Search Within


Applied Filters:
Showing 1-30 of 75 results for "G9885" within Papers
Effect of once weekly administration of mifepristone on ovarian function in normal women
Chen X and Xiao B
Contraception, 56(3), 175-180 (1997)
Song Hwan Bae et al.
Journal of the science of food and agriculture, 92(8), 1765-1770 (2011-12-17)
Makgeolli brewed from rice contains about 150 g kg(-1) alcohol and has a fragrance as well as an acidic and sweet taste. During the brewing process, by-products such as rice bran and brewery cake are produced. At the end of
Bao-Li Wang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 232, 118160-118160 (2020-03-01)
Ceritinib is a second-generation anaplastic lymphoma kinase (ALK) inhibitor for mainly treating non-small cell lung cancer (NSCLC). This investigation focused on to clarify in detail the binding behavior between human α-1 acid glycoprotein (HAG) and ceritinib by means of multi-spectroscopic
Protein adsorption onto auto-assembled polyelectrolyte films
Ladam G, et al.
Langmuir, 17(3), 878-882 (2001)
Cong Bi et al.
Journal of chromatography. A, 1432, 49-57 (2016-01-23)
In the circulatory system, many drugs are reversibly bound to serum proteins such as human serum albumin (HSA) and alpha1-acid glycoprotein (AGP), resulting in both free and protein-bound fractions for these drugs. This report examined the use of microcolumns containing
Yoshihiro Ono et al.
Cancer science, 103(2), 317-324 (2011-11-01)
Transforming growth factor-β (TGF-β) is involved in the regulation of cell proliferation, differentiation, and apoptosis and is associated with epithelial-mesenchymal transition (EMT). Inhibition of the TGF-β pathway is an attractive strategy for the treatment of cancer. We recently screened for
Eleanor Brindle et al.
PloS one, 9(12), e115164-e115164 (2014-12-20)
Deficiencies of vitamin A and iron affect a significant portion of the world's population, and efforts to characterize patterns of these deficiencies are hampered by a lack of measurement tools appropriate for large-scale population-based surveys. Vitamin A and iron are
Noriko Suzuki
Current protocols, 1(7), e200-e200 (2021-07-28)
Tissue glycans usually contain various structures, from simple to highly complicated, in different quantities. N-Glycans are particularly heterogeneous, with up to pentaantennary structures, different branch sequences, and several isomeric structures. 2-Aminopyridine (PA) tagging on released N-glycans is useful for separating
Kazuya Muguruma et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 39(12), 1770-1772 (2012-12-27)
A 57-year-old woman suffering from lower abdominal malaise was diagnosed with cStage IV advanced gastric cancer because of simultaneous liver metastasis and peritoneal dissemination. Because she was regarded as inoperable, she was administered combined immunochemotherapy comprising S-1/paclitaxel(PTX) and Krestin(PSK). One
Wooseok Kim et al.
Analytical biochemistry, 571, 40-48 (2019-02-25)
Sialylation can influence the stability, half-life, and immunogenicity of glycoproteins, but sialylated N-glycans are known to be difficult to analyze. Human alpha1-acid glycoprotein (AGP) is reported to have glycans that consist of sialylated N-glycans. The N-glycan profiling of AGP is
Hideya Onishi et al.
Cancer letters, 335(2), 289-298 (2013-03-15)
To develop an effective therapeutic approach to pancreatic ductal adenocarcinoma (PDAC), we focused on the antitumor mechanism of protein-bound polysaccharide (PSK) under hypoxia. PSK decreased proliferation in PDAC cells under hypoxia but not normoxia. PSK also showed anti-tumor effects in
Mohammad Rehan Ajmal et al.
Journal of biomolecular structure & dynamics, 37(6), 1390-1401 (2018-04-20)
Alpha1-acid glycoprotein (AAG) is a major acute phase protein of human plasma. Binding of clofazimine to AAG is investigated using optical spectroscopy and molecular docking tools. We found significant quenching of intrinsic fluorescence of AAG upon the binding of clofazimine
Tetsuya Hirata et al.
Biochimica et biophysica acta. General subjects, 1864(12), 129726-129726 (2020-09-06)
N-Glycosylation is crucial for protein folding, trafficking, and functions. N-Glycans have a different number of N-acetylglucosamine (GlcNAc) branches in a protein-selective manner, and the β1,6-linked GlcNAc branch on specific proteins produced by N-acetylglucosaminyltransferase-V (GnT-V or MGAT5) promotes cancer malignancy. However
Noriyuki Hirahara et al.
Anticancer research, 32(7), 2631-2637 (2012-07-04)
Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101) and is clinically used in combination therapy for gastrointestinal cancer and small-cell lung carcinoma. We have previously demonstrated that PSK induces apoptosis and inhibites proliferation of promyelomonocytic leukemia HL-60 cells, but
Subramani Karthikeyan et al.
Journal of chemical information and modeling, 59(1), 326-338 (2018-11-28)
The present study focuses on the determination of the biologically significant N-acetylneuraminic acid (NANA) drug binding interaction mechanism between bovine serum albumin (BSA) and human α-1 acid glycoprotein (HAG) using various optical spectroscopy and computational methods. The steady state fluorescence
Lu Ren et al.
Food & function, 3(11), 1118-1130 (2012-08-07)
Mushrooms were considered as a special delicacy by early civilizations and valued as a credible source of nutrients including considerable amounts of dietary fiber, minerals, and vitamins (in particularly, vitamin D). Mushrooms are also recognized as functional foods for their
Ann H Rosendahl et al.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 12(6), 467-474 (2012-12-12)
Polysaccharide-K (PSK, Krestin(®)) is a natural remedy and one of the most commonly used medicinal mushroom extracts. It has been used as oral adjuvant treatment in cancer therapy in Japan and other Asian countries for more than 40 years. PSK
Derek Thibault et al.
Nature communications, 10(1), 5729-5729 (2019-12-18)
While Tn-Seq is a powerful tool to determine genome-wide bacterial fitness in high-throughput, culturing transposon-mutant libraries in pools can mask community or other complex single-cell phenotypes. Droplet Tn-Seq (dTn-Seq) solves this problem by microfluidics facilitated encapsulation of individual transposon mutants
Shuto Yokohata et al.
Microbiology and immunology, 67(2), 58-68 (2022-12-09)
Anginosus group streptococci (AGS) are opportunistic pathogens of the human oral cavity; however, their pathogenicity has not been discussed in detail. Oral streptococci live in the gingival sulcus, from where they can easily translocate into the bloodstream due to periodontal
Hirotaka Hoshi et al.
Oncology reports, 25(4), 905-913 (2011-01-21)
Protein-bound polysaccharide K (PSK) is extracted and purified from Coriolus versicolor (CM101), and is used as an anti-cancer agent. In this study, focusing on the direct actions of PSK, we investigated whether PSK reaches tumor and immune tissues with its
Mohammad Rehan Ajmal et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 159, 199-208 (2016-02-07)
In the current study we have investigated the interaction of newly approved kinase inhibitors namely Cabozantinib (CBZ) and Tofacitinib (TFB) with human Alpha-1 acid glycoprotein (AAG) under simulated physiological conditions using fluorescence quenching measurements, circular dichroism, dynamic light scattering and
Edward P Garvey et al.
Antimicrobial agents and chemotherapy, 52(3), 901-908 (2007-12-28)
The naphthyridinone GSK364735 potently inhibited recombinant human immunodeficiency virus type 1 (HIV-1) integrase in a strand transfer assay (mean 50% inhibitory concentration +/- standard deviation, 8 +/- 2 nM). As expected based on the structure of the drug, it bound
Christopher J Day et al.
Scientific reports, 7(1), 1495-1495 (2017-05-06)
Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2-3-linked N-glycolylneuraminic acid (Neu5Gc). Neu5Gc is not expressed on normal human cells, but is expressed by cancer cells.
Jae Woong Choi et al.
Journal of microbiology and biotechnology, 30(9), 1297-1304 (2020-07-07)
Elevated serum levels of alpha-1-acid glycoprotein (AGP) are known to be associated with several types of cancer. In addition, some reports have indicated that changes in glycosylation of AGP are associated with cancer progression. However, changes in AGP levels of
Seiji Umehara et al.
International journal of oncology, 41(1), 61-66 (2012-05-04)
PSK, a protein-bound polysaccharide, is widely used in Japan as an immunopotentiating biological response modifier for cancer patients. PSK exerts antitumor activities through stimulation of the host's immune response; however, few studies have addressed the direct actions of PSK on
Toru Aoyama et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 38(12), 1921-1923 (2011-12-29)
S-1 mono-therapy for advanced gastric cancer is hard to continue in some patients due to adverse events. We retrospectively examined the patients who received S-1/Krestin( PSK) immunochemotherapy for advanced gastric cancer. During September 2006 to August 2008, 3 patients had
Mohammad Rehan Ajmal et al.
Journal of pharmaceutical and biomedical analysis, 135, 106-115 (2016-12-25)
The binding interaction between clofarabine, an important anticancer drug and two important carrier proteins found abundantly in human plasma, Human Serum Albumin (HSA) and α-1 acid glycoprotein (AAG) was investigated by spectroscopic and molecular modeling methods. The results obtained from
Deborah Chang et al.
Analytical and bioanalytical chemistry, 413(29), 7305-7318 (2021-10-13)
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current
Qiang Jin et al.
Biosensors & bioelectronics, 83, 193-199 (2016-04-30)
A near-infrared fluorescent probe (DDAB) for highly selective and sensitive detection of carboxylesterase 2 (CE2) has been designed, synthesized, and systematically studied both in vitro and in vivo. Upon addition of CE2, the ester bond of DDAB could be rapidly
Koji Tamagawa et al.
Langenbeck's archives of surgery, 397(3), 475-480 (2011-12-31)
We previously demonstrated that hepatic ischemia and reperfusion (I/R) injury increased liver metastasis and cancer growth of RCN-H4 cells. Using a rat model of hepatic I/R-induced liver metastasis, we investigated the metastasis-suppressing effect of polysaccharide-K (PSK), a biological response modifier
Page 1 of 3