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Showing 1-30 of 35 results for "H3284" within Papers
Jehad Almaliti et al.
Journal of medicinal chemistry, 59(23), 10642-10660 (2016-11-05)
A number of analogues of the marine-derived histone deacetylase inhibitor largazole incorporating major structural changes in the depsipeptide ring were synthesized. Replacing the thiazole-thiazoline fragment of largazole with a bipyridine group gave analogue 7 with potent cell growth inhibitory activity
Anne Gärtner et al.
EMBO reports, 19(11) (2018-09-12)
Post-translational modifications by ubiquitin-related SUMO modifiers regulate cellular signaling networks and protein homeostasis. While SUMO1 is mainly conjugated to proteins as a monomer, SUMO2/3 can form polymeric chains. Poly-SUMOylation is best understood in the SUMO-targeted ubiquitin ligase (StUbL) pathway, where
Bruna Codispoti et al.
Oncotarget, 8(27), 43782-43798 (2017-02-12)
Transplantation of hematopoietic stem cells (HSCs) is a well-established therapeutic approach for numerous disorders. HSCs are typically derived from bone marrow or peripheral blood after cytokine-induced mobilization. Umbilical cord blood (CB) represents an appealing alternative HSC source, but the small
Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters
Imbriano C, et al.
Molecular and cellular biology, 25(9), 3737-3751 (2005)
Nayana Tusamda Wakhloo et al.
Biomaterials, 234, 119746-119746 (2020-01-17)
Cell deformation occurs in many critical biological processes, including cell extravasation during immune response and cancer metastasis. These cells deform the nucleus, their largest and stiffest organelle, while passing through narrow constrictions in vivo and the underlying mechanisms still remain
J Taunton et al.
Science (New York, N.Y.), 272(5260), 408-411 (1996-04-19)
Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity. Both
Wenjuan Wang et al.
The Journal of biological chemistry, 299(1), 102812-102812 (2022-12-21)
CXXC5, a member of the CXXC family of zinc-finger proteins, is associated with numerous pathological processes. However, the pathophysiological function of CXXC5 has not been clearly established. Herein, we found that CXXC5 interacts with the CRL4B and NuRD complexes. Screening
Shuai Leng et al.
Cell death and differentiation, 28(12), 3329-3343 (2021-06-25)
Pancreatic cancer is a common malignant tumor with poor prognosis. Recently, cancer stem cells (CSCs) were identified in several solid tumors, including pancreatic cancer. Although accumulating evidence indicates that sirtuin 1 (SIRT1) exerts biological functions in various cancers, how it
Kyathanahalli S Janardhan et al.
Toxicologic pathology, 46(5), 488-510 (2018-07-04)
Immunohistochemistry (IHC) is a valuable tool in pathology. This review provides a brief description of the technical aspects of IHC and a detailed discussion on the variables that affect the results, interpretation, and reproducibility of IHC results. Lists of antibodies
Ruiqiong Liu et al.
Nucleic acids research, 46(13), 6608-6626 (2018-05-31)
Histone post-translational modifications regulate chromatin structure and function largely through interactions with effector proteins that often contain multiple histone-binding domains. PHF1 [plant homeodomain (PHD) finger protein 1], which contains two kinds of histone reader modules, a Tudor domain and two
R Palermo et al.
Oncogene, 31(33), 3807-3817 (2011-11-29)
Post-translational modifications of Notch3 and their functional role with respect to Notch3 overexpression in T-cell leukemia are still poorly understood. We identify here a specific novel property of Notch3 that is acetylated and deacetylated at lysines 1692 and 1731 by
Yongqiang Hou et al.
Science advances, 6(16), eaaz0356-eaaz0356 (2020-06-05)
TUDOR domain-containing proteins (TDRDs) are chiefly responsible for recognizing methyl-lysine/arginine residue. However, how TDRD dysregulation contributes to breast tumorigenesis is poorly understood. Here, we report that TUDOR domain-containing PHF20L1 as a H3K27me2 reader exerts transcriptional repression by recruiting polycomb repressive
Xin Yin et al.
Cell death and differentiation, 29(11), 2203-2217 (2022-05-10)
Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor that has emerged as a prominent transcription repressing factor in carcinogenesis. However, the role of RUNX2 in breast cancer metastasis remains poorly understood. Here, we show that RUNX2 recruits the
Giuseppina Caretti et al.
The Journal of biological chemistry, 278(33), 30435-30440 (2003-05-29)
Regulation of transcription during the cell-cycle is under the control of E2 factors (E2Fs), often in cooperation with nuclear factor Y (NF-Y), a histone-like CCAAT-binding trimer. NF-Y is paradigmatic of a constitutive, ubiquitous factor that pre-sets the promoter architecture for
Emanuela Chiarella et al.
PloS one, 9(12), e114795-e114795 (2014-12-17)
Lentiviral vectors are widely used to investigate the biological properties of regulatory proteins and/or of leukaemia-associated oncogenes by stably enforcing their expression in hematopoietic stem and progenitor cells. In these studies it is critical to be able to monitor and/or
Histone deacetylase HDAC1 expression correlates with the progression and prognosis of lung cancer: a meta-analysis
Cao L L, et al.
Medicine, 96(31) (2017)
Influenza A virus dysregulates host histone deacetylase 1 that inhibits viral infection in lung epithelial cells
Nagesh P T and Husain M
Journal of virology, JVI-00126 (2016)
Ahmed T Negmeldin et al.
European journal of medicinal chemistry, 143, 1790-1806 (2017-11-19)
Histone deacetylase (HDAC) enzymes govern the post-translational acetylation state of lysine residues on protein substrates, leading to regulatory changes in cell function. Due to their role in cancers, HDAC proteins have emerged as promising targets for cancer treatment. Four HDAC
Adriana Agnese Amaro et al.
Cancers, 15(3) (2023-02-12)
Metastatic uveal melanoma (MUM) is a highly aggressive, therapy-resistant disease. Driver mutations in Gα-proteins GNAQ and GNA11 activate MAP-kinase and YAP/TAZ pathways of oncogenic signalling. MAP-kinase and MEK-inhibitors do not significantly block MUM progression, likely due to persisting YAP/TAZ signalling.
Ludovica Lospinoso Severini et al.
Cancers, 11(10) (2019-10-12)
: Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1) has been designed
Yoshihiro Dohi et al.
Nature structural & molecular biology, 15(12), 1246-1254 (2008-11-18)
Cellular senescence is one of the key strategies to suppress expansion of cells with mutations. Senescence is induced in response to genotoxic and oxidative stress. Here we show that the transcription factor Bach1 (BTB and CNC homology 1, basic leucine
Barbara Ulmasov et al.
Cellular and molecular gastroenterology and hepatology, 2(4), 499-518 (2017-02-09)
Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth factor β (TGFB). Integrins of the αv family promote TGFB signaling in mice, probably by interacting with the Arg-Gly-Asp (RGD) sequence
An-Chih Wu et al.
Journal of experimental & clinical cancer research : CR, 41(1), 47-47 (2022-02-04)
Glioblastoma (GBM) is the most aggressive and lethal brain tumor. Although the histone deacetylase (HDAC)/transcription factor axis promotes growth in GBM, whether HDACs including HDAC6 are involved in modulating long non-coding RNAs (lncRNAs) to affect GBM malignancy remains obscure. Integrative
Geetha Padige et al.
Journal of biomolecular screening, 20(10), 1277-1285 (2015-08-02)
Histone deacetylase (HDAC) proteins are promising targets for cancer treatment, with several HDAC inhibitors used clinically as anticancer drugs. Most HDAC inhibitors nonspecifically interact with all or many of the 11 HDAC isoforms. Isoform-selective HDAC inhibitors would be useful tools
Wen-Bin Yang et al.
Cell death & disease, 12(10), 884-884 (2021-09-30)
DNA repair promotes the progression and recurrence of glioblastoma (GBM). However, there remain no effective therapies for targeting the DNA damage response and repair (DDR) pathway in the clinical setting. Thus, we aimed to conduct a comprehensive analysis of DDR
Dhanusha A Nalawansha et al.
ACS chemical biology, 12(1), 254-264 (2016-12-16)
Lysine Specific Demethylase 1 (LSD1) catalyzes the demethylation of histone 3 to regulate gene expression. With a fundamental role in gene regulation, LSD1 is involved in multiple cellular processes, including embryonic development, cell proliferation, and metastasis. Significantly, LSD1 is overexpressed
Yasuhiro Suzuki et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(12), 2021-2031 (2015-07-30)
Recombinant tissue-type plasminogen activator (rt-PA) modulates cerebrovascular permeability and exacerbates brain injury in ischemic stroke, but its mechanisms remain unclear. We studied the involvement of vascular endothelial growth factor (VEGF)-mediated endocytosis in the increase of blood-brain barrier (BBB) permeability potentiated
Pablo A Perez et al.
Journal of cellular physiology, 233(2), 1402-1413 (2017-05-26)
In this study, we focused on ERβ regulation in the adenohypophysis under different estrogenic milieu, by analyzing whether ER modulates the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression and its subcellular localization on anterior pituitary glands from
Jie Gao et al.
Cell death and differentiation, 28(9), 2818-2836 (2021-05-07)
The biological function of PRMT5 remains poorly understood in cervical cancer metastasis. Here, we report that PRMT5 physically associates with the transcription factor Snail and the NuRD(MTA1) complex to form a transcriptional-repressive complex that catalyzes the symmetrical histone dimethylation and
PDT-induced epigenetic changes in the mouse cerebral cortex: a protein microarray study
Demyanenko S V, et al.
Biochim. Biophys. Acta Gen. Subj., 1840(1), 262-270 (2014)
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