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Showing 1-30 of 216 results for "I4506" within Papers
Jean-Pierre Bellier et al.
Frontiers in neuroanatomy, 13, 37-37 (2019-05-02)
Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine (ACh), has an exon-skipping splice variant which is expressed preferentially in the peripheral nervous system (PNS) and thus termed peripheral ChAT (pChAT). A rabbit antiserum previously produced against rat pChAT (rpChAT) has been
Dung Hoang Nguyen et al.
Journal of neuroinflammation, 9, 224-224 (2012-09-25)
Evidence suggests that the inflammatory events in the acute phase of spinal cord injury (SCI) exacerbate the initial trauma to the cord leading to poor functional recovery. As a result, minimizing the detrimental aspects of the inflammatory response after SCI
Sushupta M Vijapur et al.
Journal of neurotrauma, 37(14), 1609-1626 (2020-03-01)
Traumatic brain injury (TBI) and can lead to persistent hypogonadotropic hypogonadism (PHH) and poor outcomes. We hypothesized that autoimmune and inflammatory mechanisms contribute to PHH pathogenesis. Men with moderate-to-severe TBI (n = 143) were compared with healthy men (n = 39). The TBI group
Yinglan Guo et al.
Science advances, 9(47), eadj2641-eadj2641 (2023-11-24)
Staphylococcus epidermidis expresses glycerol phosphate wall teichoic acid (WTA), but some health care-associated methicillin-resistant S. epidermidis (HA-MRSE) clones produce a second, ribitol phosphate (RboP) WTA, resembling that of the aggressive pathogen Staphylococcus aureus. RboP-WTA promotes HA-MRSE persistence and virulence in
Ahil N Ganesh et al.
ACS applied materials & interfaces, 9(14), 12195-12202 (2017-03-21)
While the formation of colloidal aggregates leads to artifacts in early drug discovery, their composition makes them attractive as nanoparticle formulations for targeted drug delivery as the entire nanoparticle is composed of drug. The typical transient stability of colloidal aggregates
Panpan Meng et al.
Scientific reports, 11(1), 40-40 (2021-01-10)
Glypican-3 (GPC3) is a cell surface heparan sulfate proteoglycan that is being evaluated as an emerging therapeutic target in hepatocellular carcinoma (HCC). GPC3 has been shown to interact with several extracellular signaling molecules, including Wnt, HGF, and Hedgehog. Here, we
Xiaojie Yu et al.
Blood, 127(1), 132-138 (2015-10-27)
Patients with immune thrombocytopenia (ITP) commonly have antiplatelet antibodies that cause thrombocytopenia through Fcγ receptors (FcγRs). Antibodies specific for FcγRs, designed to inhibit antibody-FcγR interaction, had been shown to improve ITP in refractory human patients. However, the development of such
Audrey Gossart et al.
Colloids and surfaces. B, Biointerfaces, 179, 114-120 (2019-04-06)
Biomaterial implants often lead to specific tissue reactions that could compromise their bio-integration and/or optimal cellular interactions. Polyurethanes (PU) are of particular interest as coatings to mask CoCr's bioactivity, since they are generally more biocompatible than metal substrates, present a
Bryan Q Spring et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(10), E933-E942 (2014-02-28)
Drug-resistant micrometastases that escape standard therapies often go undetected until the emergence of lethal recurrent disease. Here, we show that it is possible to treat microscopic tumors selectively using an activatable immunoconjugate. The immunoconjugate is composed of self-quenching, near-infrared chromophores
Yohei Tsukada et al.
Scientific reports, 11(1), 745-745 (2021-01-14)
Angiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditions have been generated for this purpose in mice, but it is difficult
Vanessa A York et al.
Bio-protocol, 5(12) (2016-07-28)
Natural killer (NK) cells comprise 5-20% of peripheral blood mononuclear cells (PBMC) in humans. In addition to their fundamental roles in the defense against viral infections and tumor surveillance, NK cells help shape adaptive immune responses through their production of
Ruipeng Wang et al.
Journal of leukocyte biology, 91(2), 299-309 (2011-11-03)
NK cells control tumor and virus-infected cells through releasing cytotoxic granules and proinflammatory cytokines. IFN-γ and TNF-α secretions and cytotoxicity are regarded as two distinct functions of NK cells with little synergy in between as results of early association of
Danny L Costantini et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 48(8), 1357-1368 (2007-07-17)
The cytotoxicity and tumor-targeting properties of the anti-HER2/neu monoclonal antibody trastuzumab modified with peptides (CGYGPKKKRKVGG) harboring the nuclear localization sequence ([NLS] italicized) of simian virus 40 large T-antigen and radiolabeled with (111)In were evaluated. Trastuzumab was derivatized with sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (sulfo-SMCC)
Anton M Sholukh et al.
medRxiv : the preprint server for health sciences (2020-12-18)
Determinants of protective immunity against SARS-CoV-2 infection require the development of well-standardized, reproducible antibody assays to be utilized in concert with clinical trials to establish correlates of risk and protection. This need has led to the appearance of a variety
Takaaki Abe et al.
Transfusion, 51(11), 2327-2336 (2011-04-08)
In most cases of anaphylactic transfusion reaction, the mechanisms underlying its development are unclear. We found a donor whose transfused blood components were implicated in two cases of anaphylactic transfusion reaction, and we found that the donor plasma showed mast
Praveenkumar K Shetty et al.
PloS one, 7(9), e44299-e44299 (2012-09-08)
Alternative survival pathways are commonly seen to be upregulated upon inhibition of receptor tyrosine kinases (RTK), including Her-2. It is established that treatment with Herceptin leads to selective overexpression and activation of epidermal growth factor receptor (EGFR) and Src which
Agnes Ulfig et al.
eLife, 8 (2019-07-13)
Hypochlorous acid (HOCl), a powerful antimicrobial oxidant, is produced by neutrophils to fight infections. Here, we show that N-chlorination, induced by HOCl concentrations encountered at sites of inflammation, converts blood plasma proteins into chaperone-like holdases that protect other proteins from
Fumiyoshi Okano et al.
Cancer research communications, 3(4), 640-658 (2023-04-21)
Specific targets for cancer treatment are highly desirable, but still remain to be discovered. While previous reports suggested that CAPRIN-1 localizes in the cytoplasm, here we now show that part of this molecule is strongly expressed on the cell membrane
Irene Ros-Gañán et al.
Clinical & translational immunology, 11(2), e1375-e1375 (2022-03-02)
Pre-existing neutralising antibodies (NAbs) to adeno-associated viruses (AAVs) remain an impediment for systemically administered AAV-mediated gene therapy treatment in many patients, and various strategies are under investigation to overcome this limitation. Here, IgG-degrading enzymes (Ides) derived from bacteria of the
Maja Sidstedt et al.
Analytical and bioanalytical chemistry, 410(10), 2569-2583 (2018-03-06)
Blood samples are widely used for PCR-based DNA analysis in fields such as diagnosis of infectious diseases, cancer diagnostics, and forensic genetics. In this study, the mechanisms behind blood-induced PCR inhibition were evaluated by use of whole blood as well
Liwei Cao et al.
Nature protocols, 13(6), 1196-1212 (2018-05-05)
N-glycans contribute to the folding, stability and functions of the proteins they decorate. They are produced by transfer of the glycan precursor to the sequon Asn-X-Thr/Ser, followed by enzymatic trimming to a high-mannose-type core and sequential addition of monosaccharides to
Joachim Høg Mortensen et al.
Journal of drug delivery, 2013, 209205-209205 (2013-11-01)
Therapeutic advances do not circumvent the devastating fact that the survival rate in glioblastoma multiforme (GBM) is less than 5%. Nanoparticles consisting of liposome-based therapeutics are provided against a variety of cancer types including GBM, but available liposomal formulations are
Andis Klegeris et al.
Immunology, 106(3), 381-388 (2002-07-09)
Complement (C) activation is believed to play an adverse role in several chronic degenerative disease processes, including atherosclerosis, myocardial infarction and Alzheimer's disease. We developed several in vitro quantitative assays to evaluate processes which activate C in human serum, and
Iago Pereiro et al.
Analytical chemistry, 92(15), 10187-10195 (2020-06-10)
Surface assays, such as ELISA and immunofluorescence, are nothing short of ubiquitous in biotechnology and medical diagnostics today. The development and optimization of these assays generally focuses on three aspects: immobilization chemistry, ligand-receptor interaction, and concentrations of ligands, buffers, and
Roya M Dayam et al.
JCI insight, 7(11) (2022-04-27)
BACKGROUNDLimited information is available on the impact of immunosuppressants on COVID-19 vaccination in patients with immune-mediated inflammatory diseases (IMID).METHODSThis observational cohort study examined the immunogenicity of SARS-CoV-2 mRNA vaccines in adult patients with inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis
Athena P Y Li et al.
NPJ vaccines, 6(1), 25-25 (2021-02-18)
The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled trial in older adults to compare cellular and antibody responses of
Helle Sadam et al.
EBioMedicine, 64, 103211-103211 (2021-01-26)
Optic neuritis (ON) can occur as an isolated episode or will develop to multiple sclerosis (MS) a chronic autoimmune disease. What predicts ON progression to MS remains poorly understood. We characterised the antibody epitope repertoire in three independent clinical cohorts
Federico Traldi et al.
International journal of molecular sciences, 24(3) (2023-02-12)
Biomedical applications of nanoparticles require a fundamental understanding of their interactions and behavior with biological interfaces. Protein corona formation can alter the morphology and properties of nanomaterials, and knowledge of the interfacial behavior of the complexes, using in situ analytical
Hideki Furuya et al.
Practical laboratory medicine, 22, e00189-e00189 (2020-12-10)
The objective of our study was to assess the analytical performance of a multiplex assay (Oncuria™) to quantify protein biomarkers towards a bladder cancer associated diagnostic signature in voided urine. ology: Using Luminex xMAP technology, a custom immunoassay was developed
Lijuan Jiang et al.
iScience, 26(10), 107749-107749 (2023-09-13)
Glucocorticoid-induced osteoporosis (GIOP) is a severe and common complication of long-term usage of glucocorticoids (GCs) and lacks of efficient therapy. Here, we investigated the mechanism of anti-inflammation effect and osteoclastogenesis side effect of GCs and immunoglobulin G (IgG) treatment against
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