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Showing 1-16 of 16 results for "I4036" within Papers
Rafael D Melani et al.
medRxiv : the preprint server for health sciences (2021-07-17)
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS , a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and
Ulrike Binsker et al.
The Journal of clinical investigation, 130(2), 927-941 (2019-11-07)
Successful infection by mucosal pathogens requires overcoming the mucus barrier. To better understand this key step, we performed a survey of the interactions between human respiratory mucus and the human pathogen Streptococcus pneumoniae. Pneumococcal adherence to adult human nasal fluid
Rafael D Melani et al.
Journal of proteome research, 21(1), 274-288 (2021-12-09)
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS, a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and heavy
Baweleta Isho et al.
Science immunology, 5(52) (2020-10-10)
While the antibody response to SARS-CoV-2 has been extensively studied in blood, relatively little is known about the antibody response in saliva and its relationship to systemic antibody levels. Here, we profiled by enzyme-linked immunosorbent assays (ELISAs) IgG, IgA and
Karen Colwill et al.
Clinical & translational immunology, 11(3), e1380-e1380 (2022-04-01)
Antibody testing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been instrumental in detecting previous exposures and analyzing vaccine-elicited immune responses. Here, we describe a scalable solution to detect and quantify SARS-CoV-2 antibodies, discriminate between natural infection- and vaccination-induced
Pedro Curto et al.
mBio, 12(6), e0305921-e0305921 (2021-12-08)
Rickettsiae are obligate intracellular Gram-negative bacteria transmitted by arthropod vectors. Despite their reduced genomes, the function(s) of the majority of rickettsial proteins remains to be uncovered. APRc is a highly conserved retropepsin-type protease, suggested to act as a modulator of
Tobias Schlesinger et al.
PloS one, 15(11), e0242917-e0242917 (2020-11-25)
The viral load and tissue distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain important questions. The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced
Isabella Quinti et al.
Frontiers in cellular and infection microbiology, 11, 655896-655896 (2021-04-24)
A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It
Hans Verkerke et al.
Journal of clinical microbiology, 59(4) (2021-01-21)
Accurate diagnosis of acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical for appropriate management of patients with this disease. We examined the possible complementary role of laboratory-developed class-specific clinical serology in assessing SARS-CoV-2 infection in hospitalized patients.
Qiao Zhong et al.
Journal of immunology (Baltimore, Md. : 1950), 200(12), 3913-3925 (2018-05-02)
Prevalence of circulating immunocomplexes (ICs) strongly correlates with rheumatoid arthritis (RA) in humans. Deposits of IgG-ICs are abundant in affected joints of patients, yet molecular mechanisms for the pathogenic roles of such ICs are not fully understood. In this study
Development of a Duplex Serological Multiplex Assay for the Simultaneous Detection of Epstein-Barr Virus IgA and IgG Antibodies in Nasopharyngeal Carcinoma Patients.
Schieber, et al.
Cancers, 15 (2023)
Maaike V J Braham et al.
iScience, 26(1), 105741-105741 (2023-01-03)
To investigate B-cell differentiation and maturation occurring in the germinal center (GC) using in vitro culture systems, key factors and interactions of the GC reaction need to be accurately simulated. This study aims at improving in vitro GC simulation using 3D culture
Andrea Reboldi et al.
Science (New York, N.Y.), 352(6287), aaf4822-aaf4822 (2016-05-14)
Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer's patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the
Lucia Pažitná et al.
Journal of biotechnology, 314-315, 34-40 (2020-04-17)
Glycosylation of therapeutic glycoproteins significantly affects their physico-chemical properties, bioactivity and immunogenicity. The determination of glycan composition is highly important regarding their development and production. Therefore, there is a demand for analytical techniques enabling rapid and reliable glycoprofiling of therapeutic
Prajkta Chivte et al.
Journal of mass spectrometry and advances in the clinical lab, 21, 31-41 (2021-09-15)
More than a year after the COVID-19 pandemic was declared, the need still exists for accurate, rapid, inexpensive and non-invasive diagnostic methods that yield high specificity and sensitivity towards the current and newly emerging SARS-CoV-2 strains. Compared to the nasopharyngeal
Domenik Prozeller et al.
Biointerphases, 15(3), 031009-031009 (2020-06-04)
The overall success of nanocarriers in biomedical applications depends on their interaction with different proteins in blood. Immunoglobulins as a major protein class of the blood proteome may considerably influence the identity of the nanocarriers in blood. However, there is
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