L6544

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Showing 1-11 of 11 results for "L6544" within Papers

DREAM mediated regulation of GCM1 in the human placental trophoblast.

Dora Baczyk et al.

PloS one, 8(1), e51837-e51837 (2013-01-10)

The trophoblast transcription factor glial cell missing-1 (GCM1) regulates differentiation of placental cytotrophoblasts into the syncytiotrophoblast layer in contact with maternal blood. Reduced placental expression of GCM1 and abnormal syncytiotrophoblast structure are features of hypertensive disorder of pregnancy--preeclampsia. In-silico techniques

Myometrial immune cells contribute to term parturition, preterm labour and post-partum involution in mice.

Oksana Shynlova et al.

Journal of cellular and molecular medicine, 17(1), 90-102 (2012-12-05)

This study aimed to determine the mechanism of uterine activation during labour, both term (TL) and preterm (PTL). We hypothesized that the peripheral leucocytes are recruited to uterine tissues by locally produced cytokines where they contribute to the initiation of

The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.

Nicolas Bisson et al.

PloS one, 7(11), e50996-e50996 (2012-12-12)

The kidney filtration barrier is formed by the combination of endothelial cells, basement membrane and epithelial cells called podocytes. These specialized actin-rich cells form long and dynamic protrusions, the foot processes, which surround glomerular capillaries and are connected by specialized

DNA-methylation patterns imply a common cellular origin of virus- and UV-associated Merkel cell carcinoma.

Jan Gravemeyer et al.

Oncogene, 41(1), 37-45 (2021-10-21)

Merkel cell carcinoma (MCC) is a neuroendocrine tumor either induced by integration of the Merkel cell polyomavirus into the cell genome or by accumulation of UV-light-associated mutations (VP-MCC and UV-MCC). Whether VP- and UV-MCC have the same or different cellular

High mobility group box-1 (HMGB1; amphoterin) is required for zebrafish brain development.

Xiang Zhao et al.

The Journal of biological chemistry, 286(26), 23200-23213 (2011-04-30)

Hmgb1 (high mobility group box-1; amphoterin) is highly expressed in brain during early development of vertebrate and nonvertebrate species. However, its role in brain development remains elusive. Here we have cloned the zebrafish Hmgb1 and specifically manipulated Hmgb1 expression using

Mutations in Caenorhabditis briggsae identify new genes important for limiting the response to EGF signaling during vulval development.

Devika Sharanya et al.

Evolution & development, 17(1), 34-48 (2015-01-30)

Studies of vulval development in the nematode C. elegans have identified many genes that are involved in cell division and differentiation processes. Some of these encode components of conserved signal transduction pathways mediated by EGF, Notch, and Wnt. To understand

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.

Allison N Lau et al.

eLife, 9 (2020-07-11)

Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolites relative to the time

Infiltration of myeloid cells into decidua is a critical early event in the labour cascade and post-partum uterine remodelling.

Oksana Shynlova et al.

Journal of cellular and molecular medicine, 17(2), 311-324 (2013-02-06)

Leucocyte infiltration in the decidua (maternal-foetal interface) before, during and after term (TL) and preterm labour (PTL) was studied in mouse. We also investigated the mechanism of peripheral leucocyte recruitment into decidua by analysing the tissue cytokine profiles. Decidual tissues

The BLADE-ON-PETIOLE genes of Arabidopsis are essential for resistance induced by methyl jasmonate.

Juan Vicente Canet et al.

BMC plant biology, 12, 199-199 (2012-11-03)

NPR1 is a gene of Arabidopsis thaliana required for the perception of salicylic acid. This perception triggers a defense response and negatively regulates the perception of jasmonates. Surprisingly, the application of methyl jasmonate also induces resistance, and NPR1 is also

Deletion of the Aspergillus flavus orthologue of A. nidulans fluG reduces conidiation and promotes production of sclerotia but does not abolish aflatoxin biosynthesis.

Perng-Kuang Chang et al.

Applied and environmental microbiology, 78(21), 7557-7563 (2012-08-21)

The fluG gene is a member of a family of genes required for conidiation and sterigmatocystin production in Aspergillus nidulans. We examined the role of the Aspergillus flavus fluG orthologue in asexual development and aflatoxin biosynthesis. Deletion of fluG in

PPAR- γ Regulates Trophoblast Differentiation in the BeWo Cell Model.

Khrystyna Levytska et al.

PPAR research, 2014, 637251-637251 (2014-04-09)

Common pregnancy complications, such as severe preeclampsia and intrauterine growth restriction, disrupt pregnancy progression and impair maternal and fetal wellbeing. Placentas from such pregnancies exhibit lesions principally within the syncytiotrophoblast (SCT), a layer in direct contact with maternal blood. In

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