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Showing 1-30 of 142 results for "GF10195646" within Papers
Yang Liu et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 13(23), 6667-6673 (2007-05-31)
Well-aligned zinc oxide microrod and microtube arrays with high aspect ratios were fabricated on zinc foil by a simple solution-phase approach in an aqueous solution of ethylenediamine (en). The shape of the ZnO microstructures can be easily modulated from rods
Charley C Staats et al.
Frontiers in cellular and infection microbiology, 3, 65-65 (2013-10-18)
Zinc is a ubiquitous metal in all life forms, as it is a structural component of the almost 10% of eukaryotic proteins, which are called zinc-binding proteins. In zinc-limiting conditions such as those found during infection, pathogenic fungi activate the
Marcella C Galvão et al.
Life sciences, 120, 54-60 (2014-12-03)
Previous investigations by our group have shown that prenatal treatment with lipopolysaccharide (LPS; 100 μg/kg, intraperitoneally) on gestation day (GD) 9.5 in rats, which mimics infections by Gram-negative bacteria, induces short- and long-term behavioral and neuroimmune changes in the offspring.
Kohei Takeshita et al.
Nature structural & molecular biology, 21(4), 352-357 (2014-03-04)
The voltage-gated proton channel Hv1 (or VSOP) has a voltage-sensor domain (VSD) with dual roles of voltage sensing and proton permeation. Its gating is sensitive to pH and Zn(2+). Here we present a crystal structure of mouse Hv1 in the
Brittany L Mortensen et al.
Journal of bacteriology, 196(14), 2616-2626 (2014-05-13)
Acinetobacter baumannii is a leading cause of ventilator-associated pneumonia in intensive care units, and the increasing rates of antibiotic resistance make treating these infections challenging. Consequently, there is an urgent need to develop new antimicrobials to treat A. baumannii infections.
Xuan-Yu Min et al.
International journal of radiation biology, 90(10), 909-913 (2014-05-16)
To develop a new biological dosimeter based on serum zinc concentration. Male mice (8 weeks old) were exposed to different doses (0, 1.0, 2.0, 4.0, or 8.0 Gy) of gamma rays from a (60)Co source. Blood was then collected from
Georges Chreifi et al.
Biochemistry, 53(25), 4216-4223 (2014-05-14)
The nitric oxide synthase (NOS) dimer is stabilized by a Zn(2+) ion coordinated to four symmetry-related Cys residues exactly along the dimer 2-fold axis. Each of the two essential tetrahydrobiopterin (H4B) molecules in the dimer interacts directly with the heme
Dönem Avci et al.
Molecular cell, 56(5), 630-640 (2014-12-03)
Proteolysis by aspartyl intramembrane proteases such as presenilin and signal peptide peptidase (SPP) underlies many cellular processes in health and disease. Saccharomyces cerevisiae encodes a homolog that we named yeast presenilin fold 1 (Ypf1), which we verify to be an
Wolfgang Maret
Metal ions in life sciences, 13, 389-414 (2014-01-29)
The vast knowledge of the physiologic functions of zinc in at least 3000 proteins and the recent recognition of fundamental regulatory functions of zinc(II) ions released from cells or within cells links this nutritionally essential metal ion to numerous diseases.
Zhengquan Li et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 10(22), 5823-5828 (2004-10-09)
A solution surface-erosion route was successfully employed to produce one-dimensional (1D) ZnO nanostructures. ZnO nanorod arrays and three-dimensional urchin-like assemblies could be selectively obtained with different manipulations. In this process, zinc foil was introduced to an organic solution system and
Susan J Zunino et al.
The British journal of nutrition, 112(3), 369-380 (2014-05-17)
Obese individuals are at an increased risk of developing CVD, hypertension, type 2 diabetes, and bacterial and viral infections when compared with the normal-weight population. In a 9-week randomised, double-blind, cross-over study, twenty-four obese subjects aged between 20 and 60
S S Park et al.
Journal of wound care, 24(1), 23-33 (2014-12-30)
Wound healing is enhanced in the presence of an external electrical field. The purpose of this study was first to investigate whether microelectric potentials (EPs) can be generated when the innovative design of a silver (Ag)- and zinc (Zn)-printed wound
Caroline M Rufo et al.
Nature chemistry, 6(4), 303-309 (2014-03-22)
Enzymes fold into unique three-dimensional structures, which underlie their remarkable catalytic properties. The requirement to adopt a stable, folded conformation is likely to contribute to their relatively large size (>10,000 Da). However, much shorter peptides can achieve well-defined conformations through
Priscilla K Walker et al.
Health physics, 106(4), 523-527 (2014-02-25)
Beam shaping in scattered and uniform scanned proton beam therapy (PBT) is made commonly by brass apertures. Due to proton interactions, these devices become radioactive and could pose safety issues and radiation hazards. Nearly 2,000 patient-specific devices per year are
Nicola M Lowe et al.
Critical reviews in food science and nutrition, 53(10), 1110-1123 (2013-08-21)
Zinc was selected as a priority micronutrient for EURRECA, because there is significant heterogeneity in the Dietary Reference Values (DRVs) across Europe. In addition, the prevalence of inadequate zinc intakes was thought to be high among all population groups worldwide
Yongmei Zhao et al.
Stroke, 45(4), 1139-1147 (2014-03-20)
Zinc has been reported to possess both neurotoxic and neuroprotective capabilities. The effects of elevated intracellular zinc accumulation following transient focal cerebral ischemia remain to be fully elucidated. Here, we investigated whether removing zinc with the membrane-permeable zinc chelator, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Woon Ju Song et al.
Science (New York, N.Y.), 346(6216), 1525-1528 (2014-12-20)
The generation of new enzymatic activities has mainly relied on repurposing the interiors of preexisting protein folds because of the challenge in designing functional, three-dimensional protein structures from first principles. Here we report an artificial metallo-β-lactamase, constructed via the self-assembly
Pritesh Hiralal et al.
ACS nano, 4(5), 2730-2734 (2010-04-27)
Solid-state and flexible zinc carbon (or Leclanche) batteries are fabricated using a combination of functional nanostructured materials for optimum performance. Flexible carbon nanofiber mats obtained by electrospinning are used as a current collector and cathode support for the batteries. The
Xiang Sheng et al.
Biochemistry, 53(27), 4455-4466 (2014-06-26)
Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to produce oxaloacetate. Its activity is directly related to insulin release and thus PC has recently attracted great interest as a potential target for diabetes treatment. In this article, the catalytic mechanism
Beatriz Garrido-Rodriguez et al.
Chemosphere, 107, 379-385 (2014-01-29)
Batch type and column experiments were used to study competitive adsorption-desorption and transport for Cd, Cu, Ni and Zn in a mine soil, both un-amended and amended with mussel shell. Batch type experiments showed that adsorption was affected by the
Johan Hattne et al.
Nature methods, 11(5), 545-548 (2014-03-19)
X-ray free-electron laser (XFEL) sources enable the use of crystallography to solve three-dimensional macromolecular structures under native conditions and without radiation damage. Results to date, however, have been limited by the challenge of deriving accurate Bragg intensities from a heterogeneous
Yanhui Shi et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9390-9395 (2014-07-01)
Multicomponent self-assembly, wherein two unique donor precursors are combined with a single metal acceptor instead of the more common two-component assembly, can be achieved by selecting Lewis-basic sites and metal nodes that select for heteroligated coordination spheres. Platinum(II) ions show
Metals: setting a trap for copper.
Valeria Culotta
Nature chemical biology, 10(12), 986-987 (2014-10-27)
Helena Stecka et al.
Environmental monitoring and assessment, 186(10), 6145-6155 (2014-05-30)
A simple and fast solid phase extraction procedure was developed to pre-concentrate traces of Cu and Zn prior to their determination in honey samples by flame atomic absorption spectrometry. The sample preparation included dissolution of honey samples and the passage
Rebecca G Mitchell et al.
Environmental pollution (Barking, Essex : 1987), 187, 162-169 (2014-02-08)
Urban gardens provide affordable fresh produce to communities with limited access to healthy food but may also increase exposure to lead (Pb) and other soil contaminants. Metals analysis of 564 soil samples from 54 New York City (NYC) community gardens
Sonia Melino et al.
The FEBS journal, 281(3), 657-672 (2013-11-14)
Natural antimicrobial peptides represent a primordial mechanism of immunity in both vertebrate and nonvertebrate organisms. Among them, histatins belong to a family of human salivary metal-binding peptides displaying potent antibacterial, antifungal and wound-healing activities. These properties, along with the ability
Laura M Lamberti et al.
Nutrients, 5(11), 4715-4740 (2013-11-29)
Evidence supporting the impact of therapeutic zinc supplementation on the duration and severity of diarrhea among children under five is largely derived from studies conducted in South Asia. China experiences a substantial portion of the global burden of diarrhea, but
A Di Veroli et al.
Chemosphere, 112, 9-17 (2014-07-23)
Mouthpart deformities of Chironomus riparius larvae (Diptera) have been investigated to evaluate the toxic effects of contamination by heavy metals in the Genna Stream (Central Italy), situated in an area subjected to intensive swine farms (40000 heads). The livestock farming
Jun-Hui Choi et al.
Journal of bioscience and bioengineering, 118(4), 372-377 (2014-04-22)
A thrombolytic protease named kitamase possessing anticoagulant property was purified from edible and medicinal plant Aster yomena (Kitam.) Honda. Kitamase showed a molecular weight of 50 kDa by SDS-PAGE and displayed a strong fibrin zymogram lysis band corresponding to the similar
Jungsoo Kim et al.
Environmental monitoring and assessment, 187(1), 4124-4124 (2014-11-21)
Cadmium (Cd), lead (Pb), manganese (Mn), zinc (Zn), and iron (Fe) concentrations were measured in the prey and liver of grey heron (Ardea cinerea) and black-crowned night heron (Nycticorax nycticorax) chicks (24-26 days after hatching) at the Pyeongtaek colony, Korea
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