Search Within
L6641
Applied Filters:
Keyword:'L6641'
Showing 1-30 of 85 results for "L6641" within Papers
Tomonobu Uchino et al.
Cancer chemotherapy and pharmacology, 86(2), 233-243 (2020-07-16)
Erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, causes skin disorders such as dry skin, which impairs the skin barrier function. Stratum corneum (SC) lipids play an important role in skin barrier function; therefore, this study aimed
Yenisleidy de Las Mercedes Zulueta Díaz et al.
Biochimica et biophysica acta, 1859(10), 1891-1899 (2017-06-24)
Hexadecylphosphocholine (HePC, miltefosine) is an alkylphospholipid used clinically for the topical treatment of cancer and against leishmaniasis. The mechanism of action of HePC, not yet elucidated, involves its insertion into the plasma membrane, affecting lipid homeostasis. It has also been
Maryem Bezine et al.
Biochimie, 153, 56-69 (2018-02-21)
Little is known about K+ regulation playing major roles in the propagation of nerve impulses, as well as in apoptosis and inflammasome activation involved in neurodegeneration. As increased levels of 7-ketocholesterol (7KC), 24S-hydroxycholesterol (24S-OHC) and tetracosanoic acid (C24:0) have been
Quoc Dat Pham et al.
Quarterly reviews of biophysics, 51, e7-e7 (2018-01-01)
The outer layer of the skin, stratum corneum (SC) is an efficient transport barrier and it tolerates mechanical deformation. At physiological conditions, the majority of SC lipids are solid, while the presence of a small amount of fluid lipids is
Lilei Yu et al.
Food chemistry, 197(Pt A), 776-782 (2015-12-01)
The genetic diversity of phenolic content (PC), individual phenolic acids, vitamin E isomers (VE) and fatty acids (FA) in the whole grain rice were investigated. The most abundant phenolic acid was ferulic acid ranging from 155.6 to 271.1 μg/g and
Nicol Kruska et al.
Biochimica et biophysica acta, 1852(5), 925-936 (2015-01-15)
X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder resulting from defective ABCD1 transport protein. ABCD1 mediates peroxisomal uptake of free very-long-chain fatty acids (VLCFA) as well as their CoA-esters. Consequently, VLCFA accumulate in patients' plasma and tissues, which is considered
Dong-chun Ren et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 31(1), 47-49 (2008-07-01)
To study chemical constituents of Changium smyrnioides Wolff. The chemical components were isolated and purified by silica gel column and recrystallization. The chemical structures were elucidated on the basis of physico-chemical properties and spectral data. Ten compounds were isolated and
Lana Brockbals et al.
Analytical and bioanalytical chemistry, 412(24), 6241-6255 (2019-11-24)
Metabolomics studies that aim to qualitatively and quantitatively characterize the entirety of small endogenous biomolecules in an organism are widely conducted in the clinical setting. They also become more and more popular in the field of forensics (toxicology), e.g., to
Meredith D Hartley et al.
Cell chemical biology, 27(5), 551-559 (2020-03-15)
X-linked adrenoleukodystrophy (X-ALD) is a rare, genetic disease in which increased very long chain fatty acids (VLCFAs) in the central nervous system (CNS) cause demyelination and axonopathy, leading to neurological deficits. Sobetirome, a potent thyroid hormone agonist, has been shown
Lovastatin in X-linked adrenoleukodystrophy.
Marc Engelen et al.
The New England journal of medicine, 362(3), 276-277 (2010-01-22)
Xiao-jing Wang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(2), 230-231 (2011-08-10)
To study the chemical constituents of Salsola collina. The compounds were isolated by column chromatography, and their structures were identified by physical and chemical properties and spectral data. Seven compounds were isolated and identified as n-lignoceric acid (1), n-dotriacontanic acid
Li-juan Yang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 29(2), 128-130 (2006-04-19)
To study the chemical constituents of Lagotis yunnanensis W. W. Smith. Compounds were isolated from the ethanolic extract of the title herb by silica gel column chromatography, and their structures were identified by physical and chemical evidences and spectral methods.
Oswald Quehenberger et al.
Journal of lipid research, 51(11), 3299-3305 (2010-07-31)
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test
Anas Al Aidaros et al.
Metabolites, 10(10) (2020-10-15)
This article reports a targeted metabolomic method for total plasma fatty acids (FAs) of clinical or nutritional relevance. Thirty-six saturated, unsaturated, or branched-chain FAs with a chain length of C8-C28 were quantified using reversed-phase liquid chromatography-tandem mass spectrometry. FAs in
Cun Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 31(16), 1333-1335 (2006-10-26)
To isolate and identify the chemical constituents from the roots of Peucedantu praeruptorum. The constituents were isolated by column chromatography on silica gel and ODS, and identified by NMR, MS spectroscopic methods. Eight compounds, (-) sclerodin (1), palmitic acid (2)
Wei-Yi Hsu et al.
Analytical chemistry, 82(16), 6814-6820 (2010-08-14)
Peroxisomal disorders are characterized biochemically by elevated levels of very long chain fatty acids (VLCFAs) in serum. Herein, we describe a novel approach for quantification of VLCFAs in serum, namely, eicosanoic acid (C20:0), docosanoic acid (C22:0), tetracosanoic acid (C24:0), and
Corina Costachel et al.
The Journal of biological chemistry, 280(48), 39835-39842 (2005-10-06)
Galactomannan is a characteristic polysaccharide of the human filamentous fungal pathogen Aspergillus fumigatus that can be used to diagnose invasive aspergillosis. In this study, we report the isolation of a galactomannan fraction associated to membrane preparations from A. fumigatus mycelium
Thomas Nury et al.
International journal of molecular sciences, 21(2) (2020-01-23)
In the case of neurodegenerative pathologies, the therapeutic arsenal available is often directed towards the consequences of the disease. The purpose of this study is, therefore, to evaluate the ability of docosahexaenoic acid (DHA), a molecule present in certain foods
Petra Pullmannová et al.
Journal of lipid research, 60(5), 963-971 (2019-03-20)
Membrane models of the stratum corneum (SC) lipid barrier, either healthy or affected by recessive X-linked ichthyosis, constructed from ceramide [Cer; nonhydroxyacyl sphingosine N-tetracosanoyl-d-erythro-sphingosine (CerNS24) alone or with omega-O-acylceramide N-(32-linoleyloxy)dotriacontanoyl-d-erythro-sphingosine (CerEOS)], FFAs(C16-24), cholesterol (Chol), and sodium cholesteryl sulfate (CholS) were
Yunbao Liu et al.
Journal of natural products, 73(7), 1193-1195 (2010-06-23)
Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of established in vitro cell viability assays. An antioxidant assay
Rashmi Shakya et al.
Sexual plant reproduction, 23(2), 163-172 (2010-05-22)
Spatial distribution and compositional analyses of the lipidic constituents in pollen and stigma of sunflower (Helianthus annuus L. cv. Morden) were conducted using ultrastructural, histochemical, and biochemical analysis. Detection of secretions at the base of stigmatic papillae and neutral lipid
Bilal N Sheikh et al.
Nature cell biology, 22(7), 828-841 (2020-06-17)
Mutations in chromatin-modifying complexes and metabolic enzymes commonly underlie complex human developmental syndromes affecting multiple organs. A major challenge is to determine how disease-causing genetic lesions cause deregulation of homeostasis in unique cell types. Here we show that neural-specific depletion
Martín E Villanueva et al.
Journal of colloid and interface science, 543, 247-255 (2019-03-02)
The interaction of hydrophobic silver nanoparticles with different phospholipids and stratum corneum mimic (SCM) membranes is studied in Langmuir monolayers. Thus, silver nanoparticles coated with oleic acid (AgNP-OA) were synthesized, characterized and incorporated in Langmuir monolayers of single phospholipids -having
Gursev S Dhaunsi et al.
Kidney & blood pressure research, 33(1), 60-65 (2010-03-04)
Peroxisomes are known to play a role in cellular oxidative stress during pathogenesis of diabetes and hypertension. We reported earlier that FPTIII (a farnesyl protein transferase inhibitor) attenuates ischemia-reperfusion injury and renal dysfunction in diabetic hypertensive (DH) rats. In this
Ming-Xia Xie et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 31(9), 1332-1334 (2009-02-03)
To study the chemical constituents of Solanum cathayanum. Chemical constituents were isolated by chromatographic methods and identified by NMR analysis. Five compounds were isolated and identified as lignoceric acid (I), beta-sitosterol (II), lupeol (III) 8-hydroxy-3-methoxy-5H-pyrido [2, 1-c] pyrazin-5-one (IV), ethly
Hiroshi Habe et al.
Journal of oleo science, 57(4), 251-255 (2008-03-12)
In this paper, thermotolerant fungal strains which can grow on glycerol as the sole carbon source were isolated from soil samples. Morphological and molecular phylogenetic analyses of ten isolated strains showed that all strains belong to Aspergillus fumigatus. Analysis of
Zhong-Hua Sun et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 33(12), 1878-1881 (2011-05-10)
In an effort to investigate the chemical constitutes of submerged cultivation mycelium of Cordyceps jiangxiensis anamorph. The mycelia of C. jiangxiensis anamorph produced by submerged cultivation technique were separated and purified using various chromatographic techniques such as repeated liquid column
Dong Chang et al.
Journal of the American College of Nutrition, 33(5), 406-411 (2014-08-01)
To evaluate and compare the levels of free fatty acids between senile cataract patients and normal controls. Fifty consecutive patients with newly diagnosed senile cataract and 50 age- and gender-matched controls were evaluated. Subjects/patients were randomized according to selection criteria.
Wen Tang et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 19(6), 505-508 (2014-08-01)
To investigate phospholipids (PLs) biomarkers in predicting outcome of patients undergoing peritoneal dialysis (PD). Twenty PD patients were followed using baseline plasma PLs with an improved online two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry system. Significant differences were observed in eight
M Cappa et al.
Journal of endocrinological investigation, 34(10), 753-756 (2011-03-15)
X-linked adrenoleukodystrophy/adrenomieloneuropathy (ALD/AMN) is a progressive neurodegenerative disorder due to mutations in the ABCD1 gene encoding the ABC transporter ALDP. Mutations in ALDP impair peroxisomal β-oxidation of very long chain fatty acids (VLCFA), resulting in elevated levels of VLCFA in
Page 1 of 3