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Showing 1-30 of 1556 results for "H3160" within Papers
Alexandra Ursache et al.
Physiology & behavior, 138, 266-272 (2014-12-03)
Physiological responses to threat occur through both the autonomic nervous system (ANS) and the hypothalamic pituitary adrenal (HPA) axis. Activity in these systems can be measured through salivary alpha-amylase (sAA) and salivary cortisol, respectively. Theoretical work and empirical studies have
Daniel Berry et al.
Developmental psychology, 50(2), 514-525 (2013-06-19)
A considerable body of literature suggests that children's child-care experiences may impact adrenocortical functioning in early childhood. Yet emerging findings also suggest that the magnitude and sometimes the direction of child-care effects on development may be markedly different for children
Q Li et al.
Oncogene, 33(20), 2589-2600 (2013-06-12)
The major goal of breast cancer prevention is to reduce the incidence of ductal carcinoma in situ (DCIS), an early stage of breast cancer. However, the biology behind DCIS formation is not well understood. It is suspected that cancer stem
Christine M Helfer et al.
Viruses, 6(8), 3228-3249 (2014-08-21)
The cellular bromodomain protein Brd4 functions in multiple processes of the papillomavirus life cycle, including viral replication, genome maintenance, and gene transcription through its interaction with the viral protein, E2. However, the mechanisms by which E2 and Brd4 activate viral
Ashley J Parks et al.
Molecular pharmacology, 86(5), 593-608 (2014-08-28)
The aryl hydrocarbon receptor (AHR) is critically involved in several physiologic processes, including cancer progression and multiple immune system activities. We, and others, have hypothesized that AHR modulators represent an important new class of targeted therapeutics. Here, ligand shape-based virtual
Ingrid Stroo et al.
PloS one, 10(4), e0123203-e0123203 (2015-04-16)
Temporal expression of chemokines is a crucial factor in the regulation of renal ischemia/reperfusion (I/R) injury and repair. Beside their role in the migration and activation of inflammatory cells to sites of injury, chemokines are also involved in other processes
Maike Ter Wolbeek et al.
Brain, behavior, and immunity, 45, 128-138 (2014-12-03)
Neonatal glucocorticoid (GC) treatment is used to prevent bronchopulmonary dysplasia (BPD) in prematurely born babies. In the 1990s, treatment regimens with relatively high doses of dexamethasone (DEX) were common. As an alternative, hydrocortisone (HC) was used. Earlier, we compared long-term
Minna U Kaikkonen et al.
Nucleic acids research, 42(20), 12570-12584 (2014-10-30)
Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells (HAECs) and human umbilical vein endothelial cells
Pascal Dao et al.
Cancer letters, 348(1-2), 88-99 (2014-03-25)
FAK and FGFR2 signaling pathways play important roles in cancer development, progression and tumor angiogenesis. PHM16 is a novel ATP competitive inhibitor of FAK and FGFR2. To evaluate the therapeutic efficacy of this agent, we examined its anti-angiogenic effect in
Weiwei Dai et al.
Bone, 74, 48-57 (2015-01-15)
Beta-ecdysone (βEcd) is a phytoecdysteroid found in the dry roots and seeds of the asteraceae and achyranthes plants, and is reported to increase osteogenesis in vitro. Since glucocorticoid (GC) excess is associated with a decrease in bone formation, the purpose
Nadine Pinder et al.
Clinical chemistry and laboratory medicine, 53(8), 1259-1264 (2015-01-08)
Physostigmine, commonly used as an antidote in anticholinergic poisoning, is reported to have additional pharmacological effects, such as activation of the cholinergic anti-inflammatory pathway in sepsis models. Due to the narrow therapeutic range of physostigmine and its metabolite eseroline, however
Robert Holaj et al.
Journal of hypertension, 33(4), 874-882 (2014-12-10)
Aldosterone has been shown to substantially contribute to the accumulation of different types of collagen fibres and growth factors in the arterial wall, thus increasing wall thickness. A previous study showed reduction of increased common carotid intima-media thickness (IMT) in
Neha Kaushal et al.
Molecular pharmaceutics, 12(7), 2406-2417 (2015-05-29)
Rho-GTPases are small GTP-binding proteins that contribute to the epithelial-to-mesenchymal transition by regulating several cellular processes including organization of the actin cytoskeleton, cell motility, transcription, and cell proliferation. Overexpression of RhoC-GTPases (RhoC) in breast cancer has been implicated in poor
Linda Frellstedt et al.
American journal of respiratory cell and molecular biology, 51(1), 135-142 (2014-02-08)
In humans, strenuous exercise causes increased susceptibility to respiratory infections associated with down-regulated expression of Toll-like receptors (TLRs) and costimulatory and antigen-presenting molecules. Lower airway diseases are also a common problem in sport and racing horses. Because innate immunity plays
Alexander Wegner et al.
Brain, behavior, and immunity, 41, 46-54 (2014-05-13)
Inflammation-induced pain amplification and hypersensitivity play a role in the pathophysiology of numerous clinical conditions. Experimental endotoxemia has recently been implemented as model to analyze immune-mediated processes in human pain. In this study, we aimed to analyze dose- and time-dependent
Santanu Maji et al.
Oncotarget, 6(18), 16623-16637 (2015-05-27)
Oral and oropharyngeal cancers are the sixth most common cancers worldwide. Despite intensive investigation, oral squamous cell carcinomas (OSCC) represent a clinical challenge resulting in significant morbidity and mortality. Resistance to cell death is common in OSCC and is often
Sarah J Lehnert et al.
Genetica, 142(4), 281-293 (2014-06-24)
Outbreeding, mating between genetically divergent individuals, may result in negative fitness consequences for offspring via outbreeding depression. Outbreeding effects are of notable concern in salmonid research as outbreeding can have major implications for salmon aquaculture and conservation management. We therefore
Tong Guo et al.
Alternatives to laboratory animals : ATLA, 42(4), 235-243 (2014-10-08)
Pulmonary fibrosis is a progressive and irreversible disorder with no appropriate cure. A practical and effective experimental model that recapitulates the disease will greatly benefit the research community and, ultimately, patients. In this study, we tested the lung slice culture
Leslie B Hart et al.
PloS one, 10(5), e0127432-e0127432 (2015-05-21)
Inshore common bottlenose dolphins (Tursiops truncatus) are exposed to a broad spectrum of natural and anthropogenic stressors. In response to these stressors, the mammalian adrenal gland releases hormones such as cortisol and aldosterone to maintain physiological and biochemical homeostasis. Consequently
Jean-Benoît Corcuff et al.
European journal of endocrinology, 172(4), 473-481 (2015-01-28)
Severe Cushing's syndrome elicited by ectopic ACTH syndrome (EAS) or adrenal carcinoma (ACC) can threaten life in the short term. The effectiveness of oral administration of the inhibitors of steroidogenesis ketoconazole and metyrapone in this situation is poorly described. To
F Ishikawa et al.
Cell death & disease, 6, e1619-e1619 (2015-01-23)
Anchorage dependence of cellular growth and survival prevents inappropriate cell growth or survival in ectopic environments, and serves as a potential barrier to metastasis of cancer cells. Therefore, obtaining a better understanding of anchorage-dependent responses in normal cells is the
Weiwei Qi et al.
Diabetes, 64(4), 1407-1419 (2014-11-05)
Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular complication of diabetes. The current study revealed that plasma levels of pigment epithelium-derived factor (PEDF) were elevated in type 2 diabetic patients with DFU and in db/db
Sin-Hye Park et al.
PloS one, 10(11), e0143526-e0143526 (2015-11-26)
Mucus hypersecretion is an important pathological feature of chronic airway diseases, such as asthma and pulmonary diseases. MUC5AC is a major component of the mucus matrix forming family of mucins in the airways. The initiation of endoplasmic reticulum (ER)-mediated stress
Kimberly Albert et al.
Psychoneuroendocrinology, 59, 14-24 (2015-07-01)
Although ovarian hormones are thought to have a potential role in the well-known sex difference in mood and anxiety disorders, the mechanisms through which ovarian hormone changes contribute to stress regulation are not well understood. One mechanism by which ovarian
Nicola Manzella et al.
Scientific reports, 5, 13752-13752 (2015-09-05)
The DNA base excision repair pathway is the main system involved in the removal of oxidative damage to DNA such as 8-Oxoguanine (8-oxoG) primarily via the 8-Oxoguanine DNA glycosylase (OGG1). Our goal was to investigate whether the repair of 8-oxoG
Can Lu et al.
Journal of cellular biochemistry, 115(8), 1458-1466 (2014-03-13)
Parthenolide is the main bioactive component in feverfew, a common used herbal medicine, and has been extensively studied in relation to its anti-cancer properties. However there have been very few in-depth studies of the activities of this compound at the
Alice Fraveto et al.
PloS one, 10(11), e0142124-e0142124 (2015-11-17)
We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted agents. Primary cultures of mucin- and mixed-IHCCA were prepared from surgical specimens (N. 18 IHCCA patients) and evaluated for cell proliferation (MTS assay) and apoptosis (Caspase
Zhi-qiang Pan et al.
Molecular and cellular endocrinology, 394(1-2), 119-128 (2014-07-20)
Pioglitazone belongs to the class of drugs called thiazolidinediones (TZDs), which are widely used as insulin sensitizers in the treatment of diabetes. A major side effect of TZDs is fluid retention. The steroid hormone aldosterone also promotes sodium and fluid
Wei-Li Fu et al.
Tissue engineering. Part A, 21(5-6), 948-959 (2014-10-10)
Vascularization of engineered bone tissue is critical for ensuring its survival after implantation and it is the primary factor limiting its clinical use. A promising approach is to prevascularize bone grafts in vitro using endothelial progenitor cells (EPC) derived from
Filip Růžička et al.
Psychoneuroendocrinology, 52, 302-310 (2015-01-03)
Considering the functional organization of the subthalamic nucleus (STN), we hypothesized that subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease might have a differential impact on the hypothalamic-pituitary-adrenal axis in relation to the position of active stimulating contact within the
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