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Showing 1-30 of 53 results for "M3821" within Papers
Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase.
Erickson AK, et al.
The Journal of Biological Chemistry, 265, 19728-19735 (1990)
Brett W Stringer et al.
Scientific reports, 9(1), 4902-4902 (2019-03-22)
Low-passage, serum-free cell lines cultured from patient tumour tissue are the gold-standard for preclinical studies and cellular investigations of glioblastoma (GBM) biology, yet entrenched, poorly-representative cell line models are still widely used, compromising the significance of much GBM research. We
Deepak Prasad Gupta et al.
Molecular brain, 16(1), 1-1 (2023-01-03)
Knee osteoarthritis (OA) is characterized by knee cartilage degeneration and secondary bone hyperplasia, resulting in pain, stiffness, and gait disturbance. The relationship between knee OA and neurodegenerative diseases is still unclear. This study used an Alzheimer's disease (AD) mouse model
Min Jin et al.
Journal of cellular and molecular medicine, 23(2), 1470-1485 (2018-12-18)
Focal inflammation and remyelination failure are major hallmarks of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). In this study, we found that leonurine, a bioactive alkaloid, alleviated EAE disease severity along with reduced central nervous system inflammation
Luc Joyeux et al.
Scientific reports, 9(1), 9327-9327 (2019-06-30)
A randomized trial demonstrated that fetal spina bifida (SB) repair is safe and effective yet invasive. New less invasive techniques are proposed but are not supported by adequate experimental studies. A validated animal model is needed to bridge the translational
Hozo Matsuoka et al.
International journal of molecular sciences, 19(5) (2018-05-08)
Ultra-fine bubbles (<200 nm in diameter) have several unique properties and have been tested in various medical fields. The purpose of this study was to investigate the effects of oxygen ultra-fine bubbles (OUBs) on a sciatic nerve crush injury (SNC)
Francisco J Rivera et al.
Glia, 67(8), 1510-1525 (2019-05-01)
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that leads to severe neurological deficits. Due to their immunomodulatory and neuroprotective activities and their ability to promote the generation of oligodendrocytes, mesenchymal stem cells (MSCs) are
Kelly Ceyzériat et al.
Acta neuropathologica communications, 6(1), 104-104 (2018-10-17)
Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions such as Alzheimer's disease. However, the specific role of reactive astrocytes is still debated. This controversy may stem from the fact that most strategies used to modulate astrocyte reactivity and
Aleksandar Stojic et al.
Glia, 67(3), 512-524 (2018-12-24)
Optic neuritis is a common manifestation of multiple sclerosis, an inflammatory demyelinating disease of the CNS. Although it is the presenting symptom in many cases, the initial events are currently unknown. However, in the earliest stages of autoimmune optic neuritis
Gyun Jee Song et al.
Glia, 68(9), 1794-1809 (2020-02-23)
Finding causative genetic mutations is important in the diagnosis and treatment of hereditary peripheral neuropathies. This study was conducted to find new genes involved in the pathophysiology of hereditary peripheral neuropathy. We identified a new mutation in the EBP50 gene
Hugo Peluffo et al.
Journal of neuroinflammation, 12, 145-145 (2015-08-12)
It has recently become evident that activating/inhibitory cell surface immune receptors play a critical role in regulating immune and inflammatory processes in the central nervous system (CNS). The immunoreceptor CD300f expressed on monocytes, neutrophils, and mast cells modulates inflammation, phagocytosis
Bryan W Day et al.
Cancer cell, 23(2), 238-248 (2013-02-16)
Significant endeavor has been applied to identify functional therapeutic targets in glioblastoma (GBM) to halt the growth of this aggressive cancer. We show that the receptor tyrosine kinase EphA3 is frequently overexpressed in GBM and, in particular, in the most
Susan H Brunssen et al.
Brain, behavior, and immunity, 27(1), 42-53 (2012-09-19)
Adverse neurodevelopmental outcomes are linked to perinatal production of inflammatory mediators, including interleukin 6 (IL-6). While a pivotal role for maternal elevation in IL-6 has been established in determining neurobehavioral outcomes in the offspring and considered the primary target mediating
Alejandra Catenaccio et al.
Cell death & disease, 8(11), e3166-e3166 (2017-11-10)
Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells
The Axonal Guidance Cue Semaphorin 3C Contributes to Alveolar Growth and Repair
Vadivel A, et al.
PLoS ONE, 8 (2013)
Fangjun Wang et al.
Proteomics, 13(8), 1292-1305 (2013-01-22)
Sustained exposure to soluble amyloid β (Aβ42 ) oligomers is predicted to impair synaptic function in the hippocampal-entorhinal circuit, signaling synaptic loss and precipitating cognitive impairment in Alzheimer's disease. Regional changes in overall patterns of protein phosphorylation are likely crucial
Kira Kleszka et al.
Scientific reports, 10(1), 19146-19146 (2020-11-07)
Sufficient tissue oxygenation is required for regular brain function; thus oxygen supply must be tightly regulated to avoid hypoxia and irreversible cell damage. If hypoxia occurs the transcription factor complex hypoxia-inducible factor (HIF) will accumulate and coordinate adaptation of cells
Maritza Oñate et al.
Scientific reports, 6, 21709-21709 (2016-02-26)
Although protein-folding stress at the endoplasmic reticulum (ER) is emerging as a driver of neuronal dysfunction in models of spinal cord injury and neurodegeneration, the contribution of this pathway to peripheral nerve damage remains poorly explored. Here we targeted the
Johannes Völker et al.
Stem cells international, 2019, 5831240-5831240 (2019-11-30)
The inferior colliculus (IC) is a nucleus of the auditory pathway and its fourth relay station. It integrates afferent information from the superior olivary complex and the cochlear nucleus. To date, no causal therapeutic options are known for damaged neuronal
Methylcobalamin promotes the differentiation of Schwann cells and remyelination in lysophosphatidylcholine-induced demyelination of the rat sciatic nerve.
Nishimoto S, et al.
Frontiers in Cellular Neuroscience (2015)
Yuan Zhou et al.
Neuropsychiatric disease and treatment, 14, 2401-2413 (2018-10-03)
Spinal cord injury (SCI) has imposed a great impact on the quality of life of patients due to its relatively young age of onset. The pathophysiology of SCI has been proven to be complicated. Microglia plays an important role in
Brashket Seth et al.
Neurotoxicology, 70, 161-179 (2018-11-25)
During the mammalian brain development, oligodendrocyte progenitor cells (OPCs) are generated from neuroepithelium and migrate throughout the brain. Myelination is a tightly regulated process which involves time framed sequential events of OPCs proliferation, migration, differentiation and interaction with axons for
Christopher S Lacko et al.
Journal of neural engineering, 17(1), 016057-016057 (2019-10-03)
Hydrogel scaffolds hold promise for a myriad of tissue engineering applications, but often lack tissue-mimetic architecture. Therefore, in this work, we sought to develop a new technology for the incorporation of aligned tubular architecture within hydrogel scaffolds engineered from the
Pavlo G Gritsenko et al.
Nature cell biology, 22(1), 97-107 (2020-01-08)
Diffuse brain infiltration by glioma cells causes detrimental disease progression, but its multicellular coordination is poorly understood. We show here that glioma cells infiltrate the brain collectively as multicellular networks. Contacts between moving glioma cells are adaptive epithelial-like or filamentous
Yuanfeng Zhang et al.
Frontiers in neuroanatomy, 11, 53-53 (2017-07-21)
Oligodendrocyte precursor cells (OPC), neurons and astrocytes share a neural progenitor cell (NPC) in the early ventricular zone (VZ) of the embryonic neuroepithelium. Both switch to produce either of the three cell types and the generation of the right number
C M Deber et al.
Clinical biochemistry, 24(2), 113-134 (1991-04-01)
Multiple sclerosis (MS) and a number of related distinctive diseases are characterized by the active degradation of central nervous system (CNS) myelin, an axonal sheath comprised essentially of proteins and lipids. These demyelinating diseases appear to arise from complex interactions
Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections.
Ding Y, et al.
PLoS ONE, 9 (2014)
H Inouye et al.
Journal of neuroscience research, 28(1), 1-17 (1991-01-01)
To explain how the myelin proteins are involved in the organization and function of the myelin sheath requires knowing their molecular structures. Except for P2 basic protein of PNS myelin, however, their structures are not yet known. As an aid
Rodrigo López-Leal et al.
Journal of cell science, 133(12) (2020-05-16)
Functional recovery after peripheral nerve damage is dependent on the reprogramming of differentiated Schwann cells (dSCs) into repair Schwann cells (rSCs), which promotes axonal regeneration and tissue homeostasis. Transition into a repair phenotype requires expression of c-Jun and Sox2, which
Yun Xiu et al.
Journal of neuroscience research, 95(8), 1677-1689 (2016-12-10)
It is now accepted that white matter abnormalities play an important role in demyelinating diseases and a wide range of psychiatric disorders. Experimental demyelination (especially induced by cuprizone) has been investigated extensively. However, details regarding demyelination and ultrastructural changes of
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