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Showing 1-14 of 14 results for "HPA000536" within Papers
Yasmine Neirijnck et al.
Kidney international, 93(5), 1142-1153 (2018-02-21)
Congenital abnormalities of the kidney and the urinary tract (CAKUT) belong to the most common birth defects in human, but the molecular basis for the majority of CAKUT patients remains unknown. Here we show that the transcription factor SOX11 is
Simona Righi et al.
Human pathology, 59, 94-101 (2016-10-11)
Mantle cell lymphoma (MCL) usually harbors the t(11;14)(q13;q32) with overexpression of CCND1 mRNA and transcription of the cyclin D1 nuclear protein. Regardless of CCND1 status, most MCLs also express the SOX11 nuclear protein, which is thus helpful in the diagnosis
Duplication 2p25 in a child with clinical features of CHARGE syndrome.
Sperry ED, et al.
American Journal of Medical Genetics, 170(5), 1148-1154 (2016)
Impact of Sox11 over-expression in Ba/F3 cells.
Martin Lord et al.
Haematologica, 103(12), e594-e597 (2018-06-30)
Qi Miao et al.
Nature communications, 10(1), 4042-4042 (2019-09-08)
Tissue injury induces changes in cellular identity, but the underlying molecular mechanisms remain obscure. Here, we show that upon damage in a mouse model, epidermal cells at the wound edge convert to an embryonic-like state, altering particularly the cytoskeletal/extracellular matrix
Sungbo Shim et al.
Nature, 486(7401), 74-79 (2012-06-09)
The co-emergence of a six-layered cerebral neocortex and its corticospinal output system is one of the evolutionary hallmarks of mammals. However, the genetic programs that underlie their development and evolution remain poorly understood. Here we identify a conserved non-exonic element
Toni Grönroos et al.
Scientific reports, 10(1), 2043-2043 (2020-02-08)
Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and
Anne Wiemhoefer et al.
Molecular & cellular proteomics : MCP, 14(8), 2177-2193 (2015-06-05)
Tripeptidyl peptidase II (TPP2) is a serine peptidase involved in various biological processes, including antigen processing, cell growth, DNA repair, and neuropeptide mediated signaling. The underlying mechanisms of how a peptidase can influence this multitude of processes still remain unknown.
Deletions and de novo mutations of SOX11 are associated with a neurodevelopmental disorder with features of Coffin-Siris syndrome.
Hempel A, et al.
Journal of medical Genetics, 53(3), 152-162 (2016)
Yasuyuki Otsuka et al.
Clinical case reports, 5(4), 477-481 (2017-04-12)
We report here a patient with extremely indolent mantle cell lymphoma (MCL) who had progressed and required immunochemotherapy 20 years after diagnostic splenectomy. Non-nodal, indolent MCL patients may progress after such an extraordinary long indolent phase, and we recommend lifelong follow
SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma.
Vegliante MC, et al.
Blood, 28(11), 2012-2012 (2013)
Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype.
Ribera-Cortada I, et al.
Modern Pathology, 28(11), 1435-1435 (2015)
The three SoxC proteins?Sox4, Sox11 and Sox12?exhibit overlapping expression patterns and molecular properties.
Dy P, et al.
Nucleic Acids Research, 36(9), 3101-3117 (2008)
Yuan Gao et al.
Nature cell biology, 25(2), 298-308 (2023-01-20)
The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the transcriptional repressor ETV6 as a unique dependency in this tumour. Using biochemical assays and epigenomics, we show
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