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Showing 1-30 of 83 results for "M1778" within Papers
Alexandros Kosmidis-Papadimitriou et al.
Interface focus, 12(1), 20210044-20210044 (2021-12-28)
To evaluate the role of common substrates in the transmission of respiratory viruses, in particular SARS-CoV-2, uniformly distributed microdroplets (approx. 10 µm diameter) of artificial saliva were generated using an advanced inkjet printing technology to replicate the aerosol droplets and
Eleanor I Lamont et al.
Molecular oral microbiology, 36(1), 37-49 (2020-11-12)
Developing a laboratory model of oral polymicrobial communities is essential for in vitro studies of the transition from healthy to diseased oral plaque. SHI medium is an enriched growth medium capable of supporting in vitro biofilms with similar diversity to
Noha Nafee et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 125, 151-162 (2018-10-08)
With the non-selective vasodilating action, short half-life and first-pass metabolism of sildenafil (SC), local application in the lung for pulmonary arterial hypertension is of high demand. Although several nanosystems have been lately investigated, nanostructured lipid carriers (NLCs) give promises of
Paul Breen et al.
Infection and immunity, 89(9), e0015121-e0015121 (2021-06-08)
Zebrafish (Danio rerio) are an attractive model organism for a variety of scientific studies, including host-microbe interactions. The organism is particularly useful for the study of aquatic microbes that can colonize vertebrate hosts, including Vibrio cholerae, an intestinal pathogen. V.
Abiodun D Ogunniyi et al.
PloS one, 13(7), e0200195-e0200195 (2018-07-17)
There are very few articles in the literature describing continuous models of bacterial infections that mimic disease pathogenesis in humans and animals without using separate cohorts of animals at each stage of disease. In this work, we developed bioluminescent mouse
Nasir Ali et al.
PloS one, 15(12), e0242408-e0242408 (2020-12-15)
We sought to develop a smooth and low cost sample preparation and DNA extraction protocol, streamlined with a ready-to-use qPCR in a portable instrument to overcome some of the existing hurdles. Several solutions were evaluated as to their ability to
Leyuan Li et al.
Microbiome, 8(1), 33-33 (2020-03-13)
Human-targeted drugs may exert off-target effects or can be repurposed to modulate the gut microbiota. However, our understanding of such effects is limited due to a lack of rapid and scalable assay to comprehensively assess microbiome responses to drugs. Drugs
Sebastian Björklund et al.
The Review of scientific instruments, 86(5), 055105-055105 (2015-06-01)
A new method to determine water sorption-desorption isotherms with high resolution in the complete range of water activities (relative humidities) is presented. The method is based on quartz crystal microbalance with dissipation monitoring (QCM-D). The QCM-D is equipped with a
Leyuan Li et al.
Computational and structural biotechnology journal, 18, 3833-3842 (2020-12-19)
Resistant starches (RS) are dietary compounds processed by the gut microbiota into metabolites, such as butyrate, that are beneficial to the host. The production of butyrate by the microbiome appears to be affected by the plant source and type of
Lubov S Grigoryeva et al.
Bio-protocol, 11(5), e3933-e3933 (2021-04-03)
Legionella pneumophila, a Gram-negative bacterium and the causative agent of Legionnaires' disease, exports over 300 effector proteins/virulence factors, through its type II (T2SS) and type IV secretion systems (T4SS). One such T2SS virulence factor, ChiA, not only functions as a
Nina I Gabarayeva et al.
The Plant journal : for cell and molecular biology, 105(3), 736-753 (2020-11-07)
We aimed to understand the underlying mechanisms of development in the sporopollenin-containing part of the pollen wall, the exine, one of the most complex cell walls in plants. Our hypothesis is that distinct physical processes, phase separation and micellar self-assembly
Jasmim Leal et al.
Journal of controlled release : official journal of the Controlled Release Society, 322, 457-469 (2020-04-04)
Therapeutic delivery of drug and gene delivery systems have to traverse multiple biological barriers to achieve efficacy. Mucosal administration, such as pulmonary delivery in cystic fibrosis (CF) disease, remains a significant challenge due to concentrated viscoelastic mucus, which prevents drugs
Vieri Piazzini et al.
International journal of biological macromolecules, 129, 267-280 (2019-02-07)
The aim of the present study was the development of human serum albumin nanoparticles (HSA NPs) as nose-to-brain carrier. To strengthen, the efficacy of nanoparticles as drug delivery system, the influence of chitosan (CS) coating on the performance of HSA
René Stürmer et al.
Chembiochem : a European journal of chemical biology, 19(24), 2598-2608 (2018-10-30)
Mucous gels (mucus) cover internal body surfaces. The secretory mucins MUC5AC and MUC6 and the protective peptide TFF2 are characteristic constituents of gastric mucus; TFF2 is co-secreted with MUC6. Herein, we investigated two commercial mucin preparations by FPLC and proteomics
Keith A Rodvold et al.
Antimicrobial agents and chemotherapy, 53(8), 3294-3301 (2009-05-20)
Ceftobiprole is a cephalosporin with potent activity against methicillin (meticillin)-resistant Staphylococcus aureus (MRSA). In order to treat patients with severe staphylococcal pneumonia, it is important to understand the drug exposure required to mediate the killing of multiple log(10) cells in
Joanna Maria Radziwill-Bienkowska et al.
Applied microbiology and biotechnology, 100(22), 9605-9617 (2016-10-21)
Understanding the nature of mucus-microbe interactions will provide important information that can help to elucidate the mechanisms underlying probiotic adhesion. This study focused on the adhesive properties of the Lactococcus lactis subsp. cremoris IBB477 strain, previously shown to persist in
Bhushan J Toley et al.
The Analyst, 140(22), 7540-7549 (2015-09-24)
We present a method of rapid isothermal amplification of DNA without initial heat denaturation of the template, and methods and probes for (a) real-time fluorescence detection and (b) lateral flow detection of amplicons. Isothermal strand displacement amplification (iSDA) can achieve
L M Smit et al.
Muscle & nerve, 11(4), 337-348 (1988-04-01)
Two cases of a newly recognized myasthenic syndrome were investigated (CPSC syndrome). The course of the disease was observed for periods of 6 and 3 years. In infancy, exacerbations of the symptoms occurred during febrile illness, but thereafter the clinical
Robert W P Glowacki et al.
Cell host & microbe, 27(1), 79-92 (2020-01-07)
Efficient nutrient acquisition in the human gut is essential for microbial persistence. Although polysaccharides have been well-studied nutrients for the gut microbiome, other resources such as nucleic acids and nucleosides are less studied. We describe several ribose-utilization systems (RUSs) that
Andres F Zuluaga et al.
Journal of biomedical science, 22, 24-24 (2015-04-19)
Experimental models of pneumonia with penicillin non-susceptible Streptococcus pneumoniae (PNSSP) are hard to reproduce because the majority of strains with clinical relevance (like serotypes 6B, 9 V and 19 F) have low murine virulence. By optimization of culture and inoculum
Johnny X Huang et al.
Antimicrobial agents and chemotherapy, 59(10), 5925-5931 (2015-07-15)
Colistin has found increasing use in treating drug-resistant bacterial lung infections, but potential interactions with pulmonary biomolecules have not been investigated. We postulated that colistin, like aminoglycoside antibiotics, may bind to secretory mucin in sputum or epithelial mucin that lines
Yana Znamenskaya Falk et al.
The journal of physical chemistry. B, 122(30), 7539-7546 (2018-07-11)
In this work small-angle X-ray scattering (SAXS) was used to study hydration and temperature-induced changes of pig gastric mucin (PGM) within the entire concentration range. The scattering is interpreted as originating from PGM fiber-like structures that adopt rod-like bottle-brush conformation
Marcin Andrzej Kurek et al.
Journal of food science and technology, 55(5), 1632-1640 (2018-04-19)
In this study, some dietary fiber (DF) sources were investigated as fortifiers of wheat bread: oat (OB), flax (FB), and apple (AB). Adding oat and flax fibers to bread significantly changed the fatty acid profiles. OB was highest in oleic
Justine Guerin et al.
Colloids and surfaces. B, Biointerfaces, 167, 44-53 (2018-04-08)
Milk is the most popular matrix for the delivery of lactic acid bacteria, but little is known about how milk impacts bacterial functionality. Here, the adhesion mechanisms of Lactobacillus rhamnosus GG (LGG) surface mutants to a milk component, the milk
Joana Coimbra-Gomes et al.
Foods (Basel, Switzerland), 11(19) (2022-10-15)
Current market trends point at increasing demand for functional foods, namely those carrying probiotics. In the case of table olives, presence of probiotics would convey a competitive advantage to Mediterranean-based diets, already established for their cultural heritage and gastronomic character.
Vlad Dinu et al.
Scientific reports, 10(1), 960-960 (2020-01-24)
Vancomycin, a branched tricyclic glycosylated peptide antibiotic, is a last-line defence against serious infections caused by staphylococci, enterococci and other Gram-positive bacteria. Orally-administered vancomycin is the drug of choice to treat pseudomembranous enterocolitis in the gastrointestinal tract. However, the risk
Seth M Daly et al.
ACS infectious diseases, 4(5), 806-814 (2018-02-21)
The Burkholderia cepacia complex is a group of Gram-negative bacteria that are opportunistic pathogens in immunocompromised individuals, such as those with cystic fibrosis (CF) or chronic granulomatous disease (CGD). Burkholderia are intrinsically resistant to many antibiotics and the lack of
C P Chen et al.
Glycobiology, 8(1), 7-16 (1998-05-28)
The binding properties of Pseudomonas aeruginosa agglutinin-I (PA-IL) with glycoproteins (gps) and polysaccharides were studied by both the biotin/avidin-mediated microtiter plate lectin-binding assay and the inhibition of agglutinin-glycan interaction with sugar ligands. Among 36 glycans tested for binding, PA-IL reacted
Neïké Fernandez et al.
Frontiers in physiology, 9, 980-980 (2018-08-09)
Mucus is a major component of the intestinal barrier involved both in the protection of the host and the fitness of commensals of the gut. Streptococcus thermophilus is consumed world-wide in fermented dairy products and is also recognized as a
Leyuan Li et al.
Journal of proteome research, 17(1), 154-163 (2017-11-14)
In vitro culture based approaches are time- and cost-effective solutions for rapidly evaluating the effects of drugs or natural compounds against microbiomes. The nutritional composition of the culture medium is an important determinant for effectively maintaining the gut microbiome in
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