HPA001934

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Showing 1-6 of 6 results for "HPA001934" within Papers

Identification of the extracellular matrix protein Fibulin-2 as a regulator of spinal nerve organization.

Julia Schaeffer et al.

Developmental biology, 442(1), 101-114 (2018-06-27)

During amniote peripheral nervous system development, segmentation ensures the correct patterning of the spinal nerves relative to the vertebral column. Along the antero-posterior (rostro-caudal) axis, each somite-derived posterior half-sclerotome expresses repellent molecules to restrict axon growth and neural crest migration

Organization of the dermal matrix impacts the biomechanical properties of skin.

A K Langton et al.

The British journal of dermatology, 177(3), 818-827 (2017-01-31)

Human skin has the crucial roles of maintaining homeostasis and protecting against the external environment. Skin offers protection against mechanical trauma due to the reversible deformation of its structure; these biomechanical properties are amenable to dynamic testing using noninvasive devices.

Fibulin-2 exhibits high degree of variability, but no structural changes concordant with abdominal aortic aneurysms.

H Kuivaniemi et al.

European journal of human genetics : EJHG, 6(6), 642-646 (1999-01-15)

We used conformation sensitive gel electrophoresis and direct sequencing of PCR products to screen for mutations in the cDNA for fibulin-2, an extracellular matrix protein, from 11 patients with abdominal aortic aneurysms and two controls. When compared with the published

Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences.

A Utani et al.

The Journal of biological chemistry, 272(5), 2814-2820 (1997-01-31)

Epithelial cell-specific laminin-5, consisting of three chains, alpha3, beta3, and gamma2, is a component of the anchoring filament that traverses the lamina lucida beneath the hemidesmosomes of epidermal cells and functions to link these cells to the basement membrane. We

Differential reorganisation of cutaneous elastic fibres: a comparison of the in vivo effects of broadband ultraviolet B versus solar simulated radiation.

Nisamanee Charoenchon et al.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 17(7), 889-895 (2018-04-27)

Long-term exposure of human skin to ultraviolet radiation (UVR) in sunlight negatively impacts its appearance and function with photoaged skin having a characteristic leathery, rough appearance, with deep wrinkles. These clinical features of photodamage are thought to result from UVR-induced

Fibulin-2: genetic mapping and exclusion as a candidate gene in Marfan syndrome type 2.

G Collod et al.

European journal of human genetics : EJHG, 4(5), 292-295 (1996-01-01)

Fibulin-2 (FBLN2) is a new extracellular matrix protein that has been considered a candidate gene for Marfan syndrome type 2 (locus MFS2) based on chromosomal colocation at 3p24.2-p25 and disease phenotype. In the absence of polymorphic markers reported for FBLN2

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