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Showing 1-30 of 103 results for "H7250" within Papers
PingShan Zhong et al.
Journal of experimental & clinical cancer research : CR, 43(1), 138-138 (2024-05-08)
Although immune checkpoint blockade (ICB) therapy has proven to be extremely effective at managing certain cancers, its efficacy in treating pancreatic ductal adenocarcinoma (PDAC) has been limited. Therefore, enhancing the effect of ICB could improve the prognosis of PDAC. In
Qiaochu Li et al.
eLife, 9 (2020-11-25)
The ability to learn progressively declines with age. Neural hyperactivity has been implicated in impairing cognitive plasticity with age, but the molecular mechanisms remain elusive. Here, we show that chronic excitation of the Caenorhabditis elegans O2-sensing neurons during ageing causes
Jeffrey L Rhoades et al.
Cell, 176(1-2), 85-97 (2018-12-26)
Animals must respond to the ingestion of food by generating adaptive behaviors, but the role of gut-brain signaling in behavioral regulation is poorly understood. Here, we identify conserved ion channels in an enteric serotonergic neuron that mediate its responses to
Determination of some quality criteria of cold storaged marinated anchovy under vacuum and modified atmosphere conditions
Guncsen U, et al.
Turkish Journal of Fisheries and Aquatic Sciences, 11(2), 282-291 (2011)
Matthias Karer et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 71(4), 497-511 (2022-03-19)
To evaluate the contribution of endogenous diamine oxidase (DAO) in the inactivation of exogenous histamine, to find a mouse strain with increased histamine sensitivity and to test the efficacy of rhDAO in a histamine challenge model. Diamine oxidase knockout (KO)
Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice.
Li, et al.
Nature Communications, 14, 2539-2539 (2023)
Francesca Vallese et al.
Nature communications, 11(1), 6069-6069 (2020-11-29)
Membrane contact sites between virtually any known organelle have been documented and, in the last decades, their study received momentum due to their importance for fundamental activities of the cell and for the subtle comprehension of many human diseases. The
Song Han et al.
Journal of cell science, 134(13) (2021-06-11)
Mitochondria-endoplasmic reticulum contacts (MERCs) play an essential role in multiple cell physiological processes. Although Mfn2 was the first protein implicated in the formation of MERCs, there is debate as to whether it acts as a tether or antagonizer, largely based
Taylor Follansbee et al.
eLife, 11 (2022-08-17)
The rostral ventromedial medulla (RVM) is important in descending modulation of spinal nociceptive transmission, but it is unclear if the RVM also modulates spinal pruriceptive transmission. RVM ON cells are activated by noxious algesic and pruritic stimuli and are pronociceptive.
Lina Zhao et al.
PLoS biology, 20(6), e3001684-e3001684 (2022-06-22)
The ability to detect and respond to acute oxygen (O2) shortages is indispensable to aerobic life. The molecular mechanisms and circuits underlying this capacity are poorly understood. Here, we characterize the behavioral responses of feeding Caenorhabditis elegans to approximately 1%
Kenta Furutani et al.
Pain, 164(6), 1340-1354 (2022-11-16)
Specialized proresolving mediators (SPMs) have demonstrated potent analgesic actions in animal models of pathological pain. The actions of SPMs in acute and chronic itch are currently unknown. Recently, n-3 docosapentaenoic acid (DPA) was found to be a substrate for the
Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia
Martner A, et al.
Expert Review of Hematology, 3(4), 381-391 (2010)
Giulia Di Marco et al.
Cell reports, 30(7), 2321-2331 (2020-02-23)
Mitochondrial Ca2+ uptake depends on the mitochondrial calcium uniporter (MCU) complex, a highly selective channel of the inner mitochondrial membrane (IMM). Here, we screen a library of 44,000 non-proprietary compounds for their ability to modulate mitochondrial Ca2+ uptake. Two of
Lydia Ogrodzinski et al.
iScience, 26(7), 107232-107232 (2023-07-27)
E-selectin is expressed on endothelial cells in response to inflammatory cytokines and mediates leukocyte rolling and extravasation. However, studies have been hampered by lack of experimental approaches to monitor expression in real time in living cells. Here, NanoLuc Binary Technology
Amisha Patel et al.
Biosensors, 13(6) (2023-06-27)
Histamine receptor 2 (HRH2) blockers are used to treat peptic ulcers and gastric reflux. Chlorquinaldol and chloroxine, which contain an 8-hydroxyquinoline (8HQ) core, have recently been identified as blocking HRH2. To gain insight into the mode of action of 8HQ-based
Antonello Cicero et al.
International journal of environmental research and public health, 17(20) (2020-10-18)
We developed, validated, and confirmed with proficiency tests a fast ultra-high-performance liquid chromatography with diode array detector (UHPLC-DAD) method to determine histamine in fish and fishery products. The proposed method consists of two successive solid-liquid extractions: one with a dilute
Ângela Sousa et al.
Journal of chromatography. A, 1366, 110-119 (2014-09-30)
Histamine and agmatine amino acid derivatives were immobilized into monolithic disks, in order to combine the specificity and selectivity of the ligand with the high mass transfer and binding capacity offered by monolithic supports, to purify potential plasmid DNA biopharmaceuticals.
Elisa Greotti et al.
Bio-protocol, 10(3), e3504-e3504 (2021-03-04)
Calcium (Ca2+) imaging aims at investigating the dynamic changes in live cells of its concentration ([Ca2+]) in different pathophysiological conditions. Ca2+ is an ubiquitous and versatile intracellular signal that modulates a large variety of cellular functions thanks to a cell
Maëva Meynier et al.
Gut microbes, 16(1), 2298026-2298026 (2024-01-04)
Gut - brain communications disorders in irritable bowel syndrome (IBS) are associated with intestinal microbiota composition, increased gut permeability, and psychosocial disturbances. Symptoms of IBS are difficult to medicate, and hence much research is being made into alternative approaches. This
Sarit Pal et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(3), R590-R604 (2020-01-09)
Lymphatic vessels play a critical role in mounting a proper immune response by trafficking peripheral immune cells to draining lymph nodes. Mast cells (MCs) are well known for their roles in type I hypersensitivity reactions, but little is known about
Anthi A Apostolopoulou et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(28), 16606-16615 (2020-07-01)
Neural network function requires an appropriate balance of excitation and inhibition to be maintained by homeostatic plasticity. However, little is known about homeostatic mechanisms in the intact central brain in vivo. Here, we study homeostatic plasticity in the Drosophila mushroom
Francesca Bertino et al.
Cell reports. Medicine, 5(7), 101647-101647 (2024-07-18)
Congenital hydrocephalus (CH), occurring in approximately 1/1,000 live births, represents an important clinical challenge due to the limited knowledge of underlying molecular mechanisms. The discovery of novel CH genes is thus essential to shed light on the intricate processes responsible
Hong Wei et al.
Pharmacological research, 90, 58-66 (2014-10-12)
Among brain structures receiving efferent projections from the histaminergic tuberomammillary nucleus is the pontine locus coeruleus (LC) involved in descending noradrenergic control of pain. Here we studied whether histamine in the LC is involved in descending regulation of neuropathic hypersensitivity.
Mark A Landy et al.
Cell reports, 34(13), 108913-108913 (2021-04-01)
Prdm12 is a key transcription factor in nociceptor neurogenesis. Mutations of Prdm12 cause congenital insensitivity to pain (CIP) from failure of nociceptor development. However, precisely how deletion of Prdm12 during development or adulthood affects nociception is unknown. Here, we employ
Egla Yareth Bivián-Castro et al.
Bioinorganic chemistry and applications, 603651-603651 (2009-06-27)
A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. The crystal structure of [Cu(hsm)(nal)H(2)O]Cl.3H(2)O (chn) showed a pentacoordinated cooper(II) in a square pyramidal geometry surrounded by
Xu Zhan et al.
Nature communications, 14(1), 4534-4534 (2023-07-28)
Locomotor activities can enhance learning, but the underlying circuit and synaptic mechanisms are largely unknown. Here we show that locomotion facilitates aversive olfactory learning in C. elegans by activating mechanoreceptors in motor neurons, and transmitting the proprioceptive information thus generated
Youngshin Lim et al.
Scientific reports, 11(1), 21477-21477 (2021-11-04)
Interactions between the endoplasmic reticulum (ER) and mitochondria (Mito) are crucial for many cellular functions, and their interaction levels change dynamically depending on the cellular environment. Little is known about how the interactions between these organelles are regulated within the
Sarit Pal et al.
Biology open, 11(7) (2022-07-02)
Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled receptor (GPCR), which is expressed in a wide variety of cell and tissue types.
Xueting Liu et al.
The Journal of investigative dermatology, 140(9), 1856-1866 (2020-02-08)
Recurrent and intractable chronic itch is a worldwide problem, but mechanisms, especially the neural mechanisms, underlying chronic itch still remain unclear. In this study, we investigated the peripheral and spinal mechanisms responsible for prolonged itch in a mouse model of
Haley R Steele et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(15) (2021-04-21)
Itch arising from glabrous skin (palms and soles) has attracted limited attention within the field due to the lack of methodology. This is despite glabrous itch arising from many medical conditions such as plantar and palmar psoriasis, dyshidrosis, and cholestasis.
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