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Showing 1-20 of 20 results for "H6914" within Papers
Alejandro Bustamante et al.
Stroke, 48(9), 2419-2425 (2017-07-19)
Stroke diagnosis could be challenging in the acute phase. We aimed to develop a blood-based diagnostic tool to differentiate between real strokes and stroke mimics and between ischemic and hemorrhagic strokes in the hyperacute phase. The Stroke-Chip was a prospective
Jeffrey Pido-Lopez et al.
PLoS pathogens, 7(12), e1002396-e1002396 (2011-12-07)
The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria. The CD4(+) T cell response to pneumococcus is increasingly recognised as an important mediator
Asli Kocaoemer et al.
Stem cells (Dayton, Ohio), 25(5), 1270-1278 (2007-01-27)
MSCs are currently in focus regarding their clinical potential in cell therapy and tissue engineering. However, most isolation and expansion protocols for clinical-scale production of MSCs use fetal calf serum (FCS) as a supplement, which poses a potential risk for
Rikke Sick Andersen et al.
Cancer immunology, immunotherapy : CII, 60(2), 227-234 (2010-10-29)
With the aim to identify cyclin B1-derived peptides with high affinity for HLA-A2, we used three in silico prediction algorithms to screen the protein sequence for possible HLA-A2 binders. One peptide scored highest in all three algorithms, and the high
Sangeeta Sule et al.
PloS one, 6(3), e17495-e17495 (2011-03-23)
Monocytes are a key component of the innate immune system involved in the regulation of the adaptive immune response. Previous studies have focused on apoptotic cell clearance abnormalities in systemic lupus erythematosus (SLE) monocytes. However, whether SLE monocytes might express
Laura Abraira et al.
Epilepsia, 61(10), 2244-2253 (2020-08-29)
Blood biomarkers have not been widely investigated in poststroke epilepsy. In this study, we aimed to describe clinical factors and biomarkers present during acute stroke and analyze their association with the development of epilepsy at long term. A panel of
Julie Kerr-Conte et al.
Transplantation, 89(9), 1154-1160 (2010-01-26)
BACKGROUND.: The original Edmonton protocol used fresh islets, but for obvious logistic advantages most transplant centers have implemented pretransplant culture in human albumin. The aim of this study was to improve current pretransplant human islet culture techniques. METHODS.: Clinical-grade purified
Nathan P Wiederhold et al.
Antimicrobial agents and chemotherapy, 52(11), 4145-4148 (2008-09-17)
Pyrosequencing was compared to Sanger dideoxy sequencing to detect mutations in FKS1 responsible for reduced echinocandin susceptibility in Candida albicans. These methods were in complete agreement for 10 of 12 clinical isolates with elevated echinocandin MICs, supporting the potential feasibility
Andrew T Bender et al.
The Journal of molecular diagnostics : JMD, 22(8), 1030-1040 (2020-05-26)
There are ongoing research efforts into simple and low-cost point-of-care nucleic acid amplification tests (NATs) addressing widespread diagnostic needs in resource-limited clinical settings. Nucleic acid testing for RNA targets in blood specimens typically requires sample preparation that inactivates robust blood
Olívia Bacellar et al.
The Journal of infectious diseases, 200(1), 75-78 (2009-05-30)
Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than
Bonnie A Colleton et al.
Journal of virology, 83(12), 6288-6299 (2009-04-10)
Induction of an antigenically broad and vigorous primary T-cell immune response by myeloid dendritic cells (DC) in blood and tissues could be important for an effective prophylactic or therapeutic vaccine to human immunodeficiency virus type 1 (HIV-1). Here we show
Ankit Sinha et al.
Cell systems, 8(4), 345-351 (2019-04-15)
High-grade serous ovarian carcinoma (HGSC) is the most common and lethal subtype of gynecologic malignancy in women. The current standard of treatment combines cytoreductive surgery and chemotherapy. Despite the efficacy of initial treatment, most patients develop cancer recurrence, and 70%
Guillermo Garcia-Effron et al.
Antimicrobial agents and chemotherapy, 53(1), 112-122 (2008-10-29)
A detailed kinetic characterization of echinocandin inhibition was performed for mutant 1,3-beta-d-glucan synthase enzymes from clinical isolates of Candida albicans with nine different FKS1 mutations resulting in high MICs. Among 14 mutant Fks1p enzymes studied, the kinetic parameters 50% inhibitory
Hien T Ngoc Le et al.
Micromachines, 11(9) (2020-08-23)
Amyloid beta (aβ) 1-42, a peptide that is 1-42 amino acids long, is a major component of senile plaques in the brains of patients with Alzheimer's disease. Aβ detection has become an essential antecedence to predict the declining mental abilities
Kwang Hoe Kim et al.
Analytica chimica acta, 882, 38-48 (2015-06-05)
Multiple reaction monitoring (MRM) is commonly used for the quantitative analysis of proteins during mass pectrometry (MS), and has excellent specificity and sensitivity for an analyte in a complex sample. In this study, a pseudo-MRM method for the quantitative analysis
Ricardo T Fujiwara et al.
PLoS neglected tropical diseases, 3(3), e399-e399 (2009-03-25)
Hookworms survive for several years (5 to 7 years) in the host lumen, inducing a robust but largely ineffective immune response. Among the most striking aspects of the immune response to hookworm (as with many other helminths) is the ablation
Julio Villatoro-Hernandez et al.
Microbial cell factories, 7, 22-22 (2008-07-30)
Chemokines are a large group of chemotactic cytokines that regulate and direct migration of leukocytes, activate inflammatory responses, and are involved in many other functions including regulation of tumor development. Interferon-gamma inducible-protein-10 (IP-10) is a member of the C-X-C subfamily
Jai Rautela et al.
Journal of leukocyte biology, 108(4), 1397-1408 (2021-01-20)
The ability to genetically modify CD8 T cells using viral gene delivery has facilitated the development of next generation of cancer immunotherapies such as chimeric Ag receptor (CAR) T cells engineered to specifically kill tumor cells. Development of immunotherapies targeting
Philip E Mason et al.
Journal of chromatography. A, 1216(1), 154-158 (2008-12-03)
Previous work has demonstrated proof-of-concept for carrying out the clinically useful Jaffe reaction between creatinine and picrate within a capillary tube using electrophoretically mediated microanalysis (EMMA). Here, it is shown that careful control of reagent plug length as well as
A Poloni et al.
Cytotherapy, 11(2), 153-162 (2009-03-21)
Mesenchymal stromal cells (MSC) are promising candidates for cell therapy and tissue engineering and may be used to treat acute graft-versus-host disease (GvHD). However, major obstacles for their clinical use are the required cell dose and the biosafety and potential
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