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Showing 1-30 of 42 results for "I5154" within Papers
Misty W Stevens et al.
mAbs, 6(2), 547-555 (2014-02-05)
Ch-mAb7F9, a human-mouse chimeric monoclonal antibody (mAb) designed to bind (+)-methamphetamine (METH) with high affinity and specificity, was produced as a treatment medication for METH abuse. In these studies, we present the preclinical characterization that provided predictive evidence that ch-mAb7F9
Gaëtan Vanier et al.
Biotechnology journal, 13(4), e1700496-e1700496 (2017-12-02)
Microalgae are unicellular eukaryotic organisms which represent an emerging alternative to other cell biofactories commonly used to produce monoclonal antibodies. Microalgae display several biotechnological advantages such as their rapid growth rate and their phototrophic lifestyle allowing low production costs as
Ruben J Boado et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(12), 2299-2304 (2009-09-11)
The brain drug development of glial-derived neurotrophic factor (GDNF) is prevented by the lack of transport of this protein across the blood-brain barrier (BBB). GDNF transport across the BBB can be made possible by re-engineering the neurotrophin as a fusion
Rangaiah Shashidharamurthy et al.
Journal of immunology (Baltimore, Md. : 1950), 183(12), 8216-8224 (2009-12-17)
CD32A, the major phagocytic FcgammaR in humans, exhibits a polymorphism in the ligand binding domain. Individuals homozygous for the R allelic form of CD32A (CD32A(R) allele) are more susceptible to bacterial infections and autoimmune diseases as compared with H allelic
Kristina Berggren et al.
Journal of medicinal chemistry, 55(6), 2549-2560 (2012-03-01)
A series of eight peptides corresponding to the amino acid sequence of the hinge region of IgG and 17 newly synthesized peptide analogues containing a piperidine moiety as a replacement of a glycine residue were tested as potential inhibitors of
J Sousa-Valente et al.
Osteoarthritis and cartilage, 26(1), 84-94 (2017-08-29)
Aiming to delineate novel neuro-immune mechanisms for NGF/TrkA signalling in osteoarthritis (OA) pain, we evaluated inflammatory changes in the knee joints following injection of monoiodoacetate (MIA) in mice carrying a TrkA receptor mutation (P782S; TrkA KI mice). In behavioural studies
Taehong Kwon et al.
Analytical chemistry, 92(7), 5267-5275 (2020-03-14)
We demonstrate a new micro/nanofluidic system for continuous and automatic monitoring of protein product size and quantity directly from the culture supernatant during a high-cell-concentration CHO cell perfusion culture. A microfluidic device enables clog-free cell retention for a bench-scale (350
Juan Manuel García-Martínez et al.
Molecular cancer therapeutics, 20(1), 96-108 (2020-10-11)
Activation of TRAILR2 has emerged as an important therapeutic concept in cancer treatment. TRAILR2 agonistic molecules have only had limited clinical success, to date, due either to lack of efficacy or hepatotoxicity. BI 905711 is a novel tetravalent bispecific antibody
Pushpa Jayaraman et al.
Journal of immunology (Baltimore, Md. : 1950), 190(8), 4196-4204 (2013-03-15)
In vivo control of Mycobacterium tuberculosis reflects the balance between host immunity and bacterial evasion strategies. Effector Th1 cells that mediate protective immunity by depriving the bacterium of its intracellular niche are regulated to prevent overexuberant inflammation. One key immunoregulatory
Roula Antoon et al.
Cytotherapy, 24(7), 699-710 (2022-04-28)
Pancreatic cancer is a highly lethal cancer characterized by local invasiveness, early metastasis, recurrence and high resistance to current therapies. Extensive stroma or desmoplasia is a key histological feature of the disease, and interactions between cancer and stromal cells are
Taehong Kwon et al.
Scientific reports, 7(1), 6703-6703 (2017-07-29)
Continuous production of biologics, a growing trend in the biopharmaceutical industry, requires a reliable and efficient cell retention device that also maintains cell viability. Current filtration methods, such as tangential flow filtration using hollow-fiber membranes, suffer from membrane fouling, leading
William M Pardridge et al.
Pharmaceutical research, 26(10), 2227-2236 (2009-07-18)
Glial-derived neurotrophic factor (GDNF) is a potential therapy for stroke, Parkinson's disease, or drug addiction. However, GDNF does not cross the blood-brain barrier (BBB). GDNF is re-engineered as a fusion protein with a chimeric monoclonal antibody (MAb) to the human
Bor-Ching Sheu et al.
Biosensors & bioelectronics, 26(2), 822-827 (2010-07-09)
Emerging evidence indicates that the conformation of C-reactive protein (CRP) plays important roles in human inflammation and cardiovascular disease (CVD). The different conformations in the structure of CRP under different pH conditions remain an important issue to be investigated for
Riccardo V Mancuso et al.
British journal of pharmacology, 177(12), 2696-2711 (2020-01-28)
Antibodies targeting cell surface receptors are considered to enable highly selective therapeutic interventions for immune disorders and cancer. Their biological profiles are found, generally, to represent the net effects of antibody-target interactions. The former therapeutic anti-integrin αLβ2 antibody efalizumab seems
Lorenz Vogt et al.
The Journal of clinical investigation, 116(10), 2817-2826 (2006-10-04)
T cell activation by APCs is positively and negatively regulated by members of the B7 family. We have identified a previously unknown function for B7 family-related protein V-set and Ig domain-containing 4 (VSIG4). In vitro experiments using VSIG4-Ig fusion molecules
Francisco Ylera et al.
Analytical biochemistry, 441(2), 208-213 (2013-08-03)
The rapidly increasing number of therapeutic antibodies in clinical development and on the market requires corresponding detection reagents for monitoring the concentration of these drugs in patient samples and as positive controls for measurement of anti-drug antibodies. Phage display of
Felix Weber et al.
Cell reports, 22(1), 149-162 (2018-01-04)
Receptors show promise for the transport of monoclonal antibodies (mAbs) across the blood-brain barrier. However, safety liabilities associated with peripheral receptor binding and Fc effector function have been reported. We present the Brain Shuttle-mAb (BS-mAb) technology, and we investigate the
Yasmina Noubia Abdiche et al.
mAbs, 7(2), 331-343 (2015-02-07)
The neonatal Fc receptor (FcRn) is expressed by cells of epithelial, endothelial and myeloid lineages and performs multiple roles in adaptive immunity. Characterizing the FcRn/IgG interaction is fundamental to designing therapeutic antibodies because IgGs with moderately increased binding affinities for
M Focke et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 38(8), 1400-1408 (2008-06-20)
The diagnosis and specific immunotherapy of allergy is currently performed with allergen extracts prepared from natural allergen sources. To analyse commercial timothy grass pollen allergen extracts used for in vivo diagnosis regarding their qualitative and quantitative allergen composition and in
David R Martinez et al.
Cell, 178(1), 190-201 (2019-06-18)
The placental transfer of maternal IgG is critical for infant protection against infectious pathogens. However, factors that modulate the placental transfer of IgG remain largely undefined. HIV-infected women have impaired placental IgG transfer, presenting a unique "disruption model" to define
Filippo Benedetti et al.
Life (Basel, Switzerland), 11(11) (2021-11-28)
The overexpression of tyrosine kinase HER2 in numerous cancers, connected with fierce signaling and uncontrolled proliferation, makes it a suitable target for immunotherapy. The acquisition of resistance to currently used compounds and the multiplicity of signaling pathways involved prompted research
Pushpa Jayaraman et al.
The Journal of experimental medicine, 207(11), 2343-2354 (2010-10-13)
T cell immunoglobulin and mucin domain 3 (Tim3) is a negative regulatory molecule that inhibits effector T(H)1-type responses. Such inhibitory signals prevent unintended tissue inflammation, but can be detrimental if they lead to premature T cell exhaustion. Although the role
Yann Gallais et al.
Immunology and cell biology, 95(3), 306-315 (2016-10-08)
Patients treated with therapeutic biological products (BP) frequently develop anti-drug antibodies (ADA) with potential neutralizing capacities leading to loss of clinical response or serious side effects. BP aggregates have been suggested to promote immunogenicity, thus enhancing ADA production. Dendritic cells
Dong Li et al.
Human molecular genetics, 27(18), 3233-3245 (2018-06-16)
Central conducting lymphatic anomaly (CCLA) is one of the complex lymphatic anomalies characterized by dilated lymphatic channels, lymphatic channel dysmotility and distal obstruction affecting lymphatic drainage. We performed whole exome sequencing (WES) of DNA from a four-generation pedigree and examined
Crystal S F Cheung et al.
Scientific reports, 7, 42497-42497 (2017-02-12)
Using mAbs as therapeutic molecules is complicated by the propensity of mAbs to aggregate at elevated concentrations, which can lead to a variety of adverse events in treatment. Here, we describe a proof-of-concept for new methodology to detect and quantify
Julia Kronenberg et al.
Biotechnology and bioengineering, 118(10), 3770-3786 (2021-06-11)
The production of biopharmaceutical proteins in mammalian cells by transient expression or stable transformation requires robust and viable cells. Cell line engineering must therefore balance improved cell growth and viability with high productivity. We tested the ability of nonmammalian phosphatidylethanolamine-binding
Pan Kyeom Kim et al.
PloS one, 12(10), e0186380-e0186380 (2017-10-19)
Current post-exposure prophylaxis for rabies virus infection has several limitations in terms of supply, cost, safety, and efficacy. Attempts to replace human or equine rabies immune globulins (HRIG or ERIG) have been made by several companies and institutes. We developed
Stefan Harth et al.
mAbs, 11(1), 178-190 (2018-12-06)
Anti-idiotypic antibodies play an important role in pre-clinical and clinical development of therapeutic antibodies, where they are used for pharmacokinetic studies and for the development of immunogenicity assays. By using an antibody phage display library in combination with guided in
Zhongqi Zhang et al.
mAbs, 11(8), 1381-1390 (2019-08-15)
Human IgG antibodies containing terminal alpha 2,6-linked sialic acid on their Fc N-glycans have been shown to reduce antibody-dependent cell-mediated cytotoxicity and possess anti-inflammatory properties. Although terminal sialylation on complex N-glycans can happen via either an alpha 2,3-linkage or an
Po-Jen Liao et al.
Sensors (Basel, Switzerland), 10(12), 11498-11511 (2010-01-01)
We investigate a immunoassay biosensor that employs a Quartz Crystal Microbalance (QCM) to detect the specific binding reaction of the (Human IgG1)-(Anti-Human IgG1) protein pair under physiological conditions. In addition to experiments, a three dimensional time domain finite element method
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