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Showing 1-12 of 12 results for "IMM001" within Papers
Katja Zschiebsch et al.
Journal of cellular and molecular medicine, 23(2), 985-1000 (2018-11-20)
GTP cyclohydrolase (GCH1) governs de novo synthesis of the enzyme cofactor, tetrahydrobiopterin (BH4), which is essential for biogenic amine production, bioactive lipid metabolism and redox coupling of nitric oxide synthases. Overproduction of BH4 via upregulation of GCH1 in sensory neurons
Qian Wang et al.
eLife, 8 (2019-05-16)
Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence suggests that dysregulated innate immunity is likely involved. Here, we performed proteomic, transcriptomic, and electron microscopic analyses to demonstrate that mast cells are aberrantly activated in human and murine osteoarthritic
Xing-Hong Wang et al.
Communications biology, 3(1), 228-228 (2020-05-10)
The toxic kernel cake of Jatropha curcas (KCakeJ) is an emerging health and environmental concern. Although phorbol esters are widely recognized as the major toxin of KCakeJ, convincing evidence is absent. Here, we show that rather than phorbol esters an
Frida Berlin et al.
International journal of molecular sciences, 22(10) (2021-06-03)
Chronic respiratory diseases are often characterized by impaired epithelial function and remodeling. Mast cells (MCs) are known to home into the epithelium in respiratory diseases, but the MC-epithelial interactions remain less understood. Therefore, this study aimed to investigate the effect
Jia Liu et al.
Stem cells (Dayton, Ohio), 34(12), 2943-2955 (2016-06-29)
Activation of mast cells participates in the chronic inflammation associated with cerebral arteries in intracranial aneurysm formation and rupture. Several studies have shown that the anti-inflammatory effect of mesenchymal stem cells (MSCs) is beneficial for the treatment of aneurysms. However
Tsong-Min Chang et al.
Molecules (Basel, Switzerland), 26(13) (2021-07-03)
Mast cells play a crucial role in the pathogenesis of type 1 allergic reactions by binding to IgE and allergen complexes and initiating the degranulation process, releasing pro-inflammatory mediators. Recently, research has focused on finding a stable and effective anti-allergy
Poh-Yi Gan et al.
Journal of the American Society of Nephrology : JASN, 27(5), 1321-1333 (2015-09-17)
Observations in experimental murine myeloperoxidase (MPO)-ANCA-associated vasculitis (AAV) show mast cells degranulate, thus enhancing injury as well as producing immunomodulatory IL-10. Here we report that, compared with biopsy specimens from control patients, renal biopsy specimens from 44 patients with acute
Simon Gebremeskel et al.
Frontiers in immunology, 12, 650331-650331 (2021-03-30)
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as a driver of the hyperinflammatory response seen in COVID-19. However, our understanding of the specific immune
Shaun A Summers et al.
Journal of the American Society of Nephrology : JASN, 22(12), 2226-2236 (2011-10-25)
Leukocyte recruitment contributes to acute kidney injury (AKI), but the mechanisms by which leukocytes promote injury are not completely understood. The degranulation of mast cells releases inflammatory molecules, including TNF, but whether these cells participate in the pathogenesis of AKI
Abhay Ps Rathore et al.
The Journal of clinical investigation, 129(10), 4180-4193 (2019-07-03)
Dengue virus (DENV) infection causes a characteristic pathology in humans involving dysregulation of the vascular system. In some patients with dengue hemorrhagic fever (DHF), vascular pathology can become severe, resulting in extensive microvascular permeability and plasma leakage into tissues and
Shaun A Summers et al.
Kidney international, 82(6), 676-685 (2012-06-08)
Progressive renal fibrosis is the final common pathway leading to renal failure irrespective of the initiating cause. Clinical studies of renal fibrosis found that prominent mast cell accumulation correlated with worse outcomes. Mast cells are pluripotent innate immune cells that
Kenny Roman et al.
Pain, 155(7), 1328-1338 (2014-04-15)
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects up to 15% of the male population and is characterized by pelvic pain. Mast cells are implicated in the murine experimental autoimmune prostatitis (EAP) model as key to chronic pelvic pain development. The
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