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Showing 1-30 of 214 results for "M3536" within Papers
E Kieslichova et al.
Transplantation proceedings, 45(2), 770-777 (2013-03-19)
The diagnosis of sepsis is difficult in immunocompromised patients owing to their modified response to infection. Our experiment in minipigs was designed to compare responses to sepsis between experimental groups of septic minipigs with and without immunosuppression. Minipigs with identical
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Anne-Catherine Feutz et al.
Archives of toxicology, 93(8), 2375-2384 (2019-08-12)
The poor correlation of developmental toxicity studies in animals with human outcome data has emphasized the need for complementary assays based on human cells and tissues. As neural tube defects represent an important proportion of congenital malformations, we evaluated here
Matthew D Pauly et al.
Journal of virology, 89(7), 3584-3597 (2015-01-16)
Lethal mutagenesis is a broad-spectrum antiviral strategy that exploits the high mutation rate and low mutational tolerance of many RNA viruses. This approach uses mutagenic drugs to increase viral mutation rates and burden viral populations with mutations that reduce the
Sara Rostas et al.
Progress in transplantation (Aliso Viejo, Calif.), 24(1), 33-36 (2014-03-07)
To review risks associated with mycophenolic acid (MPA) preparations and evaluate their required risk evaluation and mitigation strategies (REMS) elements. Articles were identified through a non-date-limited MEDLINE and EMBASE search using the terms fetal toxicity, teratogenicity, risk evaluation and mitigation
Yutaka Kimura et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(5), 759-768 (2014-03-08)
We established a luciferase reporter assay system, the Multi-ImmunoTox Assay (MITA), to evaluate the effects on key predictivein vitro components of the human immune system. The system is composed of 3 stable reporter cell lines transfected with 3 luciferase genes
Chang-Kwon Oh et al.
Transplantation, 99(1), 180-186 (2014-07-02)
Everolimus and cyclosporine A (CsA) exhibit synergistic immunosuppressive activity when used in combination. We examined the safety and efficacy of the use of everolimus with a cyclosporine-sparing strategy in de novo renal transplant recipients. A comparative, parallel, randomized, open-label 1-year
Muhammad Qasim et al.
Experimental cell research, 322(2), 277-289 (2014-02-11)
Gastrointestinal toxicity is a common adverse effect of mycophenolic acid (MPA) treatment in organ transplant patients, through poorly understood mechanisms. Phosphorylation of myosin light chain 2 (MLC2) is associated with epithelial tight junction (TJ) modulation which leads to defective epithelial
Hickam's dictum in a patient with diarrhea.
Joseph D Feuerstein et al.
Gastroenterology, 145(5), 942-942 (2013-09-28)
Sule Unal et al.
Pediatric blood & cancer, 61(5), 928-930 (2013-12-07)
Myasthenia gravis is among the rare complications after allogeneic hematopoietic stem cell transplantation and is usually associated with chronic GVHD. Herein, we report a 2-year and 10 months of age female with Griscelli syndrome, who developed severe myasthenia gravis at
Sébastien Storck et al.
Biology of the cell, 101(3), 153-167 (2008-07-22)
Nucleolin is a major nucleolar protein which is highly expressed in rapidly dividing cells and cancer cell lines. This protein is claimed to be multifunctional and could play a role in rRNA (ribosomal RNA) synthesis, as well as in cell
Wolfgang Arns et al.
Clinical nephrology, 79(6), 421-431 (2013-04-25)
In a 6-month prospective, openlabel, multicenter study, 128 de novo kidney transplant patients receiving cyclosporine (CsA) and steroids were randomized to an intensified regimen of enteric-coated mycophenolate sodium (EC-MPS) or to a standard EC-MPS regimen to Week 6 posttransplant, after
Carter W Daniels et al.
Behavioural brain research, 283, 238-250 (2015-02-01)
This paper reviews the evidence for nicotine-induced acceleration of the internal clock when timing in the seconds-to-minutes timescale, and proposes an alternative explanation to this evidence: that nicotine reduces the threshold for responses that result in more reinforcement. These two
Sifei Han et al.
Pharmaceutical research, 32(5), 1830-1844 (2014-12-03)
Recent studies have demonstrated the potential for a triglyceride (TG) mimetic prodrug to promote the delivery of mycophenolic acid (MPA) to the lymphatic system. Here, the metabolic pathways that facilitate the lymphatic transport of the TG prodrug (1,3-dipalmitoyl-2-mycophenoloyl glycerol, 2-MPA-TG)
Yonghong Ding et al.
Neurochemical research, 40(11), 2252-2261 (2015-09-21)
Previously, we reported that nicotine withdrawal (NT) significantly increased pain sensitivity in rats. Recent reports suggest that fractalkine is involved in the spinal cord neuron-to-microglia activation via CX3CR1 signaling. However, its contribution to NT-induced hyperalgesia and the underlying mechanisms have
Fawzy A Elbarbry et al.
Clinical biochemistry, 40(11), 752-764 (2007-05-08)
Mycophenolic acid, the active metabolite of the prodrug mycophenolate mofetil, is widely used as an immunosuppressive agent in transplant patients for the prophylaxis of acute rejection. Recent prospective trials suggested the need for therapeutic drug monitoring, which raises the necessity
Ying Li et al.
PLoS computational biology, 11(2), e1004086-e1004086 (2015-02-26)
Metabolism is the major output of the circadian clock in many organisms. We developed a computational method to integrate both circadian gene expression and metabolic network. Applying this method to zebrafish circadian transcriptome, we have identified large clusters of metabolic
Deshka Doycheva et al.
The British journal of ophthalmology, 99(1), 87-91 (2014-07-26)
To assess the long-term efficacy and tolerability of both derivatives of mycophenolic acid, mycophenolate mofetil (MMF) and mycophenolate sodium (MPS), in the therapy of patients with birdshot chorioretinopathy (BSCR). Retrospective analysis of 24 patients (48 eyes) with BSCR, treated with
Azza A K El-Sheikh et al.
Translational research : the journal of laboratory and clinical medicine, 164(1), 46-56 (2014-02-04)
Mycophenolic acid (MPA) is an immunosuppressant used in transplant rejection, often in combination with cyclosporine (CsA) and tacrolimus (Tac). The drug is cleared predominantly via the kidneys, and 95% of the administered dose appears in urine as 7-hydroxy mycophenolic acid
Burkhard Tönshoff et al.
Transplantation reviews (Orlando, Fla.), 25(2), 78-89 (2011-04-02)
Mycophenolate mofetil (MMF) is widely used for maintenance immunosuppressive therapy in pediatric renal and heart transplant recipients. Children undergo developmental changes (ontogeny) of drug disposition, which may affect drug metabolism of the active compound mycophenolic acid (MPA). Therefore, a detailed
Use of mycophenolic acid in non-transplant renal diseases.
Patricia M Stassen et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 22(4), 1013-1019 (2007-02-20)
Bhadran Bose et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 63(4), 667-676 (2013-12-18)
Management of patients with lupus nephritis can be complex and challenging. We suggest that there are some widely held misconceptions about lupus, and unfortunately, these underpin the treatment of many patients. There is little evidence to support the common assumption
Liqiang Chen et al.
Journal of medicinal chemistry, 50(23), 5743-5751 (2007-10-26)
Novel tiazofurin adenine dinucleotide (TAD) analogues 25-33 containing a substituent at C2 of the adenine ring have been synthesized as inhibitors of the two isoforms of human IMP-dehydrogenase. The 2-ethyl TAD analogue 33 [Ki = 1 nM (type I), Ki
Anahita Adeli et al.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 26(3), 161-166 (2013-10-01)
Many patients with systemic lupus erythematosus have central nervous system involvement. Routine diagnostic studies may not yield evidence of neuropsychiatric dysfunction and are therefore not useful as objective measures to monitor treatment response. We present a case of a 64-year-old
Christopher J Yates et al.
Transplantation, 96(8), 726-731 (2013-08-02)
The sensitivity of fasting plasma glucose (FPG) in screening for new-onset diabetes after transplantation (NODAT) has been questioned, particularly in the presence of moderate-dose prednisolone, where peak plasma glucose occurs 7 to 8 hr after administration. Oral glucose tolerance testing
M A Alba et al.
Clinical and experimental rheumatology, 31(1 Suppl 75), S74-S83 (2013-07-24)
Granulomatosis with polyangiitis and microscopic polyangiitis are two autoimmune diseases characterised by necrotising small-vessel vasculitis and presence of antineutrophil cytoplasm autoantibodies (ANCA). Current immunosuppressive regimes that combine cyclophosphamide and glucocorticoids have dramatically improved the outcome for these patients. However, these
William J Watkins et al.
Bioorganic & medicinal chemistry letters, 16(13), 3479-3483 (2006-04-20)
The design, synthesis, and IMPDH inhibitory activity of a series of phosphonic acid-containing analogues of mycophenolic acid are described.
CMV sinusitis in a HIV-negative renal transplant recipient.
Anuksha Gujadhur et al.
Transplantation, 97(9), e55-e57 (2014-05-16)
Neal M Davies et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 22(9), 2440-2448 (2007-06-15)
Patient and graft survival following renal transplantation have improved markedly over the past decade, meaning that physician attention has turned more towards minimizing short- and long-term toxicities associated with immunosuppressive regimens. Gastrointestinal (GI) adverse events are common following renal transplantation
The medicinal chemistry of dengue fever.
Andrew J Stevens et al.
Journal of medicinal chemistry, 52(24), 7911-7926 (2009-09-11)
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