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Showing 1-20 of 20 results for "HPA040067" within Papers
Yangyang Feng et al.
Molecular carcinogenesis, 58(1), 126-134 (2018-09-23)
Coiled-coil domain containing 85 B (CCDC85B) is involved in diverse biological processes; however, its expression patterns and functions in human cancers are yet unknown. The present study demonstrated that the expression of CCDC85B in the cytoplasm of the non-small cell
Wei-Dong Li et al.
Molecular medicine reports, 19(5), 3723-3731 (2019-03-22)
Increasing evidence has suggested that hepatic lipid accumulation is associated with hepatic insulin resistance; however, the underlying mechanism is yet to be determined. It was demonstrated that the levels of microRNA‑215 (miR‑215) expression in the liver of rats fed a
Serge Cedrick Toya Mbiandjeu et al.
Antioxidants (Basel, Switzerland), 13(4) (2024-04-27)
Aging is characterized by increased oxidation and reduced efficiency of cytoprotective mechanisms. Nuclear factor erythroid-2-related factor (Nrf2) is a key transcription factor, controlling the expression of multiple antioxidant proteins. Here, we show that Nrf2-/- mice displayed an age-dependent anemia, due
Katrina M Lappin et al.
Cancer research, 82(5), 819-830 (2022-01-15)
Mutations in SF3B1 have been identified across several cancer types. This key spliceosome component promotes the efficient mRNA splicing of thousands of genes including those with crucial roles in the cellular response to DNA damage. Here, we demonstrate that depletion
Lena Molitor et al.
Nucleic acids research, 51(3), 1297-1316 (2023-01-19)
The RNA-binding protein PURA has been implicated in the rare, monogenetic, neurodevelopmental disorder PURA Syndrome. PURA binds both DNA and RNA and has been associated with various cellular functions. Only little is known about its main cellular roles and the
Ruimeng Yang et al.
EBioMedicine, 63, 103195-103195 (2021-01-09)
Pancreatic cancer (PC) is one of the most lethal solid malignancies in the world due to its excessive cell proliferation and aggressive metastatic features. Emerging evidences revealed the importance of posttranscriptional modifications of RNAs in PC progression. However, knowledge about the 5-methylcytosine
Stine A Lunding et al.
Molecular reproduction and development, 87(6), 711-719 (2020-06-09)
The Hippo pathway has been associated with regulation of early follicle growth. Studies of murine ovaries suggest that changes in the actin cytoskeleton, caused by fragmentation, result in inhibition of the Hippo pathway, and in turn, may activate follicle growth.
Mass spectrometry-based proteomic strategy for ecchymotic skin examination in forensic pathology.
Toma, et al.
Scientific Reports, 13, 6116-6116 (2023)
Moderate activation of IKK2-NF-κB in unstressed adult mouse liver induces cytoprotective genes and lipogenesis without apparent signs of inflammation or fibrosis.
Lu H, et al.
BMC Gastroenterology, 15(1), 94-94 (2015)
Hong Lu et al.
BMC gastroenterology, 15, 94-94 (2015-07-30)
The NF-kB signaling, regulated by IKK1-p52/RelB and IKK2-p65, is activated by various stresses to protect or damage the liver, in context-specific manners. Two previous studies of liver-specific expression of constitutive active IKK2 (IKK2ca) showed that strong activation of IKK2-NF-kB in
Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in DNA Repair.
Kosova A A, et al.
Biochemistry. Biokhimiia, 82(6), 643-654 (2017)
C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization.
Desmurs M, et al.
Molecular and Cellular Biology (2015)
Hong Lu et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(6), 740-752 (2018-06-19)
Methyltransferase G9a is essential for a key gene silencing mark, histone H3 dimethylation at lysine-9 (H3K9me2). Hepatic G9a expression is down-regulated by xenobiotics and diabetes. However, little is known about the role of G9a in liver. Thus, we generated mice
Yu Zhao et al.
Oncology reports, 49(1) (2022-12-02)
Chemotherapy remains one of the most important adjuvant treatments for bladder cancer (BC). However, similar to other malignancies, BC is prone to chemotherapy resistance and only approximately half of muscle‑invasive patients with BC respond to chemotherapy. The present study aimed
Jun Shao et al.
BioMed research international, 2019, 5201014-5201014 (2019-03-19)
Autophagy is involved in the development of numerous illnesses, including ischemia/reperfusion (I/R). Endothelial nitric oxide synthase (eNOS) participates in the protective effects of ischemic postconditioning (IPostC). However, it remains unclear whether eNOS-mediated autophagy serves as a critical role in IPostC
Jian Gu et al.
Molecular carcinogenesis, 61(11), 1016-1030 (2022-08-25)
Rho guanine nucleotide exchange factor 40 (ARHGEF40) is a member of the Dbl-family of guanine nucleotide factor proteins. However, its expression pattern and biological function in malignant tumors, notably in nonsmall cell lung cancer (NSCLC) are currently unknown. The present
Shefali Thakur et al.
Cells, 11(5) (2022-03-11)
Smarca5, an ATPase of the ISWI class of chromatin remodelers, is a key regulator of chromatin structure, cell cycle and DNA repair. Smarca5 is deregulated in leukemia and breast, lung and gastric cancers. However, its role in oncogenesis is not
Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells.
Cao Y, et al.
Cancer Science (2008)
Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death
Nakajima H, et al.
The Journal of Biological Chemistry, 292(11), 4727?4742-4727?4742 (2017)
Xin Gao et al.
Immunobiology, 228(5), 152706-152706 (2023-07-17)
Ischaemic stroke, accompanied by neuroinflammation, impairs blood-brain barrier (BBB) integrity through a complex mechanism involving activation of both RhoA/Rho kinase/myosin light chain-2 and neurokinin 1 receptor (NK1R). Using an in vitro model of human BBB composed of brain microvascular endothelial
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