
Feng Gao et al.
The Journal of pharmacology and experimental therapeutics, 301(2), 543-550 (2002-04-19)
The present experiment determined the effects of glutathione and ascorbic acid, the two most important hydrophilic antioxidants, on myocardial ischemia-reperfusion injury and evaluated their relative therapeutic values. Isolated rat hearts were subjected to ischemia (30 min) and reperfusion (120 min)
Simone Mitie Sunemi et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 20(4), 585-595 (2021-04-18)
This study evaluated the effect of photobiomodulation therapy (PBMt) before or after a high-intensity resistance exercise (RE) session on muscle oxidative stress. Female Wistar rats were assigned to one of the following groups: Sham (non-exercised, undergoing placebo-PBMt); NLRE (exercised, undergoing
Yanan Di et al.
Mutagenesis, 32(1), 77-90 (2016-12-25)
We used the marine bivalve (Mytilus galloprovincialis) to assess a range of biological or biomarker responses following exposure to a model-engineered nanoparticle, C
Limin Liu et al.
Cell, 116(4), 617-628 (2004-02-26)
The current perspective of NO biology is formulated predominantly from studies of NO synthesis. The role of S-nitrosothiol (SNO) formation and turnover in governing NO-related bioactivity remains uncertain. We generated mice with a targeted gene deletion of S-nitrosoglutathione reductase (GSNOR)
María Elena Quintanilla et al.
Frontiers in behavioral neuroscience, 14, 122-122 (2020-08-28)
Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present study assessed the mechanisms involved in the inhibition of: (i) oxidative stress; (ii) neuroinflammation; and
Magdalena Paczkowska-Walendowska et al.
Antioxidants (Basel, Switzerland), 10(12) (2021-12-25)
Blackberry fruits are recognized as functional foods while blackberry leaves are outside this classification and they also contain active compounds with health-promoting potential. Therefore, the aim of this study was the phytochemical analysis of blackberry leaves of varieties (Chester, Loch
Kristin K Brown et al.
Free radical biology & medicine, 45(4), 494-502 (2008-05-27)
Isothiocyanates are phytochemicals with anti-cancer properties that include the ability to trigger apoptosis. A substantial body of evidence suggests that reaction of the electrophilic isothiocyanate moiety with cysteine residues in cellular proteins and glutathione accounts for their biological activity. In
Rupam Sahoo et al.
Free radical biology & medicine, 40(4), 625-631 (2006-02-07)
Oxidative stress has been shown to alter cellular redox status in various cell types. Changes in expressions of several antioxidative and antistress-responsive genes along with activation or inactivation of various proteins were also reported during oxidative insult as well as
Janina Didžiapetrienė et al.
Medicina (Kaunas, Lithuania), 56(2) (2020-02-15)
The purpose of this study is to evaluate the level of oxidative stress before and after breast cancer surgery. Malondialdehyde (MDA) level was tested using a thiobarbituric acid (TBA) assay based on the release of a color complex due to
Pilendra Kumar Thakre et al.
Chemical research in toxicology, 33(3), 817-833 (2020-02-08)
Arsenic is an environmental carcinogen that causes many diseases in humans, including cancers and organ failures, affecting millions of people in the world. Arsenic trioxide is a drug used for the treatment of acute promyelocytic leukemia (APL). In the present
Kentaro Ozawa et al.
Proteomics, 12(12), 2024-2035 (2012-05-25)
S-Nitrosoglutathione reductase (GSNOR) is a key regulator of protein S-nitrosylation, the covalent modification of cysteine residues by nitric oxide that can affect activities of many proteins. We recently discovered that excessive S-nitrosylation from GSNOR deficiency in mice under inflammation inactivates
Amada Eugenia Ynsaurralde-Rivolta et al.
Theriogenology, 148, 140-148 (2020-03-17)
The molecule Dimethyl sulfoxide is widely used as drug solvent. However, its antioxidant property was poorly explored. In this study, we evaluated the effect of DMSO supplementation during oocyte in vitro maturation (IVM) on embryo development and quality. Bovine oocytes were
Caryn E Outten et al.
The Journal of biological chemistry, 279(9), 7785-7791 (2003-12-16)
To combat oxidative damage, eukaryotic cells have evolved with numerous anti-oxidant factors that are often distributed between cytosolic and mitochondrial pools. Glutathione reductase, which regenerates the reduced form of glutathione, represents one such anti-oxidant factor, yet nothing is known regarding
Mukesh Jain et al.
Molecular plant-microbe interactions : MPMI, 35(3), 257-273 (2021-12-22)
The lipopolysaccharides (LPS) of gram-negative bacteria trigger a nitrosative and oxidative burst in both animals and plants during pathogen invasion. Liberibacter crescens strain BT-1 is a surrogate for functional genomic studies of the uncultured pathogenic 'Candidatus Liberibacter' spp. that are
Eugine Lee et al.
Reproduction (Cambridge, England), 134(3), 405-414 (2007-08-22)
In an effort to improve the quality of in vitro produced porcine embryos, we investigated the effect of brain-derived neurotropic factor (BDNF), a neurotropin family member, on in vitro maturation (IVM) of porcine oocytes. The expression of BDNF and truncated
Edward M Henderson et al.
Trends in molecular medicine, 11(11), 481-484 (2005-10-11)
Conventionally, asthma is defined as involving both airway inflammation and airway smooth muscle hyper-responsiveness. However, Que and coworkers have recently uncoupled these concepts, showing that mice lacking an S-nitrosothiol reductase have allergen-induced airway inflammation but do not have airway hyper-responsiveness.
Mikael Molin et al.
Molecular microbiology, 60(4), 925-938 (2006-05-09)
To investigate Saccharomyces cerevisiae physiology during growth on the conditionally toxic triose dihydroxyacetone (DHA), protein expression was studied in strains overexpressing either of the two dihydroxyacetone kinase isogenes, DAK1 or DAK2, that grow well utilizing DHA as a carbon and
Claudia R Oliva et al.
The Journal of biological chemistry, 291(46), 24188-24199 (2016-09-30)
The enzyme cytochrome c oxidase (CcO) or complex IV (EC is a large transmembrane protein complex that serves as the last enzyme in the respiratory electron transport chain of eukaryotic mitochondria. CcO promotes the switch from glycolytic to oxidative
Ariel Herrera-Vásquez et al.
Journal of experimental botany, 72(5), 1891-1905 (2020-11-15)
Plants possess a robust metabolic network for sensing and controlling reactive oxygen species (ROS) levels upon stress conditions. Evidence shown here supports a role for TGA class II transcription factors as critical regulators of genes controlling ROS levels in the
Elżbieta Studzińska-Sroka et al.
Antioxidants (Basel, Switzerland), 11(10) (2022-10-28)
Lichens are a source of various biologically active compounds. However, the knowledge about them is still scarce, and their use in medicine is limited. This study aimed to investigate the therapeutic potential of the lichen Platismatia glauca and its major
Ornanong Tusskorn et al.
Naunyn-Schmiedeberg's archives of pharmacology, 391(6), 657-667 (2018-04-19)
Phenethyl isothiocyanate (PEITC) is a potential cancer prevention agent that is found in cruciferous vegetables. Previous studies have shown that the effect of PEITC-induced cell death declines rapidly after administration. The metabolic fate of PEITC is modulated by glutathione S-transferases
Islam A Berdaweel et al.
Antioxidants (Basel, Switzerland), 11(4) (2022-04-24)
Heterogeneity in the incidence of postoperative atrial fibrillation (POAF) following heart surgery implies that underlying genetic and/or physiological factors impart a higher risk of this complication to certain patients. Glutathione peroxidase-4 (GPx4) is a vital selenoenzyme responsible for neutralizing lipid
Loretta G Que et al.
Science (New York, N.Y.), 308(5728), 1618-1621 (2005-05-28)
Mechanisms that protect against asthma remain poorly understood. S-nitrosoglutathione (GSNO), an endogenous bronchodilator, is depleted from asthmatic airways, suggesting a protective role. We report that, following allergen challenge, wild-type mice exhibiting airway hyperresponsivity have increased airway levels of the enzyme
Sofi E Eriksson et al.
Free radical biology & medicine, 47(11), 1661-1671 (2009-09-22)
The selenoprotein thioredoxin reductase 1 (TrxR1) is currently recognized as a plausible anticancer drug target. Here we analyzed the effects of TrxR1 targeting in the human A549 lung carcinoma cell line, having a very high basal TrxR1 expression. We determined
Rodrigo Carlessi et al.
Methods in molecular biology (Clifton, N.J.), 2076, 241-253 (2019-10-06)
The role of oxidative stress in the pathogenesis of type 2 diabetes (T2D), especially pancreatic β-cell dysfunction and death, has become apparent in the last two decades. Peroxidase- and catalase-based antioxidant mechanisms are particularly weak in β-cells and can be
Annika Pfeiffer et al.
Free radical biology & medicine, 112, 350-359 (2017-08-16)
Bcl-xL is an anti-apoptotic protein that localizes to the outer mitochondrial membrane and influences mitochondrial bioenergetics by controlling Ca2+ influx into mitochondria. Here, we analyzed the effect of mitochondrial Bcl-xL on mitochondrial shape and function in knockout (KO), wild type and
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