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Showing 1-30 of 60 results for "L1668" within Papers
Meng Wang et al.
Retrovirology, 15(1), 65-65 (2018-09-23)
Human immunodeficiency virus type 1 (HIV-1) Tat protein plays an essential role in HIV-1 gene transcription. Tat transactivates HIV-1 long terminal repeat (LTR)-directed gene expression through direct interactions with the transactivation-responsive region (TAR) element and other cis elements in the
Yacine Maringer et al.
Science immunology, 7(78), eadd3899-eadd3899 (2022-11-02)
Several COVID-19 vaccines are approved to prevent severe disease outcome after SARS-CoV-2 infection. Whereas induction and functionality of antiviral antibody response are largely studied, the induction of T cells upon vaccination with the different approved COVID-19 vaccines is less studied.
Sara Albarella et al.
Animals : an open access journal from MDPI, 10(9) (2020-09-20)
Impaired fertility associated with disorders of sex development (DSDs) due to genetic causes in dogs are more and more frequently reported. Affected dogs are usually of specific breeds thus representing a cause of economic losses for breeders. The aim of
Pilar López-Cotarelo et al.
Scientific reports, 11(1), 21371-21371 (2021-11-03)
One of the 233 polymorphisms associated with multiple sclerosis (MS) susceptibility lies within the NDFIP1 gene, and it was previously identified as eQTL in healthy controls. NDFIP1 shows interesting immune functions and is involved in the development of the central
Shu-Fen Wu et al.
Arthritis research & therapy, 19(1), 183-183 (2017-08-11)
Overexpression of membranous CD154 in T lymphocytes has been found previously in systemic lupus erythematosus (SLE). Because hydroxychloroquine (HCQ) has been used frequently in the treatment of lupus, we sought to identify the effects of HCQ on CD154 and a
Frank W King et al.
Stem cells and development, 18(10), 1441-1450 (2009-03-04)
Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. While subpopulations of hESCs within pluripotent cultures have been identified based on expression of specific surface antigens, their significance and fates are
Yann Le Duff et al.
Microbiology spectrum, 10(3), e0024322-e0024322 (2022-06-07)
Reliable and accurate quantification of cell-associated HIV DNA (CA HIV DNA) is critical for early infant diagnosis, clinical management of patients under therapy, and to inform new therapeutics efficacy. The present study assessed the variability of CA HIV DNA quantification
Ema T Crooks et al.
PLoS pathogens, 14(5), e1007024-e1007024 (2018-05-03)
The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and avoid clashes with others. To investigate how Env glycan maturation
Neslihan Sinim Kahraman et al.
International journal of stem cells, 14(1), 47-57 (2020-10-31)
This study shows the clinical data of 1-year follow-up of 8 patients with degenerative macular diseases who received suprachoroidal adipose tissue derived mesenchymal stem cell (ADMSC) implantation. This prospective, single-center, phase 1/2 study enrolled 8 eyes of 8 patients with
Frank W King et al.
Stem cells and development, 20(3), 475-484 (2010-07-14)
Pluripotent human embryonic stem cells (hESCs) provide an unprecedented opportunity for the study of human tissue development, and the development of cell-based therapies for human disease. To realize these potential advances, however, methods for monitoring expression of intracellular proteins in
Yuanyuan Wu et al.
Poultry science, 98(1), 150-163 (2018-08-24)
This study evaluated the effects of dietary Enterococcus faecium NCIMB 11181 on growth performance and immune response in broiler chickens. A total of 360 1-day-old Arbor Acres male birds were randomly assigned to 4 treatments that administered different dosages of
Peng Li et al.
The journal of poultry science, 59(3), 197-205 (2022-08-23)
The objective of this study was to determine the effects of dietary soy saponin (SS) on the antioxidant and immune functions of laying hens. Two hundred seventy 22-week-old Hy-line gray layers were randomly allocated into three treatment groups: a control
Rapid Flow Cytometry-Based Test for the Diagnosis of Lipopolysaccharide Responsive Beige-Like Anchor (LRBA) Deficiency
Gamez-Diaz L, et al.
Frontiers in Immunology (2018)
Kriangkrai Chawansuntati et al.
Human vaccines & immunotherapeutics, 11(9), 2253-2265 (2015-06-20)
Unlike well-studied antibody responses to pandemic 2009 H1N1 influenza A virus vaccines in human immunodeficiency virus-infected (HIV+) individuals, less well understood are cell-mediated immune (CMI) responses to this antigen in this susceptible population. We investigated such influenza-specific CMI responses in
Maria C Puertas et al.
mBio, 12(3), e0056021-e0056021 (2021-06-23)
Improved assays are critical to the successful implementation of novel HIV-1 cure strategies, given the limited ability of currently available assays to quantify true effects on the viral reservoir. As interventions based on immune clearance target infected cells producing viral
T L C Wolters et al.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 57-58, 101391-101391 (2021-05-09)
Acromegaly is characterized by an excess of growth hormone (GH) and insulin like growth-factor 1 (IGF1), and it is strongly associated with cardiovascular diseases (CVD). Both acute and long-lasting pro-inflammatory effects have been attributed to IGF1. Previous results suggest the
Upasana Parthasarathy et al.
iScience, 26(2), 105948-105948 (2023-02-10)
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies are currently available. While singular components of the aberrant immune response have been investigated, comprehensive
Nina Thakkar et al.
Antimicrobial agents and chemotherapy, 53(2), 631-638 (2008-12-03)
The present studies were conducted to better define the mechanism of action of polyethylene hexamethylene biguanide (PEHMB) (designated herein as NB325), which was shown in previous studies to inhibit infection by the human immunodeficiency virus type 1 (HIV-1). Fluorescence-activated flow
Cellular RelB interacts with the transactivator Tat and enhance HIV-1 expression
Wang M, et al.
Retrovirology, 15(1), 65-65 (2018)
Julie Douthwaite et al.
Journal of immunology (Baltimore, Md. : 1950), 198(1), 528-537 (2016-11-25)
Affinity- and stability-engineered variants of CTLA4-Ig fusion molecules with enhanced pharmacokinetic profiles could yield improved therapies with the potential of higher efficacy and greater convenience to patients. In this study, to our knowledge, we have, for the first time, used
Xiao Li et al.
Inflammation, 43(4), 1269-1278 (2020-02-28)
Release of titanium ions (Ti ions) frequently occurs around dental implants and, as a consequence, higher content of Ti is typically present in peri-implantitis tissue. Unlike chronic periodontitis, Ti ions may play a role in the development of peri-implantitis. Inflammasomes
T N Nissen et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 37(1), 29-41 (2017-09-12)
Several studies have shown increased in vitro cytokine responses to non-related pathogens after Bacillus Calmette-Guérin (BCG) vaccination. A total of 158 infants (80 BCG administered within 7 days of birth; 78 controls) were bled 4 days post-randomization, and at age 3 and
Romain Piault et al.
The American naturalist, 174(4), 548-556 (2009-08-21)
Although gene by environment interactions may play a key role in the maintenance of genetic polymorphisms, little is known about the ecological factors involved in these interactions. We investigated whether food supply and parasites can mediate covariation between the degree
Balázs Opper et al.
Molecular immunology, 47(11-12), 2047-2056 (2010-05-05)
The role of calcium signaling in activation of both innate and adaptive immunity is basically important, however, the evolutionary aspects are not clarified yet. Currently limited data are available about calcium levels of coelomocytes, cellular mediators of earthworm immunity. We
Cody J Warren et al.
PLoS biology, 17(6), e3000304-e3000304 (2019-06-11)
Individuals chronically infected with HIV-1 harbor complex viral populations within their bloodstreams. Recently, it has come to light that when these people infect others, the new infection is typically established by only one or a small number of virions from
Benoit R Gauthier et al.
International journal of molecular sciences, 23(11) (2022-06-11)
Mesothelial cells form the mesothelium, a simple epithelium lining the walls of serous cavities and the surface of visceral organs. Although mesothelial cells are phenotypically well characterized, their immunoregulatory properties remain largely unknown, with only two studies reporting their capacity
M G Zenobi et al.
Journal of dairy science, 105(12), 9896-9916 (2022-10-15)
The objectives were to investigate whether supplementation with rumen-protected choline (RPC) during late pregnancy in Holstein cows affects offspring immunity and growth, and whether effects are utero-placental, colostrum dependent, or both. A total of 105 multiparous Holstein cows were assigned
Carissa Ritner et al.
PloS one, 6(1), e16004-e16004 (2011-01-20)
Unlike some organs, the heart is unable to repair itself after injury. Human embryonic stem cells (hESCs) grow and divide indefinitely while maintaining the potential to develop into many tissues of the body. As such, they provide an unprecedented opportunity
Aliy K Zhanataev et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 816-817, 24-31 (2017-05-04)
The class of carbazoles includes compounds with high biological activities and broad spectra of action. PLX01107 and PLX01008 are xenomycins, a new subclass of antimicrobial carbazole derivatives demonstrating strong antifungal activity in vitro. We performed three tests, a bacterial reverse
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