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Showing 1-30 of 40 results for "G7652" within Papers
Chang-Yi Xiao et al.
Cancer cell international, 15, 53-53 (2015-06-13)
The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsid protein (L1) of human
Alfonso Martinisi et al.
Brain : a journal of neurology, 144(3), 963-974 (2021-01-24)
Tau is a microtubule stabilizing protein that forms abnormal aggregates in many neurodegenerative disorders, including Alzheimer's disease. We have previously shown that co-expression of fragmented and full-length tau in P301SxTAU62on tau transgenic mice results in the formation of oligomeric tau
Monika Macakova et al.
Neuro-degenerative diseases, 16(3-4), 245-259 (2016-03-10)
Huntington's disease is induced by CAG expansion in a single gene coding the huntingtin protein. The mutated huntingtin (mtHtt) primarily causes degeneration of neurons in the brain, but it also affects peripheral tissues, including testes. We studied sperm and testes
Arben Merkoçi et al.
Analytical chemistry, 77(19), 6500-6503 (2005-10-01)
Gold nanoparticles modified with anti-mouse IgG have been used to trace oligonucleotides carrying a c-myc peptide. Two strategies, a dot-blot format as well as inductively coupled plasma mass spectrometry (ICPMS) have been used to detect the nanoparticle tracer. For both
Vijaya Sunkara et al.
ACS applied materials & interfaces, 15(49), 56807-56819 (2023-11-29)
Extracellular vesicles (EVs) are emerging as crucial materials for precision theragnostic applications. However, current separation methods are time-consuming, costly, and not scalable and deliver limited yields or purity. Here, we present EV precipitation by ionic strength modulation (ExoPRISM), a simple
Daryl E Enstone et al.
Scientific reports, 5, 15074-15074 (2015-10-13)
Hydrophobic protein from soybean (HPS) is present in soybean dust and is an allergen (Gly m 1) that causes asthma in allergic individuals. Past studies have shown that HPS occurs on the seed surface. To determine the microscopic localization of
Structure and function of human and murine receptors for IgG.
J C Unkeless et al.
Annual review of immunology, 6, 251-281 (1988-01-01)
D J Mulholland et al.
Biology of reproduction, 64(1), 396-407 (2001-01-03)
The seminiferous epithelium contains unique actin related cell-cell junctions, termed ectoplasmic specializations (ESs). Turnover of these junctions is fundamental to sperm release and to movement of spermatocytes from basal to adluminal compartments of the epithelium during spermatogenesis. In this study
Pan Qin et al.
Virology, 556, 1-8 (2021-01-31)
Porcine deltacoronavirus (PDCoV) is one of the emerged coronaviruses posing a significant threat to the swine industry. Previous work showed the presence of a viral accessory protein NS6 in PDCoV-infected cells. In this study, we detected the expression of the
David A Montero et al.
Frontiers in immunology, 14, 1186368-1186368 (2023-08-14)
Shiga toxin-producing Escherichia coli (STEC) is a foodborne pathogen that causes gastrointestinal infections, ranging from acute diarrhea and dysentery to life-threatening diseases such as Hemolytic Uremic Syndrome. Currently, a vaccine to prevent STEC infection is an unmet medical need. We
Quan Jin et al.
Gene therapy, 27(5), 237-244 (2019-12-11)
Recombinant adeno-associated viral (AAV) vectors are frequently used to deliver DNA into cells and are currently the leading platform for therapeutic gene delivery in humans. Presently, there is a need for optimized AAV vectors with improved transduction efficiencies in target tissues.
Adam Wenborn et al.
Scientific reports, 5, 10062-10062 (2015-05-08)
Mammalian prions exist as multiple strains which produce characteristic and highly reproducible phenotypes in defined hosts. How this strain diversity is encoded by a protein-only agent remains one of the most interesting and challenging questions in biology with wide relevance
Melissa Huang et al.
eNeuro, 9(6) (2023-01-13)
Alzheimer's Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. To investigate the link between Aβ and tau pathologies, experimental models featuring both pathologies
Vivianne J Goosens et al.
ACS synthetic biology, 10(12), 3422-3434 (2021-11-13)
Bacteria proficient at producing cellulose are an attractive synthetic biology host for the emerging field of Engineered Living Materials (ELMs). Species from the Komagataeibacter genus produce high yields of pure cellulose materials in a short time with minimal resources, and
Jiaqi Fu et al.
eLife, 11 (2022-01-28)
The intracellular pathogen Legionella pneumophila delivers more than 330 effectors into host cells by its Dot/Icm secretion system. Those effectors direct the biogenesis of the Legionella-containing vacuole (LCV) that permits its intracellular survival and replication. It has long been documented
Andrea Hujacova et al.
Diagnostics (Basel, Switzerland), 11(8) (2021-08-28)
Different biomarkers are investigated to detect the causes of severe complications in preterm infants. Extracellular vesicles (EVs) are recognized as an important part of cell-to-cell communication, and their increased levels were reported in numerous pathological states. We aimed to increase
Yun Zhang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 6(1), 67-72 (2002-07-04)
Therapeutic genes are delivered to the nuclear compartment of cancer cells following intravenous administration with a non-immunogenic "artificial virus" gene delivery system that uses receptor-specific monoclonal antibodies (MAb) to navigate the biological barriers between the blood and the nucleus of
Flora Gilde et al.
Acta biomaterialia, 46, 55-67 (2016-09-17)
Surface coatings delivering BMP are a promising approach to render biomaterials osteoinductive. In contrast to soluble BMPs which can interact with their receptors at the dorsal side of the cell, BMPs presented as an insoluble cue physically bound to a
Nani Van Gerven et al.
Molecular microbiology, 91(5), 1022-1035 (2014-01-15)
Curli are functional amyloids expressed as fibres on the surface of Enterobacteriaceae. Contrary to the protein misfolding events associated with pathogenic amyloidosis, curli are the result of a dedicated biosynthetic pathway. A specialized transporter in the outer membrane, CsgG, operates
Sylwia Jancowski et al.
The Plant journal : for cell and molecular biology, 77(4), 497-510 (2013-12-18)
Proteins detrimental to endoplasmic reticulum (ER) morphology need to be efficiently exported. Here, we identify two mechanisms that control trafficking of Arabidopsis thalianaGLL23, a 43 kDa GDSL-like lipase implicated in glucosinolate metabolism through its association with the β-glucosidase myrosinase. Using
Complement-fixing IgG1 constitutes a new subclass of mouse IgG.
P L Ey et al.
Nature, 281(5731), 492-493 (1979-10-11)
Wenchong Zou et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(3), 1801313-1801313 (2019-02-19)
Exosomes are small membrane-bound vesicles released into extracellular spaces by many types of cells. These nanovesicles carry proteins, mRNA, and miRNA, and are involved in cell waste management and intercellular communication. In the present study, it is shown that exosome
Vendula Pospichalova et al.
Journal of extracellular vesicles, 4, 25530-25530 (2015-04-04)
Flow cytometry is a powerful method, which is widely used for high-throughput quantitative and qualitative analysis of cells. However, its straightforward applicability for extracellular vesicles (EVs) and mainly exosomes is hampered by several challenges, reflecting mostly the small size of
Suh Kuan Yong et al.
Biosensors, 11(11) (2021-11-26)
The prevalence of hepatitis B virus (HBV) is a global healthcare threat, particularly chronic hepatitis B (CHB) that might lead to hepatocellular carcinoma (HCC) should not be neglected. Although many types of HBV diagnosis detection methods are available, some technical
Cassandra Terry et al.
Open biology, 6(5) (2016-06-02)
Mammalian prions are hypothesized to be fibrillar or amyloid forms of prion protein (PrP), but structures observed to date have not been definitively correlated with infectivity and the three-dimensional structure of infectious prions has remained obscure. Recently, we developed novel
Magdalena Kowalska et al.
Journal of morphology, 281(1), 110-121 (2019-11-13)
This study report about the differentiation of pancreatic acinar tissue in grass snake, Natrix natrix, embryos using light microscopy, transmission electron microscopy, and immuno-gold labeling. Differentiation of acinar cells in the embryonic pancreas of the grass snake is similar to
Rebecca S Moore et al.
Cell, 184(18), 4697-4712 (2021-08-08)
Animals face both external and internal dangers: pathogens threaten from the environment, and unstable genomic elements threaten from within. C. elegans protects itself from pathogens by "reading" bacterial small RNAs, using this information to both induce avoidance and transmit memories for
Jin-Yong Noh et al.
PloS one, 11(9), e0162946-e0162946 (2016-09-15)
Highly pathogenic avian influenza (HPAI) and Newcastle disease (ND) are considered as the most devastating poultry infections, owing to their worldwide distribution and economical threat. Vaccines have been widely used to control these diseases in the poultry industry in endemic
Eun-Jin Bae et al.
Experimental & molecular medicine, 54(6), 788-800 (2022-07-06)
Cell-to-cell propagation of α-synuclein is thought to be the underlying mechanism of Parkinson's disease progression. Recent evidence suggests that inflammation plays an important role in the propagation of protein aggregates. However, the mechanism by which inflammation regulates the propagation of
Ji Wang et al.
Autophagy, 10(5), 766-784 (2014-03-05)
HCV infection induces autophagy, but how this occurs is unclear. Here, we report the induction of autophagy by the structural HCV core protein and subsequent endoplasmic reticular (ER) stress in Huh7 hepatoma cells. During ER stress, both the EIF2AK3 and
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