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Showing 1-30 of 820 results for "G9023" within Papers
Thibault Teissier et al.
Aging cell, 18(2), e12850-e12850 (2019-02-23)
Pro-aging effects of endogenous advanced glycation end-products (AGEs) have been reported, and there is increasing interest in the pro-inflammatory and -fibrotic effects of their binding to RAGE (the main AGE receptor). The role of dietary AGEs in aging remains ill-defined
Gonzalo Federico Mayol et al.
Biochimica et biophysica acta. Molecular cell research, 1867(1), 118566-118566 (2019-11-02)
Nuclear-cytoplasmic trafficking of proteins is a highly regulated process that modulates multiple biological processes in eukaryotic cells. In Giardia lamblia, shuttling has been described from the cytoplasm to nuclei of proteins during the biological cell cycle of the parasite. This
Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect.
Sharon L Wong et al.
American journal of respiratory cell and molecular biology, 67(1), 99-111 (2022-04-27)
A significant challenge to making targeted cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies accessible to all individuals with cystic fibrosis (CF) are many mutations in the CFTR gene that can cause CF, most of which remain uncharacterized. Here, we
Shashank Rai et al.
Autophagy, 15(4), 599-612 (2018-11-08)
Macroautophagy/autophagy delivers damaged proteins and organelles to lysosomes for degradation, and plays important roles in maintaining tissue homeostasis by reducing tissue damage. The translocation of LC3 to the limiting membrane of the phagophore, the precursor to the autophagosome, during autophagy
Zhigang Shi et al.
eLife, 9 (2020-06-17)
Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that PVN leptin slowly increases SNA to muscle and brown adipose tissue, because
Michael A Wheeler et al.
Cell, 176(3), 581-596 (2019-01-22)
Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are available for their comprehensive investigation. We developed an approach that combines genomic data, screens in a novel zebrafish model, computational
O Dubourg et al.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 30(2), 103-108 (2011-11-24)
Sporadic inclusion body myositis (s-IBM) is characterized histologically by the association of concomitant inflammatory and degenerative processes. We evaluated the sensitivity and specificity of different markers of the degenerative process in order to refine the histological diagnosis. We performed an
Lynn Yap et al.
Cell reports, 26(12), 3231-3245 (2019-03-21)
Regeneration of injured human heart muscle is limited and an unmet clinical need. There are no methods for the reproducible generation of clinical-quality stem cell-derived cardiovascular progenitors (CVPs). We identified laminin-221 (LN-221) as the most likely expressed cardiac laminin. We
Nourhan Abdelfattah et al.
Nature communications, 13(1), 767-767 (2022-02-11)
A major rate-limiting step in developing more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular heterogeneity of immune infiltrates in gliomas. Here, we report an integrated analysis of 201,986 human glioma, immune, and
M S Alexander et al.
Translational psychiatry, 6(9), e901-e901 (2016-09-28)
Duchenne muscular dystrophy is caused by mutations in the DYSTROPHIN gene. Although primarily associated with muscle wasting, a significant portion of patients (approximately 25%) are also diagnosed with autism spectrum disorder. We describe social behavioral deficits in dystrophin-deficient mice and
J Jaworska-Adamu et al.
Polish journal of veterinary sciences, 21(3), 469-474 (2018-11-24)
Calretinin (CR), a calcium-binding protein from EF-hand family, is localised in non-pyramidal GABA-ergic interneurons of the hippocampus. CR takes part in maintaining calcium binding homeostasis, which suggests its neuroprotective role. Hippocampal neurons contain membrane transient receptor potential vanilloid 1 (TRPV1)
Andrew J Schneider et al.
Gene expression patterns : GEP, 34, 119075-119075 (2019-11-02)
Previous studies identified Sox9 as a critical mediator of prostate development but the precise stage when Sox9 acts had not been determined. A genetic approach was used to delete Sox9 from mouse urogenital sinus epithelium (UGE) prior to prostate specification.
Jinghan Feng et al.
Molecular neurobiology, 55(8), 6369-6386 (2018-01-08)
Activated autophagy/mitophagy has been intensively observed in ischemic brain, but its roles remain controversial. Peroxynitrite (ONOO-), as a representative of reactive nitrogen species, is considered as a critical neurotoxic factor in mediating cerebral ischemia-reperfusion (I/R) injury, but its roles in
Heather Griffin et al.
Current protocols in microbiology, 41, 14B-14B (2016-05-08)
Molecular events during the papillomavirus life cycle can be mapped in infected tissue biopsies using antibodies to viral and cellular gene products, or by in situ hybridization approaches that detect viral DNA or viral transcription products. For proteins, ease of
Thomas E Winkler et al.
Lab on a chip, 20(7), 1212-1226 (2020-03-07)
We see affordability as a key challenge in making organs-on-chips accessible to a wider range of users, particularly outside the highest-resource environments. Here, we present an approach to barrier-on-a-chip fabrication based on double-sided pressure-sensitive adhesive tape and off-the-shelf polycarbonate. Besides
Matthew J Stebbins et al.
Methods (San Diego, Calif.), 101, 93-102 (2015-11-01)
The blood-brain barrier (BBB) is a critical component of the central nervous system (CNS) that regulates the flux of material between the blood and the brain. Because of its barrier properties, the BBB creates a bottleneck to CNS drug delivery.
Stanislav Khirug et al.
Molecular neurobiology, 58(3), 1145-1161 (2020-10-26)
A striking result from epidemiological studies show a correlation between low alcohol intake and lower incidence for ischemic stroke and severity of derived brain injury. Although reduced apoptosis and inflammation has been suggested to be involved, little is known about
Jacob A Ross et al.
Acta neuropathologica communications, 8(1), 167-167 (2020-10-21)
X-linked myotubular myopathy (XLMTM) is a life-threatening skeletal muscle disease caused by mutations in the MTM1 gene. XLMTM fibres display a population of nuclei mispositioned in the centre. In the present study, we aimed to explore whether positioning and overall
Maria Pierantoni et al.
Scientific reports, 11(1), 17313-17313 (2021-08-29)
Achilles tendons are mechanosensitive, and their complex hierarchical structure is in part the result of the mechanical stimulation conveyed by the muscles. To fully understand how their microstructure responds to mechanical loading a non-invasive approach for 3D high resolution imaging
Roberto Chiarelli et al.
International journal of molecular sciences, 23(22) (2022-11-27)
The increasing industrial use of vanadium (V), as well as its recent medical use in various pathologies has intensified its environmental release, making it an emerging pollutant. The sea urchin embryo has long been used to study the effects induced
Martyna Åupicka et al.
Reproductive biology and endocrinology : RB&E, 13, 110-110 (2015-09-30)
Adenomyosis is a proliferative uterine dysfunction with unknown aetiology. One possible mechanism of its development involves disturbances in stem cell differentiation in uterine tissue. Previously, we identified pluripotent/multipotent cells in the bovine uterus, therefore our present study focused on determining
A M Thompson et al.
Molecular and cellular neurosciences, 109, 103554-103554 (2020-09-25)
The current study sought to characterize the pro-survival effects of erythropoietin (EPO) in a toxicant model of Parkinson's disease (PD). EPO treatment induced time-dependent elevations of antioxidant glutathione peroxidase (GPx) and anti-apoptotic factors (pAkt and pBad/Bad) within the striatum and
Francesca Solagna et al.
Acta physiologica (Oxford, England), 230(1), e13496-e13496 (2020-05-15)
Resistance exercise increases muscle mass over time. However, the early signalling events leading to muscle growth are not yet well-defined. Here, we aim to identify new signalling pathways important for muscle remodelling after exercise. We performed a phosphoproteomics screen after
Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells affects germ cell survival in developing mouse gonads.
Piprek, et al.
Reproduction (Cambridge, England), 163, 199-207 (2022)
E W McCleskey et al.
Annual review of physiology, 61, 835-856 (1999-04-01)
Nociceptors are the first cells in the series of neurons that lead to the sensation of pain. The essential functions of nociceptors--transducing noxious stimuli into depolarizations that trigger action potentials, conducting the action potentials from the peripheral sensory site to
Jakub Kralik et al.
International journal of molecular sciences, 22(21) (2021-11-14)
Degenerative diseases of the retina are responsible for the death of photoreceptors and subsequent loss of vision in patients. Nevertheless, the inner retinal layers remain intact over an extended period of time, enabling the restoration of light sensitivity in blind
Rosario Avolio et al.
Cell reports, 38(2), 110211-110211 (2022-01-13)
Oncogene-induced senescence (OIS) is a form of stable cell-cycle arrest arising in response to oncogenic stimulation. OIS must be bypassed for transformation, but the mechanisms of OIS establishment and bypass remain poorly understood, especially at the post-transcriptional level. Here, we
Monitoring basal autophagy in the retina utilizing CAG-mRFP-EGFP-MAP1LC3B reporter mouse: technical and biological considerations.
Ramachandra Rao, et al.
Autophagy, 18, 1187-1201 (2022)
Chantal J M van Opbergen et al.
International journal of molecular sciences, 20(17) (2019-08-24)
Human variants in plakophilin-2 (PKP2) associate with most cases of familial arrhythmogenic cardiomyopathy (ACM). Recent studies show that PKP2 not only maintains intercellular coupling, but also regulates transcription of genes involved in Ca2+ cycling and cardiac rhythm. ACM penetrance is
Yifan Feng et al.
Oxidative medicine and cellular longevity, 2022, 1106313-1106313 (2022-03-30)
Corneal neovascularization (CoNV) in response to chemical burns is a leading cause of vision impairment. Although glutamine metabolism plays a crucial role in macrophage polarization, its regulatory effect on macrophages involved in chemical burn-induced corneal injury is not known. Here
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