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Showing 1-30 of 85 results for "L6641" within Papers
M Cappa et al.
Journal of endocrinological investigation, 34(10), 753-756 (2011-03-15)
X-linked adrenoleukodystrophy/adrenomieloneuropathy (ALD/AMN) is a progressive neurodegenerative disorder due to mutations in the ABCD1 gene encoding the ABC transporter ALDP. Mutations in ALDP impair peroxisomal β-oxidation of very long chain fatty acids (VLCFA), resulting in elevated levels of VLCFA in
Wen Tang et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 19(6), 505-508 (2014-08-01)
To investigate phospholipids (PLs) biomarkers in predicting outcome of patients undergoing peritoneal dialysis (PD). Twenty PD patients were followed using baseline plasma PLs with an improved online two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry system. Significant differences were observed in eight
Dong Chang et al.
Journal of the American College of Nutrition, 33(5), 406-411 (2014-08-01)
To evaluate and compare the levels of free fatty acids between senile cataract patients and normal controls. Fifty consecutive patients with newly diagnosed senile cataract and 50 age- and gender-matched controls were evaluated. Subjects/patients were randomized according to selection criteria.
Walid Elfalleh et al.
International journal of food sciences and nutrition, 62(3), 200-206 (2010-12-02)
Pomegranate seed oil is considered a powerful health-benefiting agent due to its anti-oxidative and anticarcinogenic properties. Lipids from 21 pomegranate cultivars (15 Tunisian and 6 Chinese) were extracted and fatty acids were identified. Total lipids (16% on a dry weight
Aris A Polyzos et al.
Cell metabolism, 29(6), 1258-1273 (2019-04-02)
The basis for region-specific neuronal toxicity in Huntington disease is unknown. Here, we show that region-specific neuronal vulnerability is a substrate-driven response in astrocytes. Glucose is low in HdhQ(150/150) animals, and astrocytes in each brain region adapt by metabolically reprogramming
A Petroni et al.
Life sciences, 73(12), 1567-1575 (2003-07-17)
X-Adrenoleukodystrophy (X-ALD) is a peroxisomal disorder associated with the abnormal accumulation of very long chain fatty acids (VLCFA) in plasma and tissues. We have demonstrated that the androgen dihydrotestosterone (DHT) and 5 alpha-androstan-3 alpha,17 beta-diol (3 alpha-diol) have favorable effect
Adrian Paz Ramos et al.
Journal of lipid research, 59(1), 137-143 (2017-11-03)
The stratum corneum (SC), the top layer of skin, dictates the rate of both water loss through the skin and absorption of exogenous molecules into the body. The crystalline organization of the lipids in the SC is believed to be
Lana Brockbals et al.
Drug testing and analysis, 12(8), 1171-1182 (2020-05-07)
Postmortem redistribution (PMR) describes the artificial postmortem concentration changes of xenobiotics that may pose major challenges in forensic toxicology. Only a few studies have systematically investigated time-dependent postmortem drug concentration changes so far and the a posteriori estimation of the
Martín E Villanueva et al.
Journal of colloid and interface science, 543, 247-255 (2019-03-02)
The interaction of hydrophobic silver nanoparticles with different phospholipids and stratum corneum mimic (SCM) membranes is studied in Langmuir monolayers. Thus, silver nanoparticles coated with oleic acid (AgNP-OA) were synthesized, characterized and incorporated in Langmuir monolayers of single phospholipids -having
Zhen Chen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1126-1127, 121771-121771 (2019-08-30)
Fatty acids (FA) have been important in clinical diagnosis for long, which makes the increasing need for a fast, reliable, and economic approach to determine FA of short-, medium-, long-, and very long-chain by widely available equipment and with high-throughput
Adrian Paz Ramos et al.
Langmuir : the ACS journal of surfaces and colloids, 36(46), 13899-13907 (2020-11-11)
The stratum corneum (SC), the outermost layer of mammal epidermis, acts as a barrier dictating the rate of absorption of exogenous molecules through the skin, as well as to prevent excessive water loss from the body. The SC consists of
Tomás Rezanka et al.
Progress in lipid research, 48(3-4), 206-238 (2009-04-02)
Very long chain fatty acids (FAs) are important components of different classes of lipids in all organisms from bacteria to man. They include also, usually as minor components, odd-numbered FAs. These have so far been given little attention because of
Alejandro Ibáñez et al.
PeerJ, 5, e3689-e3689 (2017-08-23)
Chemical signals are widely used in the animal kingdom, enabling communication in various social contexts, including mate selection and the establishment of dominance. Femoral glands, which produce and release waxy secretions into the environment, are organs of central importance in
Murthy Jonnada et al.
Electrophoresis, 38(12), 1592-1601 (2017-01-29)
Fatty acids (FAs) have been selectively derivatized with a fluorescent tag, 6-aminoquinoline (6AQ), which yielded fluorescent FA-6AQ derivatives that have excitation (λ
Rashmi Shakya et al.
Sexual plant reproduction, 23(2), 163-172 (2010-05-22)
Spatial distribution and compositional analyses of the lipidic constituents in pollen and stigma of sunflower (Helianthus annuus L. cv. Morden) were conducted using ultrastructural, histochemical, and biochemical analysis. Detection of secretions at the base of stigmatic papillae and neutral lipid
Bilal N Sheikh et al.
Nature cell biology, 22(7), 828-841 (2020-06-17)
Mutations in chromatin-modifying complexes and metabolic enzymes commonly underlie complex human developmental syndromes affecting multiple organs. A major challenge is to determine how disease-causing genetic lesions cause deregulation of homeostasis in unique cell types. Here we show that neural-specific depletion
Ying Zhao et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 33(4), 555-556 (2010-09-18)
To study the chemical constituents from Solanum nigrum. Compounds were isolated and purified by silica gel, Sephadex LH-20 and preparative HPLC. Their structures were identified by physicochemical properties and spectral analysis. Six compounds were isolated and identified as (+)-pinoresinol (I)
Xiao-jing Wang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(2), 230-231 (2011-08-10)
To study the chemical constituents of Salsola collina. The compounds were isolated by column chromatography, and their structures were identified by physical and chemical properties and spectral data. Seven compounds were isolated and identified as n-lignoceric acid (1), n-dotriacontanic acid
Zhong-Hua Sun et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 33(12), 1878-1881 (2011-05-10)
In an effort to investigate the chemical constitutes of submerged cultivation mycelium of Cordyceps jiangxiensis anamorph. The mycelia of C. jiangxiensis anamorph produced by submerged cultivation technique were separated and purified using various chromatographic techniques such as repeated liquid column
Hiroshi Habe et al.
Journal of oleo science, 57(4), 251-255 (2008-03-12)
In this paper, thermotolerant fungal strains which can grow on glycerol as the sole carbon source were isolated from soil samples. Morphological and molecular phylogenetic analyses of ten isolated strains showed that all strains belong to Aspergillus fumigatus. Analysis of
Ming-Xia Xie et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 31(9), 1332-1334 (2009-02-03)
To study the chemical constituents of Solanum cathayanum. Chemical constituents were isolated by chromatographic methods and identified by NMR analysis. Five compounds were isolated and identified as lignoceric acid (I), beta-sitosterol (II), lupeol (III) 8-hydroxy-3-methoxy-5H-pyrido [2, 1-c] pyrazin-5-one (IV), ethly
Meredith D Hartley et al.
Cell chemical biology, 27(5), 551-559 (2020-03-15)
X-linked adrenoleukodystrophy (X-ALD) is a rare, genetic disease in which increased very long chain fatty acids (VLCFAs) in the central nervous system (CNS) cause demyelination and axonopathy, leading to neurological deficits. Sobetirome, a potent thyroid hormone agonist, has been shown
Lovastatin in X-linked adrenoleukodystrophy.
Marc Engelen et al.
The New England journal of medicine, 362(3), 276-277 (2010-01-22)
Yunbao Liu et al.
Journal of natural products, 73(7), 1193-1195 (2010-06-23)
Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of established in vitro cell viability assays. An antioxidant assay
Gursev S Dhaunsi et al.
Kidney & blood pressure research, 33(1), 60-65 (2010-03-04)
Peroxisomes are known to play a role in cellular oxidative stress during pathogenesis of diabetes and hypertension. We reported earlier that FPTIII (a farnesyl protein transferase inhibitor) attenuates ischemia-reperfusion injury and renal dysfunction in diabetic hypertensive (DH) rats. In this
Wei-Yi Hsu et al.
Analytical chemistry, 82(16), 6814-6820 (2010-08-14)
Peroxisomal disorders are characterized biochemically by elevated levels of very long chain fatty acids (VLCFAs) in serum. Herein, we describe a novel approach for quantification of VLCFAs in serum, namely, eicosanoic acid (C20:0), docosanoic acid (C22:0), tetracosanoic acid (C24:0), and
Li-juan Yang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 29(2), 128-130 (2006-04-19)
To study the chemical constituents of Lagotis yunnanensis W. W. Smith. Compounds were isolated from the ethanolic extract of the title herb by silica gel column chromatography, and their structures were identified by physical and chemical evidences and spectral methods.
Lana Brockbals et al.
Analytical and bioanalytical chemistry, 412(24), 6241-6255 (2019-11-24)
Metabolomics studies that aim to qualitatively and quantitatively characterize the entirety of small endogenous biomolecules in an organism are widely conducted in the clinical setting. They also become more and more popular in the field of forensics (toxicology), e.g., to
Nicol Kruska et al.
Biochimica et biophysica acta, 1852(5), 925-936 (2015-01-15)
X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder resulting from defective ABCD1 transport protein. ABCD1 mediates peroxisomal uptake of free very-long-chain fatty acids (VLCFA) as well as their CoA-esters. Consequently, VLCFA accumulate in patients' plasma and tissues, which is considered
Lilei Yu et al.
Food chemistry, 197(Pt A), 776-782 (2015-12-01)
The genetic diversity of phenolic content (PC), individual phenolic acids, vitamin E isomers (VE) and fatty acids (FA) in the whole grain rice were investigated. The most abundant phenolic acid was ferulic acid ranging from 155.6 to 271.1 μg/g and
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