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Showing 1-30 of 43 results for "L2407" within Papers
C Martínez-Campa et al.
British journal of cancer, 101(9), 1613-1619 (2009-09-24)
Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase expression, evaluate the ability of melatonin to regulate cyclooxygenases and
M L Dubocovich
The Journal of pharmacology and experimental therapeutics, 246(3), 902-910 (1988-09-01)
The pharmacological potencies of 2-substituted N-acetyltryptamines were determined on the presynaptic melatonin receptor site of rabbit retina labeled in vitro with [3H]dopamine. Calcium-dependent release of [3H]dopamine was elicited by electrical stimulation at 3 Hz for 2 min (20 mA, 2
Ivonne Bazwinsky-Wutschke et al.
Journal of pineal research, 53(4), 344-357 (2012-05-24)
The pineal hormone melatonin exerts its influence on the insulin secretion of pancreatic islets by a variety of signalling pathways. The purpose of the present study was to analyse the impact of melatonin on the phosphorylated transcription factor cAMP-response element-binding
Fenju Qin et al.
Reproductive biomedicine online, 31(5), 638-646 (2015-09-21)
The aim of the present study was to elucidate whether the GATA-4/SF-1 signalling pathway is involved in the inhibitory effects of melatonin on testosterone production in both the TM3 Leydig cell line and in C57BL/6J mice. In-vitro experiments demonstrated that
M Juszczak et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(6), 777-784 (2015-01-03)
Melatonin exerts its biological role acting via G protein-coupled membrane receptors - MT1 and MT2, as well as through cytoplasmic and/or nuclear receptors. Melatonin has previously been shown to change vasopressin (AVP) and adrenocorticotropic hormone (ACTH) secretion dependently on its
Raise Ahmad et al.
Neuroimmunomodulation, 19(1), 50-59 (2011-11-10)
Despite the evidence for melatonin membrane receptors (MT1R and MT2R) on lymphoid tissues in a wide range of seasonal breeders, their specific potency has never been compared and correlated with cell-mediated immunity. We used luzindole, a nonselective MT2R antagonist, and
C X Yu et al.
Neuroscience letters, 282(3), 161-164 (2000-03-16)
The present study was undertaken to assess the effects of intracerebroventricular (i.c.v.) luzindole (a selective MT(2) melatonin receptor antagonist) and prazosin (a selective MT(3) melatonin receptor antagonist) on melatonin-induced antinociception, so as to clarify which of melatonin receptor subtypes within
Sharda Kumari et al.
FEBS letters, 585(14), 2345-2351 (2011-06-15)
Several studies have indicated the existence of direct effects of melatonin on platelets. Here we show that, melatonin at high concentration is capable of significantly raising platelet intracellular calcium even in the absence of an agonist. The effect of melatonin
Leila Moezi et al.
Epilepsy & behavior : E&B, 22(2), 200-206 (2011-08-16)
Melatonin, the major hormone produced by the pineal gland, has a number of functions in mammals, for example, its function as an anticonvulsant. Agmatine, a biogenic amine formed by decarboxylation of L-arginine by arginine decarboxylase, also has anticonvulsant effects. This
Rafael Ochoa-Sanchez et al.
Progress in neuro-psychopharmacology & biological psychiatry, 39(2), 318-325 (2012-07-14)
Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety. Most of the physiological actions of MLT in the brain are mediated by two high-affinity G-protein-coupled receptors, denoted MT(1) and MT(2). However, the particular role of
Sergio Domínguez-López et al.
Journal of psychopharmacology (Oxford, England), 26(6), 830-844 (2011-07-07)
Melatonin (MLT) and serotonin (5-HT) are two biosynthetically related compounds implicated in several common physiological functions and the etiology of mood disorders. How they interact, though, is not yet fully understood. In this study, single-unit extracellular recordings were used to
Anna Sommansson et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(1), G95-G105 (2013-05-04)
Increased intestinal permeability is often associated with epithelial inflammation, leaky gut, or other pathological conditions in the gastrointestinal tract. We recently found that melatonin decreases basal duodenal mucosal permeability, suggesting a mucosal protective mode of action of this agent. The
Adriana Migliaro et al.
Brain, behavior and evolution, 87(4), 232-241 (2016-05-25)
Timing is crucial for social interactions. Animal behavior is synchronized with biotic and abiotic environment variables ensuring that the activity phase of conspecifics occurs during the same period of the day. As biological rhythms are embedded in the complex integrative
Tobias Fink et al.
Critical care medicine, 42(1), e22-e31 (2013-10-23)
Melatonin has been demonstrated to improve survival after experimental sepsis via antioxidant effects. Yet, recent evidence suggests that this protective capacity may also rely on melatonin receptor activation. Therefore, the present study was designed to investigate whether selective melatonin receptor-agonist
M D Mubashshir et al.
Journal of receptor and signal transduction research, 32(2), 114-119 (2012-03-13)
The hormone melatonin regulates the biological clock and assist in various other physiologies of vertebrates. Present work is intended to check the affinity of saccharin towards the melatonin receptors and the possible role of saccharin interference in the melatonin physiology.
Ugurlu M Umit et al.
Journal of investigative surgery : the official journal of the Academy of Surgical Research, 25(6), 345-353 (2012-12-12)
Recent studies have analyzed the efficacy of various agents in experimental chemoprevention trials. In our study, the effects of melatonin (Mel) and its antagonist Luzindole (Luz) on Heme oxygenase-1 (HO-1) in a NMU (N-methyl-N-nitrosourea)-induced rat mammary carcinoma model are investigated.
Haluk Kelestimur et al.
Brain research, 1435, 24-28 (2011-12-20)
Melatonin is suggested to have effects on hypothalamic-pituitary-gonadal (HPG) axis. The pulsatile pattern of GnRH release, which results in the intermittent release of gonadotropic hormones from the pituitary, has a critical importance for reproductive function but the factors responsible from
Luciana Pinato et al.
Brain structure & function, 220(2), 827-840 (2013-12-24)
Although melatonin is mainly produced by the pineal gland, an increasing number of extra-pineal sites of melatonin synthesis have been described. We previously demonstrated the existence of bidirectional communication between the pineal gland and the immune system that drives a
Xin-Ping Cheng et al.
Journal of pharmacological sciences, 119(2), 177-185 (2012-06-08)
In the present study, we investigated the effect of melatonin on the GABA-induced current (I(GABA) and GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in cultured rat hippocampal neurons using the whole-cell patch-clamp technique. We found that melatonin rapidly and reversibly enhanced
Kuan-Hung Chen et al.
Journal of cellular and molecular medicine, 24(18), 10402-10419 (2020-07-31)
This study tested the hypothesis that melatonin (Mel) therapy preserved the brain architectural and functional integrity against ischaemic stroke (IS) dependently through suppressing the inflammatory/oxidative stress downstream signalling pathways. Adult male B6 (n = 6 per each B6 group) and TLR4 knockout
Ismail Ben Soussia et al.
Pflugers Archiv : European journal of physiology, 464(3), 273-285 (2012-07-28)
Melatonin has been reported to present with vasorelaxant and anti-fibrotic properties. We hypothesized that melatonin may down-regulate volume-regulated anion channels (VRAC) in fibroblasts to limit their migration and proliferation. While acute exposure of L929 fibroblasts to melatonin did not result
Jing-Li Tao et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-02-03)
In mammalian ovaries, the avascular environment within follicular cavity is supposed to cause hypoxic status in granulosa cells (GCs), leading to apoptotic cell death accompanied by cumulative reactive oxygen species (ROS) production. Melatonin (N-acetyl-5-methoxytryptamine, MT), a broad-spectrum antioxidant that exists
Md Mubashshir et al.
Journal of receptor and signal transduction research, 31(5), 381-386 (2011-09-21)
The present study was undertaken to ascertain whether the casein derived bitter tastant Cyclo (Leu-Trp) [CLT] has an affinity or not for the particular receptors of the pineal hormone, melatonin, on the melanophores of a major carp Labeo rohita (Ham.).
Feng Xu et al.
Journal of pineal research, 68(3), e12631-e12631 (2020-01-17)
In the elderly with atherosclerosis, hypertension and diabetes, vascular calcification and ageing are ubiquitous. Melatonin (MT) has been demonstrated to impact the cardiovascular system. In this study, we have shown that MT alleviates vascular calcification and ageing, and the underlying
Roberto Pariente et al.
Cancer chemotherapy and pharmacology, 80(5), 985-998 (2017-09-29)
Melatonin has antitumor activity via several mechanisms including its antiproliferative and proapoptotic effects in addition to its potent antioxidant actions. Therefore, melatonin may be useful in the treatment of tumors in association with chemotherapy drugs. This study was performed to
Venkataramanujam Srinivasan et al.
Recent patents on endocrine, metabolic & immune drug discovery, 6(2), 139-147 (2012-04-28)
Malaria remains a global health problem affecting more than 515 million people all over the world including Malaysia. It is on the rise, even within unknown regions that previous to this were free of malaria. Although malaria eradication programs carried
Richard B Rosen et al.
Molecular vision, 18, 1640-1648 (2012-07-10)
Recently, we reported finding that circulating melatonin levels in age-related macular degeneration patients were significantly lower than those in age-matched controls. The purpose of this study was to investigate the hypothesis that melatonin deficiency may play a role in the
Nayrton Flávio Moura Rocha et al.
Chemico-biological interactions, 205(2), 148-156 (2013-07-23)
Our great interest in this work was study the synergism between l-tryptophan and dipyrone or paracetamol as well as the interaction of kynurenic acid (l-tryptophan metabolite) and these analgesics agents utilizing a robust methodology. We performed the writhing test induced
Tracy A Bedrosian et al.
Neuroscience letters, 542, 123-125 (2013-03-27)
Melatonin is the principle hormonal product of the pineal gland. It is secreted with a robust daily rhythm, peaking near the middle of the night. During the daytime, concentrations remain very low, as exposure to light robustly suppresses its secretion.
Jin-Young Sung et al.
Molecules (Basel, Switzerland), 23(4) (2018-03-24)
The activation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) via phosphorylation in the hippocampus is an important signaling mechanism for enhancing memory processing. Although melatonin is known to increase CREB expression in various animal models, the signaling mechanism
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