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Showing 1-29 of 29 results for "HPA005785" within Papers
Sebastian Schuth et al.
Journal of experimental & clinical cancer research : CR, 41(1), 312-312 (2022-10-24)
Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great potential as tumor avatars for drug response prediction in PDAC, yet they disregard the influence of stromal
Olga Ilina et al.
Nature cell biology, 22(9), 1103-1115 (2020-08-26)
Plasticity of cancer invasion and metastasis depends on the ability of cancer cells to switch between collective and single-cell dissemination, controlled by cadherin-mediated cell-cell junctions. In clinical samples, E-cadherin-expressing and -deficient tumours both invade collectively and metastasize equally, implicating additional
Mitsutaka Yoshida et al.
Biotechnology and bioengineering, 115(3), 536-544 (2017-11-07)
Extracellular vesicles (EVs) collectively represent small vesicles that are secreted from cells and carry biomolecules (e.g., miRNA, lncRNA, mRNA, proteins, lipids, metabolites, etc.) that originate in those cells. Body fluids, such as blood and saliva, include large numbers of EVs
Jun Lei et al.
American journal of obstetrics and gynecology, 212(5), 639-639 (2015-01-04)
Using a mouse model of intrauterine inflammation, we have demonstrated that exposure to inflammation induces preterm birth and perinatal brain injury. Mesenchymal stem cells (MSCs) have been shown to exhibit immunomodulatory effects in many inflammatory conditions. We hypothesized that treatment
Jing Wang et al.
Molecular medicine reports, 11(5), 3505-3510 (2015-01-13)
A high expression of CD44v6 has been reported in numerous malignant cancers, including stomach, prostate, lung and colon. However, the pathological role and the regulatory mechanisms of CD44v6 have yet to be elucidated. In the present study, the expression levels
Rachel Walker et al.
Applied immunohistochemistry & molecular morphology : AIMM, 27(4), 270-277 (2017-10-31)
Gastric cancer (GC) remains the third most common cause of cancer-related death worldwide. Infection with Helicobacter pylori is responsible for over 70% of GC incidence; colonization induces chronic inflammation, which can facilitate progression to intestinal metaplasia, dysplasia, and GC (Correa
Hitoshi Tsugawa et al.
Cellular and molecular gastroenterology and hepatology, 8(3), 319-334 (2019-05-31)
CD44 variant 9 (CD44v9)-positive cancer stem-like cells strongly contribute to the development and recurrence of gastric cancer. However, the origin of CD44v9-positive cells is uncertain. CD44v9, β-catenin, and epithelial splicing regulatory protein 1 signals were assessed by real-time reverse-transcription polymerase
Cintia D'Amato-Brito et al.
Oncotarget, 7(10), 11512-11525 (2016-02-18)
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine implicated in acute and chronic inflammatory diseases. MIF is overexpressed in various tumors. It displays a number of functions that provide a direct link between the process of inflammation and tumor
Ran Ma et al.
Laboratory investigation; a journal of technical methods and pathology, 94(7), 796-805 (2014-04-30)
Breast cancer is a unique tumor disease in terms of the stringent requirement of predictive biomarker assessments. As recommended by current international guidelines, the established markers consist of estrogen receptor (ER), progesterone receptor, human epidermal growth factor and Ki67, and
Mateusz Sikora et al.
Journal of cellular and molecular medicine, 25(14), 6634-6651 (2021-06-03)
Available therapies aimed at treating age-related osteoporosis are still insufficient. Therefore, designing reliable in vitro model for the analysis of molecular mechanisms underlying senile osteoporosis is highly required. We have isolated and characterized progenitor cells isolated from bone marrow (BMSCs)
Andreas Weigert et al.
Nature communications, 13(1), 6078-6078 (2022-10-15)
Fibrocytes are bone marrow-derived monocytic cells implicated in wound healing. Here, we identify their role in lung cancer progression/ metastasis. Selective manipulation of fibrocytes in mouse lung tumor models documents the central role of fibrocytes in boosting niche features and
Jung-Hyun Rho et al.
Gut, 67(3), 473-484 (2016-11-09)
To discover and confirm blood-based colon cancer early-detection markers. We created a high-density antibody microarray to detect differences in protein levels in plasma from individuals diagnosed with colon cancer <3 years after blood was drawn (ie, prediagnostic) and cancer-free, matched controls.
BGMUT: NCBI dbRBC database of allelic variations of genes encoding antigens of blood group systems
Patnaik SK, et al.
Nucleic Acids Research, D1023-D1029 (2011)
Gastrointestinal Pathology.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 29 Suppl 2, 158-212 (2016-01-29)
Guo-Fang Guan et al.
Molecular medicine reports, 12(3), 4352-4357 (2015-06-18)
The presence of cancer stem cells (CSCs) has major implications in the choice of cancer treatment strategy and is responsible for tumor relapse. CSCs have been isolated and characterized in several types of cancer; however, studies concerning the CSCs from
Didier J Colin et al.
International journal of molecular sciences, 19(7) (2018-06-29)
Malignant pleural mesothelioma (MPM) is a thoracic aggressive cancer caused by asbestos exposure, which is difficult to diagnose and treat. Here, we characterized an in vivo orthotopic xenograft model consisting of human mesothelioma cells (designed as H2052/484) derived from a
Kenichi Suda et al.
Molecular cancer therapeutics, 17(10), 2257-2265 (2018-07-28)
Epithelial-to-mesenchymal transition (EMT) is one of the acquired resistance mechanisms to EGFR tyrosine kinase inhibitors (TKI) in lung cancers. Because EMT is related to tumor invasion, metastases, and resistance to various treatments, it is important to prevent the emergence of
Yanjun Li et al.
Oncogenesis, 9(2), 20-20 (2020-02-15)
Given that colorectal cancer stem cells (CCSCs) play key roles in the tumor dormancy, metastasis, and relapse, targeting CCSCs is a promising strategy in cancer therapy. Here, we aimed to identify the new regulators of CCSCs and found that Cullin
Michael G Monaghan et al.
Development (Cambridge, England), 143(3), 473-482 (2015-12-18)
The elucidation of mechanisms in semilunar valve development might enable the development of new therapies for congenital heart disorders. Here, we found differences in proliferation-associated genes and genes repressed by VEGF between human semilunar valve leaflets from first and second
The role of CD44 and ERM proteins in expression and functionality of P-glycoprotein in breast cancer cells
Pokharel D, et al.
Molecules (Basel), 290-290 (2016)
Deep Pokharel et al.
Molecules (Basel, Switzerland), 21(3), 290-290 (2016-03-05)
Multidrug resistance (MDR) is often attributed to the over-expression of P-glycoprotein (P-gp), which prevents the accumulation of anticancer drugs within cells by virtue of its active drug efflux capacity. We have previously described the intercellular transfer of P-gp via extracellular
Lalit Mohan Negi et al.
Journal of drug targeting, 20(7), 561-573 (2012-07-05)
CD44 or hyaluronan receptor is a transmembrane receptor associated with aggressive tumour growth, proliferation, and metastasis. In normal physiology, this receptor has a crucial role in cell adhesion, inflammation, and repair processes. However, many tumour cells over-express this receptor and
Marc Damelin et al.
Cancer research, 71(12), 4236-4246 (2011-05-05)
Poorly differentiated tumors in non-small cell lung cancer (NSCLC) have been associated with shorter patient survival and shorter time to recurrence following treatment. Here, we integrate multiple experimental models with clinicopathologic analysis of patient tumors to delineate a cellular hierarchy
Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance
Whelan KA, et al.
Oncogene, 36(34), 4843-4843 (2017)
Gastrointestinal Pathology.
Laboratory investigation; a journal of technical methods and pathology, 96 Suppl 1, 158-212 (2016-01-28)
Helen Schneck et al.
PloS one, 10(12), e0144535-e0144535 (2015-12-24)
Circulating tumor cells (CTCs) are the potential precursors of metastatic disease. Most assays established for the enumeration of CTCs so far-including the gold standard CellSearch-rely on the expression of the cell surface marker epithelial cell adhesion molecule (EpCAM). But, these
Toward early detection of Helicobacter pylori-associated gastric cancer
Walker R, et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 21(2), 196-203 (2018)
Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguity.
Jaggupilli, A., and Elkord, E.
Clinical & Developmental Immunology, doi: 10-doi: 10 (2012)
Rachel Walker et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 21(2), 196-203 (2017-07-21)
Gastric cancer is typically diagnosed at a late stage, leading to poor prognoses. Helicobacter pylori is responsible for 70% of gastric cancers globally, and patients with this bacterial infection often present with early stages of the carcinogenic pathway such as
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