Search Within


Applied Filters:
Showing 1-30 of 3209 results for "G5500" within Papers
Adéla Melcrová et al.
Physical chemistry chemical physics : PCCP, 18(3), 2130-2142 (2015-12-23)
Determination of the saccharide structure in solution is a laborious process that can be significantly enhanced by optical spectroscopies. Raman optical activity (ROA) spectra are particularly sensitive to the chirality and conformation. However, the interpretation of them is largely dependent
Joseph G Skeate et al.
Frontiers in immunology, 11, 561843-561843 (2020-11-07)
Persistent infection with high-risk human papillomavirus (hrHPV) genotypes results in a large number of anogenital and head and neck cancers worldwide. Although prophylactic vaccination coverage has improved, there remains a need to develop methods that inhibit viral transmission toward preventing
Kensuke Seto et al.
Mycologia, 107(3), 633-640 (2015-03-25)
Lobulomycetales is one of the smallest orders of Chytridiomycota, containing only four genera and five species. In a survey in Japan we isolated a chytrid from a soil sample collected in a broadleaf forest, which grouped in Lobulomycetales by BLAST
Min Peng et al.
Human molecular genetics, 24(17), 4829-4847 (2015-06-05)
Mitochondrial respiratory chain (RC) disease therapies directed at intra-mitochondrial pathology are largely ineffective. Recognizing that RC dysfunction invokes pronounced extra-mitochondrial transcriptional adaptations, particularly involving dysregulated translation, we hypothesized that translational dysregulation is itself contributing to the pathophysiology of RC disease.
Laura Simon-Szabó et al.
PloS one, 9(6), e97868-e97868 (2014-06-05)
Lipotoxicity refers to cellular dysfunctions caused by elevated free fatty acid levels playing a central role in the development and progression of obesity related diseases. Saturated fatty acids cause insulin resistance and reduce insulin production in the pancreatic islets, thereby
Mihaela Cudalbeanu et al.
Antibiotics (Basel, Switzerland), 9(1) (2019-12-28)
This study aimed to explore for the first time the biological properties such as antifungal, antitumoral and antioxidant of Danube Delta Nymphaea alba (N. alba) leaf and root methanolic extracts. The toxicity studies of N. alba extracts showed no inhibitory
Oleg Timofeev et al.
The EMBO journal, 38(20), e102096-e102096 (2019-09-05)
Engineered p53 mutant mice are valuable tools for delineating p53 functions in tumor suppression and cancer therapy. Here, we have introduced the R178E mutation into the Trp53 gene of mice to specifically ablate the cooperative nature of p53 DNA binding.
Guping Wang et al.
Biological & pharmaceutical bulletin, 39(2), 207-214 (2015-11-27)
Heart failure represents a major health problem. The development of new drugs to treat this condition is essential. We previously discovered that AF-001 attenuates the cardiac defects caused by heart failure in zebrafish. In this paper, we report the identification
Guillaume Kreutter et al.
Journal of cellular and molecular medicine, 21(11), 2759-2772 (2017-05-20)
Islet transplantation is associated with early ischaemia/reperfusion, localized coagulation and redox-sensitive endothelial dysfunction. In animal models, islet cytoprotection by activated protein C (aPC) restores islet vascularization and protects graft function, suggesting that aPC triggers various lineages. aPC also prompts the
Hiroshi Nomoto et al.
Diabetologia, 63(1), 149-161 (2019-11-14)
The conserved hypoxia inducible factor 1 α (HIF1α) injury-response pro-survival pathway has recently been implicated in early beta cell dysfunction but slow beta cell loss in type 2 diabetes. We hypothesised that the unexplained prolonged prediabetes phase in type 1
Eva-Leonne Göttgens et al.
Cancers, 11(12) (2019-12-11)
Radiotherapy is an important treatment modality of head and neck squamous cell carcinomas (HNSCC). Multiple links have been described between the metabolic activity of tumors and their clinical outcome. Here we test the hypothesis that metabolic features determine radiosensitivity, explaining
Anita A Wasik et al.
Experimental cell research, 350(2), 336-348 (2016-12-25)
Glomerular epithelial cells, podocytes, are insulin responsive and can develop insulin resistance. Here, we demonstrate that the small GTPase septin 7 forms a complex with nonmuscle myosin heavy chain IIA (NMHC-IIA; encoded by MYH9), a component of the nonmuscle myosin
Michael Papetti et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 93(4), 464-471 (2018-02-07)
Many aspects of cell physiology, including migration, membrane function, and cell division, are best understood by observing live cell dynamics over time using video microscopy. To probe these phenomena in colon epithelial cells using simple components with a limited budget
László Balkay et al.
Magyar onkologia, 58(4), 251-260 (2014-12-18)
Deriving quantitative measures from the medical imaging methods is a key issue for the optimal oncologic therapy, when the anatomical abnormalities and changes of the metabolic state of the tissues need to be characterized. In order to improve the effectiveness
Lauren T Cordova et al.
Metabolic engineering, 44, 182-190 (2017-10-19)
Thermophilic organisms are being increasingly investigated and applied in metabolic engineering and biotechnology. The distinct metabolic and physiological characteristics of thermophiles, including broad substrate range and high uptake rates, coupled with recent advances in genetic tool development, present unique opportunities
Dat P Ha et al.
Cellular signalling, 75, 109736-109736 (2020-08-18)
GRP78, a major molecular chaperone, is critical for the folding and maturation of membrane and secretory proteins and serves as the master regulator of the unfolded protein response. Thus, GRP78 is frequently upregulated in highly proliferative cells to cope with
Minghua Li et al.
Cancers, 12(6) (2020-06-18)
HIV-1 Tat Interactive Protein 2 (HTATIP2) is a tumor suppressor, of which reduced or absent expression is associated with increased susceptibility to tumorigenesis and enhanced tumor invasion and metastasis. However, whether the absent expression of HTATIP2 is a tumor-promoting factor
Allison M Johnson et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(5), 2615-2629 (2018-01-04)
Familial cerebral cavernous malformations type III (fCCM3) is a disease of the cerebrovascular system caused by loss-of-function mutations in ccm3 that result in dilated capillary beds that are susceptible to hemorrhage. Before hemorrhage, fCCM3 lesions are characterized by a hyperpermeable
Junjie Liu et al.
Free radical biology & medicine, 147, 90-101 (2019-12-16)
The involvement of reactive oxygen species (ROS) has been suggested in the development of inflammatory bowel disease (IBD). An impaired intestinal barrier function is common in IBD patients. Here, we report the central role of NOX1/NADPH oxidase, a major source
Hye Rim Chang et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(10), 1967-1985 (2019-08-23)
Fatty acid uptake and oxidation characterize the metabolism of alternatively activated macrophage polarization in vitro, but the in vivo biology is less clear. We assessed the roles of LpL (lipoprotein lipase)-mediated lipid uptake in macrophage polarization in vitro and in
Marcel Blumensatt et al.
Basic research in cardiology, 112(1), 2-2 (2016-11-20)
Secretory products from epicardial adipose tissue (EAT) from patients with type 2 diabetes (T2D) impair cardiomyocyte function. These changes associate with alterations in miRNA expression, including the induction of miR-208a. Recent studies suggest that activation of the cardiac-specific renin-angiotensin system
Toni M West et al.
Journal of the American Heart Association, 8(15), e012273-e012273 (2019-07-18)
Background In murine heart failure models and in humans with diabetic-related heart hypertrophy, inhibition of phosphodiesterase 5 (PDE5) by sildenafil improves cardiac outcomes. However, the mechanism by which sildenafil improves cardiac function is unclear. We have observed a relationship between
Differential Proteomic Profiles of
Qiuyun Xiao et al.
Frontiers in microbiology, 8, 480-480 (2017-04-08)
Cindy Tatiana Báez-Becerra et al.
Mechanisms of ageing and development, 192, 111360-111360 (2020-09-26)
Recently, mutations in the RNA polymerase III subunit A (POLR3A) have been described as the cause of the neonatal progeria or Wiedemann-Rautenstrauch syndrome (WRS). POLR3A has important roles in transcription regulation of small RNAs, including tRNA, 5S rRNA, and 7SK
ChenQing Wu et al.
Toxicology letters, 309, 1-9 (2019-03-25)
Aflatoxin M1 (AFM1), ochratoxin A (OTA), and zearalenone (ZEA) are mycotoxins commonly found in milk. Mycotoxin contamination has caused food safety concerns worldwide since most of the toxic effects in humans are serious. The combined toxic effects of these mycotoxins
Amanda Trent et al.
The AAPS journal, 17(2), 380-388 (2014-12-21)
Delivery system design and adjuvant development are crucially important areas of research for improving vaccines. Peptide amphiphile micelles are a class of biomaterials that have the unique potential to function as both vaccine delivery vehicles and self-adjuvants. In this study
Abigail C Lay et al.
Diabetologia, 60(11), 2299-2311 (2017-08-31)
Podocytes are insulin-responsive cells of the glomerular filtration barrier and are key in preventing albuminuria, a hallmark feature of diabetic nephropathy. While there is evidence that a loss of insulin signalling to podocytes is detrimental, the molecular mechanisms underpinning the
Tanja Kaufmann et al.
Nucleic acids research, 48(21), e122-e122 (2020-10-15)
Protein-protein interactions are essential to ensure timely and precise recruitment of chromatin remodellers and repair factors to DNA damage sites. Conventional analyses of protein-protein interactions at a population level may mask the complexity of interaction dynamics, highlighting the need for
Tünde Kovács et al.
Scientific reports, 9(1), 1300-1300 (2019-02-06)
Recent studies showed that changes to the gut microbiome alters the microbiome-derived metabolome, potentially promoting carcinogenesis in organs that are distal to the gut. In this study, we assessed the relationship between breast cancer and cadaverine biosynthesis. Cadaverine treatment of
Ruoting Ding et al.
Frontiers in molecular neuroscience, 10, 195-195 (2017-07-05)
Pain hypersensitivity is the most common category of chronic pain and is difficult to cure. Oxidative stress and certain cells apoptosis, such as dorsal root ganglion (DRG) neurons, play an essential role in the induction and development of pain hypersensitivity.
Page 1 of 107