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Showing 1-30 of 80 results for "I4131" within Papers
Cheryl Yi-Pin Lee et al.
The Journal of investigative dermatology (2022-12-26)
Zika virus (ZIKV) became a public health concern when it re-emerged in 2015 owing to its ability to cause congenital deformities in the fetus and neurological complications in adults. Despite extensive data on protection, the interplay of protective and pathogenic
Hsueh-Yuan Chang et al.
mAbs, 10(6), 843-853 (2018-06-27)
Here, we present the first case-study where microdialysis is used to investigate the pharmacokinetics of antibody in different regions of rat brain. Endogenous IgG was used to understand antibody disposition at steady-state and exogenously administered trastuzumab was used to understand
Neutrophils instruct homeostatic and pathological states in naive tissues
Casanova-Acebes M, et al.
The Journal of Experimental Medicine, 215(11), 2778-2795 (2018)
Thomas B Martins et al.
Clinical and diagnostic laboratory immunology, 11(2), 325-329 (2004-03-12)
While modern immunoassays provide sensitive and specific means for the quantitation of cytokines in biological fluids, heterophile antibodies are still a well-recognized cause of interference in the measurement of cytokines in these assays. We have developed a multiplexed fluorescent microsphere
Valérie Soulard et al.
Malaria journal, 8, 128-128 (2009-06-11)
In murine models of malaria, an early proinflammatory response has been associated with the resolution of blood-stage infection. To dissect the protective immune mechanism that allow the control of parasitaemia, the early immune response of C57BL/6 mice induced during a
Raquel Romay-Tallon et al.
Biomarker research, 5, 27-27 (2017-10-12)
The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depression. Here we evaluated the possibility of performing a similar
M Celebi et al.
Andrologia, 40(4), 235-239 (2008-08-30)
Germ cell-specific apoptosis that occurs after ischaemia-reperfusion (IR) of the murine testis is dependent on neutrophil recruitment to the testis and is dependent upon the cell adhesion molecule E-selectin. In this study, we aimed to inhibit neutrophil recruitment to the
A O Oyebade et al.
Journal of dairy science (2023-08-29)
We evaluated the effects of supplementing bacterial direct-fed microbial (DFM) on performance, apparent total-tract digestibility, rumen fermentation, and immune parameters of lactating dairy cows. One-hundred and 14 multiparous Holstein cows (41 ± 7 DIM) were used in a randomized complete
Structure and function of immunoglobulins.
Schroeder Jr H W and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation
Gaillard C, et al.
Haematologica, 100(8), 1064-1075 (2015)
David J Cantor et al.
Cell reports, 26(1), 108-118 (2019-01-04)
B cell development is a highly regulated process that requires stepwise rearrangement of immunoglobulin genes to generate a functional B cell receptor (BCR). The polycomb group protein BMI1 is required for B cell development, but its function in developing B
Yan Zhang et al.
International journal of molecular sciences, 23(12) (2022-06-25)
Histones are cationic nuclear proteins that are essential for the structure and functions of eukaryotic chromatin. However, extracellular histones trigger inflammatory responses and contribute to death in sepsis by unknown mechanisms. We recently reported that inflammasome activation and pyroptosis trigger
Anuj Sehgal et al.
Nature communications, 9(1), 1272-1272 (2018-03-30)
Colony-stimulating factor 1 (CSF1) controls the growth and differentiation of macrophages.CSF1R signaling has been implicated in the maintenance of the intestinal stem cell niche and differentiation of Paneth cells, but evidence of expression of CSF1R within the crypt is equivocal.
Coline Gaillard et al.
Haematologica, 100(8), 1064-1075 (2015-06-20)
Acute promyelocytic leukemia is an aggressive malignancy characterized by the accumulation of promyelocytes in the bone marrow. PML/RARA is the primary abnormality implicated in this pathology, but the mechanisms by which this chimeric fusion protein initiates disease are incompletely understood.
D Hildeman et al.
Journal of virology, 71(12), 9672-9678 (1997-11-26)
Lymphocytic choriomeningitis virus (LCMV) infection of normal mice results in a fatal immunopathologic meningitis mediated by CD8+ cytotoxic T lymphocytes (CTL). We have previously shown that female beta2-microglobulin-deficient (beta2m-/-) mice, which are also deficient in CD8+ T cells, are susceptible
Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.
Sauter KA, Pridans C, Sehgal A, et al.
Journal of Leukocyte Biology, 96(2), 265-274 (2014)
Paweł Bieniasz-Krzywiec et al.
Cell metabolism, 30(5), 917-936 (2019-08-27)
Among mammary tumor-infiltrating immune cells, the highest expression of podoplanin (PDPN) is found in a subset of tumor-associated macrophages (TAMs). We hereby demonstrate that PDPN is involved in the attachment of this TAM subset to lymphatic endothelial cells (LECs). Mechanistically
A Gugliucci et al.
Life sciences, 62(23), 2141-2150 (1998-06-17)
As the glycation/glycoxidation hypothesis for the genesis of diabetic complications is achieving widespread acceptance, much attention is being paid to the role of low molecular weight advanced glycation (AGE) adducts, as second generation glycating agents. We set out a study
Jasmine C Wong et al.
eLife, 4 (2015-07-21)
Chromosome 7 deletions are highly prevalent in myelodysplastic syndrome (MDS) and likely contribute to aberrant growth through haploinsufficiency. We generated mice with a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 syntenic to a commonly deleted
Boyi Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(47), E7572-E7579 (2016-11-09)
Poison ivy-induced allergic contact dermatitis (ACD) is the most common environmental allergic condition in the United States. Case numbers of poison ivy ACD are increasing due to growing biomass and geographical expansion of poison ivy and increasing content of the
Benjamin Krämer et al.
Cell reports, 42(1), 111937-111937 (2023-01-15)
Group 1 innate lymphoid cells (ILCs) comprise a heterogeneous family of cytotoxic natural killer (NK) cells and ILC1s. We identify a population of "liver-type" ILC1s with transcriptional, phenotypic, and functional features distinct from those of conventional and liver-resident NK cells
M Lahn et al.
Journal of immunology (Baltimore, Md. : 1950), 160(11), 5221-5230 (1998-05-30)
Although recent findings indicate that gamma delta T cells influence both early innate and Ag-specific adaptive host responses, it has remained unclear what triggers gamma delta T cell reactivity. Investigating very early T cell activation in mouse and human models
Thomas J Ellison et al.
PloS one, 9(11), e111502-e111502 (2014-11-18)
The availability of reliable recombinant reporter virus systems has been a great boon to the study of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). Unexpectedly, we found that expression of the ostensibly constitutive green fluorescent protein (GFP) marker was progressively lost during unselected
Maria Stella Sasso et al.
Science advances, 7(13) (2021-03-26)
In melanoma, the induction of lymphatic growth (lymphangiogenesis) has long been correlated with metastasis and poor prognosis, but we recently showed it can synergistically enhance cancer immunotherapy and boost T cell immunity. Here, we develop a translational approach for exploiting
Hongyou Yu et al.
Scientific reports, 6, 35190-35190 (2016-10-22)
Angiogenesis and inflammation are implicated in aortic aneurysm and atherosclerosis and regulated by angiopoietin-2 (Angpt2). The effect of Angpt2 administration on experimental aortic aneurysm and atherosclerosis was examined. Six-month-old male apolipoprotein E deficient (ApoE-/-) mice were infused with angiotensin II
Hugh I McFarland et al.
PloS one, 7(6), e39092-e39092 (2012-06-23)
Sublethal total body γ irradiation (TBI) of mammals causes generalized immunosuppression, in part by induction of lymphocyte apoptosis. Here, we provide evidence that a part of this immune suppression may be attributable to dysfunction of immune regulation. We investigated the
Francesco Marangoni et al.
Cell, 184(15), 3998-4015 (2021-06-23)
Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how their immune-suppressive function is regulated in the tumor microenvironment (TME) remains unknown. Here, we used intravital microscopy to characterize the cellular interactions that provide tumor-infiltrating Treg cells with critical
S Casaro et al.
Journal of dairy science (2023-08-29)
The objective was to unravel the peripartum immune and metabolic changes associated with metritis in Holstein cows. Holstein cows (n = 128) had blood collected at -14, 0, 3, and 7 d relative to parturition (DRP). Flow cytometry was used
Dàlia Raïch-Regué et al.
Oncoimmunology, 5(6), e1146841-e1146841 (2016-07-30)
Dendritic cells (DC) play a pivotal role in the induction and regulation of immune responses. In cancer, DC-based vaccines have proven to be safe and to elicit protective and therapeutic immunological responses. Recently, we showed that specific mTORC2 (mechanistic target
Hiroki Kabata et al.
Mucosal immunology, 13(4), 626-636 (2020-02-19)
Thymic stromal lymphopoietin (TSLP) is a critical upstream cytokine inducing type 2 inflammation in various diseases, including asthma and atopic dermatitis. Accumulating evidence suggests that TSLP can directly stimulate a variety of immune cells, such as dendritic cells (DCs), basophils
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