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Showing 1-30 of 48 results for "HT5011" within Papers
Sophia Schedin-Weiss et al.
PloS one, 8(5), e63962-e63962 (2013-05-30)
Here, we present a highly sensitive method to study protein-protein interactions and subcellular location selectively for active multicomponent enzymes. We apply the method on γ-secretase, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate
Mangiferin induces islet regeneration in aged mice through regulating p16INK4a.
Wang H, et al.
International Journal of Molecular Medicine, 41(6), 3231-3242 (2018)
Parco M Siu et al.
BMC musculoskeletal disorders, 12, 58-58 (2011-03-10)
The molecular mechanism initiating deep pressure ulcer remains to be elucidated. The present study tested the hypothesis that the ubiquitin proteasome system is involved in the signalling mechanism in pressure-induced deep tissue injury. Adult Sprague Dawley rats were subjected to
Pierre-Alexandre Vidi et al.
Mutation research, 822, 27-33 (2017-08-29)
Agriculture in the United States employs youth ages ten and older in work environments with high pesticide levels. Younger children in rural areas may also be affected by indirect pesticide exposures. The long-term effects of pesticides on health and development
Angus P Yu et al.
Molecular and cellular endocrinology, 401, 155-164 (2014-12-03)
[D-Lys3]-GHRP-6 is regarded as a highly selective growth-hormone secretagogue receptor (GHSR) antagonist and has been widely used to investigate the dependency of GHSR-1a signalling mediated by acylated ghrelin. However, [D-Lys3]-GHRP-6 has been reported to influence other cellular processes which are
Chenjing Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 122-132 (2020-01-10)
N6-methyladenosine (m6A) modification in RNA has been implicated in diverse biological processes. However, very little is currently known about its role in nociceptive modulation. Here, we found that the level of spinal m6A modification was significantly increased in a mouse
Kun Huang et al.
Journal of hepatology, 66(5), 962-977 (2016-12-17)
PARP1 is a key mediator of cellular stress responses and critical in multiple physiological and pathophysiological processes of cells. However, whether it is involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) remains elusive. We analysed PARP1 activity in
Dezhi Chen et al.
Molecular medicine reports, 23(2) (2020-12-15)
Diabetic cardiomyopathy (DCM) is one of the primary complications of the cardiovascular system due to diabetes‑induced metabolic injury. The present study investigated the autophagy‑associated regulatory mechanisms of long non‑coding RNAs in cardiac pathological changes in diabetes mellitus (DM). Streptozotocin (STZ)‑induced
Benedicte Stavik et al.
Biochimica et biophysica acta, 1862(4), 670-678 (2016-01-31)
Neovascularization and hemorrhaging are evident in advanced atherosclerotic plaques due to hypoxic conditions, and mediate the accumulation of metabolic substrates, inflammatory cells, lipids, and other blood born factors inside the plaque. Tissue factor (TF) pathway inhibitor (TFPI) is mainly expressed
Young Woo Eom et al.
Yonsei medical journal, 52(6), 999-1007 (2011-10-27)
This study examined a rapid isolation method decreasing the time and cost of the clinical application of adipose tissue-derived stem cells (ASCs). Aliquots (10 g) of the lipoaspirates were stored at 4°C without supplying oxygen or nutrients. At the indicated
John Manion et al.
Pain, 161(2), 379-387 (2020-01-24)
Neuropathic pain causes severe suffering, and most patients are resistant to current therapies. A core element of neuropathic pain is the loss of inhibitory tone in the spinal cord. Previous studies have shown that foetal GABAergic neuron precursors can provide
Hyoungshin Park et al.
Journal of tissue engineering and regenerative medicine, 2(5), 279-287 (2008-05-31)
Electrical stimulation affects the deposition of extracellular matrices and cellular differentiation. Type I collagen is one of the most abundant extracellular matrix proteins; however, not much is known about the effects of electrical stimulation on collagen type I deposition in
Ling Liu et al.
The Journal of biological chemistry, 292(5), 1876-1883 (2016-12-21)
The stable effector functionLess (SEFL) antibody was designed as an IgG1 antibody with a constant region that lacks the ability to interact with Fcγ receptors. The engineering and stability and pharmacokinetic assessments of the SEFL scaffold is described in the
Caterina Nardella et al.
Science signaling, 2(55), ra2-ra2 (2009-01-30)
The mammalian target of rapamycin (mTOR) is a crucial effector in a complex signaling network commonly disrupted in cancer. mTOR exerts its multiple functions in the context of two different multiprotein complexes: mTOR complex 1 (mTORC1) and mTOR complex 2
Xiaozhen Liang et al.
PLoS pathogens, 7(9), e1002220-e1002220 (2011-09-21)
Human gammaherpesviruses are associated with the development of lymphoproliferative diseases and B cell lymphomas, particularly in immunosuppressed hosts. Understanding the molecular mechanisms by which human gammaherpesviruses cause disease is hampered by the lack of convenient small animal models to study
Biological characterization of a Stable Effector Functionless (SEFL) monoclonal antibody scaffold in vitro.
Liu L, et al.
The Journal of Biological Chemistry, 292(5), 1876-1883 (2017)
Carlos Pardo-Martin et al.
Nature communications, 4, 1467-1467 (2013-02-14)
Most gene mutations and biologically active molecules cause complex responses in animals that cannot be predicted by cell culture models. Yet animal studies remain too slow and their analyses are often limited to only a few readouts. Here we demonstrate
Huan Xu et al.
Neuron, 105(2), 293-309 (2020-01-07)
The molecular mechanisms that govern the maturation of oligodendrocyte lineage cells remain unclear. Emerging studies have shown that N6-methyladenosine (m6A), the most common internal RNA modification of mammalian mRNA, plays a critical role in various developmental processes. Here, we demonstrate
Songjie Cai et al.
Scientific reports, 10(1), 14249-14249 (2020-08-30)
Solid organ transplantation is a lifesaving therapy for patients with end-organ disease. Current immunosuppression protocols are not designed to target antigen-specific alloimmunity and are uncapable of preventing chronic allograft injury. As myeloid-derived suppressor cells (MDSCs) are potent immunoregulatory cells, we
Jihye Han et al.
Autophagy, 12(12), 2326-2343 (2016-10-27)
Severe hepatic inflammation is a common cause of acute or chronic liver disease. Macrophages are one of the key mediators which regulate the progress of hepatic inflammation. Increasing evidence shows that the TAM (TYRO3, AXL and MERTK) family of RTKs
Xin Wang et al.
The Journal of cell biology, 184(1), 143-158 (2009-01-14)
Ceramide transfer protein (CERT) functions in the transfer of ceramide from the endoplasmic reticulum (ER) to the Golgi. In this study, we show that CERT is an essential gene for mouse development and embryonic survival and, quite strikingly, is critical
Deirdre A Nelson et al.
Biology open, 2(5), 439-447 (2013-06-22)
Epithelial organ morphogenesis involves reciprocal interactions between epithelial and mesenchymal cell types to balance progenitor cell retention and expansion with cell differentiation for evolution of tissue architecture. Underlying submandibular salivary gland branching morphogenesis is the regulated proliferation and differentiation of
Benjamin Woodhams et al.
Nanoscale, 10(25), 12169-12179 (2018-06-20)
Nanodiamonds have demonstrated potential as powerful sensors in biomedicine, however, their translation into routine use requires a comprehensive understanding of their effect on the biological system being interrogated. Under normal fabrication processes, nanodiamonds are produced with a graphitic carbon shell
Thomas K Sin et al.
Frontiers in physiology, 6, 293-293 (2015-11-12)
Our current understanding on the molecular mechanisms by which sustained compression induces skeletal muscle injury is very limited. This study aimed to test the hypothesis that activation of SIRT1 by the natural antioxidant resveratrol could deactivate apoptotic and catabolic signaling
Ying Li et al.
PloS one, 7(3), e32910-e32910 (2012-03-14)
microRNAs (miRNAs) are small, conserved, non-coding RNAs that contribute to the control of many different cellular processes, including cell fate specification and growth control. Drosophila bantam, a conserved miRNA, is involved in several functions, such as stimulating proliferation and inhibiting
Tamara J Nicolson et al.
Diabetes, 58(9), 2070-2083 (2009-06-23)
Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated with type 2 diabetes. We describe the effects
Minae An et al.
Biomaterials, 146, 49-59 (2017-09-13)
Extracellular matrix (ECM) plays a critical role in the provision of the necessary microenvironment for the proper regeneration of the cardiac tissue. However, specific mechanisms that lead to ECM-mediated cardiac regeneration are not well understood. To elucidate the potential mechanisms
Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma.
Yang Y, et al.
International Journal of Oncology (2018)
Sammy Ferri-Borgogno et al.
Cancers, 12(9) (2020-09-25)
Background & Aims: ARID1A is postulated to be a tumor suppressor gene owing to loss-of-function mutations in human pancreatic ductal adenocarcinomas (PDAC). However, its role in pancreatic pathogenesis is not clear despite recent studies using genetically engineered mouse (GEM) models.
Karen Pauwelyn et al.
PloS one, 6(8), e23096-e23096 (2011-08-11)
Mouse embryonic stem cells (mESC) have been used to study lineage specification in vitro, including towards a hepatocyte-like fate, and such investigations guided lineage differentiation protocols for human (h)ESC. We recently described a four-step protocol to induce hepatocyte-like cells from
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