K4003

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Showing 1-7 of 7 results for "K4003" within Papers

Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo.

Satotaka Omori et al.

Cell metabolism, 32(5), 814-828 (2020-09-20)

Cell senescence plays a key role in age-associated organ dysfunction, but the in vivo pathogenesis is largely unclear. Here, we generated a p16-CreERT2-tdTomato mouse model to analyze the in vivo characteristics of p16high cells at a single-cell level. We found tdTomato-positive p16high

Spatiotemporal changes in mechanical matrisome components of the human ovary from prepuberty to menopause.

E Ouni et al.

Human reproduction (Oxford, England), 35(6), 1391-1410 (2020-06-17)

How do elastic matrisome components change during the lifetime of the human ovary? The deposition and remodeling of mechanical matrisome components (collagen, elastin, elastin microfibril interface-located protein 1 (EMILIN-1), fibrillin-1 and glycosaminoglycans (GAGs)) that play key roles in signaling pathways

Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels.

Kate Lykke Lambertsen et al.

PloS one, 7(10), e47744-e47744 (2012-10-19)

The calmodulin/calcium-activated K(+) channel KCa3.1 is expressed in red and white blood cells, epithelia and endothelia, and possibly central and peripheral neurons. However, our knowledge about its contribution to neurological functions and behavior is incomplete. Here, we investigated whether genetic

High frequency early in vitro flowering of Dendrobium Madame Thong-In (Orchidaceae).

Guek Eng Sim et al.

Plant cell reports, 26(4), 383-393 (2006-10-07)

We have successfully developed a method to induce early in vitro flowering of the self-pollinated seedlings of a tropical orchid hybrid, Dendrobium Madame Thong-In. Transition of vegetative shoot apical meristem to inflorescence meristem was observed when young protocorms were cultured

Impact of Endotoxins in Gelatine Hydrogels on Chondrogenic Differentiation and Inflammatory Cytokine Secretion In Vitro.

Wilhelmina M G A C Groen et al.

International journal of molecular sciences, 21(22) (2020-11-19)

Gelatine methacryloyl (GelMA) hydrogels are widely used in studies aimed at cartilage regeneration. However, the endotoxin content of commercially available GelMAs and gelatines used in these studies is often overlooked, even though endotoxins may influence several cellular functions. Moreover, regulations

Asymbiotic germination response to photoperiod and nutritional media in six populations of Calopogon tuberosus var. tuberosus (Orchidaceae): evidence for ecotypic differentiation.

Philip J Kauth et al.

Annals of botany, 102(5), 783-793 (2008-09-02)

Ecotypic differentiation has been explored in numerous plant species, but has been largely ignored in the Orchidaceae. Applying a specific germination protocol for widespread seed sources may be unreliable due to inherent physiological or genetic differences in localized populations. It

Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping.

Giovanni Di Liberto et al.

Cell, 175(2), 458-471 (2018-09-04)

Inflammatory disorders of the CNS are frequently accompanied by synaptic loss, which is thought to involve phagocytic microglia and complement components. However, the mechanisms accounting for aberrant synaptic connectivity in the context of CD8+ T cell-driven neuronal damage are poorly understood.

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