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Showing 1-7 of 7 results for "HPA019039" within Papers
Chen Zhao et al.
Cancer, 98(1), 18-23 (2003-07-02)
Amplification of DNA in certain chromosomal regions plays a crucial role in the development and progression of human malignancies, specifically when protooncogenic target genes within those amplicons are overexpressed. Comparative genomic hybridization studies have revealed frequent amplification at 20q in
Steffen Israel et al.
Scientific reports, 9(1), 13356-13356 (2019-09-19)
Early mouse embryos have an atypical translational machinery that consists of cytoplasmic lattices and is poorly competent for translation. Hence, the impact of transcriptomic changes on the operational level of proteins is predicted to be relatively modest. To investigate this
Andreas Eisenreich et al.
Circulation research, 104(5), 589-599 (2009-01-27)
Tumor necrosis factor (TNF)-alpha-stimulated human umbilical vein endothelial cells express 2 naturally occurring forms of tissue factor (TF), the primary initiator of blood coagulation: the soluble alternatively spliced isoform and the full-length TF isoform. The regulatory pathways enabling this phenomenon
TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors.
Érica Aparecida de Oliveira et al.
Pharmacological research, 173, 105911-105911 (2021-09-25)
In melanomas, therapy resistance can arise due to a combination of genetic, epigenetic and phenotypic mechanisms. Due to its crucial role in DNA supercoil relaxation, TOP1 is often considered an essential chemotherapeutic target in cancer. However, how TOP1 expression and
Yoshiaki Onishi et al.
Nucleic acids research, 40(19), 9482-9492 (2012-08-21)
The Bmal1 gene is essential for the circadian system, and its promoter has a unique open chromatin structure. We examined the mechanism of topoisomerase I (Top1) to understand the role of the unique chromatin structure in Bmal1 gene regulation. Camptothecin
Prasad Rallabhandi et al.
The Journal of biological chemistry, 277(42), 40020-40026 (2002-08-01)
Previous studies identified a small fraction of putatively sumoylated topoisomerase I (TOP1) under basal conditions ( approximately 1%), and anticancer camptothecins that trap the TOP1-DNA covalent intermediate markedly increase the sumoylation of TOP1 (<or=10%). To study the role of the
Ann-Katrine Jakobsen et al.
Experimental and molecular pathology, 99(1), 56-64 (2015-05-20)
Topoisomerase I (TOP1) regulates DNA topology during replication and transcription whereas tyrosyl-DNA phosphodiesterase 1 (TDP1) is involved in the repair of several types of DNA damages, including damages from defective TOP1 catalysis. TOP1 is the target of chemotherapeutic drugs of
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