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Showing 1-30 of 31 results for "H9772" within Papers
Barbora WaclawikovĆ” et al.
PLoS biology, 19(1), e3001070-e3001070 (2021-01-23)
Microbial conversion of dietary or drug substrates into small bioactive molecules represents a regulatory mechanism by which the gut microbiota alters intestinal physiology. Here, we show that a wide variety of gut bacteria can metabolize the dietary supplement and antidepressant
Shao Wei Hu et al.
iScience, 23(11), 101651-101651 (2020-10-30)
Traumatic experiences generate stressful neurological effects in the exposed persons and animals. Previous studies have demonstrated that in many species, including Drosophila, the defeated animal has a higher probability of losing subsequent fights. However, the neural basis of this "loser
Ryan T Oglesby et al.
Magnetic resonance in medicine, 84(5), 2389-2399 (2020-04-18)
The diagnosis of monoamine-related psychiatric disorders is based on the phenomenological evaluation of symptoms and behavior by trained clinicians. The CEST technique can be sensitive to monoamines such as serotonin. This study quantifies the CEST properties of the compounds in
Denis A Nikishin et al.
International journal of molecular sciences, 20(12) (2019-06-27)
The origin of serotonin in the ovary is the key question for understanding mechanisms of serotonergic regulation of reproductive function. We performed a study of the expression and functional activity of the serotonin transporter (SERT) and the enzyme for the
Huixi Zou et al.
Journal of natural products, 72(1), 44-52 (2008-12-31)
This study reports that a series of tryptophan derivatives with modifications on the side chain or at the indole ring were accepted by two cyclic dipeptide prenyltransferases, CdpNPT and FtmPT1, and converted to prenylated derivatives. The structures of the enzymatic
I Pintelon et al.
Cell and tissue research, 321(1), 21-33 (2005-05-20)
Pulmonary neuroepithelial bodies (NEBs) are extensively innervated organoid groups of neuroendocrine cells that lie in the epithelium of intrapulmonary airways. Our present understanding of the morphology of NEBs is comprehensive, but direct physiological studies have so far been challenging because
Sabah Haq et al.
Science advances, 7(45), eabi6442-eabi6442 (2021-11-06)
[Figure: see text].
Maryam Goudarzi et al.
Radiation and environmental biophysics, 53(4), 645-657 (2014-07-23)
Metabolomics has been shown to have utility in assessing responses to exposure by ionizing radiation (IR) in easily accessible biofluids such as urine. Most studies to date from our laboratory and others have employed Ī³-irradiation at relatively high dose rates
Robert Haberzettl et al.
Behavioural brain research, 277, 204-210 (2014-05-02)
In humans, the ingestion of the combination of two or more serotonin (5-HT)-enhancing drugs but also of a single drug in overdose can induce serious adverse effects, which are characteristics of the serotonin syndrome (SS). In mice, acute administration of
Aida Ormazabal et al.
Journal of neuroscience methods, 142(1), 153-158 (2005-01-18)
The analysis of biogenic amines (BA) and pterins in cerebrospinal fluid (CSF) is essential for the early diagnosis of neurotransmission defects in the paediatric age. Our aim was to standardize previously reported HPLC procedures for the analysis of BA and
Sebastiaan P van Kessel et al.
BMC biology, 18(1), 137-137 (2020-10-21)
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most common gastrointestinal symptom. Aromatic bacterial metabolites are attracting considerable
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Yun Han Kwon et al.
Cellular and molecular gastroenterology and hepatology, 7(4), 709-728 (2019-02-05)
Serotonin (5-hydroxytryptamine [5-HT]) is synthesized mainly within enterochromaffin (EC) cells in the gut, and tryptophan hydroxylase 1 (Tph1) is the rate-limiting enzyme for 5-HT synthesis in EC cells. Accumulating evidence suggests the importance of gut microbiota in intestinal inflammation. Considering
Hai-Ling Yu et al.
Neuroscience letters, 593, 24-28 (2015-03-18)
Oleoylethanolamide (OEA) is an endocannabinoid analogy that belongs to a family of endogenous acylethanolamides. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of mental disorder-related behaviors. In the present study, we
Olga Gordeeva et al.
Archives of toxicology, 95(1), 253-269 (2020-09-15)
Pluripotent stem cells recapitulate in vitro the early developmental stages and are considered promising cell models for predictive developmental toxicity studies. To investigate the consistency between adverse drug effects on early development and the early stages of embryonic stem cell
Erin J Golden et al.
eLife, 10 (2021-05-20)
Embryonic taste bud primordia are specified as taste placodes on the tongue surface and differentiate into the first taste receptor cells (TRCs) at birth. Throughout adult life, TRCs are continually regenerated from epithelial progenitors. Sonic hedgehog (SHH) signaling regulates TRC
Ke Chen et al.
Experimental brain research, 237(11), 2925-2938 (2019-09-09)
It was shown in previous studies that endurance training enhanced excitability of rat spinal motoneurons. However, the influence of the training on the spinal interneurons remains unclear. In this study, we investigated the training effects on spinal interneurons in dorsal
Lu Jin et al.
Journal of animal science, 97(12), 5009-5015 (2019-11-08)
The goal of this experiment was to demonstrate the ability of an infusion of serotonin (5-HT; 5-hydroxytryptamine) precursors to increase 5-HT production during the transition from pregnancy to lactation and its effects on gene expression related to calcium (Ca) transporters
Enhanced synthesis of 5-hydroxy-l-tryptophan through tetrahydropterin regeneration
Hara R and Kino K
AMB Express, 3(1), 70-70 (2013)
Daniel B Schwab et al.
Journal of experimental zoology. Part A, Ecological and integrative physiology, 333(9), 660-669 (2020-09-23)
Environment-responsive development contributes significantly to the phenotypic variation visible to selectionĀ and as such possesses the potential to shape evolutionary trajectories. However, evaluation of the contributions of developmental plasticity to evolutionary diversification necessitates an understanding of the developmental mechanisms underpinning plastic
M G Marrero et al.
Scientific reports, 10(1), 9712-9712 (2020-06-18)
Dairy calves are born with a naĆÆve immune system, making the pre-weaning phase a critical window for immune development. In the U.S., 40-60% of dairy farms feed milk replacer to pre-weaned calves, which are devoid of bioactive factors with immunological
Celeste M Sheftel et al.
PloS one, 15(10), e0241192-e0241192 (2020-10-24)
Mammary-derived serotonin has been implicated in breast-to-bone communication during lactation by increasing parathyroid hormone related-protein (PTHrP) in the mammary gland. It is well established that PTHrP acts on the bone to liberate calcium for milk synthesis during lactation; however, the
Sena L Field et al.
Scientific reports, 11(1), 9665-9665 (2021-05-08)
In mammals, peripheral serotonin is involved in regulating energy balance. Herein, we characterized the transcriptomic profile and microstructure of adipose and muscle in pre-weaned calves with increased circulating serotonin. Holstein bull calves (21āĀ±ā2Ā days old) were fed milk replacer supplemented with
Andrew N Bubak et al.
PloS one, 14(1), e0203980-e0203980 (2019-01-30)
Despite the conserved function of aggression across taxa in obtaining critical resources such as food and mates, serotonin's (5-HT) modulatory role on aggressive behavior appears to be largely inhibitory for vertebrates but stimulatory for invertebrates. However, critical gaps exist in
Dany Gaillard et al.
Scientific reports, 9(1), 17934-17934 (2019-12-01)
Head and neck cancer patients receiving conventional repeated, low dose radiotherapy (fractionated IR) suffer from taste dysfunction that can persist for months and often years after treatment. To understand the mechanisms underlying functional taste loss, we established a fractionated IR
M G Marrero et al.
Domestic animal endocrinology, 69, 42-50 (2019-07-08)
Peripheral serotonin has been shown to regulate important physiological functions such as energy homeostasis and immunity, particularly in rodent and humans, but its role is poorly understood in livestock species. Herein, we tested the safety and effectiveness of increasing serotonin
Deepali Gupta et al.
European journal of pharmacology, 735, 59-67 (2014-04-22)
Depression and anxiety are the most debilitating mood disorders with poor therapeutic recovery rates. In the last decades, 5-HT3 receptor antagonists have been identified as potential agents for mood disorders. The current investigation focuses on evaluating the, antidepressant and anti-anxiety
S L Field et al.
Domestic animal endocrinology, 74, 106519-106519 (2020-08-03)
Peripheral serotonin regulates energy metabolism in several mammalian species, however, the potential contribution of serotonergic mechanisms as metabolic and endocrine regulators in growing dairy calves remain unexplored. Objectives were to characterize the role of serotonin in glucose and insulin metabolism
Magdalena Monier et al.
Frontiers in behavioral neuroscience, 12, 334-334 (2019-01-29)
Mate-copying is a form of social learning in which the mate-choice decision of an individual (often a female) is influenced by the mate-choice of conspecifics. Drosophila melanogaster females are known to perform such social learning, and in particular, to mate-copy
Meghan K Connelly et al.
Physiological reports, 9(7), e14798-e14798 (2021-04-10)
Serotonin plays a diverse role in maternal and mammary metabolism. Recent research in the dairy cow has shown a relationship between serotonin and calcium, with increased serotonin concentrations improving calcium homeostasis in the peri-partum dairy cow. Therefore, the objective was
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