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Showing 1-30 of 241 results for "I5381" within Papers
Bart Cornelissen et al.
Cancer biotherapy & radiopharmaceuticals, 24(2), 163-173 (2009-05-05)
Probing intranuclear proteins in breast cancer (BC) cells by using radiolabeled antibodies is restricted by delivery barriers presented by cell and nuclear membranes. Our aim was to construct immunoconjugates (ICs) bispecific for epidermal growth factor receptors (EGFRs) and the intranuclear
Phat L Tran et al.
Analytical and bioanalytical chemistry, 398(2), 759-768 (2010-07-24)
An alternative approach for fabricating a protein array at nanoscale is suggested with a capability of characterization and/or localization of multiple components on a nanoarray. Fluorescent micro- and nanobeads each conjugated with different antibodies are assembled by size-dependent self-assembly (SDSA)
Hyeon-Ji Kang et al.
Experimental & molecular medicine, 53(9), 1390-1401 (2021-09-24)
Obesity is now recognized as a disease. This study revealed a novel role for pyruvate dehydrogenase kinase (PDK) in diet-induced hypertrophic obesity. Mice with global or adipose tissue-specific PDK2 deficiency were protected against diet-induced obesity. The weight of adipose tissues
Yilin Liu et al.
ACS applied nano materials, 4(12), 13826-13837 (2021-12-28)
The SARS-CoV-2 global pandemic created an unprecedented need for rapid, sensitive, and inexpensive point-of-care (POC) diagnostic tests to treat and control the disease. Many POC SARS-CoV-2 lateral flow immunoassays (LFAs) have been developed and/or commercialized, but with only limited sensitivity
Sanne Marlijn Janssen et al.
Cell death discovery, 6, 1-1 (2020-03-04)
Melanoma is among the most aggressive cancers due to its tendency to metastasize early. Phenotype switching between a proliferative and an invasive state has been suggested as a critical process for metastasis, though the mechanisms that regulate state transitions are
Manfred B Lutz et al.
European journal of immunology (2022-10-29)
This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional characterization of mouse and human dendritic cells (DC) from
Janet L Markman et al.
Nature communications, 11(1), 1613-1613 (2020-04-03)
In men, the incidence of melanoma rises rapidly after age 50, and nearly two thirds of melanoma deaths are male. The immune system is known to play a key role in controlling the growth and spread of malignancies, but whether
Abril Marcela Herrera-Solorio et al.
EMBO reports, 20(4) (2019-03-06)
Post-translational modifications of histone H3 N-terminal tails are key epigenetic regulators of virulence gene expression and sexual commitment in the human malaria parasite Plasmodium falciparum Here, we identify proteolytic clipping of the N-terminal tail of nucleosome-associated histone H3 at amino
A Gonçalves et al.
Oncogene, 25(7), 981-989 (2005-09-28)
A total of 30-50% of early breast cancer (EBC) patients considered as high risk using standard prognostic factors develop metastatic recurrence despite standard adjuvant systemic treatment. A means to better predict clinical outcome is needed to optimize and individualize therapeutic
Age-associated features of norovirus infection analysed in mice.
Kennedy, et al.
Nature microbiology, 8, 1095-1107 (2023)
Tremaine Powell et al.
Biotechnology progress, 22(1), 106-110 (2006-02-04)
A new concept for line patterning of immunoglobulin G (IgG) in nanometer scale using gold nanoparticles (AuNPs) self-assembled in a nanochannel written with an electron beam is proposed and demonstrated. AuNPs are synthesized by reducing KAuCl4 with NaBH4, producing AuNPs
Miguel Sierra-Miranda et al.
Cellular microbiology, 19(9) (2017-04-05)
The telomeres of the malaria parasite Plasmodium falciparum are essential not only for chromosome end maintenance during blood stage development in humans but also to generate genetic diversity by facilitating homologous recombination of subtelomeric, multigene virulence families such as var
Timothy J Hark et al.
Cell systems, 12(2), 141-158 (2020-12-17)
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer's disease (AD). To observe protein turnover at early stages of amyloid beta (Aβ) proteotoxicity, we performed pulse-chase proteomics on mouse brains in three genetic models of AD that knock
Kevin Myant et al.
Genome research, 21(1), 83-94 (2010-12-15)
LSH, a member of the SNF2 family of chromatin remodeling ATPases encoded by the Hells gene, is essential for normal levels of DNA methylation in the mammalian genome. While the role of LSH in the methylation of repetitive DNA sequences
QiXing Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(8), 3161-3170 (2019-02-06)
Sepsis claims an estimated 30 million episodes and 6 million deaths per year, and treatment options are rather limited. Human neutrophil peptides 1-3 (HNP1-3) are the most abundant neutrophil granule proteins but their neutrophil content varies because of unusually extensive
Stacey Spencer et al.
mAbs, 4(3), 319-325 (2012-04-26)
The successful development of antibody therapeutics depends on the molecules having properties that are suitable for manufacturing, as well as use by patients. Because high solubility is a desirable property for antibodies, screening for solubility has become an essential step
V V Cantarelli et al.
Cellular microbiology, 3(11), 745-751 (2001-11-07)
Enteropathogenic Escherichia coli (EPEC) is able to inject its own receptor, a transmembrane protein called translocated intimin receptor, Tir, into the host epithelial cell. The bacterium then uses an outer membrane protein, intimin, to bind to Tir and remains firmly
Thomas B Martins et al.
Clinical and diagnostic laboratory immunology, 11(2), 325-329 (2004-03-12)
While modern immunoassays provide sensitive and specific means for the quantitation of cytokines in biological fluids, heterophile antibodies are still a well-recognized cause of interference in the measurement of cytokines in these assays. We have developed a multiplexed fluorescent microsphere
I Tröndle et al.
Molecular human reproduction, 23(3), 141-154 (2017-01-29)
Does irradiation evoke adverse effects in germ and somatic cells in testis xenografts from prepubertal monkeys? In addition to the expected depletion of germ cells, a dose-dependent effect of irradiation was observed at the mRNA and protein level in Sertoli
Daniel J Blackwell et al.
Biophysical journal, 111(6), 1192-1202 (2016-09-23)
The cardiac sarco/endoplasmic reticulum calcium ATPase (SERCA) establishes the intracellular calcium gradient across the sarcoplasmic reticulum membrane. It has been proposed that SERCA forms homooligomers that increase the catalytic rate of calcium transport. We investigated SERCA dimerization in rabbit left
Lorna M FitzPatrick et al.
Stem cell reports, 10(6), 1766-1781 (2018-04-24)
Human neural development begins at embryonic day 19 and marks the beginning of organogenesis. Neural stem cells in the neural tube undergo profound functional, morphological, and metabolic changes during neural specification, coordinated by a combination of exogenous and endogenous cues.
Jinsong He et al.
Cancer science, 114(3), 896-907 (2022-03-30)
Breast cancer (BC) is a serious threat to women's health worldwide. Non-SMC condensin I complex subunit D2 (NCAPD2) is a regulatory subunit of the coagulin I complex, which is mainly involved in chromosome coagulation and separation. The clinical significance, biological
Miho M Suzuki et al.
Nature communications, 14(1), 4521-4521 (2023-08-23)
Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop formation are known to impede S phase progression. Nonetheless, cancer cells continuously proliferate under such high-stressed conditions through incompletely understood mechanisms. Here, we report taurine upregulated gene 1 (TUG1) long noncoding
Joanna Brühl et al.
Epigenetics & chromatin, 12(1), 52-52 (2019-08-23)
Maintenance of genome integrity during DNA replication is crucial to the perpetuation of all organisms. In eukaryotes, the bypass of DNA lesions by the replication machinery prevents prolonged stalling of the replication fork, which could otherwise lead to greater damages
Rhonda M Brand et al.
Biomolecules, 5(4), 3009-3028 (2015-11-13)
Alcoholics suffer from immune dysfunction that can impede vaccine efficacy. If ethanol (EtOH)-induced immune impairment is in part a result of direct exposure of immune cells to EtOH, then reduced levels of exposure could result in less immune dysfunction. As
Pascal Ickrath et al.
Biomedical reports, 10(2), 119-126 (2019-02-06)
T cell subpopulations in nasal polyps differ from peripheral lymphocytes in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). However, little is known about the modulatory influence of the inflamed nasal polyp epithelial cells on the phenotype of the T
David Soto et al.
Science signaling, 12(586) (2019-06-20)
Autosomal dominant mutations in GRIN2B are associated with severe encephalopathy, but little is known about the pathophysiological outcomes and any potential therapeutic interventions. Genetic studies have described the association between de novo mutations of genes encoding the subunits of the
Elena Kotsyuba et al.
Frontiers in neuroanatomy, 16, 844654-844654 (2022-04-26)
Identifying the neurotransmitters secreted by specific neurons in crustacean eyestalks is crucial to understanding their physiological roles. Here, we combined immunocytochemistry with confocal microscopy and identified the neurotransmitters dopamine (DA), serotonin (5-HT), and acetylcholine (ACh) in the optic neuropils and
Yu Hara et al.
Canadian respiratory journal, 2018, 9627420-9627420 (2018-06-01)
Hemeoxygenase-1 (HO-1) is an essential enzyme in heme catabolism and has been proposed as a biomarker of lung disease prognosis. We modified a commercial HO-1 enzyme-linked immunosorbent assay (ELISA) kit to achieve higher sensitivity and evaluated if serum HO-1 could
Daniel Bergman et al.
Veterinary clinical pathology, 48 Suppl 1, 59-69 (2019-07-19)
Canine anti-mouse antibodies are a potential source of immunoassay interference, but erroneous immunoassay results are not always easily identifiable. Anti-Müllerian hormone (AMH) is a marker for the presence of gonads in dogs, but elevated AMH concentrations in neutered dogs could
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