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Showing 1-30 of 775 results for "L2880" within Papers
Wen-Bin Zhang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 97, 818-824 (2017-11-08)
Histone deacetylase 6 (HDAC6) is considered a new target for anticancer, anti-inflammatory, and neurodegenerative treatment. ACY-1215 is a selective histone deacetylase 6 inhibitor, and it has been recognized as a potential anticancer and anti-inflammation drug. The aim of our study
Haitang Wang et al.
Molecular medicine reports, 16(3), 2807-2813 (2017-07-06)
At present, the timing of glutamine administration remains controversial. The aim of the present study was to confirm the early protective mechanisms of alanyl‑glutamine (Ala‑Gln) against lipopolysaccharide (LPS)‑induced lung injury, as well as to detect the best time for Ala‑Gln
Huiying Liu et al.
Cell death & disease, 10(9), 664-664 (2019-09-13)
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are major causes of respiratory failure, but currently, no effective pharmacotherapy exists for these disorders. Alveolar macrophages play a critical role in both the acute/initial phase and chronic/resolving phase of
Hyun Ju Park et al.
International journal of environmental research and public health, 17(13) (2020-07-08)
Wild ginseng, Panax ginseng Meyer, is a traditional medicine widely used in Asia. Due to low reward and high costs, wild ginseng is produced by a plant cell culture technique called cultured ginseng roots (GR). The health benefits of wild
Shelby O'Connor et al.
Molecular and cellular biology, 24(11), 4895-4908 (2004-05-15)
Constitutive NF-kappaB activity has emerged as an important cell survival component of physiological and pathological processes, including B-cell development. In B cells, constitutive NF-kappaB activity includes p50/c-Rel and p52/RelB heterodimers, both of which are critical for proper B-cell development. We
Fang Cao et al.
Inflammation, 44(6), 2486-2498 (2021-09-01)
Acute lung injury (ALI) is a type of serious clinical syndrome leading to morbidity and mortality. However, the precise pathogenesis of ALI remains elusive. Here, we implemented an integrative meta-analysis of six GEO microarray studies with 76 samples in the
Xiao Han et al.
British journal of pharmacology, 177(13), 2991-3008 (2020-02-16)
Macrophage infiltration and activation is a critical step during acute pancreatitis (AP). We have shown that pancreas-specific D2 receptor signalling protects against AP severity. As it is unclear to what extent myeloid-specific D2 receptor mediates AP, we investigated the role
Haley L Dugan et al.
Immunity, 54(6), 1290-1303 (2021-05-23)
Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for understanding antibody recall upon secondary exposure. Here, we used single-cell sequencing to profile SARS-CoV-2-reactive B cells in 38 COVID-19 patients. Using oligo-tagged antigen baits, we isolated B
Andy Darma et al.
Iranian journal of microbiology, 12(5), 445-450 (2021-02-20)
Probiotics have been widely used for host immune system enhancement but with limited knowledge regarding the immunomodulation mechanisms by which they assist the mucosal innate immune response. We investigated the effects of probiotics on the modulation of the innate mucosal
Joe M McCord et al.
Antioxidants (Basel, Switzerland), 9(6) (2020-06-18)
Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 activity declines with age, making the elderly more susceptible to oxidative stress-mediated
Xiuying Wang et al.
Animal nutrition (Zhongguo xu mu shou yi xue hui), 7(3), 609-620 (2021-08-12)
Xylooligosaccharide (XOS) has been considered to be an effective prebiotic, but its exact mechanisms remain unknown. This research was conducted to evaluate the effects of XOS on pig intestinal bacterial community and mucosal barrier using a lipopolysaccharide (LPS)-caused gut damage
Dong-Gu Kim et al.
Molecular medicine reports, 21(1), 258-266 (2019-11-21)
The major role of inner medullary collecting duct (IMCD) cells is to maintain water and sodium homeostasis. In addition to the major role, it also participates in the protection of renal and systemic inflammation. Although IMCD cells could take part
Guang-Yu Jiao et al.
Experimental physiology, 100(8), 967-976 (2015-06-09)
What is the central question of this study? Higher levels of positive end-expiratory pressure (PEEP) have recently been used in patients with acute respiratory distress syndrome (ARDS). In normal physiological conditions, the ability of the diaphragm to generate pressure is
Di-Feng Fang et al.
Nature communications, 5, 4513-4513 (2014-07-30)
CD40, a member of tumour necrosis factor receptor (TNFR) superfamily, has a pivotal role in B-cell-mediated immunity through various effector pathways including AKT kinase, but the signal transduction of CD40-meidated AKT activation is poorly understood. Here we report that the
Tomiharu Niida et al.
Cardiovascular research, 93(2), 371-379 (2011-12-03)
IκBNS regulates a subset of Toll-like receptor (TLR)-dependent genes including interleukin-6 (IL-6) by inhibiting nuclear factor-κB (NF-κB). IL-6 is an inflammatory biomarker for cardiovascular diseases. The aim of this study was to determine whether IκBNS changes arterial inflammation and intimal
James F Colbert et al.
American journal of physiology. Renal physiology, 313(2), F553-F559 (2017-05-19)
Sepsis outcomes are heavily dependent on the development of septic organ injury, but no interventions exist to interrupt or reverse this process. microRNA-223 (miR-223) is known to be involved in both inflammatory gene regulation and host-pathogen interactions key to the
Esma Gamze Aksel et al.
Tropical animal health and production, 53(1), 65-65 (2021-01-05)
This is the first study investigating the changes in some gene expressions related to the TLR pathway in vivo in sheep. Lipopolysaccharide (LPS) and lipoteichoic acid (LTA) molecules were administrated separately and in combination to the Akkaraman lambs via intranasal
Etsuko Kajimoto et al.
PloS one, 15(11), e0242076-e0242076 (2020-11-20)
This study aimed to determine the association between umbilical cord leucine-rich alpha-2 glycoprotein (LRG) and fetal infection and investigate the underlying mechanism of LRG elevation in fetuses. We retrospectively reviewed the medical records of patients who delivered at Osaka University
Michael Phillips et al.
Health physics, 108(5), 538-546 (2015-03-27)
There is widespread interest in the development of tools to estimate radiation exposures. Exhaled breath provides a novel matrix for assessing biomarkers that could be correlated with exposures. The use of exhaled breath for estimating radiation exposure is warranted, as
Yu-Xuan Zhang et al.
Journal of immunology (Baltimore, Md. : 1950), 206(6), 1140-1150 (2021-02-03)
Intestinal microbiota are closely related to host physiology. Over the long course of evolution and interaction, both commensal bacteria and their host have evolved multiple strategies to adapt to each other. However, in invertebrates, the regulatory mechanism of intestinal microbiota
Tracy Thennes Schmidt et al.
American journal of physiology. Lung cellular and molecular physiology, 305(4), L291-L300 (2013-06-19)
Loss of lung-fluid homeostasis is the hallmark of acute lung injury (ALI). Association of catenins and actin cytoskeleton with vascular endothelial (VE)-cadherin is generally considered the main mechanism for stabilizing adherens junctions (AJs), thereby preventing disruption of lung vascular barrier
Pu Sun et al.
Journal for immunotherapy of cancer, 9(8) (2021-08-11)
The phosphatidylinositol 3-kinase (PI3K) is frequently hyperactivated in cancer and plays important roles in both malignant and immune cells. The effect of PI3Kα inhibitors on the tumor microenvironment (TME) remains largely unknown. Here, we investigated the modulation of the TME
Yan Wang et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 40(4), 747-759 (2019-03-22)
Long noncoding RNAs (lncRNA) expression profiles change in the ischemic brain after stroke, but their roles in specific cell types after stroke have not been studied. We tested the hypothesis that lncRNA modulates brain injury by altering macrophage functions. Using
Shin-E Lin et al.
Physiological reports, 3(12) (2015-12-25)
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is expressed in the epithelium of various primate tissues, including lung airway and alveoli. In human lung, CEACAM6 is developmentally and hormonally regulated, protects surfactant function, has anti-apoptotic activity and is dysregulated in
Elias Leiva-Salcedo et al.
Mediators of inflammation, 2011, 152625-152625 (2011-09-24)
The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and
Tessa Knox et al.
Scientific reports, 9(1), 6136-6136 (2019-04-18)
Histone deacetylases (HDACs) are involved in diverse cellular regulatory mechanisms including non-canonical functions outside the chromatin environment. Several publications have demonstrated that selective HDAC inhibitors (HDACi) can influence tumor immunogenicity and the functional activity of specific immune cells. In particular
17α-ethinylestradiol and 4-tert-octylphenol concurrently disrupt the immune response of common carp.
Magdalena Maciuszek et al.
Fish & shellfish immunology, 107(Pt A), 238-250 (2020-10-11)
The aquatic environment is massively polluted with endocrine-disrupting compounds (EDCs) including synthetic estrogens (e.g. 17α-ethinylestradiol, EE2) and alkylphenols (e.g. 4-tert-octylphenol, 4t-OP). A major mechanism of action for estrogenic EDCs is their interaction with estrogen receptors and consequently their modulation of
Deepak Prasad Gupta et al.
Toxins, 12(4) (2020-04-23)
Neuroinflammation is involved in various neurological diseases. Activated microglia secrete many pro-inflammatory factors and induce neuronal cell death. Thus, the inhibition of excessive proinflammatory activity of microglia leads to a therapeutic effect that alleviates the progression of neuronal degeneration. In
Martina Holubová et al.
The Journal of pharmacology and experimental therapeutics, 366(3), 422-432 (2018-06-20)
Ghrelin, the only known orexigenic gut hormone produced primarily in the stomach, has lately gained attention as a potential treatment of anorexia and cachexia. However, its biologic stability is highly limited; therefore, a number of both peptide and nonpeptide ghrelin
Ruizheng Shi et al.
PLoS pathogens, 14(5), e1007026-e1007026 (2018-05-19)
Innate immune recognition is classically mediated by the interaction of host pattern-recognition receptors and pathogen-associated molecular patterns; this triggers a series of downstream signaling events that facilitate killing and elimination of invading pathogens. In this report, we provide the first
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