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Showing 1-30 of 161 results for "I2018" within Papers
Irene Andrés-Blasco et al.
The Journal of endocrinology, 227(3), 179-191 (2015-10-02)
Metabolic syndrome and type 2 diabetes mellitus constitute a major problem to global health, and their incidence is increasing at an alarming rate. Non-alcoholic fatty liver disease, which affects up to 90% of obese people and nearly 70% of the
Charting a high-resolution roadmap for regeneration of pancreatic I? cells by in vivo transdifferentiation from adult acinar cells.
Liu, et al.
Science Advances, 9, eadg2183-eadg2183 (2023)
Protective effect of yacon leaves decoction against early nephropathy in experimental diabetic rats.
Honore S M, et al.
Food And Chemical Toxicology, 50(5), 1704-1715 (2012)
Sergey N Zolov et al.
The Journal of biological chemistry, 296, 100712-100712 (2021-04-30)
The retinal insulin receptor (IR) exhibits basal kinase activity equivalent to that of the liver of fed animals, but unlike the liver, does not fluctuate with feeding and fasting; it also declines rapidly after the onset of insulin-deficient diabetes. The
Seiga Ohmine et al.
Stem cell research & therapy, 2(6), 46-46 (2011-11-18)
The induced pluripotent stem cell (iPSC) technology allows generation of patient-specific pluripotent stem cells, thereby providing a novel cell-therapy platform for severe degenerative diseases. One of the key issues for clinical-grade iPSC derivation is the accessibility of donor cells used
Christopher Gribben et al.
Cell stem cell, 28(11), 2000-2008 (2021-09-04)
Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA sequencing (scRNA-seq) approaches, we show that ductal cells contribute to the β cell
Alonso Camacho-Ramírez et al.
Tissue & cell, 57, 78-83 (2019-04-06)
The aim of this study is to describe in depth how different bariatric surgeries affect to the cellularity of β-cells in the pancreatic islet. There are much data regarding the possible physiological mechanisms involved in resolution of type 2 diabetes
Jin-Yong Chung et al.
iScience, 26(4), 106439-106439 (2023-04-07)
Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these adaptations in β-cells and other islet cell types, we performed single-cell RNA
Himadri Singh et al.
Islets, 6(5-6), e998099-e998099 (2015-04-04)
WNIN/GR-Ob mutant rat is a novel animal model to study metabolic syndrome (obesity, insulin resistance, hyperinsulinemia, impaired glucose tolerance and cardiovascular diseases). We have investigated the islet characteristics of obese mutants at different age groups (1, 6 and 12 months)
Yi Quan et al.
The Korean journal of internal medicine, 35(6), 1443-1456 (2020-04-14)
Coenzyme Q10 (CoQ10) has antioxidant effects and is commercially available and marketed extensively. However, due to its low bioavailability, its effects are still controversial. We developed a water-soluble CoQ10-based micelle formulation (CoQ10-W) and tested it in an experimental model of
Sohei Tsukita et al.
EBioMedicine, 15, 163-172 (2016-12-16)
Major symptoms of diabetes mellitus manifest, once pancreatic β-cell numbers have become inadequate. Although natural regeneration of β-cells after injury is very limited, bone marrow (BM) transplantation (BMT) promotes their regeneration through undetermined mechanism(s) involving inter-cellular (BM cell-to-β-cell) crosstalk. We
Andreas Blutke et al.
Molecular metabolism, 6(8), 931-940 (2017-07-29)
The prevalence of diabetes mellitus and associated complications is steadily increasing. As a resource for studying systemic consequences of chronic insulin insufficiency and hyperglycemia, we established a comprehensive biobank of long-term diabetic INSC94Y transgenic pigs, a model of mutant INS
Weixiang Liu et al.
Nutrition & metabolism, 16, 34-34 (2019-05-30)
Blueberry is rich in bioactive substances and possesses powerful antioxidant potential, which can protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The aim of this study was to determine how blueberry affects glucose metabolism and pancreatic β-cell proliferation in
Jae Hyeon Kim et al.
Cell transplantation, 20(11-12), 1805-1815 (2011-03-15)
Instant blood-mediated inflammatory reaction (IBMIR) causes rapid islet loss in islet transplantation. Endothelial colony-forming cells (ECFCs) display unique abilities to promote angiogenesis and repair vascular injury compared to those of endothelial cells (ECs), which inhibits the allogeneic and xenogeneic
Irini Topalidou et al.
Molecular biology of the cell, 31(1), 59-79 (2019-11-14)
Dense-core vesicles (DCVs) are secretory vesicles found in neurons and endocrine cells. DCVs package and release cargoes including neuropeptides, biogenic amines, and peptide hormones. We recently identified the endosome-associated recycling protein (EARP) complex and the EARP-interacting-protein EIPR-1 as proteins important
Kentaro Nakamura et al.
Transplant international : official journal of the European Society for Organ Transplantation, 29(9), 1039-1050 (2016-06-17)
Cell death cluster in transplanted cells remains a critical obstacle for regeneration strategies. This study describes a novel platform for cell transplantation (CellSaic) consisting of human mesenchymal stem cells (hMSCs) and petaloid pieces of recombinant peptide (RCP), which can prevent
Jing Yang et al.
International journal of molecular medicine, 44(2), 608-616 (2019-06-08)
Hypercholesterolemia is a key factor leading to β‑cell dysfunction, but its underlying mechanisms remain unclear. Secretagogin (Scgn), a Ca2+ sensor protein that is expressed at high levels in the islets, has been shown to play a key role in regulating
Yusuke Mochizuki et al.
Biomedicines, 8(9) (2020-09-04)
The subcutaneous transplantation of microencapsulated islets has been extensively studied as a therapeutic approach for type I diabetes. However, due to the lower vascular density and strong inflammatory response in the subcutaneous area, there have been few reports of successfully
M Zhao et al.
Diabetologia, 48(10), 2051-2061 (2005-09-01)
The aim of the study was to investigate the potential of human pancreatic non-endocrine cells to transdifferentiate into endocrine cells that would be capable of secreting insulin in response to glucose and ameliorating insulin-deficient diabetes after transplantation. Cell fractions enriched
Divya P Kumar et al.
The Journal of biological chemistry, 291(13), 6626-6640 (2016-01-14)
The physiological role of the TGR5 receptor in the pancreas is not fully understood. We previously showed that activation of TGR5 in pancreatic β cells by bile acids induces insulin secretion. Glucagon released from pancreatic α cells and glucagon-like peptide
Ishant Khurana et al.
NPJ Regenerative medicine, 6(1), 7-7 (2021-02-14)
The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in
Alyaa Farid et al.
Saudi journal of biological sciences, 29(7), 103313-103313 (2022-06-17)
Melatonin, a pleiotropic hormone, has many regulatory effects on the circadian and seasonal rhythms, sleep and body immune system. It is used in the treatment of blind circadian rhythm sleep disorders, delayed sleep phase and insomnia. It is a potent
Ayumi Horikawa et al.
PloS one, 16(7), e0254373-e0254373 (2021-07-13)
Human induced pluripotent stem cells (hiPSCs) are considered a promising source of pancreatic β-cells for the treatment of diabetes. However, this approach is limited by issues such as low efficiency and high cost. Here, we have developed a new protocol
Ioannis Giannios et al.
Stem cells (Dayton, Ohio), 37(5), 640-651 (2019-01-27)
Understanding the mechanisms that promote the specification of pancreas progenitors and regulate their self-renewal and differentiation will help to maintain and expand pancreas progenitor cells derived from human pluripotent stem (hPS) cells. This will improve the efficiency of current differentiation
Décio L Eizirik et al.
PLoS genetics, 8(3), e1002552-e1002552 (2012-03-14)
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. Signaling events occurring in the pancreatic beta cells are decisive for their survival or
Manal M Elbandrawy et al.
Saudi journal of biological sciences, 29(5), 3871-3880 (2022-07-19)
Type 2 diabetes (T2DM) is a chronic metabolic disorder. Although therapeutic pharmaceutical agents continue to advance, herbal medicines are potential complementary treatments for the promotion of glucose homeostasis, with minimal adverse effects. Conventionally, ellagic acid (EA) has been utilized for
Rebecca L Hull et al.
Diabetes care, 41(4), 823-830 (2018-02-14)
Cystic fibrosis-related diabetes (CFRD) is a common complication of cystic fibrosis (CF), increasing patient morbidity and mortality. Poor understanding of CFRD pathogenesis limits the development of targeted therapies to treat and/or prevent the disease. The aim of this study was
Roger Lehmann et al.
Diabetes, 56(3), 594-603 (2007-03-01)
Many factors influence the outcome of islet transplantation. As islets in the early posttransplant setting are supplied with oxygen by diffusion only and are in a hypoxic state in the portal system, we tested whether small human islets are superior
Oliver Kluth et al.
Cell reports, 26(11), 3027-3036 (2019-03-14)
An insufficient adaptive beta-cell compensation is a hallmark of type 2 diabetes (T2D). Primary cilia function as versatile sensory antennae regulating various cellular processes, but their role on compensatory beta-cell replication has not been examined. Here, we identify a significant
Gillian I Bell et al.
Current protocols in stem cell biology, 26, 2B-2B (2014-02-11)
This unit describes our current knowledge regarding the isolation human bone marrow-derived progenitor cells for the paracrine stimulation of islet regeneration after transplantation into immunodeficient mouse models of diabetes. By using high aldehyde dehydrogenase (ALDH(hi) ) activity, a conserved function
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