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Showing 1-30 of 1304 results for "G3893" within Papers
T Tsuji et al.
Disease markers, 17(4), 247-257 (2002-01-16)
In proteome analysis, it is necessary to separate proteins as a first step prior to characterization. Thus, the overall performance of the analysis depends strongly on the separation tool, which is usually two-dimensional electrophoresis (2DE). We have utilized 2DE to
Conor Delaney et al.
EMBO molecular medicine, 13(2), e12889-e12889 (2020-12-23)
Cerebrovascular pathologies occur in up to 80% of cases of Alzheimer's disease; however, the underlying mechanisms that lead to perivascular pathology and accompanying blood-brain barrier (BBB) disruption are still not fully understood. We have identified previously unreported mutations in colony
Marco Skardelly et al.
Frontiers in cellular neuroscience, 8, 318-318 (2014-10-30)
Numerous studies have reported a beneficial impact of neural progenitor cell transplantation on functional outcome after traumatic brain injury (TBI) during short and medium follow-up periods. However, our knowledge regarding long-term functional effects is fragmentary while a direct comparison between
Tianyu Wang et al.
eLife, 9 (2020-01-31)
1300 nm three-photon calcium imaging has emerged as a useful technique to allow calcium imaging in deep brain regions. Application to large-scale neural activity imaging entails a careful balance between recording fidelity and perturbation to the sample. We calculated and
Atul Malhotra et al.
Stem cell research & therapy, 11(1), 17-17 (2020-01-10)
Neonatal ventilation exacerbates brain injury in lambs with fetal growth restriction (FGR), characterized by neuroinflammation and reduced blood-brain barrier integrity, which is normally maintained by the neurovascular unit. We examined whether umbilical cord blood stem cell (UCBC) treatment stabilized the
Ben A Barres
Cold Spring Harbor protocols, 2014(12), 1342-1347 (2014-12-03)
Purifying and culturing cells from the central nervous system (CNS) has proved to be an incredibly powerful tool for dissecting fundamental neuron and glial properties, and especially powerful in understanding neuronal-glial interactions. In a series of detailed protocols, we have
Inma Luque-Molina et al.
Stem cell reports, 13(1), 132-146 (2019-06-11)
In the adult subependymal zone (SEZ), neural stem cells (NSCs) apically contacting the lateral ventricle on activation generate progenitors proliferating at the niche basal side. We here show that Tailless (TLX) coordinates NSC activation and basal progenitor proliferation by repressing
Oksana Kutsyr et al.
Scientific reports, 11(1), 6692-6692 (2021-03-25)
The gut microbiome is known to influence the pathogenesis and progression of neurodegenerative diseases. However, there has been relatively little focus upon the implications of the gut microbiome in retinal diseases such as retinitis pigmentosa (RP). Here, we investigated changes
Luisa Fernanda Toro-Fernández et al.
Frontiers in cellular neuroscience, 15, 643717-643717 (2021-11-19)
Glutamate excitotoxicity triggers overactivation of CDK5 and increases calcium influx in neural cells, which promotes dendritic retraction, spine loss, increased mitochondrial calcium from the endoplasmic reticulum, and neuronal death. Our previous studies showed that CDK5 knockdown (KD) in astrocytes improves
Filippo Mirabella et al.
Immunity, 54(11), 2611-2631 (2021-11-11)
Early prenatal inflammatory conditions are thought to be a risk factor for different neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy causes abnormal behavior in offspring, but whether these defects result from altered synaptic developmental trajectories remains unclear. Here we
Aline M Thomas et al.
Integrative biology : quantitative biosciences from nano to macro, 6(7), 694-705 (2014-05-31)
Spinal cord injury (SCI) results in loss of sensory and motor function below the level of injury and has limited available therapies. Multiple channel bridges have been investigated as a means to create a permissive environment for regeneration, with channels
M Dallaporta et al.
Journal of neuroendocrinology, 21(1), 57-67 (2008-12-20)
Leptin, an adipocyte-derived hormone, regulates food intake and body weight by acting principally on the hypothalamus, which displays the highest expression of leptin receptor (Ob-R). Nevertheless, other regions of the brain express Ob-R and constitute leptin's target sites. The dorsal
Fumihiro Matsuura et al.
Journal of neuroscience research, 99(6), 1666-1688 (2021-03-18)
Nervous systems are designed to become extra sensitive to afferent nociceptive stimuli under certain circumstances such as inflammation and nerve injury. How pain hypersensitivity comes about is key issue in the field since it ultimately results in chronic pain. Central
María del Mar Romero-Alemán et al.
Journal of anatomy, 223(1), 22-37 (2013-05-10)
We analysed the astroglia response that is concurrent with spontaneous axonal regrowth after optic nerve (ON) transection in the lizard Gallotia galloti. At different post-lesional time points (0.5, 1, 3, 6, 9 and 12 months) we used conventional electron microscopy and
Corinne S Wilson et al.
Journal of neurochemistry, 151(2), 255-272 (2019-04-30)
Volume-regulated anion channel (VRAC) is a glutamate-permeable channel that is activated by physiological and pathological cell swelling and promotes ischemic brain damage. However, because VRAC opening requires cytosolic ATP, it is not clear if and how its activity is sustained
Pietro Scaturro et al.
Nature, 561(7722), 253-257 (2018-09-05)
Zika virus (ZIKV) has recently emerged as a global health concern owing to its widespread diffusion and its association with severe neurological symptoms and microcephaly in newborns1. However, the molecular mechanisms that are responsible for the pathogenicity of ZIKV remain
Animesh Alexander Raha et al.
Journal of Alzheimer's disease : JAD, 55(1), 199-217 (2016-09-24)
Neuroinflammation and activation of innate immunity are early events in neurodegenerative diseases including Alzheimer's disease (AD). Recently, a rare mutation in the gene Triggering receptor expressed on myeloid cells 2 (TREM2) has been associated with a substantial increase in the
Kun-Yu Li et al.
Glia, 68(11), 2361-2376 (2020-05-30)
Astrocytes are fundamental for maintaining brain homeostasis and are commonly involved in the progression of neurodegenerative diseases including Alzheimer's disease (AD). In response to injury or toxic material, astrocytes undergo activation that results in hypertrophy and process ramification. Although numerous
Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia.
Kecsk??s, et al.
Frontiers in Aging Neuroscience, 15, 1175281-1175281 (2023)
Natsuko Kondo et al.
Scientific reports, 12(1), 8718-8718 (2022-05-25)
Brain radiation necrosis (RN) or neurocognitive disorder is a severe adverse effect that may occur after radiation therapy for malignant brain tumors or head and neck cancers. RN accompanies inflammation which causes edema or micro-bleeding, and no fundamental treatment has
J M Madison et al.
Molecular psychiatry, 20(6), 703-717 (2015-03-04)
Bipolar disorder (BD) is a common neuropsychiatric disorder characterized by chronic recurrent episodes of depression and mania. Despite evidence for high heritability of BD, little is known about its underlying pathophysiology. To develop new tools for investigating the molecular and
Vuk Palibrk et al.
Cell death & disease, 7(7), e2320-e2320 (2016-07-30)
Regulation of innate immune responses and activation of tissue regenerative processes are key elements in the pathophysiology of brain injuries. The promyelocytic leukemia (PML) gene was originally identified on a breakpoint of chromosomal translocation t(15;17) associated with acute PML. We
Patrick T Ronaldson et al.
Journal of neurochemistry, 89(3), 788-800 (2004-04-17)
We investigated the cellular/subcellular localization and functional expression of P-glycoprotein, an ATP-dependent membrane-associated efflux transporter, in astrocytes, a brain parenchyma compartment that is poorly characterized for the expression of membrane drug transporters. Analyses were carried out on primary cultures of
Audrey Ragagnin et al.
Brain pathology (Zurich, Switzerland), 28(2), 240-263 (2017-03-08)
In prion diseases, the brain lesion profile is influenced by the prion "strain" properties, the invasion route to the brain, and still unknown host cell-specific parameters. To gain insight into those endogenous factors, we analyzed the histopathological alterations induced by
Vanessa Ginet et al.
Annals of neurology, 76(5), 695-711 (2014-08-26)
Neonatal hypoxic-ischemic encephalopathy (HIE) still carries a high burden by its mortality and long-term neurological morbidity in survivors. Apart from hypothermia, there is no acknowledged therapy for HIE, reflecting the lack of mechanistic understanding of its pathophysiology. (Macro)autophagy, a physiological
Nibedita Lenka
Methods in molecular biology (Clifton, N.J.), 330, 33-54 (2006-07-19)
The embryonic stem (ES) cells derived from the inner cell mass of the blastula stage embryo bear the complete repertoire of the complex organizational blueprint of an organism. These fascinating cells are bestowed with pluripotent characteristics and can be directed
Hideo Hagihara et al.
Cell reports, 37(2), 109820-109820 (2021-10-14)
Lactate has diverse roles in the brain at the molecular and behavioral levels under physiological and pathophysiological conditions. This study investigates whether lysine lactylation (Kla), a lactate-derived post-translational modification in macrophages, occurs in brain cells and if it does, whether
Jing-Wei Zhao et al.
The European journal of neuroscience, 29(9), 1853-1869 (2009-05-29)
Brain injury induces gliosis and scar formation; its principal cell types are mainly astrocytes and some oligodendrocytes. The origin of the astrocytes and oligodendrocytes in the scar remains unclear together with the underlying mechanism of their fate choice. We examined
Takashi Fujishiro et al.
International journal of molecular sciences, 21(4) (2020-02-23)
We investigated structural changes and astrocyte responses of the lateral geniculate nucleus (LGN) in a ferret model of ocular hypertension (OH). In 10 ferrets, OH was induced via the injection of cultured conjunctival cells into the anterior chamber of the
Adam Feher et al.
Scientific reports, 12(1), 22023-22023 (2022-12-21)
Glioblastoma (GBM) is the most aggressive glial tumor, where ion channels, including KCa1.1, are candidates for new therapeutic options. Since the auxiliary subunits linked to KCa1.1 in GBM are largely unknown we used electrophysiology combined with pharmacology and gene silencing
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