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Showing 1-30 of 431 results for "H1029" within Papers
S A Kaliberov et al.
Cancer gene therapy, 23(9), 303-314 (2016-08-06)
The combination of radiation with radiosensitizing gene delivery or oncolytic viruses promises to provide an advantage that could improve the therapeutic results for glioblastoma. X-rays can induce significant molecular changes in cancer cells. We isolated the GIRLRG peptide that binds
Alexander Belyy et al.
Nature communications, 14(1), 8226-8226 (2023-12-13)
The bacterial Makes caterpillars floppy 1 (Mcf1) toxin promotes apoptosis in insects, leading to loss of body turgor and death. The molecular mechanism underlying Mcf1 intoxication is poorly understood. Here, we present the cryo-EM structure of Mcf1 from Photorhabdus luminescens
Yangbo Hu et al.
Nucleic acids research, 40(14), 6547-6557 (2012-05-10)
RbpA is an RNA polymerase (RNAP)-binding protein whose presence increases the tolerance levels of Mycobacteria to the first-line anti-tuberculosis drug rifampicin by an unknown mechanism. Here, we show that the role of Mycobacterium tuberculosis RbpA in resistance is indirect because
Qing Tang et al.
Genes & development, 30(24), 2710-2723 (2017-01-15)
Mutations in the U2 snRNP component SF3B1 are prominent in myelodysplastic syndromes (MDSs) and other cancers and have been shown recently to alter branch site (BS) or 3' splice site selection in splicing. However, the molecular mechanism of altered splicing
R L Toth et al.
Phytopathology, 89(11), 1015-1021 (2008-10-24)
ABSTRACT A panel of 11 different single-chain variable fragment antibodies (scFv) that bind to potato leafroll virus (PLRV) has been studied to assess each one's suitability as practical diagnostic tools. The scFv, previously obtained from naive phage display libraries, were
Orsolya Mózner et al.
Biomedicines, 11(12) (2023-12-23)
We have developed a simple, rapid, high-throughput RBD-based ELISA to assess the humoral immunity against emerging SARS-CoV-2 virus variants. The cDNAs of the His-tagged RBD proteins of the virus variants were stably engineered into HEK cells secreting the protein into
Candida Fasano et al.
Computational and structural biotechnology journal, 20, 1860-1875 (2022-05-03)
SMYD3 overexpression in several human cancers highlights its crucial role in carcinogenesis. Nonetheless, SMYD3 specific activity in cancer development and progression is currently under debate. Taking advantage of a library of rare tripeptides, which we first tested for their in
Tatiana M T Rezende et al.
Biomolecules, 14(1) (2024-01-23)
Culex quinquefasciatus resistance to the binary (Bin) toxin, the major larvicidal component from Lysinibacillus sphaericus, is associated with mutations in the cqm1 gene, encoding the Bin-toxin receptor. Downregulation of the cqm1 transcript was found in the transcriptome of larvae resistant
Yen-Ling Lin et al.
The Plant cell, 32(4), 1285-1307 (2020-02-16)
Proliferating cells actively coordinate growth and cell division to ensure cell-size homeostasis; however, the underlying mechanism through which size is controlled is poorly understood. Defect in a SUMO protease protein, suppressor of mat3 7 (SMT7), has been shown to reduce
Jorge Vera-Otarola et al.
PLoS pathogens, 17(9), e1009931-e1009931 (2021-09-22)
The capped Small segment mRNA (SmRNA) of the Andes orthohantavirus (ANDV) lacks a poly(A) tail. In this study, we characterize the mechanism driving ANDV-SmRNA translation. Results show that the ANDV-nucleocapsid protein (ANDV-N) promotes in vitro translation from capped mRNAs without
Laura Molina-García et al.
Methods in molecular biology (Clifton, N.J.), 1779, 289-312 (2018-06-11)
Bacteria are the simplest cellular model in which amyloidosis has been addressed. It is well documented that bacterial consortia (biofilms) assemble their extracellular matrix on an amyloid scaffold, yet very few intracellular amyloids are known in bacteria. Here, we describe
Marscha Hirschi et al.
Nature, 545(7652), 66-70 (2017-04-21)
Membrane transporters move substrates across the membrane by alternating access of their binding sites between the opposite sides of the membrane. An emerging model of this process is the elevator mechanism, in which a substrate-binding transport domain moves a large
Melanie Howell et al.
BMC microbiology, 5, 6-6 (2005-02-05)
Epstein-Barr virus (EBV) latently infects about 90% of the human population and is associated with benign and malignant diseases of lymphoid and epithelial origin. BHRF1, an early lytic cycle antigen, is an apoptosis suppressing member of the Bcl-2 family. In
Luigi Scietti et al.
Scientific reports, 6, 27996-27996 (2016-06-16)
During bacterial pathogenesis extensive contacts between the human and the bacterial extracellular proteomes take place. The identification of novel host-pathogen interactions by standard methods using a case-by-case approach is laborious and time consuming. To overcome this limitation, we took advantage
Hana Popelka et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(47), E10112-E10121 (2017-11-09)
The Atg20 and Snx4/Atg24 proteins have been identified in a screen for mutants defective in a type of selective macroautophagy/autophagy. Both proteins are connected to the Atg1 kinase complex, which is involved in autophagy initiation, and bind phosphatidylinositol-3-phosphate. Atg20 and
Antiviral effect of SARS-CoV-2 N-specific CD8+ T cells induced in lungs by engineered extracellular vesicles.
Manfredi, et al.
NPJ vaccines, 8, 83-83 (2023)
Suman Sundaresh et al.
Bioinformatics (Oxford, England), 22(14), 1760-1766 (2006-04-29)
We present a study of antigen expression signals from a newly developed high-throughput protein microarray technique. These signals are a measure of antibody-antigen binding activity and provide a basis for understanding humoral immune responses to various infectious agents and supporting
Isabel C Vallecillo-Viejo et al.
RNA biology, 15(1), 104-114 (2017-11-04)
Site-directed RNA editing (SDRE) is a general strategy for making targeted base changes in RNA molecules. Although the approach is relatively new, several groups, including our own, have been working on its development. The basic strategy has been to couple
Hui Zhang et al.
Nature communications, 12(1), 4151-4151 (2021-07-08)
The chemokine receptor CCR5 plays a vital role in immune surveillance and inflammation. However, molecular details that govern its endogenous chemokine recognition and receptor activation remain elusive. Here we report three cryo-electron microscopy structures of Gi1 protein-coupled CCR5 in a
Swetha Devi Velivela et al.
Genetics, 208(2), 655-672 (2017-12-20)
Loss of V-ATPase activity in organelles, whether through V-ATPase inhibition or V-ATPase (
Christian Renz et al.
Journal of cell science, 133(10) (2020-04-09)
Polyubiquitin chains linked via lysine (K) 63 play an important role in endocytosis and membrane trafficking. Their primary source is the ubiquitin protein ligase (E3) Rsp5/NEDD4, which acts as a key regulator of membrane protein sorting. The heterodimeric ubiquitin-conjugating enzyme
Lykourgos-Panagiotis Zalmas et al.
Cell cycle (Georgetown, Tex.), 12(18), 3037-3051 (2013-08-27)
The cellular response to DNA damage, mediated by the DNA repair process, is essential in maintaining the integrity and stability of the genome. E2F-7 is an atypical member of the E2F family with a role in negatively regulating transcription and
Debabrata Das et al.
G3 (Bethesda, Md.), 12(5) (2022-04-08)
Generation of functional gametes is accomplished through a multilayered and finely orchestrated succession of events during meiotic progression. In the Caenorhabditis elegans germline, the HORMA-domain-containing protein HTP-3 plays pivotal roles for the establishment of chromosome axes and the efficient induction
Ying Mao et al.
Development (Cambridge, England), 146(13) (2019-05-31)
The niche controls stem cell self-renewal and differentiation in animal tissues. Although the exocyst is known to be important for protein membrane trafficking and secretion, its role in stem cells and niches has never been reported. Here, this study shows
Christine E Broster Reix et al.
Microbiology spectrum, 9(2), e0091521-e0091521 (2021-10-28)
Trypanosoma brucei belongs to a genus of protists that cause life-threatening and economically important diseases of human and animal populations in Sub-Saharan Africa. T. brucei cells are covered in surface glycoproteins, some of which are used to escape the host
Huijie Zhao et al.
Journal of cell science, 133(13) (2020-06-07)
The Cep63-Cep152 complex located at the mother centriole recruits Plk4 to initiate centriole biogenesis. How the complex is targeted to mother centrioles, however, is unclear. In this study, we show that Cep57 and its paralog, Cep57l1, colocalize with Cep63 and
Frances C Tilley et al.
Journal of cell science, 131(11) (2018-05-05)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic human disease, with around 12.5 million people affected worldwide. ADPKD results from mutations in either PKD1 or PKD2, which encode the atypical G-protein coupled receptor polycystin-1 (PC1) and the
Pengcheng Wang et al.
Molecular cell, 69(1), 100-112 (2018-01-02)
As sessile organisms, plants must adapt to variations in the environment. Environmental stress triggers various responses, including growth inhibition, mediated by the plant hormone abscisic acid (ABA). The mechanisms that integrate stress responses with growth are poorly understood. Here, we
A conserved module regulates receptor kinase signalling in immunity and development.
DeFalco, et al.
Nature plants, 8, 356-365 (2022)
Marita Zoma et al.
Nature communications, 12(1), 4147-4147 (2021-07-08)
The TMPRSS2-ERG gene fusion is the most frequent alteration observed in human prostate cancer. However, its role in disease progression is still unclear. In this study, we uncover an important mechanism promoting ERG oncogenic activity. We show that ERG is
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