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Showing 1-30 of 115 results for "G4501" within Papers
Forough Ghasemi et al.
Analytica chimica acta, 882, 58-67 (2015-06-05)
Developments of sensitive, rapid, and cheap systems for identification of a wide range of biomolecules have been recognized as a critical need in the biology field. Here, we introduce a simple colorimetric sensor array for detection of biological thiols, based
Takumi Satoh et al.
Neuroscience research, 55(1), 34-39 (2006-03-01)
The reduced form of glutathione (GSH; gamma-glutamyl cysteinyl glycine) is supposedly the most powerful reducing battery in the central nervous system against oxidative stress. We evaluated the contribution of GSH and GSSG to MEGA-PRESS (a frequency-selective refocusing technique) signals assessed
Aleksandra Kezic et al.
American journal of nephrology, 37(4), 291-301 (2013-04-04)
Reactive oxygen species play an important role in the pathogenesis of kidney ischemia/reperfusion injury (IRI) which may be influenced by immunosuppressive therapy. Pertinent to this, we investigated the effects of the mTOR inhibitor everolimus on redox settings and the activity
Marta Siernicka et al.
Immunology, 146(1), 173-183 (2015-06-23)
Natural killer (NK) cells are considered critical components of the innate and adaptive immune responses. Deficiencies in NK cell activity are common, such as those that occur in cancer patients, and they can be responsible for dysfunctional immune surveillance. Persistent
A P Burlina et al.
European journal of pediatrics, 158(5), 406-409 (1999-05-20)
We measured N-acetylaspartate and its precursor/product N-acetylaspartylglutamate (NAAG) in urine of patients with Canavan disease using capillary zone electrophoresis. Abnormal levels of NAAG were found in 32 of 43 patients examined. Elevated NAAG was also present in the CSF of
Leung-Kim Hung et al.
The Journal of bone and joint surgery. American volume, 95(7), e41-e41 (2013-04-05)
Adhesion formation is a complication of hand flexor tendon repair. Normal gliding function of flexor tendons can be impaired by an excessive fibrotic response, which may be caused by intraoperative and postoperative hemorrhage. As tissue damage and hemorrhage can disturb
A Slivka et al.
Neuroscience letters, 74(1), 112-118 (1987-02-10)
Prior animal studies have indicated that levels of oxidized glutathione (GSSG) in brain and other organs are low, comprising several percent, or less, of the total glutathione. An exception is seen in reports for autopsy and biopsy specimens of human
Oxidized glutathione levels in erythrocytes of glucose-6-phosphate-dehydrogenase-deficient subjects.
S K Srivastava et al.
Lancet (London, England), 2(7558), 23-24 (1968-07-06)
Sandeep Kumar Dash et al.
Journal of applied toxicology : JAT, 34(11), 1130-1144 (2014-01-31)
The aim of the present study was to develop zinc sulfide nanoparticles (ZnS NPs) and to study their cytotoxicity against the KG-1A (human acute myeloid leukemia) cell line. ZnS NPs were synthesized using the pyrolytic method and characterized by X-ray
Francine R Ianiski et al.
The Journal of pharmacy and pharmacology, 66(12), 1747-1754 (2014-08-19)
In this study, the antioxidant action of ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide, a novel unsymmetrical divinyl sulfide, against oxidative damage induced by sodium nitroprusside (SNP) in brains of mice was investigated. Mice received SNP (0.335 μmol/site, intracerebroventricular) 30 min after administration of sulfide
R A Wevers et al.
Clinical chemistry, 41(5), 744-751 (1995-05-01)
This study describes a standardized method for recording single-pulse 1H-nuclear magnetic resonance (1H-NMR) spectra from cerebrospinal fluid (CSF). Quantitative data for alanine, valine, threonine, and lactic acid correlated well with data obtained with conventional techniques. The pH of the samples
C Syburra et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 71(3), 112-115 (1999-12-28)
It is well known that brain and nervous system cells are prone to oxidative damage because of their relatively low content of antioxidants, especially enzymatic ones, and of the high levels of both membrane polyunsaturated fatty acids (PUFA) and iron
Elena Ganea et al.
Current eye research, 31(1), 1-11 (2006-01-20)
Glutathione and the related enzymes belong to the defence system protecting the eye against chemical and oxidative stress. This review focuses on GSH and two key enzymes, glutathione reductase and glucose-6-phosphate dehydrogenase in lens, cornea, and retina. Lens contains a
P Zafrilla et al.
The journal of nutrition, health & aging, 17(3), 219-222 (2013-03-06)
The aim of this study was to analyze biomarkers of oxidative stress in patients with wet age related macular degeneration (AMD). Case-control study that includes 163 patients with wet AMD (age group of 55-82 years with the mean age of
Ciriaco Carru et al.
Electrophoresis, 23(11), 1716-1721 (2002-08-16)
We describe a very rapid high-performance capillary electrophoresis method for the separation and quantification of reduced (GSH) and oxidized (GSSG) glutathione in red blood cells. Two procedures for sample preparation have been compared, Microcon-10 membrane filtration and acid precipitation. The
Vladimir L Kolossov et al.
Experimental biology and medicine (Maywood, N.J.), 239(4), 394-403 (2014-03-04)
The glutathione couple GSH/GSSG is the most abundant cellular redox buffer and is not at equilibrium among intracellular compartments. Perturbation of glutathione poise has been associated with tumorigenesis; however, due to analytical limitations, the underlying mechanisms behind this relationship are
Roshil Budhram et al.
Advances in experimental medicine and biology, 775, 321-343 (2013-02-09)
In this study, the actions of taurine (TAU), a sulfonate, and thiotaurine (TTAU), a thiosulfonate, on diabetes-mediated biochemical alterations in red blood cells (RBCs) and plasma and on the RBC membrane, morphology and spectrin distribution were examined in rats. Diabetes
T Kondo et al.
American journal of hematology, 26(1), 37-45 (1987-09-01)
The oxidized form of glutathione transport was studied in human erythrocytes in pyrimidine 5'-nucleotidase (P5N) deficiency, a disorder in which the amounts of CTP and UTP in the erythrocytes are elevated. The inhibition of ATP-requiring oxidized glutathione (GSSG) transport by
Zrinka Karačić et al.
Biological chemistry, 393(12), 1523-1532 (2013-05-15)
Human dipeptidyl peptidase III (DPP III) is a member of the metallopeptidase family M49, involved in protein metabolism and oxidative stress response. DPPIII crystal structure shows the two lobe-like domains separated by a wide cleft. The human enzyme has a
Joshua B Owen et al.
Methods in molecular biology (Clifton, N.J.), 648, 269-277 (2010-08-12)
Glutathione (GSH) is the most abundant antioxidant in aerobic cells, present in micromolar (microM)-concentrations in bodily fluids and in millimolar (mM) concentrations in tissue. GSH is critical for protecting the brain from oxidative stress, acting as a free radical scavenger
Daniel J Garama et al.
Molecular and cellular biology, 35(21), 3646-3656 (2015-08-19)
Increased production of mitochondrion-derived reactive oxygen species (ROS) is characteristic of a metabolic shift observed during malignant transformation. While the exact sources and roles of ROS in tumorigenesis remain to be defined, it has become clear that maintaining redox balance
Sung-Shin Hong et al.
Journal of ethnopharmacology, 168, 268-278 (2015-04-14)
Gongjin-Dan is a representative traditional Oriental medicine herbal drug that has been used to treat chronic fatigue symptoms for several hundred years. We evaluated the anti-fatigue effects of Gongjin-Dan and the underlying mechanisms in a chronic forced exercise mouse model.
Jun-Lin Ou et al.
The FEBS journal, 280(22), 5829-5840 (2013-09-17)
Curcumin (Cur) is a commonly used colouring agent and spice in food. Previously, we reported that Cur inhibits type A influenza virus (IAV) infection by interfering with viral haemagglutination (HA) activity. To search for a stable Cur analogue with potent
Claire M Doskey et al.
PloS one, 10(7), e0132572-e0132572 (2015-07-15)
The biological consequences upon exposure of cells in culture to a dose of xenobiotic are not only dependent on biological variables, but also the physical aspects of experiments e.g. cell number and media volume. Dependence on physical aspects is often
Antonella Caccamo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(3), 906-913 (2013-01-18)
The accumulation of TDP-43 (transactive response DNA-binding protein 43) and its 25 kDa C-terminal fragment (TDP-25) is a hallmark of several neurodegenerative disorders, including frontotemporal lobar degeneration (FTLD-TDP) and amyotrophic lateral sclerosis (ALS). The majority of FTLD-TDP cases are due
N Mohell et al.
Cell death & disease, 6, e1794-e1794 (2015-06-19)
Two main causes of platinum resistance are mutation in the tumor suppressor gene TP53 and drug-induced increase in intracellular glutathione concentration. Mutations in TP53 occur in about 50% of human tumors. APR-246 (PRIMA-1(MET)) is the first clinical-stage compound that reactivates
Valerio Leoni et al.
Clinical chemistry and laboratory medicine, 42(2), 186-191 (2004-04-06)
24S-Hydroxycholesterol (24OHC) and 27-hydroxycholesterol (27OHC) are two structurally similar oxysterols of different origins--the former almost exclusively formed in the brain and the latter formed to a lesser extent in the brain than in most other organs. HYPOTHESIS TO BE TESTED:
Elizabeth Mathew et al.
Advances in experimental medicine and biology, 775, 345-369 (2013-02-09)
This study has compared the actions of the sulfur-containing compounds taurine (TAU) and thiotaurine (TTAU) with those of insulin (INS) on the oxidative stress that develops in the aorta and heart as a result of diabetes. Diabetes was induced in
David Vauzour et al.
The Biochemical journal, 463(1), 41-52 (2014-06-19)
Parkinson's disease is characterized by the progressive and selective loss of dopaminergic neurons in the substantia nigra. It has been postulated that endogenously formed CysDA (5-S-cysteinyldopamine) and its metabolites may be, in part, responsible for this selective neuronal loss, although
Roman Kireev et al.
European journal of pharmacology, 701(1-3), 185-193 (2012-12-12)
Fatty livers occur in up to 20% of potential liver donors and increase cellular injury during the ischemia/reperfusion phase, so any intervention that could enable a better outcome of grafts for liver transplantation would be very useful. The effect of
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