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Showing 1-30 of 51 results for "M0876" within Papers
M Sta et al.
Neurobiology of disease, 42(3), 211-220 (2011-01-12)
Increasing evidence suggests a role for the immune system in amyotrophic lateral sclerosis (ALS). To determine the extent of the immune activation in ALS we analyzed the expression and cellular distribution of components of innate and adaptive immunity in spinal
Vincenza M Coiro et al.
Protein science : a publication of the Protein Society, 13(11), 2979-2991 (2004-10-23)
Glutamate synthase (GltS) is a complex iron-sulfur flavoprotein that catalyzes the reductive transfer of L-glutamine amide group to the C2 carbon of 2-oxoglutarate yielding two molecules of L-glutamate. Molecular dynamics calculations in explicit solvent were carried out to gain insight
C M Parsons et al.
The British journal of nutrition, 46(1), 77-86 (1981-07-01)
1. The relative potencies of three lysine, one tryptophan and six methionine analogues to their corresponding l-amino acids were determined. 2. Male poults, 9 d of age, were used in five 14 d experiments. Experimental diets were formed by adding
Jun Zeng et al.
Journal of proteome research, 13(7), 3420-3431 (2014-05-24)
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. The lack of effective screening methods for early diagnosis has been a longstanding bottleneck to improve the survival rate. In the present study, a capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF/MS)-based metabolomics
Anneli Nordqvist et al.
Bioorganic & medicinal chemistry, 16(10), 5501-5513 (2008-05-09)
A combination of a literature survey, structure-based virtual screening and synthesis of a small library was performed to identify hits to the potential antimycobacterial drug target, glutamine synthetase. The best inhibitor identified from the literature survey was (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid (4
Effects of singlet oxygen on the biological activity of DNA and its involvement in single strand-break formation.
H Wefers et al.
Basic life sciences, 49, 473-477 (1988-01-01)
Chelsey M VanDrisse et al.
Applied and environmental microbiology, 82(24), 7041-7051 (2016-10-04)
Acetylation of small molecules is widespread in nature, and in some cases, cells use this process to detoxify harmful chemicals. Streptomyces species utilize a Gcn5 N-acetyltransferase (GNAT), known as Bar, to acetylate and detoxify a self-produced toxin, phosphinothricin (PPT), a
Shin Nishiumi et al.
Journal of bioscience and bioengineering, 123(6), 754-759 (2017-03-16)
Metabolomics has recently been developed, and there have been a considerable number of metabolomics-based biomarker studies in the medical research field. Therefore, as a first step toward the practical use of metabolite biomarkers, a simple and quick sample preparation method
Ryuichiro Tanaka
Bioscience, biotechnology, and biochemistry, 71(12), 3055-3062 (2007-12-12)
In addition to serine (L:D = 68:32), methionine sulfoxide (MSO), L-methionine sulfone (L-MSO(2)), and disodium gamma-cyclic di-L-glutamate were identified in a methanol extract of Bombyx mori L. pupae. MSO was isolated in a diastereomeric mixture of L(+)- and D(+)-MSO in
Effects of feed crops and boiling on chicken egg yolk and white determined by a metabolome analysis.
Tatsuki Ogura et al.
Food chemistry, 327, 127077-127077 (2020-06-03)
Compositional analyses of eggs have primarily focused on nutritional components, including large molecules, such as proteins. However, few reports have investigated the effects of heating and hen feed crops on taste components, such as free amino acids and sugars. Herein
An association between glutamine synthetase activity and adipocyte differentiation in cultured 3T3-L1 cells.
R E Miller et al.
Archives of biochemistry and biophysics, 209(2), 486-503 (1981-07-01)
Kristy L Hentchel et al.
Journal of bacteriology, 197(2), 314-325 (2014-11-05)
Protein and small-molecule acylation reactions are widespread in nature. Many of the enzymes catalyzing acylation reactions belong to the Gcn5-related N-acetyltransferase (GNAT; PF00583) family, named after the yeast Gcn5 protein. The genome of Salmonella enterica serovar Typhimurium LT2 encodes 26
Periodate oxidation of methionine in proteins.
R B Yamasaki et al.
Analytical biochemistry, 126(1), 183-189 (1982-10-01)
M K Unnikrishnan et al.
Agents and actions, 31(1-2), 110-112 (1990-08-01)
The oxidation of methionine in peptides is often associated with the loss of biological activity. Since methionine showed good antiinflammatory activity, its oxidized products methionine sulfoxide and methionine sulfone were tested. The sulfone was more active than the sulfoxide although
Binning Wu et al.
Frontiers in plant science, 11, 619598-619598 (2021-02-16)
Increasing incidence of chronic diseases in the 21st century has emphasized the importance of developing crops with enhanced nutritional value. Plant-based diets are associated with reduced incidence of many chronic diseases. The growing population and increased food demand have prioritized
Anthony C B Molteno et al.
Investigative ophthalmology & visual science, 50(3), 1187-1197 (2008-11-04)
To identify cell types and extracellular matrix components in Molteno implant capsules. Histologic features including cytology, distribution of apoptotic cells, cytoantigens, collagens, basement membranes, elastic fibers, and glycoproteins were examined by light microscopy. Findings were correlated with the clinical features
J Kunert
Journal of basic microbiology, 25(1), 29-37 (1985-01-01)
The dermatophyte Microsporum gypseum was cultivated on a glucose-arginine medium to which on out of six sulfur-containing amino acids was added (L-cystine, L-djenkolic acid, DL-lanthionine DL-homocystine, L-methionine, or L-methionine-sulfone at a concentration of 5 mM with respect to sulfur content).
C Binda et al.
Structure (London, England : 1993), 8(12), 1299-1308 (2001-02-24)
The complex iron-sulfur flavoprotein glutamate synthase catalyses the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine, a reaction in the plant and bacterial pathway for ammonia assimilation. The enzyme functions through three distinct active centers carrying out L-glutamine hydrolysis, conversion
M Gössl et al.
Atherosclerosis, 206(2), 362-368 (2009-04-17)
To assess the role of coronary vasa vasorum (VV) spatial distribution in determining the location of early atherosclerotic lesion development. Six, 3-month-old, female, crossbred swine were fed 2% high-cholesterol (HC) diet for 3 months prior to euthanasia. Six other pigs
Lake-Ee Quek et al.
iScience, 23(2), 100855-100855 (2020-02-15)
Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable isotope tracers presents unique computational challenges. Here, we developed an efficient 13C-tracer dynamic metabolic flux analysis (13C-DMFA) framework for modeling central carbon fluxes that vary over time. We used
A Blomme et al.
Oncogene, 36(15), 2116-2130 (2016-10-25)
Myoferlin is a multiple C2-domain-containing protein that regulates membrane repair, tyrosine kinase receptor function and endocytosis in myoblasts and endothelial cells. Recently it has been reported as overexpressed in several cancers and shown to contribute to proliferation, migration and invasion
F J Cejudo et al.
Biochemical and biophysical research communications, 123(2), 431-437 (1984-09-17)
Addition of NH4Cl at low concentrations to Azotobacter chroococcum cells caused an immediate cessation of nitrogenase activity, which was recovered once the added NH+4 was exhausted from the medium. In the presence of inhibitors of ammonium assimilation, such as L-methionine-DL-sulfoximine
Satoshi Kofuji et al.
Nature cell biology, 21(8), 1003-1014 (2019-08-03)
In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minimally understood. Here we show that IMP dehydrogenase-2 (IMPDH2), the rate-limiting
F M Lagerwerf et al.
Rapid communications in mass spectrometry : RCM, 10(15), 1905-1910 (1996-01-01)
The positive- and negative-ion collision-induced dissociation spectra of peptides containing methionine, methionine sulphoxide and methionine sulphone have been studied. Characteristic fragmentations were identified and evaluated as possible indicators for the presence of oxidized methionine residues in peptides. It was found
Elżbieta Jankowska et al.
Journal of inorganic biochemistry, 121, 1-9 (2013-01-15)
A potentiometric, spectroscopic (UV-visible, CD and EPR) and electrospray ionization mass spectrometric (ESI-MS) study of Cu(II) binding to the neurokinin A with point mutation (S5A) (ANKA), His-Lys-Thr-Asp-Ala(5)-Phe-Val-Gly-Leu-Met-NH2 and its N-acethyl derivative (Ac-ANKA), Ac-His-Lys-Thr-Asp-Ala(5)-Phe-Val-Gly-Leu-Met-NH2 were carried out. For the ANKA and
M M Or-Rashid et al.
Amino acids, 24(1-2), 135-139 (2003-03-08)
An in vitro experiment was conducted to test the ability of mixed rumen bacteria (B), protozoa (P), and their mixture (BP) to utilize the oxidized forms of methionine (Met) e.g., methionine sulfoxide (MSO), methionine sulfone (MSO(2)). Rumen contents were collected
Shuxin Liu et al.
Scientific reports, 7(1), 8150-8150 (2017-08-16)
Uremia has been a rapidly increasing health problem in China. Hemodialysis (HD) is the main renal replacement therapy for uremia. The results of large-scale clinical trials have shown that the HD pattern is crucial for long-term prognosis of maintenance hemodialysis
Y Mora et al.
Journal of general microbiology, 133(7), 1667-1674 (1987-07-01)
A glycine-resistant Neurospora crassa mutant (am-132;glyr), derived from the am-132 mutant, was isolated and characterized. [am-132 itself has a deletion in the structural gene for NADP-dependent glutamate dehydrogenase (GDH).] This new mutation also conferred resistance to serine and methionine sulphoximine
Shahlizah Sahul Hamid et al.
Planta, 249(6), 1921-1947 (2019-03-21)
Among seaweed groups, brown algae had characteristically high concentrations of mannitol, and green algae were characterised by fructose. In red algae, metabolite profiles of individual species should be evaluated. Seaweeds are metabolically different from terrestrial plants. However, general metabolite profiles
Tatsunori Nishimura et al.
Oncogene, 38(14), 2464-2481 (2018-12-12)
Tumor recurrence is attributable to cancer stem-like cells (CSCs), the metabolic mechanisms of which currently remain obscure. Here, we uncovered the critical role of folate-mediated one-carbon (1C) metabolism involving mitochondrial methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) and its downstream purine synthesis pathway.
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