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Showing 1-30 of 104 results for "I1892" within Papers
Oral Ibuprofen and the patent ductus arteriosus: a new approach to an old problem.
Martin Kluckow
Jornal de pediatria, 89(1), 4-5 (2013-04-03)
Chong He et al.
PLoS genetics, 10(12), e1004860-e1004860 (2014-12-19)
The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains unclear. Here we show that ibuprofen increased the lifespan of Saccharomyces
M Petersen-Braun et al.
MMW Fortschritte der Medizin, 155 Suppl 1, 32-39 (2013-05-18)
Pain, inflammation or swelling of soft tissues orjoints is often treated with oral or topical formulation of lbuprofen. Thetherapeutic effect of a topical gel formulation of Ibuprofen (doc Ibuprofen Schmerzgel) was investigated in an observational trial. A total of 170
Qi-en Che et al.
Expert opinion on drug delivery, 11(10), 1513-1523 (2014-06-21)
The aim of this study was to investigate the mechanisms of different skin permeability of ibuprofen racemate and enantiomers. The percutaneous permeation of ibuprofen racemate and enantiomers through rabbit normal skin and damaged skin (without stratum corneum [SC]) was investigated
J Kruse et al.
Die Pharmazie, 68(2), 93-99 (2013-03-09)
In this paper we propose the use of lactic acid oligomers (OLAs) as prodrug moieties. Two synthetic approaches are presented, on the one hand a non selective oligomerisation of lactic acid and on the other hand a block synthesis to
M Giovannini et al.
La Pediatria medica e chirurgica : Medical and surgical pediatrics, 35(5), 205-211 (2014-02-13)
In the last few years we have observed an upward trend in the employment of ibuprofen as anti-inflammatory and antipyretic therapy. Therefore the pediatrician has often a precious option in the anti-inflammatory and antipyretic treatment in children instead of using
Aboozar Khajeh et al.
Biochimica et biophysica acta, 1838(10), 2431-2438 (2014-06-10)
In this work, molecular dynamics (MD) simulations with atomistic details were performed to examine the influence of the cholesterol on the interactions and the partitioning of the hydrophobic drug ibuprofen in a fully hydrated 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayer. Analysis of MD
Fareeha Batool et al.
Materials (Basel, Switzerland), 11(4) (2018-04-13)
Ibuprofen (IBU) has been shown to improve periodontal treatment outcomes. The aim of this study was to develop a new anti-inflammatory scaffold by functionalizing an electrospun nanofibrous poly-ε-caprolactone membrane with IBU (IBU-PCL) and to evaluate its impact on periodontal inflammation
Bryant Catherine et al.
Dental update, 40(8), 659-660 (2013-11-28)
A telephone survey was used to assess adequacy of pain control after third molar removal in a series of three audits. After each audit, factors contributing to failure to control pain adequately and poor patient compliance with our analgesic regimen
James F Markworth et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(11), R1281-R1296 (2013-10-04)
Classical proinflammatory eicosanoids, and more recently discovered lipid mediators with anti-inflammatory and proresolving bioactivity, exert a complex role in the initiation, control, and resolution of inflammation. Using a targeted lipidomics approach, we investigated circulating lipid mediator responses to resistance exercise
Joshua R Bedwell et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 151(6), 963-966 (2014-09-11)
To compare the performance of ibuprofen vs codeine for postoperative pain management after tonsillectomy as measured by need for emergency department (ED) treatment for pain and/or dehydration. Retrospective case series with chart review. Tertiary children's hospital. Consecutive series of patients
Sheena Derry et al.
The Cochrane database of systematic reviews, 3(3), CD010107-CD010107 (2013-04-02)
There is good evidence that combining two different analgesics in fixed doses in a single tablet can provide better pain relief in acute pain and headache than either drug alone, and that the drug-specific effects are essentially additive. This appears
Katarzyna Krukiewicz et al.
Bioelectrochemistry (Amsterdam, Netherlands), 108, 13-20 (2015-11-26)
As numerous therapeutic agents are not well tolerated when administrated systemically, localized and controlled delivery can help to decrease their toxicity by applying an optimized drug concentration at extended exposure time. Among different types of drug delivery systems, conjugated polymers
Lukasz Pajchel et al.
Materials science & engineering. C, Materials for biological applications, 91, 734-742 (2018-07-24)
MCM-48 is crystalline, mesoporous silicate used in catalysis and for adsorption various molecules to create useful materials for chemistry, pharmacy and medicine. In this work, the MCM-48 silicate has been coated with nanohydroxyapatite (HA) to design a new drug delivery
Brianne K Connizzo et al.
Clinical orthopaedics and related research, 472(8), 2433-2439 (2013-08-29)
Current clinical treatment after tendon repairs often includes prescribing NSAIDs to limit pain and inflammation. The negative influence of NSAIDs on bone repair is well documented, but their effects on tendon healing are less clear. While NSAIDs may be detrimental
Christopher J Derry et al.
The Cochrane database of systematic reviews, 12(12), CD009281-CD009281 (2014-12-17)
This is an updated version of the original Cochrane review published in Issue 3, 2012. Caffeine has been added to common analgesics such as paracetamol, ibuprofen, and aspirin, in the belief that it enhances analgesic efficacy. Evidence to support this
Slavica Sunaric et al.
Acta poloniae pharmaceutica, 70(3), 403-411 (2013-06-14)
Solid-phase extraction method followed by direct UV spectrophotometry at 264 nm was developed and applied for the selective ibuprofen determination in two-component formulation of ibuprofen and pseudoephedrine-HCl, combined powder which contains ibuprofen in the form of salt with L-arginine and
Eriko Fukushima et al.
The Journal of pharmacology and experimental therapeutics, 349(1), 165-173 (2014-02-06)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to cause gastric mucosal damage as a side effect. Acetaminophen, widely used as an analgesic and antipyretic drug, has gastroprotective effects against gastric lesions induced by absolute ethanol and certain NSAIDs. However, the mechanisms
Elena Redondo-Castro et al.
Experimental neurology, 252, 95-103 (2013-11-20)
Ibuprofen is commonly used as an anti-inflammatory analgesic drug, although it is not amongst the first-line treatments for neuropathic pain. Its main effects are mediated by non-specific inhibition of COX enzymes, but it also exerts some COX-independent effects, such as
Kelli G Sharp et al.
Experimental neurology, 248, 321-337 (2013-07-09)
This study was undertaken as part of the NIH "Facilities of Research Excellence-Spinal Cord Injury" project to support independent replication of published studies. Here, we repeat key parts of a study reporting that rats treated with ibuprofen via subcutaneous minipump
Rossella Laurano et al.
Frontiers in bioengineering and biotechnology, 8, 708-708 (2020-08-09)
The design of adaptable drug delivery systems able to encapsulate and release drugs with different wettability has been attracting widespread interest. Additionally, many attempts have been made to tune hydrophobic/hydrophilic drug release kinetics over time, avoiding the so-called burst release.
Hiroki Hashizume et al.
Biochemical pharmacology, 183, 114303-114303 (2020-10-31)
Nonsteroidal anti-inflammatory drugs (NSAIDs) containing carboxylic acid are conjugated with coenzyme A (CoA) or glucuronic acid in the body. It has been suggested that these conjugates are associated with toxicities, such as liver injury and anaphylaxis, through their binding via
T E Morozova et al.
Terapevticheskii arkhiv, 85(3), 118-124 (2013-05-31)
The paper presents data on the pharmacokinetics of the nonsteroidal anti-inflammatory drug ibuprofen and a review of the evidence base that suggests its clinical efficacy and safety in different categories of patients and discusses new, potentially possible indications for the
Katarzyna Krukiewicz et al.
Bioelectrochemistry (Amsterdam, Netherlands), 134, 107528-107528 (2020-04-16)
Neuroinflammation is often associated with poor functional recovery and may contribute to or initiate the development of severe neurological disorders, such as epilepsy, Parkinson's disease or Alzheimer's disease. Ibuprofen (IBU), being one of the most commonly used non-steroidal anti-inflammatory drugs
Ana Paula Serafini Immich et al.
Materials science & engineering. C, Materials for biological applications, 33(7), 4002-4008 (2013-08-06)
The primary advantages of electrospun membranes include the ability to obtain very thin fibers that are on the order of magnitude of several nanometers with a considerable superficial area and the possibility for these membranes to be manipulated and processed
Katarzyna Przejczowska-Pomierny et al.
Chirality, 29(9), 500-511 (2017-07-06)
A direct fluorometric high-performance liquid chromatography (HPLC) method was developed and validated for the analysis of ibuprofen enantiomers in mouse plasma (100 μl) and tissues (brain, liver, kidneys) using liquid-liquid extraction and 4-tertbutylphenoxyacetic acid as an internal standard. Separation of enantiomers
Piercarlo Sarzi-Puttini et al.
Clinical and experimental rheumatology, 31(5), 731-738 (2013-05-29)
The aim of this systematic review of the literature and meta-analysis of randomised controlled trials (RCTs) was to compare the efficacy of orally administered ketoprofen with that of ibuprofen and/or diclofenac. The literature was systematically reviewed in accordance with the
Rupa L Iyengar et al.
The American journal of medicine, 126(11), 1017-1017 (2013-09-03)
Studies have demonstrated the success of augmentation of antidepressant therapy with nonsteroidal anti-inflammatory drugs (NSAID) in decreasing depressive symptoms; however, little is known about the benefit of NSAID therapy on depressive symptoms. This study pooled data from 5 postapproval trials
Jia-Qian Jiang et al.
PloS one, 8(2), e55729-e55729 (2013-02-15)
Pharmaceuticals and their metabolites are inevitably emitted into the waters. The adverse environmental and human health effects of pharmaceutical residues in water could take place under a very low concentration range; from several µg/L to ng/L. These are challenges to
Elizabeth G Raymond et al.
Obstetrics and gynecology, 122(3), 558-564 (2013-08-08)
To compare the effectiveness of two oral analgesic regimens in first-trimester medical abortion. We randomly assigned 250 participants undergoing first-trimester abortion with mifepristone and misoprostol at three clinics to two ibuprofen regimens: therapeutic (800 mg every 4-6 hours as needed
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