G4918

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Showing 1-8 of 8 results for "G4918" within Papers

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.

Bart Tummers et al.

Immunity, 52(6), 994-1006 (2020-05-20)

Cell death pathways regulate various homeostatic processes. Autoimmune lymphoproliferative syndrome (ALPS) in humans and lymphoproliferative (LPR) disease in mice result from abrogated CD95-induced apoptosis. Because caspase-8 mediates CD95 signaling, we applied genetic approaches to dissect the roles of caspase-8 in

Synthesis, Antimicrobial and Hypoglycemic Activities of Novel N-(1-Adamantyl)carbothioamide Derivatives.

Ebtehal S Al-Abdullah et al.

Molecules (Basel, Switzerland), 20(5), 8125-8143 (2015-05-09)

The reaction of 1-adamantyl isothiocyanate 4 with the various cyclic secondary amines yielded the corresponding N-(1-adamantyl)carbothioamides 5a-e, 6, 7, 8a-c and 9. Similarly, the reaction of 4 with piperazine and trans-2,5-dimethylpiperazine in 2:1 molar ratio yielded the corresponding N,N'-bis(1-adamantyl)piperazine-1,4-dicarbothioamides 10a

Altered states of telomere deprotection and the two-stage mechanism of replicative aging.

Ying Zou et al.

Molecular and cellular biology, 29(9), 2390-2397 (2009-02-19)

The molecular distinctions between mortality stages 1 (M1; senescence) and 2 (M2; crisis) of human replicative aging are ill defined. We demonstrate a qualitative difference between telomeric end associations at M1 and the end fusions that produce dicentric chromosomes and

Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death.

Kelly N Owens et al.

PLoS genetics, 4(2), e1000020-e1000020 (2008-05-06)

Inner ear sensory hair cell death is observed in the majority of hearing and balance disorders, affecting the health of more than 600 million people worldwide. While normal aging is the single greatest contributor, exposure to environmental toxins and therapeutic

Chronic exposures to monomethyl phthalate in Western clawed frogs.

Justine Mathieu-Denoncourt et al.

General and comparative endocrinology, 219, 53-63 (2015-02-11)

Polymer flexibility and elasticity is enhanced by plasticizers. However, plasticizers are often not covalently bound to plastics and thus can leach from products into the environment. Much research effort has focused on their effects in mammalian species, but data on

Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption.

Aleksandra S Chikina et al.

Cell, 183(2), 411-428 (2020-09-25)

The colon is primarily responsible for absorbing fluids. It contains a large number of microorganisms including fungi, which are enriched in its distal segment. The colonic mucosa must therefore tightly regulate fluid influx to control absorption of fungal metabolites, which

Quantification of Bacteria Residing in Caenorhabditis elegans Intestine.

M Fernanda Palominos et al.

Bio-protocol, 10(9), e3605-e3605 (2021-03-05)

Quantification of intestinal colonization by pathogenic or commensal bacteria constitute a critical part of the analysis to understand host-microbe interactions during different time points of their interplay. Here we detail a method to isolate non-pathogenic and pathogenic bacteria from C.

Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.

W Joshua Frazier et al.

Journal of immunology (Baltimore, Md. : 1950), 183(11), 7411-7419 (2009-11-06)

MAPKs are crucial for TNF-alpha and IL-6 production by innate immune cells in response to TLR ligands. MAPK phosphatase 1 (Mkp-1) deactivates p38 and JNK, abrogating the inflammatory response. We have previously demonstrated that Mkp-1(-/-) mice exhibit exacerbated inflammatory cytokine

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